Multiplexed genetic profiling of human blood platelets using fluorescent microspheres.

abstract：:Antithrombotic potency of recombinant hirudins rHV2, rHV2-Lys47 and rHV2-Arg47 was studied in a model of experimental thrombosis induced by tissue factor in the rat. Venous thrombosis was induced by i.v. injection of 25 mg/kg tissue factor followed by stasis of the inferior vena cava. In this model natural recombinant...

journal_title：Thrombosis and haemostasis

authors： Freund M,Cazenave JP,Courtney M,Degryse E,Roitsch C,Bernat A,Delebassée D,Defreyn G,Maffrand JP

更新日期：1990-04-12 00:00:00

abstract：:Tissue factor (TF) plays a pivotal role in thrombus formation and atherogenesis in acute coronary syndrome. Tissue factor pathway inhibitor (TFPI) is a specific physiological inhibitor of TF/FVIIa complex that regulates TF-induced coagulation. Adiponectin (Adp) is an adipocyte-specific adipocytokine with anti-atheroge...

journal_title：Thrombosis and haemostasis

authors： Chen YJ,Zhang LQ,Wang GP,Zeng H,Lü B,Shen XL,Jiang ZP,Chen FP

更新日期：2008-08-01 00:00:00

abstract：:This review collects evidence about immune and inflammatory functions of platelets from a clinician's point of view. A focus on clinically relevant immune functions aims at stimulating further research, because the complexity of platelet immunity is incompletely understood and not yet translated into patient care. Pla...

journal_title：Thrombosis and haemostasis

authors： Duerschmied D,Bode C,Ahrens I

更新日期：2014-10-01 00:00:00

abstract：:Edoxaban is an oral, direct, once-daily, factor Xa inhibitor developed for stroke prevention in patients with atrial fibrillation and for the treatment and secondary prevention of recurrent thromboembolism in patients with acute symptomatic venous thromboembolism. Among elderly patients who require anticoagulation the...

journal_title：Thrombosis and haemostasis

authors： Parasrampuria DA,Marbury T,Matsushima N,Chen S,Wickremasingha PK,He L,Dishy V,Brown KS

更新日期：2015-04-01 00:00:00

abstract：INTRODUCTION: Bleeds such as intra-ventricular (IVH) and pulmonary haemorrhage (PH) are life-threatening events in extremely low birth weight (ELBW) infants. Serial coagulation monitoring by measuring the international normalized ratio (INR) with small volume samples might facilitate early diagnosis and possibly preven...

journal_title：Thrombosis and haemostasis

authors： Thanhaeuser M,Binder C,Derhaschnig U,Jilma B,Kornsteiner-Krenn M,Huber-Dangl M,Repa A,Kreissl A,Berger A,Haiden N

更新日期：2018-07-01 00:00:00

abstract：:Recent data has shown that hormone therapy (HT) increases the risk of cardiovascular and thromboembolic disease, particularly in users of oral HT. Phytoestrogens are popular alternatives to oestrogen therapy; however, their effects on cardiovascular risk are unknown. We investigated the effect of the phytoestrogen, ge...

journal_title：Thrombosis and haemostasis

authors： Kelly LA,O'Leary JJ,Seidlova-Wuttke D,Wuttke W,Norris LA

更新日期：2010-12-01 00:00:00

abstract：:The urinary excretion rate of antithrombin III related antigen (AT III RA) was examined in cerebral stroke. The excretion rate of AT III RA in cerebral hemorrhage (CH) was 12.33 +/- 1.61 X 10(-4) ml/min. The patients with CH were further classified into two groups: in group CH-I, whose consciousness state was stupor o...

journal_title：Thrombosis and haemostasis

authors： Matsuo T,Shinomiya K,Okuno S,Matsuo C,Matsuo O

更新日期：1984-12-29 00:00:00

abstract：:East Asian patients have reduced anti-ischemic benefits and increased bleeding risk during antithrombotic therapies compared with Caucasian patients. As potent P2Y12 receptor inhibitors (e.g., ticagrelor and prasugrel) and direct oral anticoagulants are commonly used in current daily practice, the unique risk-benefit ...

