Contrast medium attenuates platelet activation and platelet-leukocyte cross-talk.

abstract：:Emicizumab, a bispecific monoclonal antibody, bridges activated factor IX (FIXa) and FX, replacing the function of missing FVIIIa to restore effective hemostasis in persons with hemophilia A (PwHA). Here we assess pharmacokinetic (PK) and pharmacodynamic (PD) biomarkers in PwHA with FVIII inhibitors in the Phase III H...

journal_title：Thrombosis and haemostasis

authors： Schmitt C,Adamkewicz JI,Xu J,Petry C,Catalani O,Young G,Negrier C,Callaghan MU,Levy GG

更新日期：2020-10-21 00:00:00

abstract：:We investigated the presence of the gene mutation of factor V, FV R506Q or factor V Leiden, responsible for activated protein C resistance, in DNA samples of 127 probands and 188 relatives from 128 families with antithrombin deficiency. The factor V mutation was identified in 18 families. Nine families were available ...

journal_title：Thrombosis and haemostasis

authors： van Boven HH,Reitsma PH,Rosendaal FR,Bayston TA,Chowdhury V,Bauer KA,Scharrer I,Conard J,Lane DA

更新日期：1996-03-01 00:00:00

abstract：:To understand the role of the factor X (fX) activation peptide (AP), a deletion mutagenesis approach was employed. Two single-chain, variant enzymes were generated in which 41 residues were deleted from the AP: fX (des-137-183) and fX(des-137-183;N191A), which lacks a carbohydrate moiety at Asn191 due to an alanine su...

journal_title：Thrombosis and haemostasis

authors： Rudolph AE,Mullane MP,Porche-Sorbet R,Daust HA,Miletich JP

更新日期：2002-11-01 00:00:00

abstract：:The alphaII(b)beta3 integrin and FcgammaRII receptors mediate, respectively, platelet adhesion and spreading on fibrinogen and immunoglobulin (IgG) coated surfaces. Platelet adhesion to fibrinogen resulted in a partial conversion of the faster to the slower migrating (phosphorylated) form of Ca(+2)-sensitive cytosolic...

journal_title：Thrombosis and haemostasis

authors： Haimovich B,Ji P,Ginalis E,Kramer R,Greco R

更新日期：1999-04-01 00:00:00

abstract：:In patients with von Willebrand disease (VWD) replacement therapy with factor VIII/von Willebrand (VWF) concentrates is increasingly applied as prophylactic regimen. Since 2000, 82 consecutively enrolled patients with clinically relevant bleeding episodes (spontaneous, peri- or postoperative) were diagnosed with VWD [...

journal_title：Thrombosis and haemostasis

authors： Halimeh S,Krümpel A,Rott H,Bogdanova N,Budde U,Manner D,Faeser B,Mesters R,Nowak-Göttl U

更新日期：2011-04-01 00:00:00

abstract：:The aim of this study was to investigate the anti-thrombotic effects of an inhibitor of the plasminogen activator inhibitor-1 (PAI-1) in rats given endotoxin. In studies in vitro, PRAP-1, a Fab-fragment of a polyclonal antibody against human PAI-1, was shown to inhibit PAI-1 activity in rat plasma as well as to stimul...

journal_title：Thrombosis and haemostasis

authors： Abrahamsson T,Nerme V,Strömqvist M,Akerblom B,Legnehed A,Pettersson K,Westin Eriksson A

更新日期：1996-01-01 00:00:00

abstract：:We have previously shown that both mental stress and administration of the muscarinic receptor agonist methacholine induce an acute release of tissue-type plasminogen activator (t-PA) across the human forearm. There are data indicating that the regulated acute release of t-PA from the endothelium is closely interrelat...

journal_title：Thrombosis and haemostasis

authors： Jern C,Selin L,Tengborn L,Jern S

更新日期：1997-08-01 00:00:00

abstract：:Findings from a recent study suggest that earlier start of treatment with factor VIII in patients with severe hemophilia is associated with a higher risk to develop inhibitors. We set out to assess the association between age of first administration of clotting factor VIII and the risk to develop inhibitors in infants...

journal_title：Thrombosis and haemostasis

authors： van der Bom JG,Mauser-Bunschoten EP,Fischer K,van den Berg HM

更新日期：2003-03-01 00:00:00

abstract：:Serum amyloid P component (SAP), and its acute phase homologue C-reactive protein (CRP), prolonged activated partial thromboplastin times (APTT) in cell free plasma when assayed at physiological concentrations in the presence of heparin. SAP also inhibited clot formation initiated through the extrinsic and terminal ph...

journal_title：Thrombosis and haemostasis

authors： Fiedel BA,Ku CS

更新日期：1986-06-30 00:00:00

abstract：:Ultra-low-molecular-weight heparins (ULMWHs) with better efficacy and safety ratios are under development; however, there are few structural data available. The main structural features and molecular weight of ULMWHs were studied and compared to enoxaparin. Their monosaccharide composition and average molecular weight...

journal_title：Thrombosis and haemostasis

authors： Lima MA,Viskov C,Herman F,Gray AL,de Farias EH,Cavalheiro RP,Sassaki GL,Hoppensteadt D,Fareed J,Nader HB

