Ultrasound thrombolysis.

abstract：:Serine proteases are proteolytic enzymes with an active serine residue in their catalytic site. Kallikreins are a subgroup of the serine protease family and are known to have diverse physiological functions. The human tissue kallikrein gene family has now been fully characterized and includes 15 members, clustered in ...

journal_title：Thrombosis and haemostasis

authors： Yousef GM,Diamandis EP

更新日期：2003-07-01 00:00:00

abstract：:The primary goal of this study was to develop a method for evaluating fibrin-specific antibodies as thrombus detecting agents. The apparatus and assay conditions were chosen by testing antibody 64C5, which binds to the amino terminus of the fibrin beta chain, for its ability to bind to human blood clots. Using 125I-la...

journal_title：Thrombosis and haemostasis

authors： Liau CS,Haber E,Matsueda GR

更新日期：1987-02-03 00:00:00

abstract：OBJECTIVE:To assess the safety and efficacy of a fixed dose of recombinant activated factor VII (rFVIIa; NovoSeven) in the home setting for mild to moderately severe joint, muscle; and mucocutaneous bleeding episodes in patients with haemophilia A or B with inhibitors. DESIGN:Multicentre, open-label, single arm, phase...

journal_title：Thrombosis and haemostasis

authors： Key NS,Aledort LM,Beardsley D,Cooper HA,Davignon G,Ewenstein BM,Gilchrist GS,Gill JC,Glader B,Hoots WK,Kisker CT,Lusher JM,Rosenfield CG,Shapiro AD,Smith H,Taft E

更新日期：1998-12-01 00:00:00

abstract：:It is now recognised that acute myocardial infarction results from the rupture of atherosclerotic plaques. Lymphocytes and macrophages, which infiltrate rupture sites, contribute to plaque degradation by expressing urokinase (u-PA) bound to cell membrane by urokinase receptor (u-PAR) and by secreting metalloproteinase...

journal_title：Thrombosis and haemostasis

authors： Ganné F,Vasse M,Beaudeux JL,Peynet J,François A,Mishal Z,Chartier A,Tobelem G,Vannier JP,Soria J,Soria C

更新日期：2000-10-01 00:00:00

abstract：:The methylenetetrahydrofolate reductase (MTHFR) 677 C→T polymorphism may be associated with elevated total homocysteine (tHcy) levels, an independent risk factor for cardiovascular disease. It was the study objective to evaluate in vivo lipid peroxidation and platelet activation in carriers of the MTHFR 677 C→T polymo...

journal_title：Thrombosis and haemostasis

authors： Dragani A,Falco A,Santilli F,Basili S,Rolandi G,Cerasa L,Lattanzio S,Ciabattoni G,Patrono C,Davì G

更新日期：2012-09-01 00:00:00

abstract：:Microvascular thrombosis is considered an important pathogenetic factor in renal failure associated with obstructive jaundice but the mechanisms leading to fibrin deposition are still unknown. The plasma levels of plasminogen activator inhibitor (PAI) in 29 patients with obstructive jaundice were found significantly i...

journal_title：Thrombosis and haemostasis

authors： Colucci M,Altomare DF,Chetta G,Triggiani R,Cavallo LG,Semeraro N

更新日期：1988-08-30 00:00:00

abstract：:The esterase activity of highly purified human urokinase on Nalpha-acetylglycl-L-lysine methyl ester is strongly inhibited by 1 X 10(-5) to 1 X 10(-2)M Cu++, Hg++, Ni++, Co++, Fe+++, and Mn++ solutions, whereas Na+, K+, Ca++, and Mg++ are weakly effective. This inhibition is parallel with the inhibition of activation ...

