Abstract：
:In patients with deep vein thrombosis (DVT), the factors which predispose to concomitant symptomatic pulmonary embolism (PE) have remained uncertain. From a prospective cohort of 5,451 consecutive patients with ultrasound-confirmed DVT, we analyzed 4,211 patients with a known status for presence (n=639) or absence (n=3572) of symptomatic PE. Age and gender were similar in DVT plus PE (63.7+/-15.6 years; 49% men) and DVT patients (63.4+/-17.3 years; 46% men). Body mass index (BMI) was higher in patients with DVT plus PE (median 29.0, range 15.4-67.0 kg/m2) than in patients with DVT (median 26.8, range 9.7-64.4 kg/m2; p<0.001). Chronic lung disease (17% vs. 12%; p<0.001), a personal history of PE (11% vs. 6%; p<0.001), and a family history of DVT or PE (8% vs. 4%; p<0.001) were more frequent in DVT plus PE patients. Twenty-seven percent of DVT plus PE patients received prophylaxis prior to the thromboembolic event compared with 32% of DVT patients (p=0.002). Proximal DVT (OR 1.84, 95% CI 1.39-2.43), prior PE (OR 1.68, 95% CI 1.20-2.35), obesity (BMI >30 kg/m2) (OR 1.65, 95% CI 1.33-2.04), chronic lung disease (OR 1.51, 95% CI 1.13-2.01), as well as omission of prophylaxis (OR 1.30, 95% CI 1.04-1.64) emerged as independent predictors of concomitant symptomatic PE.
journal_name
Thromb Haemostjournal_title
Thrombosis and haemostasisauthors
Kucher N,Tapson VF,Goldhaber SZ,DVT FREE Steering Committee.doi
10.1160/TH04-09-0587keywords:
subject
Has Abstractpub_date
2005-03-01 00:00:00pages
494-8issue
3eissn
0340-6245issn
2567-689Xpii
05030494journal_volume
93pub_type
杂志文章abstract：:To add an increased level of safety to antihemophilic factor replacement therapy, a full-length, recombinant Factor VIII (rFVIII) product has been developed without human-derived plasma proteins during purification and formulation and using an additional solvent/detergent viral inactivation step. This first clinical t...
journal_title：Thrombosis and haemostasis
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：2000-06-01 00:00:00
abstract：:An index patient with pseudohomozygosity for factor V Leiden was identified. Each of his two children inherited a different paternal factor V allele; a daughter was heterozygous for factor V Leiden, with 100% factor V activity, and a son was heterozygous for factor V deficiency, with 50% factor V activity. Genomic DNA...
journal_title：Thrombosis and haemostasis
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journal_title：Thrombosis and haemostasis
pub_type： 杂志文章
doi：
更新日期：1981-06-30 00:00:00
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journal_title：Thrombosis and haemostasis
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doi：
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journal_title：Thrombosis and haemostasis
pub_type： 杂志文章
doi：
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journal_title：Thrombosis and haemostasis
pub_type： 杂志文章
doi：
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journal_title：Thrombosis and haemostasis
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journal_title：Thrombosis and haemostasis
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doi：
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journal_title：Thrombosis and haemostasis
pub_type： 杂志文章
doi：
更新日期：1995-03-01 00:00:00
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journal_title：Thrombosis and haemostasis
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doi：10.1160/TH16-06-0484
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journal_title：Thrombosis and haemostasis
pub_type： 杂志文章
doi：
更新日期：1996-01-01 00:00:00
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doi：10.1160/TH10-08-0528
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journal_title：Thrombosis and haemostasis
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doi：10.1055/s-0040-1712448
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journal_title：Thrombosis and haemostasis
pub_type： 临床试验
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journal_title：Thrombosis and haemostasis
pub_type： 杂志文章
doi：
更新日期：1994-02-01 00:00:00
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journal_title：Thrombosis and haemostasis
pub_type： 杂志文章
doi：
更新日期：1993-01-11 00:00:00
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journal_title：Thrombosis and haemostasis
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journal_title：Thrombosis and haemostasis
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journal_title：Thrombosis and haemostasis
pub_type： 杂志文章
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journal_title：Thrombosis and haemostasis
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journal_title：Thrombosis and haemostasis
pub_type： 杂志文章,评审
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journal_title：Thrombosis and haemostasis
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doi：
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journal_title：Thrombosis and haemostasis
pub_type： 杂志文章
doi：
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journal_title：Thrombosis and haemostasis
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doi：10.1160/TH04-08-0541
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