Delayed elimination of fibrin from the lungs in rats given alpha 2-antiplasmin.

Abstract:

:Injection of human alpha 2-antiplasmin resulted in delayed elimination of fibrin from the lungs in rats with thrombin-induced intravascular coagulation. The amount of alpha 2-antiplasmin injected was chosen so as to simulate the posttraumatic increase of this inhibitor in man. By injecting trace amounts only of radiolabelled alpha 2- antiplasmin a specific uptake of this protein in the lungs was noted after the thrombin-induced coagulation. The results may indicate that the posttraumatic increase in alpha 2-antiplasmin is of significance for the delayed elimination of fibrin seen in patients following trauma.

journal_name

Thromb Haemost

authors

Carlin G,Einarsson M,Saldeen T

subject

Has Abstract

pub_date

1981-12-23 00:00:00

pages

757-8

issue

4

eissn

0340-6245

issn

2567-689X

journal_volume

46

pub_type

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