Increased level of oxidized LDL-dependent monocyte-derived microparticles in acute coronary syndrome.

abstract：:Positively charged macromolecule, polylysine (mol. wt. 15,000; 23,000; 180,000) could induce the platelet aggregation in low concentration but high concentration was required in the case of neutral macromolecule, dextran (mol. wt. 40,000; 250,000; 2,000,000). The larger molecules of polylysine and dextran were more ef...

journal_title：Thrombosis and haemostasis

authors： Taketomi Y,Kuramoto A

更新日期：1978-08-31 00:00:00

abstract：:To investigate the inhibitory mechanism of tissue factor pathway inhibitor (TFPI), an attempt was made to examine the inhibitory activity of TFPI toward the factor VIIa-truncated tissue factor (TF1-219) complex, which lacks its transmembrane and cytoplasmic domains. Factor VIIa-TF1-219 activity was significantly inhib...

journal_title：Thrombosis and haemostasis

authors： Kazama Y

更新日期：1997-03-01 00:00:00

abstract：:Standard pharmacokinetic (PK) assessments are demanding for persons with hemophilia A, requiring a 72hr washout and 5-11 timed blood samples. A no-washout, single-clinic visit, sparse sampling population PK (PPK) protocol is an attractive alternative. Here, we compared PK parameters obtained with a traditional washout...

journal_title：Thrombosis and haemostasis

authors： Blanchette V,Zunino L,Grassmann V,Barnes C,Carcao M,Curtain J,Jackson SC,Khoo L,Komrska V,Lillicrap D,Morfini M,Romanova G,Stephens D,Zapotocka E,Rand ML,Blatny J

更新日期：2021-01-27 00:00:00

abstract：:Plasminogen activator inhibitor type-1 (PAI-1) is a physiologic modulator of the fibrinolytic system. We have shown previously that PAI-1 biosynthesis in cultured cells depends on several factors in serum. Because platelets are richly endowed with specific growth factors and because the release reaction is an integral...

journal_title：Thrombosis and haemostasis

authors： Hopkins WE,Westerhausen DR,Fujii S,Billadello JJ,Sobel BE

更新日期：1991-08-01 00:00:00

abstract：:The increased risk for deep vein thrombosis (DVT) after orthopaedic surgery has been well documented as well as hypercoagulable state during both total hip arthroplasty (THA) and total knee replacement (TKR). To investigate the influence of the surgical procedure [posterolateral (PL) or lateral (L) approach for THA, u...

journal_title：Thrombosis and haemostasis

authors： Fedi S,Gori AM,Falciani M,Cellai AP,Aglietti P,Baldini A,Vena LM,Prisco D,Abbate R,Gensini GF

更新日期：1999-06-01 00:00:00

abstract：:Tecarfarin is a novel vitamin K antagonist that is metabolised by carboxyl estererase, thereby eliminating the variability associated with cytochrome-mediated metabolism. EmbraceAC was designed to compare the quality of anticoagulation with tecarfarin and warfarin as determined by time in therapeutic range (TTR). In t...

journal_title：Thrombosis and haemostasis

authors： Whitlock RP,Fordyce CB,Midei MG,Ellis D,Garcia D,Weitz JI,Canafax DM,Albrecht D,Milner PG

更新日期：2016-08-01 00:00:00

abstract：:The urinary excretion rate of antithrombin III related antigen (AT III RA) was examined in cerebral stroke. The excretion rate of AT III RA in cerebral hemorrhage (CH) was 12.33 +/- 1.61 X 10(-4) ml/min. The patients with CH were further classified into two groups: in group CH-I, whose consciousness state was stupor o...

journal_title：Thrombosis and haemostasis

authors： Matsuo T,Shinomiya K,Okuno S,Matsuo C,Matsuo O

更新日期：1984-12-29 00:00:00

abstract：:Elucidation of the pathophysiological basis of platelet disorders in murine models requires a reliable method for the frequent determinations of platelet counts in individual mice. Here, we present a rapid, reproducible and accurate flow cytometric method for enumeration of platelets that involves fluorescent staining...

