Inhibitor to factor VIII in mild haemophilia.

abstract：:In this study, we investigate the influence of three factor VII (FVII) gene polymorphisms on activated FVII levels (FVIIa), and also on the risk of myocardial infarction (MI) in patients with advanced coronary atherosclerotic disease (CAD). The -323A2 allele in the promoter is known to be associated with low FVII leve...

journal_title：Thrombosis and haemostasis

authors： Bozzini C,Girelli D,Bernardi F,Ferraresi P,Olivieri O,Pinotti M,Martinelli N,Manzato F,Friso S,Villa G,Pizzolo F,Beltrame F,Corrocher R

更新日期：2004-09-01 00:00:00

abstract：:Heparin and low-molecular-weight heparin (LMWH) are commonly monitored by determination of activated clotting times or chromogenic assays. Despite their wide use, these assays determine the biological activity and not the concentration of the anticoagulants. They may be inaccurate in some circumstances such as certain...

journal_title：Thrombosis and haemostasis

authors： Szelke H,Harenberg J,Krämer R

更新日期：2009-11-01 00:00:00

abstract：:An algal sulfated galactan has high anticoagulant and antithrombotic activities. Its serpin-dependent anticoagulant action is due to promoting thrombin and factor (F)Xa inhibition by antithrombin and heparin cofactor II. Here, we evaluated the anticoagulant effect of the algal sulfated galactan using serpin-free plasm...

journal_title：Thrombosis and haemostasis

authors： Glauser BF,Rezende RM,Melo FR,Pereira MS,Francischetti IM,Monteiro RQ,Rezaie AR,Mourão PA

更新日期：2009-12-01 00:00:00

abstract：:3-phosphoinositide-dependent protein kinase 1 (PDK1), a member of the protein A,G and C (AGC) family of proteins, is a Ser/Thr protein kinase that can phosphorylate and activate other protein kinases from the AGC family, including Akt at Thr308, all of which play important roles in mediating cellular responses. The fu...

journal_title：Thrombosis and haemostasis

authors： Dangelmaier C,Manne BK,Liverani E,Jin J,Bray P,Kunapuli SP

更新日期：2014-03-03 00:00:00

abstract：:To determine a possible relation of changes in plasma levels of plasminogen activator inhibitor 1 (PAI-1) and tissue plasminogen activator (t-PA) to the development of coronary restenosis after successful coronary angioplasty (PTCA), we followed 104 patients with a low grade residual stenosis after PTCA (less than 30%...

journal_title：Thrombosis and haemostasis

authors： Huber K,Jörg M,Probst P,Schuster E,Lang I,Kaindl F,Binder BR

更新日期：1992-02-03 00:00:00

abstract：:Thrombomodulin (TM), a marker of endothelial cell damage, has been localized to the placental syncytiotrophoblast. A prospective cohort study of twenty-five pregnant women who were admitted with a clinical diagnosis of placental abruption was undertaken. Abruption was confirmed after delivery in eight cases (Group 1)....

journal_title：Thrombosis and haemostasis

authors： Magriples U,Chan DW,Bruzek D,Copel JA,Hsu CD

更新日期：1999-01-01 00:00:00

abstract：:We have developed a simple assay that measures the circulating activated protein C (APC) in plasma. The assay requires collection of duplicate blood samples, one in citrate plus heparin and the other in citrate plus inhibitors of the enzyme. In the heparin tube, APC reacts completely and irreversibly with its major pl...

journal_title：Thrombosis and haemostasis

authors： Espana F,Zuazu I,Vicente V,Estellés A,Marco P,Aznar J

更新日期：1996-01-01 00:00:00

abstract：:The strong effect of protein adsorption on blood and tissue compatibility is well known. Little is presently known about the mechanisms which control the composition of the adsorbed protein layer which forms upon exposure of surfaces to mixtures of proteins. Reexamination of the ability of hemoglobin to inhibit the ad...

journal_title：Thrombosis and haemostasis

authors： Horbett TA

更新日期：1984-04-30 00:00:00

abstract：:Factor IXa (FIXa) is a vitamin K-dependent coagulation serine protease which binds to factor VIIIa (FVIIIa) on negatively charged phospholipid vesicles (PCPS) to catalyse the activation of factor X (FX) to factor Xa (FXa) in the intrinsic pathway. Fluorescence resonance energy transfer (FRET) studies have indicated th...

journal_title：Thrombosis and haemostasis

authors： Qureshi SH,Yang L,Rezaie AR

更新日期：2012-12-01 00:00:00

abstract：:Diabetic subjects have been shown to have altered fibrin network structures. One possible cause may be fibrinogen glycation resulting in altered structure/function properties. We investigated the effect of glucose control on fibrinogen glycation and fibrin network structure in type 2 diabetes. Blood samples were taken...

journal_title：Thrombosis and haemostasis

authors： Pieters M,Covic N,Loots du T,van der Westhuizen FH,van Zyl DG,Rheeder P,Jerling JC,Weisel JW

更新日期：2006-11-01 00:00:00

abstract：:It has been reported that lanosterol can sensitize isolated rat platelets to agonists such as ADP and thrombin (4). The purpose of this paper was to determine whether lanosterol had similar effects on human platelets and whether this was achieved by changes in membrane fluidity. Lanosterol did increase the sensitivity...

