The influence of thrombin on the platelet-aggregating activity of human factor VIII. A study with insolubilized thrombin.

abstract：:We have recently demonstrated that the proinflammatory cytokine, interleukin-6 (IL-6), could upregulate the production of protein S in the human hepatoma cell line, HepG-2, but not in endothelial cells. In this study, we have demonstrated that the combination of exogenous IL-6 and soluble IL-6 receptor (sIL-6R) could ...

journal_title：Thrombosis and haemostasis

authors： Hooper WC,Phillips DJ,Evatt BL

更新日期：1997-05-01 00:00:00

abstract：:Patients with diabetes display increased platelet activation. Recent data show a markedly increased risk for cardiovascular events already in pre-diabetic individuals with impaired glucose tolerance (IGT). We investigated whether IGT is associated with platelet activation. Blood samples were collected from young lean ...

journal_title：Thrombosis and haemostasis

authors： Schäfer A,Widder J,Eigenthaler M,Bischoff H,Ertl G,Bauersachs J

更新日期：2004-07-01 00:00:00

abstract：:In this review the interaction between invasive human pathogens expressing plasmin(ogen) receptors and/or producing plasminogen activators with the human plasmin(ogen) system is described. Evidence is presented for multiple mechanisms by which human pathogens can acquire a surface bound form of plasmin that cannot be ...

journal_title：Thrombosis and haemostasis

authors： Boyle MD,Lottenberg R

更新日期：1997-01-01 00:00:00

abstract：:The fibrinolytic capacity of 121 patients with a history of venous thrombosis and/or pulmonary embolism was studied by venous occlusion technique, at earliest 3 months after the last thromboembolic episode. After discontinuation of oral anticoagulation treatment the clinical course of the patients was followed and new...

journal_title：Thrombosis and haemostasis

authors： Korninger C,Lechner K,Niessner H,Gössinger H,Kundi M

更新日期：1984-10-31 00:00:00

abstract：:Antibodies directed against ADAMTS13 have been detected in the majority of patients with acquired thrombotic thrombocytopenic purpura (TTP). We have previously localized a major antigenic determinant within the spacer domain of ADAMTS13. To identify the amino acid residues of the spacer domain that are involved in bin...

journal_title：Thrombosis and haemostasis

authors： Luken BM,Turenhout EA,Kaijen PH,Greuter MJ,Pos W,van Mourik JA,Fijnheer R,Voorberg J

更新日期：2006-09-01 00:00:00

abstract：:Intraluminal thrombus formation in aortic abdominal aneurysms (AAA) is associated with adverse clinical prognosis. Interplay between coagulation and inflammation, characterised by leukocyte infiltration and cytokine production, has been implicated in AAA thrombus formation. We studied leukocyte (CD45+) content by flow...

journal_title：Thrombosis and haemostasis

authors： Sagan A,Mrowiecki W,Mikolajczyk TP,Urbanski K,Siedlinski M,Nosalski R,Korbut R,Guzik TJ

更新日期：2012-11-01 00:00:00

abstract：:By the use of a fluorogenic thrombin substrate and continuous calibration of each individual sample, it is now possible to obtain a thrombin generation (TG) curve (or thrombogram) in plasma, with or without platelets, in an easy routine procedure at high throughput and with an acceptable experimental error (<5%). Evid...

journal_title：Thrombosis and haemostasis

authors： Hemker HC,Al Dieri R,De Smedt E,Béguin S

更新日期：2006-11-01 00:00:00

abstract：:Antiphospholipid-protein antibodies (APA) are a family of immunoglobulins which have been defined by varying laboratory test systems. Lupus anticoagulants (LA) and anticardiolipin antibodies (ACA) are the two most prominent members of this family of antibodies. LA are detected utilizing various phospholipid (PL) depen...

journal_title：Thrombosis and haemostasis

authors： Triplett DA

更新日期：1995-07-01 00:00:00

abstract：:Limited data exist on thrombophilia and the risk of venous thrombosis (VT) during pregnancy and postpartum. The objectives of the present study were to investigate the role of haemostatic risk factors for pregnancy-related VT and their phenotypic expression in deep-vein thrombosis (DVT) and pulmonary embolism (PE). To...

journal_title：Thrombosis and haemostasis

authors： Bergrem A,Dahm AE,Jacobsen AF,Sandvik L,Sandset PM

更新日期：2012-12-01 00:00:00

abstract：:In proliferative retinopathies, like proliferative diabetic retinopathy and retinopathy of prematurity (ROP), the hypoxia response is sustained by the failure of the retina to revascularise its ischaemic areas. Non-resolving retina ischaemia/hypoxia results in upregulation of pro-angiogenic factors and pathologic neov...

journal_title：Thrombosis and haemostasis

authors： Economopoulou M,Avramovic N,Klotzsche-von Ameln A,Korovina I,Sprott D,Samus M,Gercken B,Troullinaki M,Grossklaus S,Funk RH,Li X,Imhof BA,Orlova VV,Chavakis T

