Tyrosine phosphorylation / dephosphorylation balance is involved in thrombin-evoked microtubular reorganisation in human platelets.

abstract：:Hyperglycaemia impairs fibrinolytic activity on the surface of endothelial cells, but the underlying mechanisms are not fully understood. In this study, we tested the hypothesis that hyperglycaemia causes dysfunction of the endothelial membrane protein annexin A2, thereby leading to an overall reduction of fibrinolyti...

journal_title：Thrombosis and haemostasis

authors： Dai H,Yu Z,Fan X,Liu N,Yan M,Chen Z,Lo EH,Hajjar KA,Wang X

更新日期：2013-06-01 00:00:00

abstract：:We examined the effect of a synthetic thrombin inhibitor, MCI-9038, on two experimental animal models of disseminated intravascular coagulation (DIC). In a model that DIC induced by the intravenous infusion of thrombin, MCI-9038 suppressed the decrease of platelet count by about 50% at a dose of 0.2 micrograms/kg/min ...

journal_title：Thrombosis and haemostasis

authors： Hara H,Tamao Y,Kikumoto R,Okamoto S

更新日期：1987-04-07 00:00:00

abstract：:The core protein components of the plasminogen activator (PA) system are two plasminogen activators, two plasminogen activator inhibitors and a urokinase type plasminogen activator-specific cell surface receptor. Various types of biological regulation are exerted through the interplay of these components mutually and ...

journal_title：Thrombosis and haemostasis

authors： Nagamine Y,Medcalf RL,Muñoz-Cánoves P

更新日期：2005-04-01 00:00:00

abstract：:Microvascular endothelial damage underlies the pathological changes in haemorrhagic colitis and the haemolytic uraemic syndrome (HUS) caused by enterohaemorrhagic Escherichia coli (EHEC). Shiga toxins (Stxs) are presently the best characterised EHEC virulence factors that can cause the microvascular endothelium injury...

journal_title：Thrombosis and haemostasis

authors： Bielaszewska M,Karch H

更新日期：2005-08-01 00:00:00

abstract：:The role of circulating microparticles (MP) of different origin and tissue factor (TF)-bearing in overweight and obese patients with and without metabolic syndrome is still a matter of debate. In a case-control study, the presence of hypercoagulability was evaluated in overweight and obese patients by measuring MP, th...

journal_title：Thrombosis and haemostasis

authors： Campello E,Zabeo E,Radu CM,Spiezia L,Gavasso S,Fadin M,Woodhams B,Vettor R,Simioni P

更新日期：2015-01-01 00:00:00

abstract：:Carboxypeptidase U (CPU, EC 3.4.17.20) is a recently described basic carboxypeptidase which circulates in plasma as the zymogen procarboxypeptidase U (proCPU). In the current study, we report on the presence of the proCPU/CPU system in different mammalian species--pig, guinea pig, dog, mouse, rabbit, rat and human. Th...

journal_title：Thrombosis and haemostasis

authors： Schatteman KA,Goossens FJ,Scharpé SS,Hendriks DF

更新日期：1999-12-01 00:00:00

abstract：:Omega-3 fatty acids (n-3 FA) may reduce atherogenesis and thrombosis. We investigated the effects of n-3 FAs on procoagulant activity and cytokine expression in whole blood cultures from patients with atherosclerosis. Eleven of the 23 included patients had received 5.1 g n-3 FA daily for 6 months (group I) whereas 12 ...

journal_title：Thrombosis and haemostasis

authors： Seljeflot I,Johansen O,Arnesen H,Eggesbø JB,Westvik AB,Kierulf P

更新日期：1999-04-01 00:00:00

abstract：:The availability of mice with tissue-specific expression of recombinase Cre is the limiting step for a successful gene targeting by the Cre-LoxP methodology. This work aimed at generating transgenic mice with restricted expression of recombinase Cre in megakaryocytes and platelets, driven by the promoter of the αIIb g...

journal_title：Thrombosis and haemostasis

authors： Nowakowski A,Alonso-Martín S,Arias-Salgado EG,Fernández D,Vilar M,Ayuso MS,Parrilla R

更新日期：2011-01-01 00:00:00

abstract：:The interaction of beta 2-glycoprotein-I (beta 2-G-I), a plasma constituent of unknown function, with blood platelets was studied. The following results were obtained: 1) beta 2-G-I binds to washed human platelets isolated by centrifugation (WP) at one kind of specific, saturable binding sites. The dissociation consta...

journal_title：Thrombosis and haemostasis

authors： Nimpf J,Wurm H,Kostner GM

更新日期：1985-08-30 00:00:00

abstract：:Abdominal aortic aneurysm (AAA) evolution is unpredictable, and there is no therapy except surgery for patients with an aortic size> 5 cm (large AAA). We aimed to identify new potential biomarkers that could facilitate prognosis and treatment of patients with AAA. A differential quantitative proteomic analysis of plas...