journal_title：Thrombosis and haemostasis

authors： Kim HK,Tantry US,Smith SC Jr,Jeong MH,Park SJ,Kim MH,Lim DS,Shin ES,Park DW,Huo Y,Chen SL,Bo Z,Goto S,Kimura T,Yasuda S,Chen WJ,Chan M,Aradi D,Geisler T,Gorog DA,Sibbing D,Lip GYH,Angiolillo DJ,Gurbel PA,J

更新日期：2020-11-10 00:00:00

abstract：:The influence of ionic and non-ionic contrast media (CM) on platelet and leukocyte activation and platelet-leukocyte crosstalk was investigated in hirudinized whole blood. The blood was incubated with and without the ionic CM ioxaglate and the nonionic CM iodixanol at 37 degrees C for 5 min, without or with stirring. ...

journal_title：Thrombosis and haemostasis

authors： Ji Q,Ghaly M,Hjemdahl P,Tornvall P,Li N

更新日期：2005-05-01 00:00:00

abstract：:Platelet microparticles (PMPs) are small vesicles released from blood platelets upon activation. The procoagulant activity of PMPs has been previously mainly characterized by their ability to bind coagulation factors VIII and Va in reconstructed systems. It can be supposed that PMPs can contribute to the development o...

journal_title：Thrombosis and haemostasis

authors： Sinauridze EI,Kireev DA,Popenko NY,Pichugin AV,Panteleev MA,Krymskaya OV,Ataullakhanov FI

更新日期：2007-03-01 00:00:00

abstract：:The gel-chromatography of the beta-alanine precipitate of human plasma and of purified fibrinogen shows the presence of different classes of fibrinogen complexes. A first class of complexes is detectable in correspondence with the ascending branch of the fibrinogen peak ("shoulder" complexes or high molecular weight f...

journal_title：Thrombosis and haemostasis

authors： Serneri GGE,Gensini GF,Abbate R,Favilla S

更新日期：1979-07-01 00:00:00

abstract：:Platelet aggregation is frequently impaired in myeloproliferative disorders (MPD). The presence of spontaneous platelet aggregation (SPA) or alterations of the aggregation pattern after ADP, epinephrine and collagen have been a frequent feature in the series of 52 patients here presented. The occurrence of SPA was not...

journal_title：Thrombosis and haemostasis

authors： Cortelazzo S,Barbui T,Bassan R,Dini E

更新日期：1980-06-18 00:00:00

abstract：:Staphylokinase is a potent highly fibrin-selective thrombolytic agent, but it induces a humoral immune response in most treated patients. Staphylokinase-specific T-lymphocytes can be found in normal healthy individuals, from whom a large panel of staphylokinase-specific T-cells were cloned. The staphylokinase amino ac...

journal_title：Thrombosis and haemostasis

authors： Warmerdam PA,Plaisance S,Vanderlick K,Vandervoort P,Brepoels K,Collen D,De Maeyer M

更新日期：2002-04-01 00:00:00

abstract：:It has been reported that lanosterol can sensitize isolated rat platelets to agonists such as ADP and thrombin (4). The purpose of this paper was to determine whether lanosterol had similar effects on human platelets and whether this was achieved by changes in membrane fluidity. Lanosterol did increase the sensitivity...

journal_title：Thrombosis and haemostasis

authors： Hassall DG,Bruckdorfer KR,Sulpice JC,Lutton C

更新日期：1985-12-17 00:00:00

abstract：:The fibrin-mediated enhancement of the activation of plasminogen by tissue-type plasminogen activator observed with normal fibrin, is strongly decreased with fibrin Dusard, although the binding of tissue-type plasminogen activator to this fibrin is normal. This impaired fibrin-mediated plasminogen activation is most l...

