Cyclic nucleotides in platelet function.

abstract：:Wound healing is a complicated biological process that consist of partially overlapping inflammatory, proliferation and tissue remodelling phases. A successful wound healing depends on a proper activation and subsequent termination of the inflammatory phase. The failure to terminate the inflammation halts the completi...

journal_title：Thrombosis and haemostasis

authors： Sulniute R,Shen Y,Guo YZ,Fallah M,Ahlskog N,Ny L,Rakhimova O,Broden J,Boija H,Moghaddam A,Li J,Wilczynska M,Ny T

更新日期：2016-05-02 00:00:00

abstract：:To assess the thrombotic risk of aprotinin in aortocoronary bypass surgery, we retrospectively analyzed the results of a trial, originally designed to compare the effects of one-year treatment with various antithrombotic drugs in the prevention of vein-graft occlusion. Graft patency at one year was assessed by angiogr...

journal_title：Thrombosis and haemostasis

authors： van der Meer J,Hillege HL,Ascoop CA,Dunselman PH,Mulder BJ,van Ommen GV,Pfisterer M,van Gilst WH,Lie KI

更新日期：1996-01-01 00:00:00

abstract：:Antiphospholipid antibodies are a risk factor for venous and arterial thrombosis and may contribute to the development of atherosclerosis.The aim of this study was to investigate whether antibodies to human beta2-glycoprotein 1 (beta2GP1), as a model of antiphospholipid antibodies, modify the phenotype of atherosclero...

journal_title：Thrombosis and haemostasis

authors： Dunoyer-Geindre S,Kwak BR,Pelli G,Roth I,Satta N,Fish RJ,Reber G,Mach F,Kruithof EK,de Moerloose P

更新日期：2007-01-01 00:00:00

abstract：:Oxidative modification of LDL, which dysregulates the homeostasis between blood and vascular cells, and alterations of endothelial function are considered among the early events in the pathogenesis of atherosclerosis. This study was designed to evaluate the impact of progressive LDL oxidation on the thrombotic respons...

journal_title：Thrombosis and haemostasis

authors： Banfi C,Camera M,Giandomenico G,Toschi V,Arpaia M,Mussoni L,Tremoli E,Colli S

更新日期：2003-03-01 00:00:00

abstract：:The methylenetetrahydrofolate reductase (MTHFR) 677 C→T polymorphism may be associated with elevated total homocysteine (tHcy) levels, an independent risk factor for cardiovascular disease. It was the study objective to evaluate in vivo lipid peroxidation and platelet activation in carriers of the MTHFR 677 C→T polymo...

journal_title：Thrombosis and haemostasis

authors： Dragani A,Falco A,Santilli F,Basili S,Rolandi G,Cerasa L,Lattanzio S,Ciabattoni G,Patrono C,Davì G

更新日期：2012-09-01 00:00:00

abstract：:The administration of recombinant activated factor VII (rFVIIa) by continuous infusion has provided a safe and convenient alternative to bolus injections in haemophiliacs with inhibitors, but it has only been reported in a single case with congenital factor VII (FVII) deficiency. The results of 12 consecutive surgical...

journal_title：Thrombosis and haemostasis

authors： Schulman S,Tjønnfjord GE,Wallensten R,Martinowitz U,Kenet G

更新日期：2005-12-01 00:00:00

abstract：:One of the most severe and important complication in the treatment of haemophilia A (HA) patients is the formation of inhibitors. The mechanism that leads to factor (F)VIII inhibitor formation is complicated. Both genetic and environmental factors have been mentioned to play decisive roles. Recently, polymorphisms in ...

journal_title：Thrombosis and haemostasis

authors： Lu Y,Ding Q,Dai J,Wang H,Wang X

更新日期：2012-01-01 00:00:00

abstract：:alpha-Granule protein storage is important for producing platelets with normal haemostatic function. The low to undetectable levels of several megakaryocyte-synthesized alpha-granule proteins in normal plasma suggest megakaryocytes are important to sequester these proteins in vivo. alpha-Granule protein storage in vit...

