Unbalanced effects of dermatan sulfates with different sulfation patterns on coagulation, thrombosis and bleeding.

abstract：:Ridogrel (6.3 x 10(-6) to 10(-4) M) inhibited contractions of isolated rat caudal arteries and rabbit femoral arteries caused by U-46619. The slope of an Arunlakshana-Schild plot (pA2-value: 3.4 x 10(-6) M) on the caudal artery was slightly higher than one (1.14). This effect was maximal within 20 min of incubation of...

journal_title：Thrombosis and haemostasis

authors： Janssens WJ,Cools FJ,Hoskens LA,Van Nueten JM

更新日期：1990-08-13 00:00:00

abstract：:The incidence of newly diagnosed malignancy is increased in patients with unexplained venous thromboembolism during the first year after a thromboembolic event in comparison to controls (odds ratio, 3.9-36). Extensive screening with computed tomography, endoscopy and tumor markers can identify most of these undetected...

journal_title：Thrombosis and haemostasis

authors： Prins MH,Hettiarachchi RJ,Lensing AW,Hirsh J

更新日期：1997-07-01 00:00:00

abstract：:Platelets are suggested to play a crucial role in cancer progression and the prothrombotic state of cancer patients. Here, we aimed to examine the activation status of platelets in cancer patients and investigate their association with risk of death and occurrence of venous thromboembolism (VTE) in a prospective obser...

journal_title：Thrombosis and haemostasis

authors： Riedl J,Kaider A,Marosi C,Prager GW,Eichelberger B,Assinger A,Pabinger I,Panzer S,Ay C

更新日期：2017-01-05 00:00:00

abstract：:Several studies have highlighted a specific role for membrane cholesterol domains in platelet signalling. Upon adhesion to von Willebrand factor (VWF) or collagen, cholesterol-rich domains (CRDs) accumulate in filopodial extensions and selectively harbour counterpart receptors (GPIb and GPVI) and associated signalling...

journal_title：Thrombosis and haemostasis

authors： van Lier M,Verhoef S,Cauwenberghs S,Heemskerk JW,Akkerman JW,Heijnen HF

更新日期：2008-06-01 00:00:00

abstract：:In patients with deep vein thrombosis (DVT), the factors which predispose to concomitant symptomatic pulmonary embolism (PE) have remained uncertain. From a prospective cohort of 5,451 consecutive patients with ultrasound-confirmed DVT, we analyzed 4,211 patients with a known status for presence (n=639) or absence (n=...

journal_title：Thrombosis and haemostasis

authors： Kucher N,Tapson VF,Goldhaber SZ,DVT FREE Steering Committee.

更新日期：2005-03-01 00:00:00

abstract：BACKGROUND: Carotid atherosclerosis is an important cause of stroke. Intra-plaque haemorrhage (IPH) on magnetic resonance imaging (MRI) increases stroke risk. Development of IPH is only partly understood. Thrombin is an essential enzyme in haemostasis. Experimental animal studies have shown conflicting results on the r...

journal_title：Thrombosis and haemostasis

authors： Crombag GAJC,Spronk HM,Nelemans P,Schreuder FHBM,Truijman MTB,van Dijk AC,de Rotte AAJ,Liem MI,Daemen MJAP,van der Steen AFW,Mess WH,Nederkoorn PJ,Hendrikse J,van der Lugt A,Wildberger JE,Ten Cate H,van Oostenbrugge RJ,

更新日期：2018-08-01 00:00:00

abstract：:Thrombin triggers activation of platelets through protease-activated receptor 1 (PAR-1) and PAR-4. Both receptors are widely expressed and exert multiple platelet-independent functions. PAR signalling contributes to healing responses after injury, by promoting cytokine activity and cellular growth and mobility. Uncont...

journal_title：Thrombosis and haemostasis

authors： Fender AC,Rauch BH,Geisler T,Schrör K

更新日期：2017-11-01 00:00:00

abstract：:Clinical observations have shown that heparin has antiinflammatory activities. The effect of heparin on neutrophil chemotaxis was evaluated in vitro in the Boyden Chamber. This method enabled differentiation between the direct effects of heparin on neutrophil migration and locomotion, and its effects on chemotactic fa...

journal_title：Thrombosis and haemostasis

authors： Matzner Y,Marx G,Drexler R,Eldor A

更新日期：1984-10-31 00:00:00

abstract：:We aimed to determine the association between autoantibodies against apolipoprotein A-1 (anti-apoA-1 IgG) and prevalent cardiovascular (CV) disease (CVD) as well as markers of CV risk in the general population. Cross-sectional data were obtained from 6649 subjects (age 52.6 ± 10.7 years, 47.4 % male) of the population...

journal_title：Thrombosis and haemostasis

authors： Antiochos P,Marques-Vidal P,Virzi J,Pagano S,Satta N,Bastardot F,Hartley O,Montecucco F,Mach F,Waeber G,Vollenweider P,Vuilleumier N

