New splicing mutations in the human factor XIIIA gene, each producing multiple mutant transcripts of varying abundance.

abstract：:Research into cancer-associated thrombosis (CAT) entails managing dynamic data that pose an analytical challenge. Thus, methods that assume proportional hazards to investigate prognosis entail a risk of misinterpreting or overlooking key traits or time-varying effects. We examined the AGAMENON registry, which collects...

journal_title：Thrombosis and haemostasis

authors： Carmona-Bayonas A,Jimenez-Fonseca P,Garrido M,Custodio A,Hernandez R,Lacalle A,Cano JM,Aguado G,Martínez de Castro E,Alvarez Manceñido F,Macias I,Visa L,Martín Richard M,Mangas M,Sánchez Cánovas M,Longo F,Iglesias Rey L,

更新日期：2019-11-01 00:00:00

abstract：:Inherited thrombophilia has been shown to be linked with fetal loss. We performed a case-control study on the association between thrombosis-related polymorphisms in the factor V (FV) gene (Leiden, Cambridge, Hong Kong; HR2 haplotype) and idiopathic recurrent pregnancy loss (RPL) in Tunisian women. A total of 348 wome...

journal_title：Thrombosis and haemostasis

authors： Zammiti W,Mtiraoui N,Mercier E,Abboud N,Saidi S,Mahjoub T,Almawi WY,Gris JC

更新日期：2006-04-01 00:00:00

abstract：:The 50 laboratories of the Netherlands Federation of Thrombosis Services, covering a population of 9 million and responsible for the laboratory control of approximately 150,000 patients under oral anticoagulation, have participated since 1974 in a voluntary external and internal quality control program. The external p...

journal_title：Thrombosis and haemostasis

authors： van Dijk-Wierda CA,Hermans J,Loeliger EA,Roos J

更新日期：1977-06-30 00:00:00

abstract：:Many studies showed that the occurrence of cardiovascular and cerebrovascular events exhibits a seasonal and monthly variation. Evidences of a seasonal and monthly variation in the incidence of venous thromboembolism (VTE) are more conflicting. We conducted a systematic review and a meta-analysis of the literature to ...

journal_title：Thrombosis and haemostasis

authors： Dentali F,Ageno W,Rancan E,Donati AV,Galli L,Squizzato A,Venco A,Mannucci PM,Manfredini R

更新日期：2011-09-01 00:00:00

abstract：:The haematopoietic hormone erythropoietin (EPO) has neuroprotective properties and is currently being explored for treatment of stroke and other neurological disorders. Short-term, high-dose treatment with EPO seems to improve neurological function of stroke patients but may be associated with increased thrombotic ris...

journal_title：Thrombosis and haemostasis

authors： Kirkeby A,Torup L,Bochsen L,Kjalke M,Abel K,Theilgaard-Monch K,Johansson PI,Bjørn SE,Gerwien J,Leist M

更新日期：2008-04-01 00:00:00

abstract：:Clotting factor VIII (fVIII)-inhibitory antibodies represent a major problem in the treatment of haemophilia A. To understand the inactivation mechanisms and to pave the way towards modifications of recombinant clotting factors that reduce their immunogenicity, the exact localization of immunodominant epitopes is requ...

journal_title：Thrombosis and haemostasis

authors： Mühle C,Schulz-Drost S,Khrenov AV,Saenko EL,Klinge J,Schneider H

更新日期：2004-03-01 00:00:00

abstract：:Complement C3 is a novel risk factor for cardiovascular disease (CVD), but the underlying mechanism is currently unknown. We determined the associations of the anaphylatoxin C3a, the activation product of C3, and of C3 itself with estimates of atherosclerosis and CVD. We studied associations of C3a and C3 with carotid...

journal_title：Thrombosis and haemostasis

authors： Hertle E,van Greevenbroek MM,Arts IC,van der Kallen CJ,Geijselaers SL,Feskens EJ,Jansen EH,Schalkwijk CG,Stehouwer CD