journal_title：Thrombosis and haemostasis

authors： Burillo E,Lindholt JS,Molina-Sánchez P,Jorge I,Martinez-Pinna R,Blanco-Colio LM,Tarin C,Torres-Fonseca MM,Esteban M,Laustsen J,Ramos-Mozo P,Calvo E,Lopez JA,Vega de Ceniga M,Michel JB,Egido J,Andrés V,Vazquéz J,Meilha

更新日期：2015-06-01 00:00:00

abstract：BACKGROUND: This study assessed changes in anticoagulation therapy over time in patients with atrial fibrillation (AF). METHODS: Analyses were performed on a claims-based dataset of 4 million health-insured individuals. The study population consisted of patients newly initiating a non-vitamin-K oral anticoagulants (NO...

journal_title：Thrombosis and haemostasis

authors： Hohnloser SH,Basic E,Nabauer M

更新日期：2019-06-01 00:00:00

abstract：:The effect of negatively-charged polymers, used in some artificial devices, on plasma clotting and kinin systems was studied in vitro using polyelectrolyte complexes. Contact activation was observed as an immediate, transient and surface-dependent phenomenon. After incubation of the plasma with the polymer a small dec...

journal_title：Thrombosis and haemostasis

authors： Boffa MC,Dreyer B,Pusineri C

更新日期：1984-02-28 00:00:00

abstract：:The role of platelets in regulating vascular homeostasis has expanded beyond mediation of haemostasis and thrombosis. The discovery of platelet RNA and the presence of subpopulations of platelets containing varying amounts of RNA suggest a role for platelet transcripts in vascular function. As the RNA in anucleated pl...

journal_title：Thrombosis and haemostasis

authors： Clancy L,Beaulieu LM,Tanriverdi K,Freedman JE

更新日期：2017-05-03 00:00:00

abstract：:In order to detect impaired synthesis of blood coagulation factors associated to consumption coagulopathy, a simultaneous evaluation of factor II-related antigen (II rAg) and of antithrombin III (AT III) was carried out in 16 patients affected with severe defibrination. An in vitro preliminary study on plasma and seru...

journal_title：Thrombosis and haemostasis

authors： Sié P,Letrenne E,Caranobe C,Genestal M,Cathala B,Boneu B

更新日期：1982-06-28 00:00:00

abstract：:The cloning of the cDNA encoding von Willebrand factor (vWF) has revealed that it is synthesized as a large precursor (pre-pro-vWF) molecule and it is now clear that the prosequence or vWAgII is responsible for the intracellular multimerization of vWF. We have cloned the complete vWF cDNA and expressed it using a reco...

journal_title：Thrombosis and haemostasis

authors： Meulien P,Nishino M,Mazurier C,Dott K,Piétu G,Jorieux S,Pavirani A,Girma JP,Oufkir D,Courtney M

更新日期：1992-01-23 00:00:00

abstract：:Injection of human alpha 2-antiplasmin resulted in delayed elimination of fibrin from the lungs in rats with thrombin-induced intravascular coagulation. The amount of alpha 2-antiplasmin injected was chosen so as to simulate the posttraumatic increase of this inhibitor in man. By injecting trace amounts only of radiol...

journal_title：Thrombosis and haemostasis

authors： Carlin G,Einarsson M,Saldeen T

更新日期：1981-12-23 00:00:00

abstract：:The binding properties of purified bovine fibrinogen to bovine aortic endothelial cells have been examined in a tissue culture system. Endothelial cells bound 125I-fibrinogen in a calcium dependent fashion. Removal of calcium by EDTA instantaneously detached most of the cell-associated fibrinogen. Binding of fibrinoge...

journal_title：Thrombosis and haemostasis

authors： Delvos U,Preissner KT,Müller-Berghaus G

更新日期：1985-02-18 00:00:00

abstract：:Platelets and coagulation are involved in bacterial colonisation of the host. Streptocococcus pneumoniae (pneumococcus) are important etiologic agents of respiratory tract infections in humans. The formation of pneumococci-platelet associations may facilitate haematogenous dissemination of pneumococci by providing an ...

journal_title：Thrombosis and haemostasis

authors： Niemann S,Kehrel BE,Heilmann C,Rennemeier C,Peters G,Hammerschmidt S

更新日期：2009-10-01 00:00:00

abstract：:Thrombus formation is recognized pathologically in the affected arteries and is supposed to play a major role in the pathogenesis of Takayasu's arteritis; however, hemostatic conditions in this disorder have not been elucidated fully. We determined plasma levels of molecular markers for platelet activity (platelet fac...

journal_title：Thrombosis and haemostasis

authors： Akazawa H,Ikeda U,Yamamoto K,Kuroda T,Shimada K

更新日期：1996-05-01 00:00:00

abstract：:An increased prevalence of hypertension is reported in haemophilia patients, but data from large, unbiased studies are lacking. The aim of our study was to cross-sectionally assess the prevalence of hypertension in a large cohort of 701 haemophilia patients. Blood pressure (BP) measurements performed in 386 Dutch and ...