更新日期：2013-03-01 00:00:00

abstract：:In hereditary angioedema (HAE), normal C1-inhibitor (C1-INH) is low and the contact system activated. Recently, the findings of a tissue factor mutant selectively deficient in promoting the conversion of FVII to FVIIa, but with retained cofactor for FVIIa, made it possible to examine reliably the pre-existing content ...

journal_title：Thrombosis and haemostasis

authors： Nielsen EW,Morrissey J,Olsen JO,Osterud B

更新日期：1995-10-01 00:00:00

abstract：:In 70-80% of cases, pulmonary embolism is the consequence of lower extremity deep vein thrombosis. It has been demonstrated that the most common coagulation defect predisposing to venous thrombosis, resistance to activated protein C (APC), is not associated with an increased risk for pulmonary embolism, but the eviden...

journal_title：Thrombosis and haemostasis

authors： Martinelli I,Cattaneo M,Panzeri D,Mannucci PM

更新日期：1997-03-01 00:00:00

abstract：:The effect of IgGs from 4 patients with antiphospholipid antibodies and elevated excretion of urinary 11-dehydro-thromboxane B2 was evaluated on the production of prostacyclin by human endothelial cells in culture. After 6 h incubation, there was no change in 6-keto-prostaglandin F1 alpha in the supernatant. However p...

journal_title：Thrombosis and haemostasis

authors： Habib A,Martinuzzo ME,Carreras LO,Lévy-Toledano S,Maclouf J

更新日期：1995-08-01 00:00:00

abstract：BACKGROUND: Accurate diagnosis of symptomatic low von Willebrand factor (VWF) remains a major challenge in von Willebrand disease (VWD). However, present tests do not adequately take into account flow forces that, at very high shear rates, reveal a weakness in the VWF-platelet glycoprotein glycoprotein Ib bond in norma...

journal_title：Thrombosis and haemostasis

authors： Grabowski EF,Van Cott EM,Bornikova L,Boyle DC,Silva RL

更新日期：2020-05-01 00:00:00

abstract：:Hormone replacement therapy has been associated with venous thromboembolism. Controversy exists regarding the appropriate management of hormone replacement in the perioperative setting and in other situations--such as acute illness--predisposing to acute venous thromboembolism. We performed a case-control study to det...

journal_title：Thrombosis and haemostasis

authors： Hurbanek JG,Jaffer AK,Morra N,Karafa M,Brotman DJ

更新日期：2004-08-01 00:00:00

abstract：:Autoantibodies to the zwitterionic phospholipid (PL), phosphatidylethanolamine (PE) have been described in patients with thrombotic diseases. Recently, we reported that many antiphosphatidylethanolamine antibodies (aPE) are not specific for PE per se, but are directed to plasma proteins which can bind PE, for example,...

journal_title：Thrombosis and haemostasis

authors： Sugi T,Mclntyre JA

更新日期：1996-09-01 00:00:00

abstract：:An increased prevalence of hypertension is reported in haemophilia patients, but data from large, unbiased studies are lacking. The aim of our study was to cross-sectionally assess the prevalence of hypertension in a large cohort of 701 haemophilia patients. Blood pressure (BP) measurements performed in 386 Dutch and ...

journal_title：Thrombosis and haemostasis

authors： Fransen van de Putte DE,Fischer K,Makris M,Tait RC,Collins PW,Meijer K,Roosendaal G,Chowdary P,Schutgens RE,Mauser-Bunschoten EP

更新日期：2012-10-01 00:00:00

abstract：:Catabolism of coagulation factor VIII (FVIII) is mediated by low-density lipoprotein receptor-related protein (LRP). The ligand-binding sites of LRP are formed by complement-type repeats (CR), and CR clusters II and IV bind most of LRP ligands. FVIII contains two major LRP-binding sites located in the A2 and A3 domain...

journal_title：Thrombosis and haemostasis

authors： Sarafanov AG,Makogonenko EM,Andersen OM,Mikhailenko IA,Ananyeva NM,Khrenov AV,Shima M,Strickland DK,Saenko EL

更新日期：2007-12-01 00:00:00

abstract：:Increased procoagulant activity in the alveolar compartment and uncontrolled inflammation are hallmarks of the acute respiratory distress syndrome (ARDS). Here, we investigated whether the contact phase system of coagulation is activated and may regulate inflammatory responses in human lungs. Components of the contact...

journal_title：Thrombosis and haemostasis

authors： Hess R,Wujak L,Hesse C,Sewald K,Jonigk D,Warnecke G,Fieguth HG,de Maat S,Maas C,Bonella F,Preissner KT,Weiss B,Schaefer L,Kuebler WM,Markart P,Wygrecka M

更新日期：2017-10-05 00:00:00

abstract：:One hundred patients were included in a randomized open trial to assess the systemic factor Xa (FXa) and thrombin inhibitory effect as well as the safety profile of low molecular weight heparin (LMWH) given subcutaneously in conjunction with streptokinase (SK) in patients with acute myocardial infarction (MI). The tre...