journal_title：Thrombosis and haemostasis

authors： Veljkovic DK,Cramer EM,Alimardani G,Fichelson S,Massé JM,Hayward CP

更新日期：2003-11-01 00:00:00

abstract：:Five expert laboratories have participated in a cross-laboratory study to co-evaluate and compare three commercial Factor VIII/von Willebrand factor (VWF) concentrates. A total of nine factor concentrate lots were evaluated, comprising AHF (High Purity) (AHF HP; x3), Biostate (x3) and Humate/Haemate (x3). All laborato...

journal_title：Thrombosis and haemostasis

authors： Favaloro EJ,Bukuya M,Martinelli T,Tzouroutis J,Duncan E,Welldon K,Collecutt M,Aumann H,Thom J,Gilmore G

更新日期：2002-03-01 00:00:00

abstract：:Alteplase is standard therapy for patients with acute, massive pulmonary embolism. The novel plasminogen activator desmoteplase displays high fibrin specificity and selectivity for fibrinbound plasminogen. In a preclinical model desmoteplase was twice as potent with a shorter lysis time and lower reocclusion rate. We ...

journal_title：Thrombosis and haemostasis

authors： Tebbe U,Bramlage P,Graf A,Lechleitner P,Bode C,Riess FC,Clemens N,Al-Rawi Y,Konstantinides S,Goldhaber SZ

更新日期：2009-03-01 00:00:00

abstract：:Plasminogen activator inhibitor 1 (PAI-1) is the main inhibitor of tissue-type and urokinase-type plasminogen activators (t/uPA) and plays an important role in fibrinolysis. Inhibition of PAI-1 activity prevents thrombosis and accelerates fibrinolysis, indicating that PAI-1 inhibitors may be used as effective antithro...

journal_title：Thrombosis and haemostasis

authors： Peng S,Xue G,Gong L,Fang C,Chen J,Yuan C,Chen Z,Yao L,Furie B,Huang M

更新日期：2017-06-28 00:00:00

abstract：:We investigated the extent to which fibroblasts isolated from diverse tissues differ in their capacity to modulate inflammation by comparing the global gene expression profiles of cultured human fibroblasts from skin, acute and chronically inflamed synovium, lymph node and tonsil. The responses of these fibroblasts to...

journal_title：Thrombosis and haemostasis

authors： Parsonage G,Falciani F,Burman A,Filer A,Ross E,Bofill M,Martin S,Salmon M,Buckley CD

更新日期：2003-10-01 00:00:00

abstract：OBJECTIVE:To assess the safety and efficacy of a fixed dose of recombinant activated factor VII (rFVIIa; NovoSeven) in the home setting for mild to moderately severe joint, muscle; and mucocutaneous bleeding episodes in patients with haemophilia A or B with inhibitors. DESIGN:Multicentre, open-label, single arm, phase...

journal_title：Thrombosis and haemostasis

authors： Key NS,Aledort LM,Beardsley D,Cooper HA,Davignon G,Ewenstein BM,Gilchrist GS,Gill JC,Glader B,Hoots WK,Kisker CT,Lusher JM,Rosenfield CG,Shapiro AD,Smith H,Taft E

更新日期：1998-12-01 00:00:00

abstract：:A high throughput 384-well plate assay of blood function in 60 microl reactions with the fluorogenic thrombin substrate, boc-VPR-MCA, allowed for real-time monitoring of coagulation under a diverse set of reaction conditions. Using recalcified, citrated whole blood diluted 3-fold with corn trypsin inhibitor (to block ...

journal_title：Thrombosis and haemostasis

authors： Lo K,Diamond SL

更新日期：2004-10-01 00:00:00

abstract：:The blockade of platelet membrane glycoprotein IIb/IIIa by a monoclonal antibody, 7E3, was measured by flow cytometry using a fluorescein isothiocyanate-conjugated disintegrin, FITC-crotavirin, as the probe. After treatment of platelets with 7E3 or 7E3 F(ab')2, there is a good correlation between the inhibition of pla...