journal_title：Thrombosis and haemostasis

authors： Sumi H,Takada Y,Takada A

更新日期：1978-02-28 00:00:00

abstract：:Previous studies have demonstrated that cell-permeable cytoplasmic tail (CT) alpha(II)beta peptides can modulate the activation of alpha(IIb)b(3). As alpha(V) CT contains an alpha(II)beta homologous region, a series of cell-permeable alpha(V) and alpha(IIb) peptides were generated to determine if alpha(V) CT can modul...

journal_title：Thrombosis and haemostasis

authors： Haas TA

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND: Clinical effectiveness of recombinant human soluble thrombomodulin (rhTM) in sepsis or sepsis-induced coagulopathy remains a matter of dispute. Recently, the Sepsis Coagulopathy Asahi Recombinant LEThrombomodulin (SCARLET) trial, the latest multinational multi-centre phase III randomized controlled trial, w...

journal_title：Thrombosis and haemostasis

authors： Yamakawa K,Murao S,Aihara M

更新日期：2019-01-01 00:00:00

abstract：:This article describes the results of a dietary intervention study performed in three different centers. In the study the effect of a diet enriched with fish on the coagulation tendency of blood was investigated. Two groups of 40 volunteers were given a dietary supplement consisting of 135 g of canned mackerel or meat...

journal_title：Thrombosis and haemostasis

authors： Muller AD,van Houwelingen AC,van Dam-Mieras MC,Bas BM,Hornstra G

更新日期：1989-06-30 00:00:00

abstract：:Seven healthy male volunteers were subjected to exercise of short (STR; 1.7 km), middle (MTR; 4.8 km) and long (LTR; 10.5 km) term runs at a speed close to maximal capacity. Blood samples were drawn before, immediately after exercise and at intervals over the next 10 h. FVIIIR:Ag (von Willebrand factor) rose 2.2-3.2 f...

journal_title：Thrombosis and haemostasis

authors： Hansen JB,Wilsgård L,Olsen JO,Osterud B

更新日期：1990-11-30 00:00:00

abstract：:The emergency management of ST-elevation myocardial infarction (STEMI) involves treatment with dual-antiplatelet therapy (DAPT) and primary percutaneous coronary intervention (PPCI). Pain is generally treated with opiates, which may delay gastric transit and reduce DAPT absorption. We sought to assess the effect of mo...

journal_title：Thrombosis and haemostasis

authors： Farag M,Spinthakis N,Srinivasan M,Sullivan K,Wellsted D,Gorog DA

更新日期：2018-03-01 00:00:00

abstract：:The effect of negatively-charged polymers, used in some artificial devices, on plasma clotting and kinin systems was studied in vitro using polyelectrolyte complexes. Contact activation was observed as an immediate, transient and surface-dependent phenomenon. After incubation of the plasma with the polymer a small dec...

journal_title：Thrombosis and haemostasis

authors： Boffa MC,Dreyer B,Pusineri C

更新日期：1984-02-28 00:00:00

abstract：:Thrombin-induced platelet release reaction examined with secretion of calcium and N-acetylglucosaminidase was significantly enhanced in the platelets from reserpine-treated rabbits as compared with the control. On the other hand, 32P-incorporation into phosphatidic acid was suppressed in the reserpinized platelets in ...

journal_title：Thrombosis and haemostasis

authors： Watanabe Y,Soda M,Fukamachi N,Kobayashi B

更新日期：1983-08-30 00:00:00

abstract：:Cysteinyl leukotrienes (i.e. LTC4, LTD4), produced by activated leukocytes or by transcellular metabolism may act at different levels on vascular smooth muscle cells (VSMC) during inflammatory process or atherosclerosis. We studied the effect of LTC4, LTD4, and LTE4 on the in vitro proliferation of rat VSMC, measured ...

journal_title：Thrombosis and haemostasis

authors： Porreca E,Di Febbo C,Di Sciullo A,Angelucci D,Nasuti M,Vitullo P,Reale M,Conti P,Cuccurullo F,Poggi A