journal_title：Thrombosis and haemostasis

authors： Lijnen HR,Soria J,Soria C,Collen D,Caen JP

更新日期：1984-02-28 00:00:00

abstract：:Alpha-enolase is an ubiquitous cytoplasmic glycolytic enzyme which also exhibits cell surface mediated functions and a structural role in the lens of some species. An alpha-enolase related molecule (alpha-ERM) is present on the surfaces of neutrophils, monocytes and monocytoid cells and has the capacity to specificall...

journal_title：Thrombosis and haemostasis

authors： Arza B,Félez J,Lopez-Alemany R,Miles LA,Muñoz-Cánoves P

更新日期：1997-09-01 00:00:00

abstract：:Tissue factor is the primary initiator of coagulation cascade and plays an essential role in haemostasis and thrombosis. In addition, tissue factor and coagulation proteases contribute to many cellular responses via activation of protease activated receptors. The heart is an organ with high levels of constitutive tiss...

journal_title：Thrombosis and haemostasis

authors： Antoniak S,Sparkenbaugh E,Pawlinski R

更新日期：2014-11-01 00:00:00

abstract：:In a series of 16 propositi with symptomatic protein S deficiency and a protein S gene mutation, we identified a sporadic case of a novel mutation that probably affects gene expression. The mutation, a G to C transversion leading to the substitution of Ala 484 by Pro, was not found in the protein S gene of the patient...

journal_title：Thrombosis and haemostasis

authors： Borgel D,Jude B,Aiach M,Gandrille S

更新日期：1996-06-01 00:00:00

abstract：:Platelet activation and aggregation are critical in the pathogenesis of acute ischemic cerebrovascular diseases. The aim of our study was to characterize platelet function in patients with acute ischemic stroke or transient ischemic attack (TIA), and to evaluate the effect of platelet activation on clinical outcome. O...

journal_title：Thrombosis and haemostasis

authors： Fateh-Moghadam S,Htun P,Tomandl B,Sander D,Stellos K,Geisler T,Langer H,Walton K,Handschu R,Garlichs C,Daniel WG,Gawaz M

更新日期：2007-06-01 00:00:00

abstract：:Much research in venous thrombotic diseases focuses on the acute thrombotic process such as anticoagulation and risk factors. Deep-vein thrombosis directly leads to post thrombotic syndrome, and this can cause significant patient disability. Little research has focused on the vein wall injury response to the thromboti...

journal_title：Thrombosis and haemostasis

authors： Deroo S,Deatrick KB,Henke PK

更新日期：2010-10-01 00:00:00

abstract：:Heparin is one of the oldest biological medicines, and has an established place in the prevention and treatment of venous thrombosis. Low-molecular-weight heparins (LMWH) have been developed by several manufacturers and have advantages in terms of pharmacokinetics and convenience of administration. They have been show...

journal_title：Thrombosis and haemostasis

authors： Gray E,Mulloy B,Barrowcliffe TW

更新日期：2008-05-01 00:00:00

abstract：:Activated protein C (APC) is a serine proteinase that regulates blood coagulation. In plasma it is inhibited mainly by the protein C inhibitor (PCI). The plasma concentrations of APC-PCI complex is increased in hypercoagulative states such as deep venous thrombosis. Formation of the APC-PCI complex induces a drastic c...

journal_title：Thrombosis and haemostasis

authors： Strandberg K,Kjellberg M,Knebel R,Lilja H,Stenflo J

更新日期：2001-08-01 00:00:00

abstract：:Thirty-one individuals from 18 unrelated families with antithrombin deficiency have been identified as having a single point mutation within codon 384 (13268 GCA-->TCA) resulting in an alanine to serine substitution. Six families (11 individuals) were identified by the screening of individuals with thromboembolic dise...

