当前位置： SCI文献检索 > THROMBOSIS AND HAEMOSTASIS期刊下所有文献 > The HR2 haplotype of factor V: effects on factor V levels, normalized activated protein C sensitivity ratios and the risk of venous thrombosis.

The HR2 haplotype of factor V: effects on factor V levels, normalized activated protein C sensitivity ratios and the risk of venous thrombosis.

Abstract：

:We studied the HR2 haplotype of the factor V gene in a case-control study for venous thrombosis including 474 patients with a first deep-vein thrombosis and 474 age- and sex-matched healthy controls (Leiden Thrombophilia Study, LETS). We investigated both the original His1299Arg (A4070G) polymorphism and the Met385Thr (T1328C) polymorphism. This latter polymorphism, located in exon 8 (heavy chain), is always present in the HR2 haplotype, but also occurs on its own in a His1299 (wt) background. The HR2 haplotype was not associated with an increased risk of venous thrombosis (OR = 1.2, 95% confidence interval: 0.8-2.0). We did not find an association between the HR2 haplotype and a reduced sensitivity for activated protein C (APC) in non-carriers of factor V Leiden (FVL). However, in compound heterozygous FVL/HR2 carriers the sensitivity for APC was reduced. The HR2 haplotype was also associated with reduced factor V antigen levels in both patients and controls. Sequence analysis of the promoter region of factor V in HR2 homozygotes did not reveal any sequence variations that could explain the reduced FV levels. Our results show that the HR2 haplotype is not associated with an increased risk of venous thrombosis or with a reduced sensitivity for APC in non-FVL carriers. However, the HR2 haplotype is associated with a reduced sensitivity for APC in carriers of FVL and with reduced factor V antigen levels.

journal_name

Thromb Haemost

journal_title

Thrombosis and haemostasis

authors

de Visser MC,Guasch JF,Kamphuisen PW,Vos HL,Rosendaal FR,Bertina RM

keywords:

subject

Has Abstract

pub_date

2000-04-01 00:00:00

pages

577-82

issue

4

eissn

0340-6245

issn

2567-689X

pii

00040577

journal_volume

83

pub_type

杂志文章

相关文献

THROMBOSIS AND HAEMOSTASIS文献大全
  • Dysfibrinogenemia (fibrinogen Dusard) associated with impaired fibrin-enhanced plasminogen activation.

    abstract：:The fibrin-mediated enhancement of the activation of plasminogen by tissue-type plasminogen activator observed with normal fibrin, is strongly decreased with fibrin Dusard, although the binding of tissue-type plasminogen activator to this fibrin is normal. This impaired fibrin-mediated plasminogen activation is most l...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：

    authors： Lijnen HR,Soria J,Soria C,Collen D,Caen JP

    更新日期：1984-02-28 00:00:00

  • Management of dental extraction in patients undergoing anticoagulant treatment. Results from a large, multicentre, prospective, case-control study.

    abstract：:Following favourable results from a previous study, a large, multicentre, prospective, case-control study was performed to further assess the incidence of bleeding complications after dental extraction in patients taking oral anticoagulant therapy (OAT). Four hundred fifty-one patients being treated with warfarin who ...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章,多中心研究

    doi：10.1160/TH10-02-0139

    authors： Bacci C,Maglione M,Favero L,Perini A,Di Lenarda R,Berengo M,Zanon E

    更新日期：2010-11-01 00:00:00

  • Safety and tolerability of an immediate-release formulation of theoral direct thrombin inhibitor AZD0837 in the prevention of stroke and systemic embolism in patients with atrial fibrillation.

    abstract：:AZD0837 is an investigational oral anticoagulant which is converted to the active form, AR-H067637, a selective direct thrombin inhibitor. The present study, a multicentre, randomised, parallel-group, dose-guiding study, assessed the safety and tolerability of an immediate-release formulation of AZD0837 compared with ...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1160/TH09-07-0509

    authors： Olsson SB,Rasmussen LH,Tveit A,Jensen E,Wessman P,Panfilov S,Wåhlander K