更新日期：2015-11-25 00:00:00

abstract：:During the collection of samples for plasma beta-thromboglobulin (beta-TG) determination, it is well established that artificially high values can be observed due to in-vitro release. To estimate the reliability of a single beta-TG measurement, blood samples were collected simultaneously from both arms on two separate...

journal_title：Thrombosis and haemostasis

authors： Scarabin PY,Strain L,Ludlam CA,Jones J,Kohner EM

更新日期：1987-04-07 00:00:00

abstract：:Kawasaki disease (KD) is an acute systemic vasculitis causing coronary arterial aneurysms and myocardial infarction in young children. Prominent thrombocytosis with increased megakaryocytes develops during the convalescent period. To clarify the mechanisms of thrombocytosis, we studied serum levels of thrombopoietin (...

journal_title：Thrombosis and haemostasis

authors： Ishiguro A,Ishikita T,Shimbo T,Matsubara K,Baba K,Hayashi Y,Naritaka S,Nakahata T

更新日期：1998-06-01 00:00:00

abstract：:Cardiovascular diseases are a major cause of mortality in the developed world. Efficacy of thrombolysis plays an important role in the management of acute myocardial infarction and cerebral insult both in the acute event and in the long-term outcome of these patients. New adjunctive strategies have been tested, theref...

journal_title：Thrombosis and haemostasis

authors： Pfaffenberger S,Devcic-Kuhar B,Kastl SP,Huber K,Maurer G,Wojta J,Gottsauner-Wolf M

更新日期：2005-07-01 00:00:00

abstract：:Platelets are suggested to play a crucial role in cancer progression and the prothrombotic state of cancer patients. Here, we aimed to examine the activation status of platelets in cancer patients and investigate their association with risk of death and occurrence of venous thromboembolism (VTE) in a prospective obser...

journal_title：Thrombosis and haemostasis

authors： Riedl J,Kaider A,Marosi C,Prager GW,Eichelberger B,Assinger A,Pabinger I,Panzer S,Ay C

更新日期：2017-01-05 00:00:00

abstract：:The in vitro effect of nifedipine, a calcium channel blocker of the dihydropyridine (DHP) type, on platelet aggregation was reinvestigated considering especially the capability of platelets to form endogenous nitric oxide (NO). We studied the dose-dependent antiaggregatory property of nifedipine in porcine platelet ri...

journal_title：Thrombosis and haemostasis

authors： Berkels R,Klaus W,Boller M,Rösen R

更新日期：1994-08-01 00:00:00

abstract：:We studied the HR2 haplotype of the factor V gene in a case-control study for venous thrombosis including 474 patients with a first deep-vein thrombosis and 474 age- and sex-matched healthy controls (Leiden Thrombophilia Study, LETS). We investigated both the original His1299Arg (A4070G) polymorphism and the Met385Thr...

journal_title：Thrombosis and haemostasis

authors： de Visser MC,Guasch JF,Kamphuisen PW,Vos HL,Rosendaal FR,Bertina RM

更新日期：2000-04-01 00:00:00

abstract：:Human antithrombin III was purified from fresh human plasma by affinity chromatography on heparin-Sepharose, affinity chromatography on concanavalin A Sepharose, gel filtration on Ultrogel AcA 34, ion exchange chromatography on DEAE A-50 Sephadex and preparative agarose gel electrophoresis. The hydrolytic activity of ...

journal_title：Thrombosis and haemostasis

authors： Clemmensen I

更新日期：1978-06-30 00:00:00

abstract：BACKGROUND: A strong association between on-thienopyridine platelet reactivity (PR) and the risk of both thrombotic and bleeding events in acute coronary syndrome (ACS) patients undergoing percutaneous coronary intervention (PCI) has been demonstrated. However, no study has analyzed the relationship between on-ticagrel...

journal_title：Thrombosis and haemostasis

authors： Laine M,Panagides V,Frère C,Cuisset T,Gouarne C,Jouve B,Lemesle G,Paganelli F,Alessi MC,Mancini J,Bonello L

更新日期：2020-12-01 00:00:00

abstract：:A robust two-way analysis of variance technique was applied to determine simultaneously the effects of method and thromboplastin on prothrombin time. A new approach to outlier detection for two-way analysis of variance was used. Focusing on the underlying error structure improved the uniformity of the grading procedur...

journal_title：Thrombosis and haemostasis

authors： Han Y,Lawson WB,Dodds WJ,Lawrence CE

更新日期：1985-10-30 00:00:00

abstract：:Mature circulating endothelial cells (CECs) are novel cellular markers of endothelial damage/dysfunction. The two main techniques of CEC enumeration are flow cytometry (FC) and immunomagnetic bead (IB) isolation. Both quantify CECs accurately, but a direct comparison of both methods has not been reported. We sought to...