journal_title：Thrombosis and haemostasis

authors： Perry DJ,Daly ME,Tait RC,Walker ID,Brown K,Beauchamp NJ,Preston FE,Gyde H,Harper PL,Carrell RW

更新日期：1998-02-01 00:00:00

abstract：:Paired blood samples were obtained from mothers (venous) and babies (cord venous blood) at the time of delivery by caesarean section under epidural anaesthetic. Fetal platelets failed to aggregate in response to adrenaline in vitro although adrenaline could potentiate the threshold response to adenosine diphosphate (1...

journal_title：Thrombosis and haemostasis

authors： Jones CR,McCabe R,Hamilton CA,Reid JL

更新日期：1985-02-18 00:00:00

abstract：:Our previous study has shown that Toll-like receptor 4 (TLR4) and its signalling pathway contribute to anti-β₂-glycoprotein I/β₂-glycoprotein I (anti-β₂GPI/β₂GPI)-induced tissue factor (TF) expression in human acute monocytic leukaemia cell line THP-1 and annexin A2 (ANX2) is involved in this pathway. However, its dow...

journal_title：Thrombosis and haemostasis

authors： Xu G,Wen H,Zhou H,Guo D,Zhou F,Chen D,Xie H,Wang T,Wang H

更新日期：2011-12-01 00:00:00

abstract：:The use of warfarin with a range INR of 2.0-3.0 is recommended in prevention of stroke for nonvalvular atrial fibrillation (AF) patients, in particular those older than 75 years. The risk of bleeding that is associated with this range of INR has led to evaluate lower ranges (low-dose or fixed minidose) in terms of ris...

journal_title：Thrombosis and haemostasis

authors： Perret-Guillaume C,Wahl DG

更新日期：2004-02-01 00:00:00

abstract：:Prasugrel, through its active metabolite, reduces atherothrombosis and its clinical manifestations by inhibiting platelet activation and aggregation. Platelets also contribute to inflammation through interaction with different classes of leukocytes. We investigated whether the inhibitory effect of prasugrel on platele...

journal_title：Thrombosis and haemostasis

authors： Totani L,Dell'Elba G,Martelli N,Di Santo A,Piccoli A,Amore C,Evangelista V

更新日期：2012-06-01 00:00:00

abstract：:The development of antibodies against infused factor VIII (FVIII) in patients with haemophilia A is a serious complication leading to poorly controlled bleeding and increased morbidity. No treatment has been proven to reduce high titre antibodies in patients who fail immune tolerance induction or are not candidates fo...

journal_title：Thrombosis and haemostasis

authors： Leissinger C,Josephson CD,Granger S,Konkle BA,Kruse-Jarres R,Ragni MV,Journeycake JM,Valentino L,Key NS,Gill JC,McCrae KR,Neufeld EJ,Manno C,Raffini L,Saxena K,Torres M,Marder V,Bennett CM,Assmann SF

更新日期：2014-09-02 00:00:00

abstract：:We compared the anticoagulant, antithrombotic and bleeding effects of highly sulfated dermatan sulfates from invertebrates and their mammalian counterpart. An invertebrate dermatan sulfate containing 2-O-sulfated alpha-L-iduronic acid and 4-O-sulfated N-acetyl-beta-D-galactosamine residues is a potent anticoagulant du...

journal_title：Thrombosis and haemostasis

authors： Vicente CP,Zancan P,Peixoto LL,Alves-Sá R,Araújo FS,Mourão PA,Pavão MS

更新日期：2001-11-01 00:00:00

abstract：:Microparticles (MPs) are formed from platelets (PMPs), endothelial cells (EMPs) and monocytes (MMPs), and in acute myocardial infarction (MI), there is an increase of MPs in the culprit artery. In this study MPs were evaluated in whole blood in 105 patients with MI at five time-points during a two-year follow-up (FU)....

journal_title：Thrombosis and haemostasis

authors： Christersson C,Thulin Å,Siegbahn A

更新日期：2017-07-26 00:00:00