Inhibition by recombinant hirudins of experimental venous thrombosis and disseminated intravascular coagulation induced by tissue factor in rats.

abstract：:Our aim was to demonstrate that the sequential use of the Verigene® rapid CYP2C19 test for genetic profiling and the VerifyNowTM bedside test for platelet function measurement in ACS patients may optimise P2Y12 inhibition. "Rapid" (CYP2C19*1/*1 or CYP2C19*17 carriers, n=211) and "slow" metabolisers (CYP2C19*2 carriers...

journal_title：Thrombosis and haemostasis

authors： Collet JP,Kerneis M,Hulot JS,O'Connor SA,Silvain J,Mansencal N,Brugier D,Abtan J,Barthélémy O,Vignalou JB,Payot L,Rousseau H,Vicaut E,Montalescot G,GAMMA Investigators.

更新日期：2016-01-01 00:00:00

abstract：:Apixaban does not require monitoring nor frequent dose adjustment. However, searching for the optimal dose for the individual patient may be useful in some situations. Moreover, there is a need for clinicians to know whether coagulation assays are influenced by apixaban use. The aim of this study was to determine whic...

journal_title：Thrombosis and haemostasis

authors： Douxfils J,Chatelain C,Chatelain B,Dogné JM,Mullier F

更新日期：2013-08-01 00:00:00

abstract：BACKGROUND: Cardiac-enriched micro ribonucleic acids (miRNAs) are released into the circulation following ST-elevation myocardial infarction (STEMI). Lack of standardized approaches for reverse transcription quantitative real-time polymerase chain reaction (RT-qPCR) data normalization and presence of RT-qPCR inhibitors...

journal_title：Thrombosis and haemostasis

authors： Coelho-Lima J,Mohammed A,Cormack S,Jones S,Das R,Egred M,Panahi P,Ali S,Spyridopoulos I

更新日期：2018-07-01 00:00:00

abstract：:3-phosphoinositide-dependent protein kinase 1 (PDK1), a member of the protein A,G and C (AGC) family of proteins, is a Ser/Thr protein kinase that can phosphorylate and activate other protein kinases from the AGC family, including Akt at Thr308, all of which play important roles in mediating cellular responses. The fu...

journal_title：Thrombosis and haemostasis

authors： Dangelmaier C,Manne BK,Liverani E,Jin J,Bray P,Kunapuli SP

更新日期：2014-03-03 00:00:00

abstract：:Red cell distribution width (RDW) has been shown to be an independent predictor of mortality in patients with coronary artery disease and in patients with heart failure. The current study evaluated the prognostic utility of RDW in patients undergoing percutaneous coronary intervention (PCI). We evaluated 859 patients ...

journal_title：Thrombosis and haemostasis

authors： Poludasu S,Marmur JD,Weedon J,Khan W,Cavusoglu E

更新日期：2009-09-01 00:00:00

abstract：:We investigated changes in both thrombin activatable fibrinolysis inhibitor (TAFI) antigen levels and its functional effect on in vitro fibrinolysis in normal pregnancy. 152 pregnant women and 31 women in the immediate postpartum period were studied, with pregnancy divided into 6 windows at 4 weekly intervals. As TAFI...

journal_title：Thrombosis and haemostasis

authors： Mousa HA,Downey C,Alfirevic Z,Toh CH

更新日期：2004-11-01 00:00:00

abstract：:As an adjunct to a European multicentre prospective study, five quality assessment (QA) exercises, spanning a period of 2.5 years, were undertaken. In these, fifteen laboratories from eight countries each performed ten haemostatic factor assays. The design of the QA exercises allowed the between-duplicate, between-day...

journal_title：Thrombosis and haemostasis

authors： Thompson SG,Calori G,Thomson JM,Haverkate F,Duckert F

更新日期：1991-02-12 00:00:00

abstract：:Direct oral anticoagulants may be effective and safe for treatment of venous thromboembolism (VTE) in cancer patients, but they have not been compared with low-molecular-weight heparin (LMWH), the current recommended treatment for these patients. The Hokusai VTE-cancer study is a randomised, open-label, clinical trial...

journal_title：Thrombosis and haemostasis

authors： van Es N,Di Nisio M,Bleker SM,Segers A,Mercuri MF,Schwocho L,Kakkar A,Weitz JI,Beyer-Westendorf J,Boda Z,Carrier M,Chlumsky J,Décousus H,Garcia D,Gibbs H,Kamphuisen PW,Monreal M,Ockelford P,Pabinger I,Verhamme P,G

更新日期：2015-11-25 00:00:00

abstract：:The blockade of platelet membrane glycoprotein IIb/IIIa by a monoclonal antibody, 7E3, was measured by flow cytometry using a fluorescein isothiocyanate-conjugated disintegrin, FITC-crotavirin, as the probe. After treatment of platelets with 7E3 or 7E3 F(ab')2, there is a good correlation between the inhibition of pla...