    更新日期：2010-03-01 00:00:00

  • Platelets release thrombopoietin (Tpo) upon activation: another regulatory loop in thrombocytopoiesis?

    abstract：:Thrombopoietin is produced at a constant rate by the liver and kidney and is removed from the circulation upon binding and subsequent uptake via the Tpo receptor, c-Mpl, expressed by platelets and mega-karyocytes. Apart from uptake, this study shows that platelets can also function as a storage pool for Tpo. Upon stim...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：

    authors： Folman CC,Linthorst GE,van Mourik J,van Willigen G,de Jonge E,Levi M,de Haas M,von dem Borne AE

    更新日期：2000-06-01 00:00:00

  • Measurement of soluble fibrin monomer-fibrinogen complex in plasmas derived from patients with various underlying clinical situations.

    abstract：:We previously reported a monoclonal antibody named IF-43 that specifically recognizes thrombin-modified fibrinogen (desAA- and desAABB- fibrin monomer) bound with fibrinogen or other D(1) domain-containing plasmic fragments such as fragments X,Y, and D(1), but not intact fibrinogen or cross-linked fibrin degradation p...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：

    authors： Nakahara K,Kazahaya Y,Shintani Y,Yamazumi K,Eguchi Y,Koga S,Wada H,Matsuda M

    更新日期：2003-05-01 00:00:00

  • CT-ADP Point-of-Care Assay Predicts 30-Day Paravalvular Aortic Regurgitation and Bleeding Events following Transcatheter Aortic Valve Replacement.

    abstract：BACKGROUND:Paravalvular aortic regurgitation (PVAR) remains a frequent postprocedural concern following transcatheter aortic valve replacement (TAVR). Persistence of flow turbulence results in the cleavage of high-molecular-weight von Willebrand multimers, primary haemostasis dysfunction and may favour bleedings. Recen...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：10.1055/s-0038-1639352

    authors： Kibler M,Marchandot B,Messas N,Caspar T,Vincent F,Von Hunolstein JJ,Grunebaum L,Reydel A,Rauch A,Crimizade U,Kindo M,Hoang Minh T,Trinh A,Petit-Eisenmann H,De Poli F,Leddet P,Jesel L,Ohlmann P,Susen S,Van Belle E,

    更新日期：2018-05-01 00:00:00

  • A prospective, randomized trial of prednisone and cyclophosphamide in the treatment of patients with factor VIII autoantibodies.

    abstract：:Thirty-one non-hemophilic patients with acquired antibodies to factor VIII were entered into a prospective, randomized, multi-institutional trial to determine the safety and efficacy of prednisone (P), cyclophosphamide (C), or the combination in the treatment of this disorder. Patients were eligible if they had antibo...

    journal_title：Thrombosis and haemostasis

    pub_type： 临床试验,杂志文章,多中心研究,随机对照试验

    doi：

    authors： Green D,Rademaker AW,Briët E

    更新日期：1993-11-15 00:00:00

  • Familial coagulation factor V deficiency caused by a novel 4 base pair insertion in the factor V gene: factor V Stanford.

    abstract：:An index patient with pseudohomozygosity for factor V Leiden was identified. Each of his two children inherited a different paternal factor V allele; a daughter was heterozygous for factor V Leiden, with 100% factor V activity, and a son was heterozygous for factor V deficiency, with 50% factor V activity. Genomic DNA...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：

    authors： Zehnder JL,Hiraki DD,Jones CD,Gross N,Grumet FC

    更新日期：1999-09-01 00:00:00

  • Tissue kallikreins: new players in normal and abnormal cell growth?

    abstract：:Serine proteases are proteolytic enzymes with an active serine residue in their catalytic site. Kallikreins are a subgroup of the serine protease family and are known to have diverse physiological functions. The human tissue kallikrein gene family has now been fully characterized and includes 15 members, clustered in ...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章,评审

    doi：

    authors： Yousef GM,Diamandis EP

    更新日期：2003-07-01 00:00:00

  • Ex vivo Improvement of a von Willebrand Disease Type 2A Phenotype Using an Allele-Specific Small-Interfering RNA.