journal_title：Thrombosis and haemostasis

authors： Hassall DG,Bruckdorfer KR,Sulpice JC,Lutton C

更新日期：1985-12-17 00:00:00

abstract：:Our initial finding that CD40- and CD40 ligand (CD40L)-deficient mice displayed prolonged tail bleeding and platelet function analyzer (PFA-100) closure times prompted us to further investigate the role of the CD40-CD40L dyad in primary hemostasis and platelet function. Recombinant human soluble CD40L (rhsCD40L), chem...

journal_title：Thrombosis and haemostasis

authors： Langer F,Ingersoll SB,Amirkhosravi A,Meyer T,Siddiqui FA,Ahmad S,Walker JM,Amaya M,Desai H,Francis JL

更新日期：2005-06-01 00:00:00

abstract：:We examined the ability of unfractionated heparin to modulate the procoagulant activities of stimulated endothelial cells (EC). Confluent human venous umbilical EC were incubated with heparin before or after stimulation, then rinsed extensively to eliminate any heparin in the solution. EC, stimulated for 4 h with endo...

journal_title：Thrombosis and haemostasis

authors： Cadroy Y,Gaspin D,Dupouy D,Lormeau JC,Boneu B,Sié P

更新日期：1996-01-01 00:00:00

abstract：:Hyperhomocysteinemia is a risk factor of venous thromboembolism. The risk of recurrence in patients with hyperhomocysteinemia is unknown, and the optimal therapy for these patients after acute venous thromboembolism is uncertain. In a multicenter study, 264 patients with an objectively documented single episode of idi...

journal_title：Thrombosis and haemostasis

authors： Eichinger S,Stümpflen A,Hirschl M,Bialonczyk C,Herkner K,Stain M,Schneider B,Pabinger I,Lechner K,Kyrle PA

更新日期：1998-10-01 00:00:00

abstract：:The terms glycoprotein IV (GPIV) and glycoprotein IIIb (GPIIIb) have been used interchangeably and reports in the literature have indicated this glycoprotein as having a molecular weight variously described as either 88,000 or 97,000, a fast anodal mobility on crossed electrophoresis and either 13 or less than 1 methi...

journal_title：Thrombosis and haemostasis

authors： Yamamoto N,de Romeuf C,Tandon NN,Jamieson GA

更新日期：1990-02-19 00:00:00

abstract：:We performed a prospective study in 86 consecutive patients with central vein catheter-related deep venous thrombosis (DVT) of the upper extremity, to evaluate the prevalence of pulmonary embolism (PE), and to identify clinical variables that would increase the likelihood of developing PE in an individual patient. Sin...

journal_title：Thrombosis and haemostasis

authors： Monreal M,Raventos A,Lerma R,Ruiz J,Lafoz E,Alastrue A,Llamazares JF

更新日期：1994-10-01 00:00:00

abstract：:Lysosomal Associated Membrane Protein-2 (LAMP-2) is an inherent component of lysosomal granule membranes in diverse cell types, including platelets. We examined platelets for evidence of LAMP-2 in dense granule membranes as CD63 has previously been shown to be present in both lysosomal and dense granule membranes. Imm...

journal_title：Thrombosis and haemostasis

authors： Israels SJ,McMillan EM,Robertson C,Singhory S,McNicol A

更新日期：1996-04-01 00:00:00

abstract：:Lenalidomide, a derivate of thalidomide, has recently been approved in Europe for the treatment of patients with multiple myeloma. Although the substance has a better effect/side-effect profile, especially with regard to teratogenicity and neurotoxicity, the rate of therapy-induced thrombosis seems comparable to thali...

journal_title：Thrombosis and haemostasis

authors： Gieseler F

更新日期：2008-06-01 00:00:00

abstract：:The alphaIIbeta3 receptor (GPIIb/IIIa) is the only platelet-specific integrin receptor and the most abundant adhesion/aggregation receptor on the surface of human platelets. Since mice are increasingly being used as models of human disease, we analyzed the structure and function of murine platelet alphaIIbeta3, utiliz...

journal_title：Thrombosis and haemostasis

authors： Smyth SS,Tsakiris DA,Scudder LE,Coller BS

更新日期：2000-12-01 00:00:00

abstract：:The still living members of the original bleeder family on the Aland Islands described by von Willebrand in 1926 have been reinvestigated by using modern laboratory techniques for the measurement of the Factor VIII complex and with regard to platelet aggregation. The low level of F VIII : C activity demonstrated in 19...

journal_title：Thrombosis and haemostasis

authors： Nyman D,Eriksson AW,Blombäck M,Frants RR,Wahlberg P

更新日期：1981-02-23 00:00:00

abstract：:The acidic mucopolysaccharide extracted from sea cucumber (Stichopus japonicus Selenka) (SJAMP) has been shown to cause platelets to aggregate. Using citrated platelet-rich plasma (PRP), washed platelets and formaldehyde-fixed platelets from humans, we investigated the effects of platelet inhibitors and various plasma...