journal_title：Thrombosis and haemostasis

authors： Liu CZ,Hur BT,Huang TF

更新日期：1996-10-01 00:00:00

abstract：:Paired blood samples were obtained from mothers (venous) and babies (cord venous blood) at the time of delivery by caesarean section under epidural anaesthetic. Fetal platelets failed to aggregate in response to adrenaline in vitro although adrenaline could potentiate the threshold response to adenosine diphosphate (1...

journal_title：Thrombosis and haemostasis

authors： Jones CR,McCabe R,Hamilton CA,Reid JL

更新日期：1985-02-18 00:00:00

abstract：:The introduction of venography into patient care was a major advance because it was the first accurate method for the diagnosis of DVT. Compression ultrasound has since become the preferred test for patients with suspected DVT because, unlike venography, it is simple, non-invasive and widely available. Venography has ...

journal_title：Thrombosis and haemostasis

authors： Hirsh J,Ginsberg JS,Chan N,Guyatt G,Eikelboom JW

更新日期：2014-01-01 00:00:00

abstract：:Heparin-coating improves the biocompatibility of blood contacting artificial surfaces. This led us to investigate the impact of heparin-coating (Carmeda AB, Stockholm) of polymetylmetacrylate on the expression of monocyte tissue factor procoagulant activity (TF-PCA) by surface adhesion. Also, the anticoagulant effect ...

journal_title：Thrombosis and haemostasis

authors： Barstad RM,Hamers MJ,Møller AS,Sakariassen KS

更新日期：1998-02-01 00:00:00

abstract：:The physiologic activation of the plasma kallikrein-kinin system requires the assembly of its constituents on a cell membrane. High- molecular-weight kininogen (HK) and cleaved HK (HKa) both interact with at least three endothelial cell binding proteins: urokinase plasminogen activator receptor (uPAR), globular C1q re...

journal_title：Thrombosis and haemostasis

authors： Pixley RA,Espinola RG,Ghebrehiwet B,Joseph K,Kao A,Bdeir K,Cines DB,Colman RW

更新日期：2011-06-01 00:00:00

abstract：:The emergency management of ST-elevation myocardial infarction (STEMI) involves treatment with dual-antiplatelet therapy (DAPT) and primary percutaneous coronary intervention (PPCI). Pain is generally treated with opiates, which may delay gastric transit and reduce DAPT absorption. We sought to assess the effect of mo...

journal_title：Thrombosis and haemostasis

authors： Farag M,Spinthakis N,Srinivasan M,Sullivan K,Wellsted D,Gorog DA

更新日期：2018-03-01 00:00:00

abstract：:Human platelets were separated into subpopulations using continuous flow electrophoresis, which uses electrophoretic mobility as the separative parameter. The platelets with the greatest electrophoretic mobility showed higher amounts of total sialic acid than the less electrophoretically mobile subpopulation (74.3 +/-...

journal_title：Thrombosis and haemostasis

authors： Crook M,Crawford N

更新日期：1993-01-11 00:00:00

abstract：:The inhibitory capacity of antithrombin III (AT III) was measured by a quantitative method independent of the velocity of inhibition. When AT III was in excess of thrombin in plasma or in purified system the capacity of inhibitor decreased quantitatively in proportion to the amount of thrombin neutralized. Heparin pre...

journal_title：Thrombosis and haemostasis

authors： Marciniak E

更新日期：1977-08-31 00:00:00

abstract：:High mobility group box 1 (HMGB1) acts as both a nuclear protein that regulates gene expression, as well as a pro-inflammatory alarmin that is released from necrotic or activated cells. Recently, HMGB1-expression in human atherosclerotic plaques was identified. Therapeutic blockade of HMGB1 reduced the development of ...

journal_title：Thrombosis and haemostasis

authors： Ahrens I,Chen YC,Topcic D,Bode M,Haenel D,Hagemeyer CE,Seeba H,Duerschmied D,Bassler N,Jandeleit-Dahm KA,Sweet MJ,Agrotis A,Bobik A,Peter K

更新日期：2015-11-01 00:00:00

abstract：:Platelet activation plays a pivotal role in physiological hemostasis and pathological thrombosis causing heart attack and stroke. Previous studies conclude that simultaneous activation of Gi and G12/13 signaling pathways is sufficient to cause platelet aggregation. However, using Gq knockout mice and Gq-specific inhib...

journal_title：Thrombosis and haemostasis

authors： Zhang J,Zhang Y,Zheng S,Liu Y,Chang L,Pan G,Hu L,Zhang S,Liu J,Kim S,Dong J,Ding Z

更新日期：2020-11-01 00:00:00

abstract：:ADP or thrombin caused a transient change in creatine phosphate (CP) content of rat platelets. At 25 degrees C the CP content decreased most 30 sec after the addition of ADP or thrombin and recovered thereafter. ATP or AMP was without effect. The rat platelets aggregated at 25 degrees C by ADP or thrombin, but the cha...

journal_title：Thrombosis and haemostasis

authors： Shibata S

更新日期：1979-08-31 00:00:00

abstract：:The effect of urinary protein C inhibitor (uPCI) on disseminated intravascular coagulation (DIC) was investigated using an experimental DIC in rats. uPCI (0.5 and 1.0 mg/kg) was continuously administrated into the left femoral vein of the rats with lipopolysaccharide (50 mg/kg)-induced DIC. In all doses, uPCI signific...