journal_title：Thrombosis and haemostasis

authors： Alugupalli KR,Michelson AD,Barnard MR,Leong JM

更新日期：2001-08-01 00:00:00

abstract：:This study was carried out in order to compare the coagulation balance in patients with colorectal cancer before and after surgical removal of tumor with an age matched non-malignancy control group. Furthermore, it was studied whether preoperative coagulation state in cancer patients was correlated to the postoperativ...

journal_title：Thrombosis and haemostasis

authors： Iversen LH,Okholm M,Thorlacius-Ussing O

更新日期：1996-10-01 00:00:00

abstract：:The redistribution of platelet glycoproteins (GP) Ib, IIb and IIIa in response to stimulation with human platelet specific alloantibodies, autoantibodies and a quinidine-dependent antibody was investigated using immunofluorescence and a quantitative radioimmunoassay. The platelet GPs carrying the corresponding epitope...

journal_title：Thrombosis and haemostasis

authors： Santoso S,Kiefel V,Mueller-Eckhardt C

更新日期：1987-10-28 00:00:00

abstract：:Although there is evidence that altitude increases the platelet count, its effect on the platelet precursor stimulating factor, thrombopoietin (TPO), is unclear. Unlike erythropoietin, TPO appears largely unresponsive to exogenous signals. In a study in 16 healthy volunteers, we report the effects of altitude exposure...

journal_title：Thrombosis and haemostasis

authors： Hartmann S,Krafft A,Huch R,Breymann C

更新日期：2005-01-01 00:00:00

abstract：:Haemophilia A and B have been associated with increased prevalence of low bone mineral density (BMD). However, no study has so far evaluated the effects of anti-osteoporotic therapy on BMD in haemophilia.The primary endpoint of this prospective study was to estimate the effect of 12-month therapy of oral ibandronate 1...

journal_title：Thrombosis and haemostasis

authors： Anagnostis P,Vyzantiadis TA,Charizopoulou M,Adamidou F,Karras S,Goulis DG,Karagiannis A,Garipidou V,Vakalopoulou S

更新日期：2013-08-01 00:00:00

abstract：:To add an increased level of safety to antihemophilic factor replacement therapy, a full-length, recombinant Factor VIII (rFVIII) product has been developed without human-derived plasma proteins during purification and formulation and using an additional solvent/detergent viral inactivation step. This first clinical t...

journal_title：Thrombosis and haemostasis

authors： Abshire TC,Brackmann HH,Scharrer I,Hoots K,Gazengel C,Powell JS,Gorina E,Kellermann E,Vosburgh E

更新日期：2000-06-01 00:00:00

abstract：:Carboxypeptidase U (CPU, EC 3.4.17.20) is a recently described basic carboxypeptidase which circulates in plasma as the zymogen procarboxypeptidase U (proCPU). In the current study, we report on the presence of the proCPU/CPU system in different mammalian species--pig, guinea pig, dog, mouse, rabbit, rat and human. Th...

journal_title：Thrombosis and haemostasis

authors： Schatteman KA,Goossens FJ,Scharpé SS,Hendriks DF

更新日期：1999-12-01 00:00:00

abstract：:Recently, numerous studies have suggested an association between factor XII (FXII) deficiency and recurrent pregnancy losses, and between autoantibodies to FXII and recurrent pregnancy losses. Autoantibodies to FXII rather than FXII deficiency may be a risk factor for recurrent pregnancy losses. To know the pathogenes...

journal_title：Thrombosis and haemostasis

authors： Inomo A,Sugi T,Fujita Y,Matsubayashi H,Izumi S,Mikami M

更新日期：2008-02-01 00:00:00

abstract：:Epidemiological studies suggest that hormone replacement therapy (HRT) decreases the risk of cardiovascular disease in postmenopausal women via several mechanisms, including modifications in the fibrinolytic system and lipoprotein(a) [Lp(a)] levels. The aim of this study was to examine the influence of the levels and ...

