Factor XI activation by meizothrombin: stimulation by phospholipid vesicles containing both phosphatidylserine and phosphatidylethanolamine.

abstract：:We studied human platelet aggregation and beta-TG/PF4 release induced by heparin and related GAGs in vitro both in normal PRP and in PRP after aspirin. In our experimental conditions, heparin and related GAGs always caused PF4 release in vitro from normal platelets, whether or not there was measurable platelet aggrega...

journal_title：Thrombosis and haemostasis

authors： Cofrancesco E,Colombi M,Cristoforetti G,Pogliani EM

更新日期：1984-02-28 00:00:00

abstract：:Pharmacological prophylaxis for postoperative venous thromboembolism is generally restricted to the hospital stay. A high incidence of deep vein thrombosis (DVT) and pulmonary embolism presenting after hospital discharge has been reported and thus it has been claimed that pharmacological prophylaxis should be continue...

journal_title：Thrombosis and haemostasis

authors： Agnelli G,Ranucci V,Veschi F,Rinonapoli E,Lupattelli L,Nenci GG

更新日期：1995-10-01 00:00:00

abstract：:When compared to normal megakaryocytes, those from a patient with the giant platelet syndrome exhibited numerous cytochemical abnormalities. These reflected disturbances in the metabolism of RNA, glycogen, arginine-rich histone, and various glycolytic enzymes. Ultrastructural studies of the abnormal megakaryocytes als...

journal_title：Thrombosis and haemostasis

authors： Kass L,Leichtman DA,Beals TF,Schnitzer B

更新日期：1977-10-31 00:00:00

abstract：:Endothelial cell protein C receptor (EPCR) enhances the generation of activated protein C (APC) by the thrombin-thrombomodulin complex. A soluble form of EPCR (sEPCR), which is generated by metalloprotease activity, is present in plasma. The distribution of sEPCR levels in healthy populations is bimodal. Previously, w...

journal_title：Thrombosis and haemostasis

authors： Medina P,Navarro S,Estellés A,Vayá A,Woodhams B,Mira Y,Villa P,Migaud-Fressart M,Ferrando F,Aznar J,Bertina RM,España F

更新日期：2004-05-01 00:00:00

abstract：:Factor VIII inhibitors in mild haemophilia are uncommon and the management of such patients is controversial. The development of a persistently high responding F VIII inhibitor in a mild haemophiliac is reported and the behaviour of the inhibitor discussed in the context of the various therapeutic regimes employed for...

journal_title：Thrombosis and haemostasis

authors： Kesteven PJ,Holland LJ,Lawrie AS,Savidge GF

更新日期：1984-08-31 00:00:00

abstract：:Risk scores in patients with atrial fibrillation (AF) based on clinical factors alone generally have only modest predictive value for predicting high risk patients that sustain events. Biomarkers might be an attractive prognostic tool to improve bleeding risk prediction. The new ABC-Bleeding score performed better tha...

journal_title：Thrombosis and haemostasis

authors： Esteve-Pastor MA,Rivera-Caravaca JM,Roldan V,Vicente V,Valdés M,Marín F,Lip GYH

更新日期：2017-10-05 00:00:00

abstract：:Recent data has shown that hormone therapy (HT) increases the risk of cardiovascular and thromboembolic disease, particularly in users of oral HT. Phytoestrogens are popular alternatives to oestrogen therapy; however, their effects on cardiovascular risk are unknown. We investigated the effect of the phytoestrogen, ge...

journal_title：Thrombosis and haemostasis

authors： Kelly LA,O'Leary JJ,Seidlova-Wuttke D,Wuttke W,Norris LA

更新日期：2010-12-01 00:00:00

abstract：:The efficiency of current dual antiplatelet therapy might be further improved by its combination with a glycoprotein (GP) VI-targeting strategy without increasing bleeding. GPVI-Fc, a recombinant dimeric fusion protein binding to plaque collagen and concealing binding sites for platelet GPVI, acts as a lesion-focused ...

journal_title：Thrombosis and haemostasis

authors： Mojica Muñoz AK,Jamasbi J,Uhland K,Degen H,Münch G,Ungerer M,Brandl R,Megens R,Weber C,Lorenz R,Siess W

更新日期：2017-08-01 00:00:00

abstract：:Peripheral vascular disease (PVD) is an indicator of diffuse atherosclerosis and is associated with a greatly increased incidence of coronary heart and cerebrovascular disease. Although several studies have assessed whether in vivo platelet activation takes place in patients with PVD, no data are available comparing d...

journal_title：Thrombosis and haemostasis

authors： Gresele P,Catalano M,Giammarresi C,Volpato R,Termini R,Ciabattoni G,Nenci GG,Davì G

更新日期：1997-12-01 00:00:00

abstract：:Thrombus formation at an artificial surface in contact with blood is a complex process that encompasses accretion of platelets from flowing blood and fibrin deposition. Platelet adhesion and fibrin formation are intimately intertwined reactions that are triggered by different sets of surface adsorbed plasma proteins. ...