journal_title：Thrombosis and haemostasis

authors： Fujita M,Izutani W,Komurasaki Y

更新日期：2000-07-01 00:00:00

abstract：:Factor IXa (FIXa) is a vitamin K-dependent coagulation serine protease which binds to factor VIIIa (FVIIIa) on negatively charged phospholipid vesicles (PCPS) to catalyse the activation of factor X (FX) to factor Xa (FXa) in the intrinsic pathway. Fluorescence resonance energy transfer (FRET) studies have indicated th...

journal_title：Thrombosis and haemostasis

authors： Qureshi SH,Yang L,Rezaie AR

更新日期：2012-12-01 00:00:00

abstract：:We report for the first time that saliva of the hard tick and Lyme disease vector, Ixodes scapularis, is a potent inhibitor of angiogenesis. Saliva (< or = 1:500 dilutions) or salivary gland (0.1-0.5 pairs/assay) dose-dependently inhibits microvascular endothelial cell (MVEC) proliferation. Inhibition was also detecte...

journal_title：Thrombosis and haemostasis

authors： Francischetti IM,Mather TN,Ribeiro JM

更新日期：2005-07-01 00:00:00

abstract：:Since megakaryocytes are the cellular precursors of platelets we have investigated whether they share responses to platelet agonists, in particular collagen. Although previous studies have reported responses to thrombin in non-human megakaryocytes, through studies of single cell calcium responses and protein tyrosine-...

journal_title：Thrombosis and haemostasis

authors： Mountford JC,Melford SK,Bunce CM,Gibbins J,Watson SP

更新日期：1999-09-01 00:00:00

abstract：:Shear stress has an established effect on mature endothelial cells, but less is known about how shear stress regulates endothelial progenitor cells (EPCs). In vitro expanded EPCs isolated from adult human blood represent a novel tool in regenerative vessel therapy. However, in vitro culturing may generate cells with u...

journal_title：Thrombosis and haemostasis

authors： Lund T,Hermansen SE,Andreasen TV,Olsen JO,Østerud B,Myrmel T,Ytrehus K

更新日期：2010-09-01 00:00:00

abstract：:To investigate pituitary effects on the vitamin K-dependent coagulation factors, female rats were hypophysectomized (hypox) and treated with growth hormone (GH), cortisone, thyroxine, vitamin K, or saline. After 11 days of treatment, the prothrombin time, platelet count, and factors II, VII, IX, and X were determined....

journal_title：Thrombosis and haemostasis

authors： Sävendahl LS,Grankvist K,Engström KG

更新日期：1995-04-01 00:00:00

abstract：:We compared the Ivy bleeding time method and two alternatives of the Simplate II method (incisions in horizontal and vertical direction) with each other, with regard to the sensitivity, the specificity, the costs and the burden for the patient. In the aspirin study an aspirin-induced bleeding defect was used. Seventy-...

journal_title：Thrombosis and haemostasis

authors： Srámek R,Srámek A,Koster T,Briët E,Rosendaal FR

更新日期：1992-05-04 00:00:00

abstract：:The increase in nitric oxide (NO) production in lipopolysaccharide (LPS)-induced sepsis is thought to contribute to the development of shock. However, NO could also play an antithrombotic role. Little is known about the modulating effect of NO on the endothelial overexpression and production of tissue factor (TF) and ...

journal_title：Thrombosis and haemostasis

authors： Pérez-Ruiz A,Montes R,Velasco F,López-Pedrera C,Antonio Páramo J,Orbe J,Hermida J,Rocha E

更新日期：2002-12-01 00:00:00

abstract：:Factor VIII inhibitors in mild haemophilia are uncommon and the management of such patients is controversial. The development of a persistently high responding F VIII inhibitor in a mild haemophiliac is reported and the behaviour of the inhibitor discussed in the context of the various therapeutic regimes employed for...

journal_title：Thrombosis and haemostasis

authors： Kesteven PJ,Holland LJ,Lawrie AS,Savidge GF

更新日期：1984-08-31 00:00:00

abstract：:Fibrinogen degradation products were investigated for leukocyte chemotactic activity and for enhancement of vascular permeability. Both activities increased progressively with plasmin digestion of fibrinogen. Active fragments were partially purified from 24 hr-plasmin digests. Molecular weights of the permeability inc...

journal_title：Thrombosis and haemostasis

authors： Sueishi K,Nanno S,Tanaka K

更新日期：1981-02-23 00:00:00

abstract：:A double antibody competition radioimmunoassay was developed that allowed to detect specifically as little as 15 ng antithrombin III (AT III) per ml of the assayed material. In normal plasma examined by this assay, AT III concentration averaged 199 +/- 21 micrograms/ml. Complexes of AT III with thrombin or factor Xa c...

journal_title：Thrombosis and haemostasis

authors： Marciniak E,Gora-Maslak G

更新日期：1983-02-28 00:00:00