journal_title：Thrombosis and haemostasis

authors： Estellés A,Cano A,Falcó C,España F,Gilabert J,Grancha S,Aznar J

更新日期：1999-01-01 00:00:00

abstract：:Normal adults have very few circulating endothelial cells (CECs) in their blood, but increased levels have been shown in association with conditions associated with endothelial damage such as myocardial infarction and stroke. As atrial fibrillation (AF) is associated with a hypercoagulable state and abnormalities of p...

journal_title：Thrombosis and haemostasis

authors： Freestone B,Lip GY,Chong AY,Nadar S,Lee KW,Blann AD

更新日期：2005-10-01 00:00:00

abstract：:Dabigatran is an oral, reversible thrombin inhibitor that has shown promising results in large clinical trials. Laboratory monitoring is not needed but the effects on common coagulation assays are incompletely known. Dabigatran was added to plasma from healthy subjects in the concentration range 0-1,000 μg/l and analy...

journal_title：Thrombosis and haemostasis

authors： Lindahl TL,Baghaei F,Blixter IF,Gustafsson KM,Stigendal L,Sten-Linder M,Strandberg K,Hillarp A,Expert Group on Coagulation of the External Quality Assurance in Laboratory Medicine in Sweden.

更新日期：2011-02-01 00:00:00

abstract：:Catabolism of coagulation factor VIII (FVIII) is mediated by low-density lipoprotein receptor-related protein (LRP). The ligand-binding sites of LRP are formed by complement-type repeats (CR), and CR clusters II and IV bind most of LRP ligands. FVIII contains two major LRP-binding sites located in the A2 and A3 domain...

journal_title：Thrombosis and haemostasis

authors： Sarafanov AG,Makogonenko EM,Andersen OM,Mikhailenko IA,Ananyeva NM,Khrenov AV,Shima M,Strickland DK,Saenko EL

更新日期：2007-12-01 00:00:00

abstract：:It is now recognised that acute myocardial infarction results from the rupture of atherosclerotic plaques. Lymphocytes and macrophages, which infiltrate rupture sites, contribute to plaque degradation by expressing urokinase (u-PA) bound to cell membrane by urokinase receptor (u-PAR) and by secreting metalloproteinase...

journal_title：Thrombosis and haemostasis

authors： Ganné F,Vasse M,Beaudeux JL,Peynet J,François A,Mishal Z,Chartier A,Tobelem G,Vannier JP,Soria J,Soria C

更新日期：2000-10-01 00:00:00

abstract：:This study was performed to assess the prevalence of deep vein thrombosis (DVT) in consecutive obstetric patients with clinical symptoms of DVT, using impedance plethysmography (IPG) as the diagnostic method and to establish the safety of withholding anticoagulant therapy in patients with a repeatedly normal IPG. In a...

journal_title：Thrombosis and haemostasis

authors： de Boer K,Büller HR,ten Cate JW,Levi M

更新日期：1992-01-23 00:00:00

abstract：:Heparin-associated thrombocytopenia (HAT) is a severe complication of heparin therapy. Its diagnosis is difficult. Conventional assays employ platelet aggregometry (PAA) and/or 14C-serotonin release (SRA) which are either insensitive (PAA) or require radioactive tracers (SRA). We here describe a newly developed sensit...

journal_title：Thrombosis and haemostasis

authors： Greinacher A,Michels I,Kiefel V,Mueller-Eckhardt C

更新日期：1991-12-02 00:00:00

abstract：:Thrombomodulin (TM), a marker of endothelial cell damage, has been localized to the placental syncytiotrophoblast. A prospective cohort study of twenty-five pregnant women who were admitted with a clinical diagnosis of placental abruption was undertaken. Abruption was confirmed after delivery in eight cases (Group 1)....