journal_title：Thrombosis and haemostasis

authors： Keuren JF,Wielders SJ,Willems GM,Morra M,Lindhout T

更新日期：2002-04-01 00:00:00

abstract：:The optimal long-term treatment of acute venous thromboembolism (VTE) in patients with malignancy remains undefined. In particular, based on current evidence, it is uncertain whether secondary prophylaxis using standard intensity oral anticoagulant therapy is associated with higher risks of bleeding and recurrent thro...

journal_title：Thrombosis and haemostasis

authors： Palareti G,Legnani C,Lee A,Manotti C,Hirsh J,D'Angelo A,Pengo V,Moia M,Coccheri S

更新日期：2000-11-01 00:00:00

abstract：:The spleen is a crucial organ in humans. However, little is known about the association of venous thromboembolism (VTE) with splenic injury and splenectomy in trauma patients. The aim of this study was to determine the subsequent risk of VTE following splenic injury and splenectomy. A nationwide retrospective cohort s...

journal_title：Thrombosis and haemostasis

authors： Lin JN,Chen HJ,Lin MC,Lai CH,Lin HH,Yang CH,Kao CH

更新日期：2016-01-01 00:00:00

abstract：:The simultaneous additon of suboptimal concentrations of factor VIII and intact or plasmin-lysed fibrinogen into mixtures of the vitamin K dependent factors, phospholipids, adsorbed bovine serum (supplier to factor V) and calcium, increased the amount of thrombin which was generated three to twenty times over the sum ...

journal_title：Thrombosis and haemostasis

authors： Triantaphyllopoulos DC,Ryan LT

更新日期：1976-04-30 00:00:00

abstract：:The technique of crossed immunoelectrophoresis has been used to study the binding to purified antithrombin III (At III) of heparin and other mucopolysaccharides. The technique was unable to detect differences among samples of whole heparin from various manufacturers, but proved useful in studying the binding of hepari...

journal_title：Thrombosis and haemostasis

authors： Barrowcliffe TW

更新日期：1980-02-29 00:00:00

abstract：:Cellular adhesion molecules also known as selectins promote recruitment of inflammatory cells into the arterial wall where they interact with lipid particles leading subsequently to plaque formation. The intercellular adhesion molecule-1 (ICAM-1), the vascular cell adhesion molecule-1 (VCAM-1) and the endothelial-leuk...

journal_title：Thrombosis and haemostasis

authors： Hoke M,Winter MP,Wagner O,Exner M,Schillinger M,Arnold Z,Mlekusch W,Maurer G,Koppensteiner R,Minar E,Goliasch G

更新日期：2015-08-31 00:00:00

abstract：:1. Some of the guidelines on the nomenclature for the genotype of bacterial strains can be applied for recommendations on the nomenclature for the description of recombinant mutant fibrinolytic constructs. 2. In view of the usually different size of genomic DNA and corresponding cDNA, it is recommended to employ a dis...

journal_title：Thrombosis and haemostasis

authors： Pannekoek H,Lijnen HR,Loskutoff DJ

更新日期：1990-12-28 00:00:00

abstract：:A fully representative and viable platelet population was isolated from the blood of 15 baboons by a multiwash procedure, and labelled with In-111-oxine. The recovery of the total platelet population in the circulation was 85% +/- 9. Mean platelet life span was 146 hr +/- 13. Correcting for plasma radioactivity (alway...

journal_title：Thrombosis and haemostasis

authors： Kotzé HF,Lötter MG,Badenhorst PN,Heyns AD

更新日期：1985-06-24 00:00:00

abstract：:Platelet-leukocyte interactions are recognised to have pro-inflammatory effects, which may be important in the pathophysiology of ischaemic heart disease. Clopidogrel and the novel intravenous antithrombotic agent AR-C69931MX act at the level of the platelet P2Y12 receptor, which is known to amplify platelet activatio...

journal_title：Thrombosis and haemostasis

authors： Storey RF,Judge HM,Wilcox RG,Heptinstall S

更新日期：2002-09-01 00:00:00

abstract：:Low molecular weight heparin (LMWH) is used increasingly for prophylaxis and treatment of venous thromboembolism during pregnancy. However, the prophylactic dose for patients at moderate risk varies between centers, and the recommended LMWH dose for the non pregnant patient is frequently used in pregnant women. The ai...

journal_title：Thrombosis and haemostasis

authors： Norris LA,Bonnar J,Smith MP,Steer PJ,Savidge G

更新日期：2004-10-01 00:00:00

abstract：:The aim of the present study was to analyse differences in the protein expression profile between platelets from aspirin (ASA)-resistant patients and ASA-sensitive patients. We analysed platelets from 51 clinically stable coronary ischaemic patients taking ASA (100 mg/day) divided into ASA-resistant (n=25) and ASA-sen...

journal_title：Thrombosis and haemostasis

authors： Mateos-Cáceres PJ,Macaya C,Azcona L,Modrego J,Mahillo E,Bernardo E,Fernandez-Ortiz A,López-Farré AJ