journal_title：Thrombosis and haemostasis

authors： Li JZ,Lian EC

更新日期：1988-06-16 00:00:00

abstract：:Complement C3 is a novel risk factor for cardiovascular disease (CVD), but the underlying mechanism is currently unknown. We determined the associations of the anaphylatoxin C3a, the activation product of C3, and of C3 itself with estimates of atherosclerosis and CVD. We studied associations of C3a and C3 with carotid...

journal_title：Thrombosis and haemostasis

authors： Hertle E,van Greevenbroek MM,Arts IC,van der Kallen CJ,Geijselaers SL,Feskens EJ,Jansen EH,Schalkwijk CG,Stehouwer CD

更新日期：2014-06-01 00:00:00

abstract：:We have identified two novel minor deletions (case 1; -TA or -AT at nucleotide 9831-3 in exon 5 and case 2; -A at nucleotide 7640-1 in exon 4), one novel nonsense mutation (case 3; TAT to TAA at nucleotide 7491 in exon 4), and one recurrent nonsense mutation (case 4; CGA to TGA at nucleotide 5381 in exon 3A) in Japane...

journal_title：Thrombosis and haemostasis

authors： Nakahara Y,Tsuji H,Nakagawa K,Masuda H,Kitamura H,Nishimura H,Kasahara T,Sugano T,Sawada S,Nakagawa M

更新日期：1997-04-01 00:00:00

abstract：:Sixty-four Chinese women were studied for the effects of injecting once-a-month contraceptive norethisterone enanthate/estradiol valerate between 2 to 4 1/2 years on certain coagulation and fibrinolytic parameters, and 59 women not receiving any steroidal contraception were controls. In both groups there was no signif...

journal_title：Thrombosis and haemostasis

authors： Meng YX,Jiang HY,Lu FY

更新日期：1990-12-28 00:00:00

abstract：:A nutritionally induced obesity model was used to investigate the modulation of fibrinolytic and gelatinolytic activity during the development of adipose tissue. Five week old male mice were fed a standard fat diet (SFD, 13% kcal as fat) or a high fat diet (HFD, 42% kcal as fat) for up to 15 weeks. The HFD resulted in...

journal_title：Thrombosis and haemostasis

authors： Lijnen HR,Maquoi E,Demeulemeester D,Van Hoef B,Collen D

更新日期：2002-08-01 00:00:00

abstract：:Following favourable results from a previous study, a large, multicentre, prospective, case-control study was performed to further assess the incidence of bleeding complications after dental extraction in patients taking oral anticoagulant therapy (OAT). Four hundred fifty-one patients being treated with warfarin who ...

journal_title：Thrombosis and haemostasis

authors： Bacci C,Maglione M,Favero L,Perini A,Di Lenarda R,Berengo M,Zanon E

更新日期：2010-11-01 00:00:00

abstract：:Membrane-permeable 8-(4-chlorophenylthio)-2'-O-methyl cyclic AMP (8-pCPT-2'-O-Me-cAMP) has been shown to specifically activate cAMP-regulated Epac proteins, without direct effects on protein kinase A and protein kinase G. During isometric tension measurements in thoracic aortic rings from Wistar rats, we observed that...

journal_title：Thrombosis and haemostasis

authors： Sand C,Grandoch M,Börgermann C,Oude Weernink PA,Mahlke Y,Schwindenhammer B,Weber AA,Fischer JW,Jakobs KH,Schmidt M

更新日期：2010-03-01 00:00:00

abstract：:An association has been reported between thrombotic events and the use of L-asparaginase (ASP) in children with acute lymphoblastic leukaemia (ALL). The mechanism for thrombosis is likely related to an acquired antithrombin deficiency. Since a primary prophylaxis using antithrombin concentrates may prevent thrombosis,...

journal_title：Thrombosis and haemostasis

authors： Mitchell L,Andrew M,Hanna K,Abshire T,Halton J,Wu J,Anderson R,Cherrick I,Desai S,Mahoney D,McCusker P,Chait P,Abdolell M,de Veber G,Mikulis D

更新日期：2003-08-01 00:00:00

abstract：:In 70-80% of cases, pulmonary embolism is the consequence of lower extremity deep vein thrombosis. It has been demonstrated that the most common coagulation defect predisposing to venous thrombosis, resistance to activated protein C (APC), is not associated with an increased risk for pulmonary embolism, but the eviden...

journal_title：Thrombosis and haemostasis

authors： Martinelli I,Cattaneo M,Panzeri D,Mannucci PM

更新日期：1997-03-01 00:00:00

abstract：:In haemophilia B (HB) (factor IX [FIX] deficiency), F9 genotype largely determines clinical phenotype. Aimed to characterise Argentinian families with HB, this study presents F9 genotype frequencies and their specific FIX inhibitor risk and 10 novel F9 mutations. Ninety-one DNA samples from HB patients and relat...

journal_title：Thrombosis and haemostasis

authors： Radic CP,Rossetti LC,Abelleyro MM,Candela M,Pérez Bianco R,de Tezanos Pinto M,Larripa IB,Goodeve A,De Brasi C

更新日期：2013-01-01 00:00:00