journal_title：Thrombosis and haemostasis

authors： Magriples U,Chan DW,Bruzek D,Copel JA,Hsu CD

更新日期：1999-01-01 00:00:00

abstract：:Thrombospondin, a trimeric glycoprotein contained in the platelet alpha-granules, has been proposed as a marker of in vivo platelet activation. However, it is also synthesised by a range of other cells. The extraplatelet contribution to plasma levels of thrombospondin was therefore estimated by investigating the relat...

journal_title：Thrombosis and haemostasis

authors： Dawes J,Pratt DA,Dewar MS,Preston FE

更新日期：1988-04-08 00:00:00

abstract：:Colorectal cancer (CRC) is a major cause of morbidity and mortality, and the composition of the tumour stroma is a strong predictor of survival in this cancer type. Tissue factor (TF) functions as the trigger of haemostasis together with its ligand coagulation factor VII/VIIa, and TF expression has been found in tumou...

journal_title：Thrombosis and haemostasis

authors： Eriksson O,Asplund A,Hegde G,Edqvist PH,Navani S,Pontén F,Siegbahn A

更新日期：2016-11-30 00:00:00

abstract：:Recombinant human activated factor VII (rHuFVIIa) can reduce bleeding but may be associated with arterial thrombosis. We hypothesized that rHuFVIIa would increase the occurrence of cyclic flow reductions (CFR) and reduce intra-abdominal bleeding in an experimental model. An adapted Folts' model of carotid artery lesio...

journal_title：Thrombosis and haemostasis

authors： Charbonneau S,Girard F,Boudreault D,Ruel M,Blais N,Hardy JF

更新日期：2007-02-01 00:00:00

abstract：:Thrombin incubated with 2,3-diphosphoglycerate (150 nmol 2,3-DPG/1 NIH thrombin unit) lost up to 70% of its clotting activity, whereas the esterase activity remained unchanged. No fibrinopeptide release by thrombin was observed in the presence of 2,3-DPG. The fibrin polymerization was normal. By chromatography on Ambe...

journal_title：Thrombosis and haemostasis

authors： Del Principe D,Strappini PM,Del Vecchio S,Menichelli A,Biancini G,Cosmi EV,Bastianon V,D'Arcangelo C

更新日期：1981-10-01 00:00:00

abstract：:Without thromboprophylaxis, knee arthroscopy (KA) carries a low to moderate risk of venous thromboembolism. Over 5 million arthroscopies are performed worldwide yearly. It was our study objective to assess the efficacy and safety of rivaroxaban for thromboprophylaxis after therapeutic KA. Patients undergoing KA in nin...

journal_title：Thrombosis and haemostasis

authors： Camporese G,Bernardi E,Noventa F,Bosco M,Monteleone G,Santoro L,Bortoluzzi C,Freguja S,Nardin M,Marullo M,Zanon G,Mazzola C,Damiani G,Maniscalco P,Imberti D,Lodigiani C,Becattini C,Tonello C,Agnelli G,ERIKA Study Gr

更新日期：2016-08-01 00:00:00

abstract：:By a method of counting single platelets in diluted whole blood, platelet aggregates were quantified ex-vivo. Four groups: 20 thrombotic patients, 10 non-thrombotic patients, 10 healthy old controls and 10 healthy young controls were included in the study. Using a 19 gauge needle, with and without tubing, venous blood...

journal_title：Thrombosis and haemostasis

authors： Saniabadi AR,Lowe GD,Madhok R,Spowart K,Shaw B,Barbenel JC,Forbes CD

更新日期：1986-08-20 00:00:00

abstract：:An enzyme immuno assay was developed to measure complexes of tissue-type plasminogen activator (t-PA) with C1-inhibitor in order to study the role of C1-inhibitor as an inhibitor of t-PA in plasma. In vitro experiments with melanoma and recombinant t-PA learned that purified C1-inhibitor reacts with both single chain ...

journal_title：Thrombosis and haemostasis

authors： Huisman LG,van Griensven JM,Kluft C

更新日期：1995-03-01 00:00:00