更新日期：1996-07-01 00:00:00

abstract：:Cellular adhesion molecules also known as selectins promote recruitment of inflammatory cells into the arterial wall where they interact with lipid particles leading subsequently to plaque formation. The intercellular adhesion molecule-1 (ICAM-1), the vascular cell adhesion molecule-1 (VCAM-1) and the endothelial-leuk...

journal_title：Thrombosis and haemostasis

authors： Hoke M,Winter MP,Wagner O,Exner M,Schillinger M,Arnold Z,Mlekusch W,Maurer G,Koppensteiner R,Minar E,Goliasch G

更新日期：2015-08-31 00:00:00

abstract：:Severe postpartum haemorrhages (PPH) are responsible for maternal morbidity/mortality. Their complex management sometimes requires haemostatic supplementation, and therapeutic trials on fibrinogen or activated factor VII, which may add to the thrombotic risk, are currently being considered. Furthermore, there is a ris...

journal_title：Thrombosis and haemostasis

authors： Chauleur C,Cochery-Nouvellon E,Mercier E,Aya G,Marès P,Mismetti P,Lissalde-Lavigne G,Gris JC

更新日期：2008-11-01 00:00:00

abstract：:Computer-assisted oral anticoagulant dosage is being increasingly used to meet growing demands for oral anticoagulation. The DAWN AC is one of the most widely used computer-dosage programs. Evidence of its value and that of other computer programs has been based previously only on laboratory evidence of "time in targe...

journal_title：Thrombosis and haemostasis

authors： Poller L,Keown M,Ibrahim S,Lowe G,Moia M,Turpie AG,Roberts C,van den Besselaar AM,van der Meer FJ,Tripodi A,Palareti G,Shiach C,Bryan S,Samama M,Burgess-Wilson M,Heagerty A,Maccallum P,Wright D,Jespersen J,European

更新日期：2009-03-01 00:00:00

abstract：:Data on anti-platelet therapy (APT) for prevention of atherothrombotic events in thrombocytopaenic cancer patients is lacking. We aimed to identify patient and physician characteristics associated with APT management in thrombocytopaenic patients with haematological malignancy. A clinical vignette-based experiment was...

journal_title：Thrombosis and haemostasis

authors： Leader A,Ten Cate V,Ten Cate-Hoek AJ,Spectre G,Beckers EAM,Raanani P,Giaccherini C,Pereg D,Schouten HC,Falanga A,Ten Cate H

更新日期：2019-01-01 00:00:00

abstract：:We performed a DNA analysis on a patient with severe type I factor VII deficiency by the polymerase chain reaction amplification and a direct DNA sequencing method. The proband was a 66-year-old Japanese woman who had recurrent episodes of excessive bleeding after dental extraction. The functional and antigenic levels...

journal_title：Thrombosis and haemostasis

authors： Ozawa T,Niiya K,Higuchi W,Sakuragawa N

更新日期：1997-09-01 00:00:00

abstract：:A method is described for the purification of antiactivator from bovine euglobulin-free serum by means of gelfiltration and ion exchange chromatography. The purified antiactivator has no antifibrinolytic activity. It has a molecular weight of about 115,000 and it appears to be a gamma globulin. The dissociation consta...

journal_title：Thrombosis and haemostasis

authors： Nanninga LB,Guest MM

更新日期：1979-10-31 00:00:00

abstract：:Severe type I plasminogen deficiency is the underlying cause of ligneous conjunctivitis, a rare disease characterized by wood-like pseudomembranes developing on the ocular and extraocular mucosa. Two unrelated female patients with ligneous conjunctivitis and moderate hypoplasminogenemia are described. Being of fertile...

journal_title：Thrombosis and haemostasis

authors： Teresa Sartori M,Saggiorato G,Pellati D,Casonato A,Spiezia L,Pontara E,Gavasso S,Girolami A