更新日期：2016-09-27 00:00:00

abstract：:The antithrombotic effect of MCI-9042, (+-)-2-(dimethyl-amino)-1-((o-(m- methoxyphenethyl)phenoxyl]methyl]ethyl hydrogen succinate hydrochloride was investigated in three different experimental thrombosis models in animals. Simultaneous injection of serotonin and collagen into the tail vein in mice induced acute pulmo...

journal_title：Thrombosis and haemostasis

authors： Hara H,Kitajima A,Shimada H,Tamao Y

更新日期：1991-10-01 00:00:00

abstract：:The carboxy-terminal region of hirudin (residues 54-65) has previously been shown to inhibit thrombin clotting activity without binding to the catalytic site of the enzyme. In the present study, the effect of hirudin 54-65 on thrombin interaction with specified platelet proteins has been investigated. Hirudin 54-65 wa...

journal_title：Thrombosis and haemostasis

authors： Jandrot-Perrus M,Huisse MG,Krstenansky JL,Bezeaud A,Guillin MC

更新日期：1991-09-02 00:00:00

abstract：:We have recently reported the short-term intraindividual variability of several coagulation factors and inhibitors included in the ARIC study (Chambless et al. Ann Epidemiol 1992; 2:723). In this paper, we reported the intraindividual variability results of additional hemostatic factors. Blood samples were collected f...

journal_title：Thrombosis and haemostasis

authors： Nguyen ND,Ghaddar H,Stinson V,Chambless LE,Wu KK

更新日期：1995-02-01 00:00:00

abstract：:The molecular weight profiles of low molecular weight heparin samples have been measured by high-performance gel permeation chromatography using as calibrant the heparinase-degraded material (90/686) now established as the 1st International Reference Preparation (IRP) Low Molecular Weight Heparin for Molecular Weight ...

journal_title：Thrombosis and haemostasis

authors： Mulloy B,Gee C,Wheeler SF,Wait R,Gray E,Barrowcliffe TW

更新日期：1997-04-01 00:00:00

abstract：:Tissue factor (TF) plays a critical role in tumour growth and metastasis, and its enhanced release into plasma in association with cellular microparticles (MPs) has recently been associated with pathological cancer progression. We have previously demonstrated significantly elevated levels of plasma TF antigen as well ...

journal_title：Thrombosis and haemostasis

authors： Haubold K,Rink M,Spath B,Friedrich M,Chun FK,Marx G,Amirkhosravi A,Francis JL,Bokemeyer C,Eifrig B,Langer F

更新日期：2009-06-01 00:00:00

abstract：:Electrospray ionisation mass spectrometry was used to probe the structure of the new N-linked oligosaccharide in fibrinogen Kaiserslautern (gamma 380 Lys-->Asn). The mass increase of 2177 Da in the new beta chain indicated the attachment of a fully sialylated biantennary oligosaccharide on the new Asn residue; the exp...

journal_title：Thrombosis and haemostasis

authors： Brennan SO,Loreth RM,George PM

更新日期：1998-08-01 00:00:00

abstract：:We measured and compared the levels of plasma soluble (s) P-selectin, sCD40L, platelet-derived microparticles (PDMP), monocyte-derived microparticles (MDMP), and anti-oxidized LDL antibody, to obtain a better understanding of their potential contribution to vascular complications in acute coronary syndrome (ACS). The ...

journal_title：Thrombosis and haemostasis

authors： Matsumoto N,Nomura S,Kamihata H,Kimura Y,Iwasaka T

更新日期：2004-01-01 00:00:00

abstract：:We have developed a sensitive and quantitative RT-PCR assay for the determination of tissue factor (TF) mRNA levels in human cells. An in vitro synthesized internal standard RNA was used to correct for differences in reverse transcription or amplification of various RNA samples. The PCR products were quantitated by hy...

journal_title：Thrombosis and haemostasis

authors： Pötgens AJ,Lubsen NH,van Altena G,Schoenmakers JG,Ruiter DJ,de Waal RM

更新日期：1994-02-01 00:00:00

abstract：:The content of free-catecholamines in blood platelets is much higher than in plasma and platelet catecholamines must be taken up from plasma, since platelets lack the enzymes for catecholamine synthesis. There is some evidence that platelet catecholamine content under certain circumstances may be an integrated measure...

journal_title：Thrombosis and haemostasis

authors： Kjeldsen SE,Gjesdal K,Leren P,Eide IK

更新日期：1988-10-31 00:00:00

abstract：:High physiological concentrations of plasma vasopressin (aVP) when achieved by infusion cause an increase in plasma factor VIII coagulant activity and shortening of the euglobulin clot lysis time (ECLT). To investigate the effects of aVP on components of the fibrinolytic pathway and on thrombin generation, 9 healthy v...

journal_title：Thrombosis and haemostasis

authors： Hariman H,Grant PJ,Hughes JR,Booth NA,Davies JA,Prentice CR

更新日期：1989-04-25 00:00:00

abstract：:The aim of this study was to evaluate the existence of an additive effect between standard heparin and dDAVP in the enhancement of endogenous fibrinolysis. Eight healthy volunteers were studied in a randomized double blind placebo controlled cross-over trial. The volunteers were treated i.v. with dDAVP, 0.4 micrograms...

