Double-blind, randomized comparison of systemic continuous infusion of 0.25 versus 0.50 mg/kg/24 h of alteplase over 3 to 7 days for treatment of deep venous thrombosis in heparinized patients: results of the European Thrombolysis with rt-PA in Venous Thr

Abstract:

:Thirty-two patients with acute, proximal-vein thrombosis were treated with heparin and alteplase (0.25 versus 0.5 mg/kg/24 h during 3-7 days) in a randomized, double-blind, multicenter, European (ETTT) trial. The treatment resulted in a decrease of the venographic Marder's score from 18 (6-25) to 13 (2-24) units (median, range) in Group I (0.25 mg/kg/24 h, n = 15, median decrease 3.0, p = 0.32) and from 17.5 (3-33) to 15.5 (0-27) in Group II (0.5 mg/kg/24 h, n = 16, median decrease 4.0, p = 0.23). Comparison of the sequential venograms could be performed in 14 cases of Group I and in 15 cases in Group II. A minority of patients showed substantial partial recanalization of the initially obstructed veins on the control venogram (one in each treatment group) and most of the control venograms showed either thrombus size reductions (5 in Group I, 7 in Group II) or no change or even deterioration (8 in Group I, 7 in Group II). Major bleedings were observed in 7 patients (7/32, 22%), 5 of them occurring in Group II (5/17, 29%). Thus, the results of the ETTT trial show that the used low dosages of alteplase administered intravenously over 3-7 days in heparinized patients cannot be recommended as a treatment for patients with deep venous thrombosis of lower limbs and/or pelvis. Further studies are needed to define a more suitable dosage regimen of alteplase in this indication.

journal_name

Thromb Haemost

authors

Bounameaux H,Banga JD,Bluhmki E,Coccheri S,Fiessinger JN,Haarmann W,Lockner D,Mahler F,Ninet J,Schneider PA

keywords:

subject

Has Abstract,Author List Incomplete

pub_date

1992-03-02 00:00:00

pages

306-9

issue

3

eissn

0340-6245

issn

2567-689X

journal_volume

67

pub_type

临床试验,杂志文章,多中心研究,随机对照试验
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    doi:

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    doi:

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    doi:

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    更新日期:1992-10-05 00:00:00

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    doi:

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    pub_type: 临床试验,杂志文章

    doi:

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    doi:

    authors: Takayama H,Okuma M,Uchino H

    更新日期:1982-08-24 00:00:00

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    pub_type: 杂志文章,meta分析,评审

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    journal_title:Thrombosis and haemostasis

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

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    pub_type: 临床试验,杂志文章

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    doi:

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    doi:

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    doi:

    authors: D'Souza L,Glueck HI

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    doi:

    authors: Carlin G,Einarsson M,Saldeen T

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    doi:

    authors: Vallés J,Aznar J,Santos MT

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