Risk Factors for Higher-than-Expected Residual Rivaroxaban Plasma Concentrations in Real-Life Patients.

Abstract:

INTRODUCTION:Rivaroxaban (RXA) is a direct oral factor Xa (Xa) antagonist with a short half-life and a fast onset and offset of effect. Before elective surgery, discontinuation is recommended with an interval of at least > 24 hours. In clinical practice, this is, however, not always sufficient to achieve a residual RXA plasma concentration deemed appropriate for surgery, defined as ≤ 50 mcg/L. Our study aimed at identifying factors associated with a higher-than-expected residual RXA plasma concentration in a large group of real-life patients. MATERIALS AND METHODS:This retrospective single-centre study included all patients taking RXA between 2012 and 2016 where RXA plasma concentration was determined by pharmacodynamic anti-Xa assay (518 measurements in 368 patients). Medical records were reviewed. Residual RXA plasma concentrations were then compared with expected values according to a pharmacokinetic model. RESULTS:Residual RXA plasma concentration was significantly higher-than-expected in patients with atrial fibrillation, impaired kidney function (glomerular filtration rate [GFR] < 60 mL/min), CYP3A4-, CYP2J2- and PGP-inhibitory co-medication including amiodarone. Impaired kidney function (odds ratio [OR], 2.22, 95% confidence interval [CI], 1.30-3.78, p = 0.003) and concomitant amiodarone intake (OR, 1.97, 95% CI, 1.04-3.72, p = 0.036) were significantly associated with RXA plasma concentrations > 50 mcg/L at 24 to 48 hours after the last RXA intake. CONCLUSION:In our group of real-life patients, impaired kidney function (GFR < 60 mL/min) and co-medication with amiodarone were independently associated with higher-than-expected residual RXA plasma concentrations. In these patients, standard intervals of RXA discontinuation may not always be sufficient before elective surgery and routine pre-operative determination of the residual RXA concentration could be advisable.

journal_name

Thromb Haemost

authors

Kaserer A,Schedler A,Jetter A,Seifert B,Spahn DR,Stein P,Studt JD

doi

10.1055/s-0038-1639585

subject

Has Abstract

pub_date

2018-05-01 00:00:00

pages

808-817

issue

5

eissn

0340-6245

issn

2567-689X

journal_volume

118

pub_type

杂志文章
  • Adhesion molecules and cardiovascular risk in peripheral arterial disease. Soluble vascular cell adhesion molecule-1 improves risk stratification.

    abstract::Although intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) play a relevant role in atherosclerosis, little is known about the prognostic impact of their soluble forms (s) in patients with peripheral arterial disease (PAD). The aim of this prospective study was to verify whether ...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:10.1160/TH04-07-0440

    authors: Silvestro A,Brevetti G,Schiano V,Scopacasa F,Chiariello M

    更新日期:2005-03-01 00:00:00

  • Immunisation against αIIbβ3 and αvβ3 in a type 1 variant of Glanzmann's thrombasthenia caused by a missense mutation Gly540Asp on β3.

    abstract::Treatment of bleeding in patients with Glanzmann's thrombasthenia (GT) can be hampered by iso-antibodies against the αIIbβ3 integrin, which cause rapid clearance of transfused donor platelets. Type 1 GT patients with a total absence of αIIbβ3 from the platelet surface are known to be susceptible to form such isoantibo...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:10.1160/TH15-12-0982

    authors: Wihadmadyatami H,Röder L,Berghöfer H,Bein G,Heidinger K,Sachs UJ,Santoso S

    更新日期:2016-08-01 00:00:00

  • von Willebrand factor-cleaving protease (ADAMTS13) activity in normal non-pregnant women, pregnant and post-delivery women.

    abstract::ADAMTS13 dysfunction has been involved in the pathogenesis of Thrombotic Thrombocytopenic Purpura. This disorder occurs more frequently in women and, in 13% of them, is associated with pregnancy. However, there is little information on the protease behaviour in normal pregnancy. We studied von Willebrand factor and AD...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:10.1160/TH03-11-0683

    authors: Sánchez-Luceros A,Farías CE,Amaral MM,Kempfer AC,Votta R,Marchese C,Salviú MJ,Woods AI,Meschengieser SS,Lazzari MA

    更新日期:2004-12-01 00:00:00

  • Differential detection of single-chain and two-chain urokinase-type plasminogen activator by a new immunoadsorbent-amidolytic assay (IAA).