更新日期：2014-06-01 00:00:00

abstract：:Fibrin(ogen) is the major matrix ligand for beta3 integrins. If alpha(v)beta3 is the major receptor for fibrin(ogen) on intimal smooth muscle cells, we might expect to see this integrin associated with fibrin(ogen). Eighty-four specimens obtained from endarterectomies of 14 patients were studied. Fibrin was frequently...

journal_title：Thrombosis and haemostasis

authors： Ikari Y,Yee KO,Hatsukami TS,Schwartz SM

更新日期：2000-08-01 00:00:00

abstract：:The correlation between homocysteine and vascular disease has been assessed in several clinical studies that demonstrated that elevation of plasma total homocysteine (tHcy) was an independent risk factor for atheriosclerotic disease. Major advances of homocysteine metabolism disorders have been made during the last fe...

journal_title：Thrombosis and haemostasis

authors： Di Minno MN,Tremoli E,Coppola A,Lupoli R,Di Minno G

更新日期：2010-05-01 00:00:00

abstract：STUDY OBJECTIVE:Cytokines increase endothelial tissue factor (TF) and tissue plasminogen activator inhibitor type-1 (PAI-1) expression in vitro. Tissue factor interacts with factor VII to facilitate thrombosis and PAI-1 inhibits fibrinolysis by endogenous plasminogen activators. Because cytokine release is increased in...

journal_title：Thrombosis and haemostasis

authors： Green J,Doughty L,Kaplan SS,Sasser H,Carcillo JA

更新日期：2002-02-01 00:00:00

abstract：:Data on anti-platelet therapy (APT) for prevention of atherothrombotic events in thrombocytopaenic cancer patients is lacking. We aimed to identify patient and physician characteristics associated with APT management in thrombocytopaenic patients with haematological malignancy. A clinical vignette-based experiment was...

journal_title：Thrombosis and haemostasis

authors： Leader A,Ten Cate V,Ten Cate-Hoek AJ,Spectre G,Beckers EAM,Raanani P,Giaccherini C,Pereg D,Schouten HC,Falanga A,Ten Cate H

更新日期：2019-01-01 00:00:00

abstract：:Forty-eight patients with acute proximal deep vein thrombosis (DVT) were randomised to intravenous infusions for 4 to 6 days with melagatran, a novel synthetic low molecular weight thrombin inhibitor, or unfractionated heparin adjusted by the activated partial thromboplastin time (APTT). The aim of the study was to in...

journal_title：Thrombosis and haemostasis

authors： Eriksson H,Eriksson UG,Frison L,Hansson PO,Held P,Holmström M,Hägg A,Jonsson T,Lapidus L,Leijd B,Stockelberg D,Säfwenberg U,Taghavi A,Thorsén M

更新日期：1999-03-01 00:00:00

abstract：:Recombinant factor VIIa (rVIIa) has been reported to be clinically effective and safe in haemophilic patients with inhibitor antibodies. Compared to activated prothrombin complex concentrates the risk of thrombotic complications seems to be very low after rVIIa administration. Determination of free thrombin generation...

journal_title：Thrombosis and haemostasis

authors： Gallistl S,Cvirn G,Muntean W

更新日期：1999-02-01 00:00:00

abstract：:We measured and compared the levels of plasma soluble (s) P-selectin, sCD40L, platelet-derived microparticles (PDMP), monocyte-derived microparticles (MDMP), and anti-oxidized LDL antibody, to obtain a better understanding of their potential contribution to vascular complications in acute coronary syndrome (ACS). The ...

journal_title：Thrombosis and haemostasis

authors： Matsumoto N,Nomura S,Kamihata H,Kimura Y,Iwasaka T

更新日期：2004-01-01 00:00:00

abstract：:The activation of factor XI by meizothrombin was investigated using recombinant meizothrombin (R155A meizothrombin) that is resistant to autocatalytic removal of fragment 1. Meizothrombin was capable of activating factor XI at an activation rate similar to that of thrombin. Dextran sulphate and heparin, known cofactor...