    abstract：:Von Willebrand disease (VWD) is the most common inherited bleeding disorder and is mainly caused by dominant-negative mutations in the multimeric protein von Willebrand factor (VWF). These mutations may either result in quantitative or qualitative defects in VWF. VWF is an endothelial protein that is secreted to the c...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：10.1055/s-0040-1715442

    authors： de Jong A,Dirven RJ,Boender J,Atiq F,Anvar SY,Leebeek FWG,van Vlijmen BJM,Eikenboom J

    更新日期：2020-11-01 00:00:00

  • Effect of calcium and synthetic peptides on fibrin polymerization.

    abstract：:Human fibrinogen was subjected to limited proteolytic attack by thrombin, batroxobin or Agkistrodon contortrix thrombin-like enzyme, yielding desAB-, desA- or desB-fibrin monomers, respectively. Turbidity curves demonstrated that, with all three enzymes, the polymerization process was strongly accelerated by increasin...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：

    authors： Furlan M,Rupp C,Beck EA,Svendsen L

    更新日期：1982-04-30 00:00:00

  • Multiplexed genetic profiling of human blood platelets using fluorescent microspheres.

    abstract：:Human platelets have unique and reproducible mRNA profiles, with evidence for distinct profiles in haematopoietic stem cell disorders associated with thrombocytosis. Platelet transcript profiling is traditionally studied by microarray analysis, quantitative reverse transcription-PCR or serial analysis of gene expressi...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：

    authors： Gnatenko DV,Zhu W,Bahou WF

    更新日期：2008-11-01 00:00:00

  • Polymorphisms of the beta fibrinogen gene and plasma fibrinogen concentration in Caucasian and Japanese population samples.

    abstract：:We reported previously that plasma fibrinogen was significantly higher in U.S. Caucasians than in Japanese, which may contribute to the higher mortality rate of coronary heart disease in the United States than in Japan. To examine the contribution of genetic variations to the race difference in plasma fibrinogen level...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：

    authors： Iso H,Folsom AR,Winkelmann JC,Koike K,Harada S,Greenberg B,Sato S,Shimamoto T,Iida M,Komachi Y

    更新日期：1995-01-01 00:00:00

  • Pretreatment with oral anticoagulants decreases platelet activation in patients before and after percutaneous coronary intervention.

    abstract：BACKGROUND:Platelet activation plays a major role in acute vessel closure after coronary angioplasty. In the randomized Balloon Angioplasty and Anticoagulation Study (BAAS), pretreatment with oral anticoagulants in addition to aspirin resulted in a 47% reduction of acute complications as compared with aspirin alone. Th...

    journal_title：Thrombosis and haemostasis

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：

    authors： ten Berg JM,Gerritsen WB,Haas FJ,Kelder JC,Verheugt FW,Thijs Plokker HW

    更新日期：2002-12-01 00:00:00

  • Platelet function and the bleeding time in progressive renal failure.

    abstract：:Bleeding time and platelet function tests were performed on 31 patients with progressive chronic renal failure (CRF) due to non-immunological (urological) causes, and compared with 22 healthy controls. Patients were classified as mild (plasma creatinine less than 300 mumol/l), moderate (300-600 mumol/l) or severe rena...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：

    authors： Gordge MP,Faint RW,Rylance PB,Neild GH

    更新日期：1988-08-30 00:00:00

  • Erratum to Parasrampuria et al. "Pharmacokinetics, safety, and tolerability of edoxaban in end-stage renal disease subjects undergoing haemodialysis" (Thromb Haemost 2015; 113: 719-727).

    abstract：:[This corrects the article DOI: 10.1160/TH14-06-0547.]. ...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章,已发布勘误

    doi：10.1160/TH17040001

    authors：

    更新日期：2017-04-03 00:00:00

  • The state of actin polymerization in tetracaine-treated platelets.