journal_title：Thrombosis and haemostasis

authors： Agnelli G,Levi M,Cosmi B,ten Cate JW,Nenci GG

更新日期：1989-06-30 00:00:00

abstract：:Phospholipase C (PLC)-β2 (gene PLCB2) is a critical regulator of platelet responses upon activation. Mechanisms regulating of PLC-β2 expression in platelets/MKs are unknown. Our studies in a patient with platelet PLC-β2 deficiency revealed the PLCB2 coding sequence to be normal and decreased platelet PLC-β2 mRNA, sugg...

journal_title：Thrombosis and haemostasis

authors： Mao G,Jin J,Kunapuli SP,Rao AK

更新日期：2016-10-28 00:00:00

abstract：:The terms glycoprotein IV (GPIV) and glycoprotein IIIb (GPIIIb) have been used interchangeably and reports in the literature have indicated this glycoprotein as having a molecular weight variously described as either 88,000 or 97,000, a fast anodal mobility on crossed electrophoresis and either 13 or less than 1 methi...

journal_title：Thrombosis and haemostasis

authors： Yamamoto N,de Romeuf C,Tandon NN,Jamieson GA

更新日期：1990-02-19 00:00:00

abstract：:We have studied effects of the solvent composition on the activity and the conformation of human plasminogen activator inhibitor-1 (PAI-1) from HT-1080 fibrosarcoma cells. Non-ionic detergents, includine Triton X-100, reduced the inhibitory activity of PAI-1 more than 20-fold at 0 degrees C, but less than 2-fold at 37...

journal_title：Thrombosis and haemostasis

authors： Andreasen PA,Egelund R,Jensen S,Rodenburg KW

更新日期：1999-03-01 00:00:00

abstract：:The effect of thrombin on the phosphorylating activity of platelet membranes was compared to that of trypsin. Preincubation of non-32P phosphorylated platelet membranes with or without either of these two enzymes resulted in a considerable loss of membrane protein kinase activity which was most severe when trypsin was...

journal_title：Thrombosis and haemostasis

authors： Steiner M

更新日期：1976-06-30 00:00:00

abstract：:Acid-treated human plasma is a competitive inhibitor of the hydrolysis of D-Val-Leu-Lys-Nan (S-2251) by plasmin. The rate of hydrolysis is decreased to 50% by 750 fold diluted acidified normal plasma and by 60 fold diluted acidified alpha 2-antiplasmin depleted plasma (alpha 2-antiplasmin concentration less than 2%). ...

journal_title：Thrombosis and haemostasis

authors： Lijnen HR,Maes M,Castel M,Samama M,Collen D

更新日期：1982-12-27 00:00:00

abstract：:The effect of IgGs from 4 patients with antiphospholipid antibodies and elevated excretion of urinary 11-dehydro-thromboxane B2 was evaluated on the production of prostacyclin by human endothelial cells in culture. After 6 h incubation, there was no change in 6-keto-prostaglandin F1 alpha in the supernatant. However p...

journal_title：Thrombosis and haemostasis

authors： Habib A,Martinuzzo ME,Carreras LO,Lévy-Toledano S,Maclouf J

更新日期：1995-08-01 00:00:00

abstract：:The fibrin-mediated enhancement of the activation of plasminogen by tissue-type plasminogen activator observed with normal fibrin, is strongly decreased with fibrin Dusard, although the binding of tissue-type plasminogen activator to this fibrin is normal. This impaired fibrin-mediated plasminogen activation is most l...

journal_title：Thrombosis and haemostasis

authors： Lijnen HR,Soria J,Soria C,Collen D,Caen JP

更新日期：1984-02-28 00:00:00

abstract：:The effect of aspirin on LPS-incubation of whole blood was investigated. Aspirin induced a concentration dependent increase (2.5-5-fold at 5 mM aspirin) in LPS-induced appearance of TNF-alpha and fibrinopeptide A (FPA) in plasma, despite the concomitant increase in the inhibitory cytokine IL-100. Aspirin substantially...

journal_title：Thrombosis and haemostasis

authors： Osnes LT,Haug KB,Joø GB,Westvik AB,Ovstebø R,Kierulf P

更新日期：2000-06-01 00:00:00

abstract：:Recently we prepared sulfated, low-molecular-weight lignins (LMWLs) to mimic the biological activities of heparin and heparan sulfate. Chemo-enzymatically prepared sulfated LMWLs represent a library of diverse non-sugar, aromatic molecules with structures radically different from the heparins, and have been found to p...

journal_title：Thrombosis and haemostasis

authors： Henry BL,Abdel Aziz M,Zhou Q,Desai UR

更新日期：2010-03-01 00:00:00

abstract：:Duplex ultrasound is the first-line diagnostic test for detecting lower limb deep-vein thrombosis (DVT) but it is time consuming, requires patient transport, and cannot be interpreted by most physicians. The accuracy of emergency physician-performed ultrasound (EPPU) for the diagnosis of DVT, when performed at the bed...

journal_title：Thrombosis and haemostasis

authors： Pomero F,Dentali F,Borretta V,Bonzini M,Melchio R,Douketis JD,Fenoglio LM

更新日期：2013-01-01 00:00:00