journal_title：Thrombosis and haemostasis

authors： von dem Borne PA,Mosnier LO,Tans G,Meijers JC,Bouma BN

更新日期：1997-08-01 00:00:00

abstract：:Platelet-rich clots are inefficiently lysed by current fibrinolytic agents. Platelets contain a great deal of plasminogen activator inhibitor 1 (PAI-1), the principal endogenous inhibitor of tissue-type plasminogen activator (t-PA). We have tested whether PAI-1 resistant t-PAs would be more effective thrombolytic agen...

journal_title：Thrombosis and haemostasis

authors： Shohet RV,Spitzer S,Madison EL,Bassel-Duby R,Gething MJ,Sambrook JF

更新日期：1994-01-01 00:00:00

abstract：:Antithrombin (AT) is a serine protease inhibitor that regulates the activity of coagulation proteases of both intrinsic and extrinsic pathways. We identified an AT-deficient patient with a heterozygous Thr90Ser (T90S) mutation who experiences recurrent venous thrombosis. To understand the molecular basis of the clotti...

journal_title：Thrombosis and haemostasis

authors： Lu Y,Villoutreix BO,Biswas I,Ding Q,Wang X,Rezaie AR

更新日期：2020-07-01 00:00:00

abstract：:CD36, also known as GPIIIb or GPIV, is a main protein of the platelet membrane. Accumulating evidence implicates CD36 in the pathogenesis of atherosclerosis. CD36 binds to cholesteryl-hemisuccinate coupled to agarose. This binding may be of physiologic relevance since CD36 has a long extracellular hydrophobic region a...

journal_title：Thrombosis and haemostasis

authors： Kronenberg A,Grahl H,Kehrel B

更新日期：1998-05-01 00:00:00

abstract：:The influence of storage of platelet concentrates (PC) on the adhesion capacity of platelets was studied. Twenty-four PC, 12 prepared by the buffy coat (BC) method and 12 by the platelet-rich plasma (PRP) method, were stored for 7 days at room temperature. On days 1, 3 and 7 of storage, the platelet adhesion capacity ...

journal_title：Thrombosis and haemostasis

authors： Boomgaard MN,Gouwerok CW,Homburg CH,de Groot G,IJsseldijk MJ,de Korte D

更新日期：1994-10-01 00:00:00

abstract：:The in vitro effect of nifedipine, a calcium channel blocker of the dihydropyridine (DHP) type, on platelet aggregation was reinvestigated considering especially the capability of platelets to form endogenous nitric oxide (NO). We studied the dose-dependent antiaggregatory property of nifedipine in porcine platelet ri...

journal_title：Thrombosis and haemostasis

authors： Berkels R,Klaus W,Boller M,Rösen R

更新日期：1994-08-01 00:00:00

abstract：:Background Polycystic ovarian syndrome (PCOS) affects up to 18% of reproductive-aged women with increased risks of cardiovascular disease and venous thromboembolic disease, related to metabolic and hormonal features, obesity and an apparent hypofibrinolytic state, possibly exacerbated by current PCOS treatments. Objec...

journal_title：Thrombosis and haemostasis

authors： Burchall GF,Piva TJ,Ranasinha S,Teede HJ

更新日期：2017-11-01 00:00:00

abstract：:Factor VII is a vitamin K-dependent zymogen that plays a key role in the initiation of the extrinsic pathway. A severe factor VII deficiency was identified in a 45-year old male whose plasma factor VII antigen was less than 60 ng/ml and expressed 5.2% of normal factor VII activity. DNA sequence analysis of the patient...