更新日期：2003-07-01 00:00:00

abstract：:Pathogenic species of the genus Yersinia suppress and reorient the immune system to infect lymphatic tissues, inner organs and at times also the vasculature. For this purpose yersiniae employ a type III secretion system to translocate effector proteins (Yersinia outer proteins; Yops) into immune cells. Yops often exer...

journal_title：Thrombosis and haemostasis

authors： Aepfelbacher M,Trasak C,Ruckdeschel K

更新日期：2007-09-01 00:00:00

abstract：:Vascular smooth muscle cell (VSMC) proliferation occurs in vascular obstructive events such as atherosclerosis and restenosis. We previously showed that Notch receptors are induced in smooth muscle cells during vascular remodeling. Our goal was to determine the mechanisms employed by Notch signaling to regulate prolif...

journal_title：Thrombosis and haemostasis

authors： Havrda MC,Johnson MJ,O'Neill CF,Liaw L

更新日期：2006-09-01 00:00:00

abstract：:Thirty-one individuals from 18 unrelated families with antithrombin deficiency have been identified as having a single point mutation within codon 384 (13268 GCA-->TCA) resulting in an alanine to serine substitution. Six families (11 individuals) were identified by the screening of individuals with thromboembolic dise...

journal_title：Thrombosis and haemostasis

authors： Perry DJ,Daly ME,Tait RC,Walker ID,Brown K,Beauchamp NJ,Preston FE,Gyde H,Harper PL,Carrell RW

更新日期：1998-02-01 00:00:00

abstract：:Incubation of platelet-rich plasma (PRP) with ouabain, an inhibitor of sodium/potassium ATPase (Na+/K+ ATPase), induced a significant rise in basal platelet intracellular calcium concentration [( Ca2+]i) when measured using fura 2. Ouabain induced an enhanced aggregation response to low doses of collagen in both PRP a...

journal_title：Thrombosis and haemostasis

authors： Lees AD,Wilson J,Orchard CH,Orchard MA

更新日期：1989-11-24 00:00:00

abstract：:The efficacy and safety of dabigatran for treatment of venous thromboembolism (VTE) were demonstrated in two trials. It is unclear if the results pertain to patients with cancer and VTE. Data from two randomised trials comparing dabigatran and warfarin for acute VTE were pooled. Primary efficacy outcome was symptomati...

journal_title：Thrombosis and haemostasis

authors： Schulman S,Goldhaber SZ,Kearon C,Kakkar AK,Schellong S,Eriksson H,Hantel S,Feuring M,Kreuzer J

更新日期：2015-07-01 00:00:00

abstract：:Increased red blood cell distribution width (RDW), which is a marker of anisocytosis, is associated with mortality and cardiovascular events in the general population and in patients with heart failure or coronary heart disease. We investigated whether RDW in acute cerebral infarction is predictive of functional outco...

journal_title：Thrombosis and haemostasis

authors： Kim J,Kim YD,Song TJ,Park JH,Lee HS,Nam CM,Nam HS,Heo JH

更新日期：2012-08-01 00:00:00

abstract：:Recombinant human activated factor VII (rHuFVIIa) can reduce bleeding but may be associated with arterial thrombosis. We hypothesized that rHuFVIIa would increase the occurrence of cyclic flow reductions (CFR) and reduce intra-abdominal bleeding in an experimental model. An adapted Folts' model of carotid artery lesio...

journal_title：Thrombosis and haemostasis

authors： Charbonneau S,Girard F,Boudreault D,Ruel M,Blais N,Hardy JF

更新日期：2007-02-01 00:00:00

abstract：:In health, haemostasis and angiogenesis are tightly regulated processes, but may become deregulated in cancer. Recent evidence suggests that platelet activation may link these processes as platelets can release angiogenic factors such as vascular endothelial growth factor (VEGF). Furthermore, inflammation has also bee...

journal_title：Thrombosis and haemostasis

authors： Caine GJ,Lip GY,Stonelake PS,Ryan P,Blann AD

更新日期：2004-07-01 00:00:00