    abstract：:Although there is considerable evidence that platelet activation is associated with polymerization of actin, it is not known whether there is some pre-existing F-actin even before activation. We have examined the state of actin polymerization in nonactivated platelets by deoxyribonuclease assay of G-actin and total ac...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：

    authors： Davies GE,Palek J

    更新日期：1982-10-29 00:00:00

  • Molecular signature of coronary stent thrombosis: oxidative stress and innate immunity cells.

    abstract：:The clinical impact of in-stent thrombosis is high because it is associated with high mortality and 20 % of the patients suffer a recurrent event within the two following years. The aim of this study was to characterise the morphologic and proteomic profile of in-stent thrombi (IST) in comparison to thrombi developed ...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：10.1160/TH17-03-069

    authors： Cubedo J,Blasco A,Padro T,Ramaiola I,Juan-Babot O,Goicolea J,Fernández-Díaz JA,Oteo JF,Badimon L

    更新日期：2017-08-30 00:00:00

  • A novel fibrinogen Bbeta chain frameshift mutation in a patient with severe congenital hypofibrinogenaemia.

    abstract：:Congenital afibrinogenemia and severe hypofibrinogenemia are severe bleeding disorders characterized by either undetectable or very low levels of fibrinogen in patients' plasma and platelets. A majority of the reported cases are caused by mutations in the fibrinogen Aalpha chain. In this study, we identified a genetic...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：10.1160/TH06-01-0020

    authors： Xu X,Wu J,Zhai Z,Zhou R,Wang X,Wang H,Ding K,Sun Z,Ni H

    更新日期：2006-06-01 00:00:00

  • Prevention of restenosis after percutaneous coronary interventions: the medical approach.

    abstract：:Restenosis following successful percutaneous coronary revascularization continues to represent a major problem limiting the clinical efficacy of this procedure. The underlying mechanisms of restenosis are comprised of a combination of effects from vessel recoil, negative vascular remodeling, thrombus formation and neo...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章,评审

    doi：

    authors： Rosanio S,Tocchi M,Patterson C,Runge MS

    更新日期：1999-09-01 00:00:00

  • Pharmacokinetics, safety, and tolerability of edoxaban in end-stage renal disease subjects undergoing haemodialysis.

    abstract：:Edoxaban is an oral, direct, once-daily, factor Xa inhibitor developed for stroke prevention in patients with atrial fibrillation and for the treatment and secondary prevention of recurrent thromboembolism in patients with acute symptomatic venous thromboembolism. Among elderly patients who require anticoagulation the...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章,随机对照试验

    doi：10.1160/TH14-06-0547

    authors： Parasrampuria DA,Marbury T,Matsushima N,Chen S,Wickremasingha PK,He L,Dishy V,Brown KS

    更新日期：2015-04-01 00:00:00

  • Chronological expression of PAR isoforms in acute liver injury and its amelioration by PAR2 blockade in a rat model of sepsis.

    abstract：:The liver can be injured and its functions altered by activation of the coagulation and inflammatory processes in sepsis. The objective of the present study was to investigate the pattern of protease- activated receptors (PARs) over time in a model of acute liver injury induced by lipopolysaccharide (LPS); and whether...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：

    authors： Jesmin S,Gando S,Zaedi S,Sakuraya F

    更新日期：2006-12-01 00:00:00

  • Low Affinity Platelet Factor 4 and High Affinity Platelet Factor 4 - Two Antiheparin Factors Secreted by Human Platelets.

    abstract：: ...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：10.1055/s-0038-1657075

    authors： Niewiarowski S,Rucinski B,Budzynski AZ

    更新日期：1979-07-01 00:00:00

  • Shear stress regulates inflammatory and thrombogenic gene transcripts in cultured human endothelial progenitor cells.