journal_title：Thrombosis and haemostasis

authors： Katsumi A,Matsushita T,Yamazaki T,Sugiura I,Kojima T,Saito H

更新日期：2000-02-01 00:00:00

abstract：:In this review the interaction between invasive human pathogens expressing plasmin(ogen) receptors and/or producing plasminogen activators with the human plasmin(ogen) system is described. Evidence is presented for multiple mechanisms by which human pathogens can acquire a surface bound form of plasmin that cannot be ...

journal_title：Thrombosis and haemostasis

authors： Boyle MD,Lottenberg R

更新日期：1997-01-01 00:00:00

abstract：:The increase in nitric oxide (NO) production in lipopolysaccharide (LPS)-induced sepsis is thought to contribute to the development of shock. However, NO could also play an antithrombotic role. Little is known about the modulating effect of NO on the endothelial overexpression and production of tissue factor (TF) and ...

journal_title：Thrombosis and haemostasis

authors： Pérez-Ruiz A,Montes R,Velasco F,López-Pedrera C,Antonio Páramo J,Orbe J,Hermida J,Rocha E

更新日期：2002-12-01 00:00:00

abstract：:In wound repair, fibrin has a multiplicity of activities, some of which are intrinsic to the protein itself and some attributable to other blood constituents associated with the fibrin clot. Fibrin sealants, which have been approved for hemostasis in the US and Europe, are occasionally used wounds to promote healing. ...

journal_title：Thrombosis and haemostasis

authors： Clark RA

更新日期：2003-12-01 00:00:00

abstract：:Thirty-two patients with acute, proximal-vein thrombosis were treated with heparin and alteplase (0.25 versus 0.5 mg/kg/24 h during 3-7 days) in a randomized, double-blind, multicenter, European (ETTT) trial. The treatment resulted in a decrease of the venographic Marder's score from 18 (6-25) to 13 (2-24) units (medi...

journal_title：Thrombosis and haemostasis

authors： Bounameaux H,Banga JD,Bluhmki E,Coccheri S,Fiessinger JN,Haarmann W,Lockner D,Mahler F,Ninet J,Schneider PA

更新日期：1992-03-02 00:00:00

abstract：:This review collects evidence about immune and inflammatory functions of platelets from a clinician's point of view. A focus on clinically relevant immune functions aims at stimulating further research, because the complexity of platelet immunity is incompletely understood and not yet translated into patient care. Pla...

journal_title：Thrombosis and haemostasis

authors： Duerschmied D,Bode C,Ahrens I

更新日期：2014-10-01 00:00:00

abstract：:The significance of platelet beta-adrenoceptors for platelet responses to adrenergic stimuli in vivo and in vitro was studied in healthy volunteers. Low dose infusion of the beta-adrenoceptor agonist isoprenaline decreased platelet aggregability in vivo as measured by ex vivo filtragometry. Infusion of adrenaline, a m...

journal_title：Thrombosis and haemostasis

authors： Larsson PT,Wallén NH,Martinsson A,Egberg N,Hjemdahl P

更新日期：1992-12-07 00:00:00

abstract：:Multiple clinical trials have proven that thrombolytic therapy is an effective treatment for acute myocardial infarction. Spontaneous intracranial hemorrhage (ICH) occurs in a small percentage of patients as a result of the treatment. The etiology of the ICH is unknown and there is currently no established experimenta...

journal_title：Thrombosis and haemostasis

authors： Paoni NF,Steinmetz HG,Gillett N,Refino CJ,Badillo JM,Bunting S

更新日期：1996-05-01 00:00:00

abstract：:Microparticles (MPs) are formed from platelets (PMPs), endothelial cells (EMPs) and monocytes (MMPs), and in acute myocardial infarction (MI), there is an increase of MPs in the culprit artery. In this study MPs were evaluated in whole blood in 105 patients with MI at five time-points during a two-year follow-up (FU)....

journal_title：Thrombosis and haemostasis

authors： Christersson C,Thulin Å,Siegbahn A

更新日期：2017-07-26 00:00:00