journal_title：Thrombosis and haemostasis

authors： Liu CZ,Hur BT,Huang TF

更新日期：1996-10-01 00:00:00

abstract：:We previously reported a monoclonal antibody named IF-43 that specifically recognizes thrombin-modified fibrinogen (desAA- and desAABB- fibrin monomer) bound with fibrinogen or other D(1) domain-containing plasmic fragments such as fragments X,Y, and D(1), but not intact fibrinogen or cross-linked fibrin degradation p...

journal_title：Thrombosis and haemostasis

authors： Nakahara K,Kazahaya Y,Shintani Y,Yamazumi K,Eguchi Y,Koga S,Wada H,Matsuda M

更新日期：2003-05-01 00:00:00

abstract：:Deep-vein thrombosis (DVT) is a common condition that often leads to pulmonary thromboembolism (VTE) and death. The role of prostaglandin-endoperoxide synthase (PTGS)2 in arterial thrombosis has been well established, whereas its impact in venous thrombosis remains unclear. Here, we showed that PTGS2 deletion predispo...

journal_title：Thrombosis and haemostasis

authors： Amadio P,Tarantino E,Sandrini L,Tremoli E,Barbieri SS

更新日期：2017-07-26 00:00:00

abstract：:Adjunctive use of phosphodiesterase (PDE) inhibitor can enhance antiplatelet and vasoprotective properties in patients with cardiovascular disease. The aim of this study was to evaluate the impact of PDE5 inhibitor dipyridamole on platelet function in stented patients with high platelet reactivity (HPR) during dual an...

journal_title：Thrombosis and haemostasis

authors： Park Y,Jeong YH,Tantry US,Ahn JH,Kim KH,Koh JS,Park JR,Hwang SJ,Kwak CH,Hwang JY,Gurbel PA

更新日期：2014-12-01 00:00:00

abstract：:Hot water extracts of Mo-er (1 gm by 15 ml of water), an oriental food (Auricularia auricula), inhibit strongly both human and rat platelet ADP-induced aggregation. HPLC analysis of two varieties of Mo-er, A. auricula and A. polytricha (a black tree fungus), shows that they contain adenosine (Ado), 133 and 154 microgr...

journal_title：Thrombosis and haemostasis

authors： Agarwal KC,Russo FX,Parks RE Jr

更新日期：1982-10-29 00:00:00

abstract：BACKGROUND: This study assessed changes in anticoagulation therapy over time in patients with atrial fibrillation (AF). METHODS: Analyses were performed on a claims-based dataset of 4 million health-insured individuals. The study population consisted of patients newly initiating a non-vitamin-K oral anticoagulants (NO...

journal_title：Thrombosis and haemostasis

authors： Hohnloser SH,Basic E,Nabauer M

更新日期：2019-06-01 00:00:00

abstract：:Coagulation factor XIII, a transglutaminase which stabilises blood clots by covalently cross-linking fibrin, is essential for normal haemostasis. FXIII deficiency results in a life-long bleeding disorder with added complications in wound healing and tissue repair. Sequence changes in the human FXIIIA gene, largely mis...

journal_title：Thrombosis and haemostasis

authors： Anwar R,Miloszewski KJ,Markham AF

更新日期：1998-06-01 00:00:00

abstract：:Oral anticoagulants used for the primary treatment of venous thromboembolism (VTE) include warfarin and the more recently introduced direct oral anticoagulants (DOACs), including rivaroxaban, apixaban, dabigatran and edoxaban. Information on the comparative safety of these medications in routine clinical practice is l...