    abstract：:Shear stress has an established effect on mature endothelial cells, but less is known about how shear stress regulates endothelial progenitor cells (EPCs). In vitro expanded EPCs isolated from adult human blood represent a novel tool in regenerative vessel therapy. However, in vitro culturing may generate cells with u...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：10.1160/TH09-12-0854

    authors： Lund T,Hermansen SE,Andreasen TV,Olsen JO,Østerud B,Myrmel T,Ytrehus K

    更新日期：2010-09-01 00:00:00

  • The impact of sequential quality assessment exercises on laboratory performance: the multicentre ECAT Angina Pectoris Study. Report from the European Concerted Action on Thrombosis and Disabilities (ECAT).

    abstract：:As an adjunct to a European multicentre prospective study, five quality assessment (QA) exercises, spanning a period of 2.5 years, were undertaken. In these, fifteen laboratories from eight countries each performed ten haemostatic factor assays. The design of the QA exercises allowed the between-duplicate, between-day...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章,多中心研究

    doi：

    authors： Thompson SG,Calori G,Thomson JM,Haverkate F,Duckert F

    更新日期：1991-02-12 00:00:00

  • In vitro and in vivo effects of adrenaline and phentolamine on platelet function.

    abstract：:In vitro and in vivo effects of adrenaline (ADR) on platelet aggregation, on platelet factor 3 (PF3) availability and on platelet factor 4 (PF4) release were studied in man. Inhibitory action of an alpha-blocker, phentolamine (PHEN) was investigated in the same conditions. The threshold concentration (TC) of ADR induc...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：

    authors： Ponari O,Civardi E,Megha A,Pini M,Poti' R,Dettori AG

    更新日期：1978-10-31 00:00:00

  • The effect of fibrin clots and clot-bound thrombin on the development of platelet procoagulant activity.

    abstract：:We tested different types of clot for their ability to provoke procoagulant activity in platelets: normal clots from platelet poor plasma (des AABB- or fibrin II clots), similar clots in which the adsorbed thrombin has been inhibited by hirudin, and clots obtained by the action of two snake venom enzymes that release ...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：

    authors： Kumar R,Béguin S,Hemker HC

    更新日期：1995-09-01 00:00:00

  • Differential effects of warfarin on the intracellular processing of vitamin K-dependent proteins.

    abstract：:The vitamin K-dependent carboxylation of specific glutamyl residues to gamma-carboxyglutamyl residues occurs during the endoplasmic reticulum processing of a limited number of proteins. The fate of the under-gamma-carboxylated proteins during protein processing was studied. When human hepatoma (HepG2) cells were grown...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：

    authors： Wu W,Bancroft JD,Suttie JW

    更新日期：1996-07-01 00:00:00

  • Endotoxin-induced intravascular coagulation in rabbits: effect of tissue plasminogen activator vs urokinase of PAI generation, fibrin deposits and mortality.

    abstract：:We have evaluated the effect of plasminogen activators (t-PA and urokinase) on an experimental model of disseminated intravascular coagulation (DIC) in rabbits by injection of 20 micrograms/kg/h of E. coli lipopolysaccharide during 6 h t-PA (0.2 mg/kg and 0.7 mg/kg), urokinase (3000 U/kg/h) and saline (control) were g...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：

    authors： Paloma MJ,Páramo JA,Rocha E

    更新日期：1995-12-01 00:00:00

  • Cerivastatin, an inhibitor of HMG-CoA reductase, inhibits urokinase/urokinase-receptor expression and MMP-9 secretion by peripheral blood monocytes--a possible protective mechanism against atherothrombosis.

    abstract：:It is now recognised that acute myocardial infarction results from the rupture of atherosclerotic plaques. Lymphocytes and macrophages, which infiltrate rupture sites, contribute to plaque degradation by expressing urokinase (u-PA) bound to cell membrane by urokinase receptor (u-PAR) and by secreting metalloproteinase...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：

    authors： Ganné F,Vasse M,Beaudeux JL,Peynet J,François A,Mishal Z,Chartier A,Tobelem G,Vannier JP,Soria J,Soria C

    更新日期：2000-10-01 00:00:00