journal_title：Thrombosis and haemostasis

authors： Fransen van de Putte DE,Fischer K,Makris M,Tait RC,Collins PW,Meijer K,Roosendaal G,Chowdary P,Schutgens RE,Mauser-Bunschoten EP

更新日期：2012-10-01 00:00:00

abstract：: ...

journal_title：Thrombosis and haemostasis

authors： Botney MJ,Swanson AL,Shuman MN

更新日期：1979-07-01 00:00:00

abstract：:The measurement of platelet deposition in human thrombi is essential for the evaluation of platelet-inhibitory drugs and prosthetic materials for use in patients. The rate of 111Indium-labelled platelet accumulation on Dacron arterial grafts was measured in 27 patients randomised to take either aspirin and dipyridamol...

journal_title：Thrombosis and haemostasis

authors： Norcott HC,Goldman M,Hawker RJ,Rafiqi EI,Drolc Z,McCollum CN

更新日期：1982-12-27 00:00:00

abstract：:To understand the role of the factor X (fX) activation peptide (AP), a deletion mutagenesis approach was employed. Two single-chain, variant enzymes were generated in which 41 residues were deleted from the AP: fX (des-137-183) and fX(des-137-183;N191A), which lacks a carbohydrate moiety at Asn191 due to an alanine su...

journal_title：Thrombosis and haemostasis

authors： Rudolph AE,Mullane MP,Porche-Sorbet R,Daust HA,Miletich JP

更新日期：2002-11-01 00:00:00

abstract：:Clot retraction is an essential step during primary haemostasis, thereby promoting thrombus stability and wound healing. Integrin αIIbβ3 plays a critical role in clot retraction, by inducing acto-myosin interactions that allow platelet cytoskeleton reorganisation. However, the signalling pathways that lead to clot ret...

journal_title：Thrombosis and haemostasis

authors： Egot M,Kauskot A,Lasne D,Gaussem P,Bachelot-Loza C

更新日期：2013-12-01 00:00:00

abstract：:The fibrin-specificity and procoagulant effects of recombinant staphylokinase (Sak42D) were compared with those of recombinant tissue-type plasminogen activator (rt-PA) in patients with acute myocardial infarction. Plasma samples were obtained at baseline and at 25 and 90 min, from 24 patients who were randomly assign...

journal_title：Thrombosis and haemostasis

authors： Okada K,Lijnen HR,Moreau H,Vanderschueren S,Collen D

更新日期：1996-12-01 00:00:00

abstract：:Human endothelial cells isolated from umbilical cords were solubilized in Triton X-100 and examined by crossed immunoelectrophoresis using rabbit antiserum against endothelial cells. Endogenous labelling of the endothelial cell proteins with 14C-mannose followed by crossed immunoelectrophoresis and autoradiography rev...

journal_title：Thrombosis and haemostasis

authors： Børsum T

更新日期：1990-04-12 00:00:00

abstract：:Among the nine ellagitannins, rugosin E was the most potent platelet aggregating agent with an EC50 of 1.5 +/- 0.1 microM in rabbit platelets and 3.2 +/- 0.1 microM in human platelets. The aggregations caused by rugosin E and ADP were inhibited by EGTA, PGE1, mepacrine, sodium nitroprusside and neomycin, but not by in...

journal_title：Thrombosis and haemostasis

authors： Teng CM,Kang YF,Chang YL,Ko FN,Yang SC,Hsu FL

更新日期：1997-03-01 00:00:00

abstract：:Recent prospective studies indicate endothelial dysfunction and increased risk for cardiovascular events in patients with serological evidence of multiple infections. Soluble CD14 (sCD 14) plays a key role in the neutralization of lipopolysaccharide (LPS), a well-established bacterial product inducing endothelial dysf...

journal_title：Thrombosis and haemostasis

authors： Fernández-Real JM,López-Bermejo A,Castro A,Broch M,Peñarroja G,Vendrell J,Vázquez G,Ricart W

更新日期：2005-09-01 00:00:00

abstract：:High heparin cofactor II (HCII) activity has recently been described to protect from coronary instent restenosis, presumably by inactivating thrombin in injured arteries. In this study, we investigated the association of HCII activity and restenosis after femoropopliteal stenting. We studied 63 consecutive patients wi...

journal_title：Thrombosis and haemostasis

authors： Schillinger M,Exner M,Sabeti S,Mlekusch W,Amighi J,Handler S,Quehenberger P,Kalifeh N,Wagner O,Minar E

更新日期：2004-11-01 00:00:00

abstract：:Plasma levels of D-dimer have been found useful as a marker of deep venous thrombosis in those patients in whom thrombosis is suspected, but their usefulness in postoperative screening is less clear. We have investigated the relationship of D-dimer to deep venous thrombosis in 90 patients after total hip and knee arth...

journal_title：Thrombosis and haemostasis

authors： Dunn ID,Hui AC,Triffitt PD,Crozier AE,Gregg PJ,Sinclair ME,Armstrong AL,Mitchell VE

更新日期：1994-11-01 00:00:00