Low levels of the anticoagulant activity of protein C in patients with chronic renal insufficiency: an inhibitor of protein C is present in uremic plasma.

Abstract:

:Twenty-nine of 54 uremic patients had low levels of protein C measured as anticoagulant activity, contrasting with normal levels measured as amidolytic activity or antigenic concentration. We demonstrate that this discrepancy is due to the presence of a soluble plasma inhibitor that interferes specifically with the anticoagulant activity of activated protein C. The inhibitor does not interfere with other coagulation assays. It is resistant to diisopropylfluorophosphate, high temperatures and repeated freezing and thawing. It can be dissociated from protein C by anti-protein C antibodies or by dialysis in vitro and in vivo. It binds to positively charged resins and can be eluted with high salt concentrations without losing its inhibitory capacity. The inhibitory effect is correlated with plasma creatinine levels and fluctuates with time.

journal_name

Thromb Haemost

authors

Faioni EM,Franchi F,Krachmalnicoff A,Valsecchi C,Viganò GL,Remuzzi G,Mannucci PM

subject

Has Abstract

pub_date

1991-10-01 00:00:00

pages

420-5

issue

4

eissn

0340-6245

issn

2567-689X

journal_volume

66

pub_type

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