journal_title：Thrombosis and haemostasis

authors： Nilsen DW,Gøransson L,Larsen AI,Hetland O,Kierulf P

更新日期：1997-01-01 00:00:00

abstract：:Causative mutations in the factor VIII gene of seven unrelated patients with severe haemophilia A were identified using the mutation screening procedure conformation sensitive gel electrophoresis (1) and characterised by direct sequencing. Female family members of all patients had requested either carrier status deter...

journal_title：Thrombosis and haemostasis

authors： Williams IJ,Abuzenadah A,Winship PR,Preston FE,Dolan G,Wright J,Peake IR,Goodeve AC

更新日期：1998-04-01 00:00:00

abstract：:In wound repair, fibrin has a multiplicity of activities, some of which are intrinsic to the protein itself and some attributable to other blood constituents associated with the fibrin clot. Fibrin sealants, which have been approved for hemostasis in the US and Europe, are occasionally used wounds to promote healing. ...

journal_title：Thrombosis and haemostasis

authors： Clark RA

更新日期：2003-12-01 00:00:00

abstract：:Osteoprotegerin (OPG) regulates bone metabolism by reducing the activation of osteoclasts, but may also be involved in blood vessel calcification and atherosclerosis. Within endothelial cells OPG is stored in Weibel-Palade bodies (WPBs). Blood kinetics of OPG are essentially unknown. We aimed to assess these using two...

journal_title：Thrombosis and haemostasis

authors： Buchtele N,Kovacevic KD,Brostjan C,Schwameis M,Hayden H,Derhaschnig U,Firbas C,Jilma B,Schoergenhofer C

更新日期：2020-07-01 00:00:00

abstract：:An assay system for protein C (PC) activity and PC-inhibitor in plasma was developed. The assay was based on: (1) binding of PC to wells of a microtiter plate coated with a murine monoclonal anti-PC antibody (C3) that did not interfere with the activity or activation of PC; (2) activation of immobilized PC with Protac...

journal_title：Thrombosis and haemostasis

authors： Geiger M,White TM,Griffin JH

更新日期：1989-02-28 00:00:00

abstract：:Atherosclerotic plaques are found at distinct locations in the arterial system, despite the exposure to systemic risk factors of the entire vascular tree. From the study of arterial bifurcation regions, emerges ample evidence that haemodynamics are involved in the local onset and progression of the atherosclerotic dis...

journal_title：Thrombosis and haemostasis

authors： Morbiducci U,Kok AM,Kwak BR,Stone PH,Steinman DA,Wentzel JJ

更新日期：2016-03-01 00:00:00

abstract：:We determined factor VII antigen (FVIIag) levels in 705 healthy blood donors ranging in age from 17 to 79 years using a two-site solid-phase enzyme immunoassay developed in our laboratory. The mean (+/- SD) FVIIag level for the total population was 102 +/- 31%. FVIIag levels for men (n = 375) and women (n = 330) were ...

journal_title：Thrombosis and haemostasis

authors： Howard PR,Bovill EG,Pike J,Church WR,Tracy RP

更新日期：1994-07-01 00:00:00

abstract：:Data on the in vivo function of platelets induced by the thrombopoietin receptor agonist eltrombopag are scarce. To assess a possible influence of eltrombopag we compared platelet function of eltrombopag-treated immune thrombocytopenia (ITP) patients (group 1; n=10) after treatment response to that from control ITP pa...

journal_title：Thrombosis and haemostasis

authors： Haselboeck J,Kaider A,Pabinger I,Panzer S

更新日期：2013-04-01 00:00:00

abstract：:We have investigated the intracellular mechanisms involved in microtubular remodelling by thrombin and its possible involvement in platelet aggregation and secretion. Platelet stimulation with thrombin induces a time- and concentration-dependent regulation of the microtubular content, which was found to be maximally e...

journal_title：Thrombosis and haemostasis

authors： Bouaziz A,Amor NB,Woodard GE,Zibidi H,López JJ,Bartegi A,Salido GM,Rosado JA

更新日期：2007-08-01 00:00:00

abstract：:The risk of acute cardiovascular events is highest during morning hours, and platelet activity peaks during morning hours. The effect of timing of aspirin intake on circadian rhythm and morning peak of platelet reactivity is not known. It was our objective to evaluate the effect of timing of aspirin intake on circadia...

journal_title：Thrombosis and haemostasis

authors： Bonten TN,Saris A,van Oostrom MJ,Snoep JD,Rosendaal FR,Zwaginga J,Eikenboom J,van der Meer PF,van der Bom JG

更新日期：2014-12-01 00:00:00

abstract：:Plasminogen activator inhibitor 1 (PAI-1) is the main inhibitor of tissue-type and urokinase-type plasminogen activators (t/uPA) and plays an important role in fibrinolysis. Inhibition of PAI-1 activity prevents thrombosis and accelerates fibrinolysis, indicating that PAI-1 inhibitors may be used as effective antithro...

journal_title：Thrombosis and haemostasis

authors： Peng S,Xue G,Gong L,Fang C,Chen J,Yuan C,Chen Z,Yao L,Furie B,Huang M

更新日期：2017-06-28 00:00:00