更新日期：2010-01-01 00:00:00

abstract：:We performed a DNA analysis on a patient with severe type I factor VII deficiency by the polymerase chain reaction amplification and a direct DNA sequencing method. The proband was a 66-year-old Japanese woman who had recurrent episodes of excessive bleeding after dental extraction. The functional and antigenic levels...

journal_title：Thrombosis and haemostasis

authors： Ozawa T,Niiya K,Higuchi W,Sakuragawa N

更新日期：1997-09-01 00:00:00

abstract：:Wound healing is a complicated biological process that consist of partially overlapping inflammatory, proliferation and tissue remodelling phases. A successful wound healing depends on a proper activation and subsequent termination of the inflammatory phase. The failure to terminate the inflammation halts the completi...

journal_title：Thrombosis and haemostasis

authors： Sulniute R,Shen Y,Guo YZ,Fallah M,Ahlskog N,Ny L,Rakhimova O,Broden J,Boija H,Moghaddam A,Li J,Wilczynska M,Ny T

更新日期：2016-05-02 00:00:00

abstract：:In a preceding paper the baseline data in the Münster Arteriosclerosis Study (PROCAM study) of the levels of fibrinogen, factor VIIc and factor VIIIc were described, and their correlation of age, body weight, smoking, alcohol, pill-using and menopause discussed. In this part the relationship of these coagulation facto...

journal_title：Thrombosis and haemostasis

authors： Balleisen L,Assmann G,Bailey J,Epping PH,Schulte H,van de Loo J

更新日期：1985-10-30 00:00:00

abstract：:In 7 healthy volunteers, formation of thrombin (represented by fibrinopeptide A (FPA) generation, alpha-granule release (represented by beta-thromboglobulin [beta TG] release) and the generation of thromboxane B2 (TxB2) were measured in vivo in blood emerging from a template bleeding time incision. At the site of plug...

journal_title：Thrombosis and haemostasis

authors： Kyrle PA,Westwick J,Scully MF,Kakkar VV,Lewis GP

更新日期：1987-02-03 00:00:00

abstract：:Platelets are key players in atherothrombosis. Antiplatelet therapy comprising aspirin alone or with P2Y12-inhibitors are effective for prevention of atherothrombotic complications. However, there is interindividual variability in the response to antiplatelet drugs, leaving some patients at increased risk of recurrent...

journal_title：Thrombosis and haemostasis

authors： Freynhofer MK,Gruber SC,Grove EL,Weiss TW,Wojta J,Huber K

更新日期：2015-08-31 00:00:00

abstract：:Apixaban does not require monitoring nor frequent dose adjustment. However, searching for the optimal dose for the individual patient may be useful in some situations. Moreover, there is a need for clinicians to know whether coagulation assays are influenced by apixaban use. The aim of this study was to determine whic...

journal_title：Thrombosis and haemostasis

authors： Douxfils J,Chatelain C,Chatelain B,Dogné JM,Mullier F

更新日期：2013-08-01 00:00:00

abstract：:It is known that thrombosis is a leading cause of vascular access failure and that the formation of thrombus requires platelets. The activation of platelets induces the increase in intracellular Ca 2(+) levels ([Ca(2+)](i)) leading to aggregation and thrombosis. We compared the platelet [Ca(2+)](i) before and after st...

journal_title：Thrombosis and haemostasis

authors： Chou KJ,Jan CR,Lee PT,Chen CL,Chung HM,Hwang YY,Chou JD,Fang HC

更新日期：2004-09-01 00:00:00

abstract：:Novel P2Y12 inhibitors are in development to overcome the occurrence of atherothrombotic events associated with poor responsiveness to the widely used P2Y12 inhibitor clopidogrel. Cangrelor is an intravenously administered P2Y12 inhibitor that does not need metabolic conversion to an active metabolite for its antiplat...

journal_title：Thrombosis and haemostasis

authors： Bouman HJ,van Werkum JW,Rudez G,Leebeek FW,Kruit A,Hackeng CM,Ten Berg JM,de Maat MP,Ruven HJ

更新日期：2010-02-01 00:00:00

abstract：:The prophylactic treatment of haemophilia B and the management of haemophilia A or B with inhibitors demand frequent administrations of coagulation factors due to the suboptimal half-lives of the products commercially available and currently in use, e.g. recombinant factor IX (rFIX) and recombinant factor VIIa (rFVIIa...

journal_title：Thrombosis and haemostasis

authors： Metzner HJ,Pipe SW,Weimer T,Schulte S

更新日期：2013-11-01 00:00:00

abstract：:Membrane-permeable 8-(4-chlorophenylthio)-2'-O-methyl cyclic AMP (8-pCPT-2'-O-Me-cAMP) has been shown to specifically activate cAMP-regulated Epac proteins, without direct effects on protein kinase A and protein kinase G. During isometric tension measurements in thoracic aortic rings from Wistar rats, we observed that...

journal_title：Thrombosis and haemostasis

authors： Sand C,Grandoch M,Börgermann C,Oude Weernink PA,Mahlke Y,Schwindenhammer B,Weber AA,Fischer JW,Jakobs KH,Schmidt M

更新日期：2010-03-01 00:00:00