journal_title：Thrombosis and haemostasis

authors： Roetker NS,Lutsey PL,Zakai NA,Alonso A,Adam TJ,MacLehose RF

更新日期：2018-09-01 00:00:00

abstract：:Effects of estradiol, progesterone, cortisol, thrombophlebitis and typhoid vaccine on the synthesis and catabolism of antithrombin III (AT) in dogs were studied, using I-125-labeled AT (I-125-AT) as a tracer. Five dogs were used for each study. A single intramuscular injection of 20 mg estradiol caused a 20% decrease ...

journal_title：Thrombosis and haemostasis

authors： Kobayashi N,Takeda Y

更新日期：1977-02-28 00:00:00

abstract：:Few data are available on thrombophilic risk factors and progression of atherosclerotic peripheral arterial disease (PAD). Thrombophilic alterations can be an aggravating factor when arterial stenoses are present. In a cross-sectional study, we evaluated the presence of the thrombophilic factors fibrinogen, homocystei...

journal_title：Thrombosis and haemostasis

authors： Sartori M,Favaretto E,Legnani C,Cini M,Conti E,Amato A,Palareti G

更新日期：2010-07-01 00:00:00

abstract：:We have investigated the ability of serum from uremic patients to modify the thrombogenic properties of the endothelium. The effects of uremic medium on the morphology of endothelial cells (ECs), and their resistance to flow was analyzed. The influence of uremic media on the reactivity of the extracellular matrix (ECM...

journal_title：Thrombosis and haemostasis

authors： Serradell M,Díaz-Ricart M,Cases A,Zurbano MJ,Aznar-Salatti J,López-Pedret J,Ordinas A,Escolar G

更新日期：2001-10-01 00:00:00

abstract：:The still living members of the original bleeder family on the Aland Islands described by von Willebrand in 1926 have been reinvestigated by using modern laboratory techniques for the measurement of the Factor VIII complex and with regard to platelet aggregation. The low level of F VIII : C activity demonstrated in 19...

journal_title：Thrombosis and haemostasis

authors： Nyman D,Eriksson AW,Blombäck M,Frants RR,Wahlberg P

更新日期：1981-02-23 00:00:00

abstract：:Mechanisms linking deep vein thrombosis (DVT) and subclinical atherosclerosis and risk of cardiovascular events are poorly understood. The aim of this study was to investigate the potential impact of CX3CR1/CX3CL1 axis in DVT-associated endothelial dysfunction. The study included 22 patients (age: 37.5 ± 8.2 years) wi...

journal_title：Thrombosis and haemostasis

authors： Furio E,García-Fuster MJ,Redon J,Marques P,Ortega R,Sanz MJ,Piqueras L

更新日期：2018-03-01 00:00:00

abstract：:Preinfarction angina and early reperfusion of the infarct-related artery are major determinants of reduced infarct-size in patients with acute myocardial infarction. The beneficial effects of preinfarction angina on infarct size have been attributed to the development of collateral vessels and/or to post-ischemic myoc...

journal_title：Thrombosis and haemostasis

authors： Andreotti F,Sciahbasi A,De Marco E,Maseri A

更新日期：1999-09-01 00:00:00

abstract：:Risk scores in patients with atrial fibrillation (AF) based on clinical factors alone generally have only modest predictive value for predicting high risk patients that sustain events. Biomarkers might be an attractive prognostic tool to improve bleeding risk prediction. The new ABC-Bleeding score performed better tha...

journal_title：Thrombosis and haemostasis

authors： Esteve-Pastor MA,Rivera-Caravaca JM,Roldan V,Vicente V,Valdés M,Marín F,Lip GYH

更新日期：2017-10-05 00:00:00

abstract：:Hormone replacement therapy has been associated with venous thromboembolism. Controversy exists regarding the appropriate management of hormone replacement in the perioperative setting and in other situations--such as acute illness--predisposing to acute venous thromboembolism. We performed a case-control study to det...

journal_title：Thrombosis and haemostasis

authors： Hurbanek JG,Jaffer AK,Morra N,Karafa M,Brotman DJ

更新日期：2004-08-01 00:00:00