journal_title：Thrombosis and haemostasis

authors： Goon PK,Boos CJ,Stonelake PS,Blann AD,Lip GY

更新日期：2006-07-01 00:00:00

abstract：:Tridegin is a potent inhibitor of factor XIIIa from the leech, Haementeria ghilianii, which inhibits protein cross-linking. It modifies plasmin-mediated fibrin degradation as shown by the absence of D-dimer and approximately halves the time for fibrinolysis. Plasma clots formed in the presence of Tridegin lyse more ra...

journal_title：Thrombosis and haemostasis

authors： Seale L,Finney S,Sawyer RT,Wallis RB

更新日期：1997-05-01 00:00:00

abstract：:Activated protein C (APC) is a serine proteinase that regulates blood coagulation. In plasma it is inhibited mainly by the protein C inhibitor (PCI). The plasma concentrations of APC-PCI complex is increased in hypercoagulative states such as deep venous thrombosis. Formation of the APC-PCI complex induces a drastic c...

journal_title：Thrombosis and haemostasis

authors： Strandberg K,Kjellberg M,Knebel R,Lilja H,Stenflo J

更新日期：2001-08-01 00:00:00

abstract：:The fibrin-mediated enhancement of the activation of plasminogen by tissue-type plasminogen activator observed with normal fibrin, is strongly decreased with fibrin Dusard, although the binding of tissue-type plasminogen activator to this fibrin is normal. This impaired fibrin-mediated plasminogen activation is most l...

journal_title：Thrombosis and haemostasis

authors： Lijnen HR,Soria J,Soria C,Collen D,Caen JP

更新日期：1984-02-28 00:00:00

abstract：:Individuals with type-1 diabetes mellitus (T1DM) have a higher risk of thrombosis and low plasma magnesium concentrations. As magnesium is a known regulator of fibrin network formation, we investigated potential associations between fibrin clot properties and plasma magnesium concentrations in 45 individuals with T1DM...

journal_title：Thrombosis and haemostasis

authors： Sobczak AIS,Phoenix FA,Pitt SJ,Ajjan RA,Stewart AJ

更新日期：2020-02-01 00:00:00

abstract：:Although there is considerable variability of platelet reactivity among patients treated with clopidogrel, little is known about inter-individual differences and possible role of proton pump inhibitors (PPIs) after prasugrel. We defined the extent of inter-patient variability, and evaluated the impact of PPI interacti...

journal_title：Thrombosis and haemostasis

authors： Aradi D,Kuliczkowski W,Atar D,Serebruany VL

更新日期：2012-02-01 00:00:00

abstract：:The binding properties of purified bovine fibrinogen to bovine aortic endothelial cells have been examined in a tissue culture system. Endothelial cells bound 125I-fibrinogen in a calcium dependent fashion. Removal of calcium by EDTA instantaneously detached most of the cell-associated fibrinogen. Binding of fibrinoge...

journal_title：Thrombosis and haemostasis

authors： Delvos U,Preissner KT,Müller-Berghaus G

更新日期：1985-02-18 00:00:00

abstract：:Cultured human mesangial cells (HMC) derived from normal kidneys have been shown to synthesize tissue-type plasminogen activator (t-PA) and excess amounts of PA inhibitor type 1 (PAI-1). Conflicting results have been obtained concerning the production of urokinase-type PA (u-PA) and efforts to show PA inhibitor 2 (PAI...

journal_title：Thrombosis and haemostasis

authors： Colucci M,Gesualdo L,Montemurro P,Cavallo LG,Conese M,Mascolo E,Ranieri E,Di Paolo S,Schena FP,Semeraro N

更新日期：1995-12-01 00:00:00

abstract：:Fibrin(ogen) is the major matrix ligand for beta3 integrins. If alpha(v)beta3 is the major receptor for fibrin(ogen) on intimal smooth muscle cells, we might expect to see this integrin associated with fibrin(ogen). Eighty-four specimens obtained from endarterectomies of 14 patients were studied. Fibrin was frequently...

journal_title：Thrombosis and haemostasis

authors： Ikari Y,Yee KO,Hatsukami TS,Schwartz SM

更新日期：2000-08-01 00:00:00

abstract：:Thrombin activatable fibrinolysis inhibitor (TAFI) attenuates fibrinolysis and is considered as an attractive drug target. We generated two different antibody fragments, an antigen-binding fragment (Fab) and a single-chain variable fragment (scFv), derived from three distinct monoclonal antibodies (MAs) that inhibit t...

journal_title：Thrombosis and haemostasis

authors： Develter J,Dewilde M,Gils A,Declerck PJ

更新日期：2009-07-01 00:00:00

abstract：:Accumulating evidence suggests an immune-modulatory role for platelets (PLT) and PLT-derived microvesicles. In particular, ectosomes, i.e. vesicles budding from PLT surface, have been shown to exert immunosuppressive activities on phagocytes. Here we investigated the effects mediated by PLT-derived ectosomes (PLT-Ecto...

journal_title：Thrombosis and haemostasis

authors： Sadallah S,Amicarella F,Eken C,Iezzi G,Schifferli JA

更新日期：2014-12-01 00:00:00