    abstract::A new immunoadsorbent-amidolytic assay (IAA) for the specific differential detection of two-chain urokinase-type plasminogen activator (tcu-PA) and its single-chain precursor (scu-PA) in cell culture supernatants has been developed. The assay combines the selectivity of immunoassays with the specificity of enzyme acti...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:

    authors: Corti A,Nolli ML,Cassani G

    更新日期:1986-12-15 00:00:00

  • Plasma carboxypeptidase U (CPU, CPB2, TAFIa) generation during in vitro clot lysis and its interplay between coagulation and fibrinolysis.

    abstract::Carboxypeptidase U (CPU, CPB2, TAFIa) is a basic carboxypeptidase that is able to attenuate fibrinolysis. The inactive precursor procarboxypeptidase U is converted to its active form by thrombin, the thrombin-thrombomodulin complex or plasmin. The aim of this study was to investigate and characterise the time course o...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:10.1160/TH17-02-0097

    authors: Leenaerts D,Aernouts J,Van Der Veken P,Sim Y,Lambeir AM,Hendriks D

    更新日期:2017-07-26 00:00:00

  • Thrombin-activated human platelets release two NAP-2 variants that stimulate polymorphonuclear leukocytes.

    abstract::Thrombin-activated human platelets release substance(s) of a proteic nature which induce an increase in the intracellular calcium concentration in polymorphonuclear leukocytes (PMN). Aim of this study was to characterize the platelet released product(s) responsible for PMN stimulation. PMN-stimulating activity was iso...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:

    authors: Piccardoni P,Evangelista V,Piccoli A,de Gaetano G,Walz A,Cerletti C

    更新日期:1996-11-01 00:00:00

  • Platelet thrombospondin interactions with human high and low molecular weight kininogens.

    abstract::Multifunctional proteins, e.g. high molecular weight kininogen (HK, 120 kDa) and the homotrimer, thrombospondin (TSP, 540 kDa), which have more than one domain on a single polypeptide chain, are particularly well-suited to be structural elements of extracellular matrices because of their ability to bind to several mac...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:

    authors: DeLa Cadena RA,Wyshock EG,Kunapuli SP,Schultze RL,Miller M,Walz DA,Colman RW

    更新日期:1994-07-01 00:00:00

  • Participation of Hageman factor dependent pathways in human disease states.

    abstract::Abnormalities of Hageman factor dependent pathways have been described in a wide variety of human disease states. Congenital deficiencies of factor XII (Hageman trait) prekallikrein (Fletcher trait) and high molecular weight kininogen (Williams, Fitzgerald and Flaujeac traits) although resulting in profound in vitro c...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章,评审

    doi:

    authors: Colman RW,Wong PY

    更新日期:1977-12-15 00:00:00

  • Modulation of fibrinolytic and gelatinolytic activity during adipose tissue development in a mouse model of nutritionally induced obesity.

    abstract::A nutritionally induced obesity model was used to investigate the modulation of fibrinolytic and gelatinolytic activity during the development of adipose tissue. Five week old male mice were fed a standard fat diet (SFD, 13% kcal as fat) or a high fat diet (HFD, 42% kcal as fat) for up to 15 weeks. The HFD resulted in...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:

    authors: Lijnen HR,Maquoi E,Demeulemeester D,Van Hoef B,Collen D

    更新日期:2002-08-01 00:00:00

  • Local inflammation is associated with aortic thrombus formation in abdominal aortic aneurysms. Relationship to clinical risk factors.

    abstract::Intraluminal thrombus formation in aortic abdominal aneurysms (AAA) is associated with adverse clinical prognosis. Interplay between coagulation and inflammation, characterised by leukocyte infiltration and cytokine production, has been implicated in AAA thrombus formation. We studied leukocyte (CD45+) content by flow...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:10.1160/TH12-05-0339

    authors: Sagan A,Mrowiecki W,Mikolajczyk TP,Urbanski K,Siedlinski M,Nosalski R,Korbut R,Guzik TJ

    更新日期:2012-11-01 00:00:00

  • Prostanoid and TP-receptors in atherothrombosis: is there a role for their antagonism?

    abstract::Atherosclerosis and its clinical manifestations (i.e. myocardial infarction, stroke) are major causes of mortality and morbidity in Western countries. Endothelial dysfunction is considered the first step in the cascade leading up to coronary events. Increasing evidence suggests that direct inhibition of thromboxane A2...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章,评审

    doi:10.1160/TH10-03-0195

    authors: Giannarelli C,Zafar MU,Badimon JJ

    更新日期:2010-11-01 00:00:00

  • Effect of pentosan polysulphate administration in man on the formation of covalent complexes between heparin cofactor II and thrombin generated in plasma by contact activation.

    abstract::An assay for the quantification of pentosan polysulphate (PPS) in plasma is described. As PPS has been shown to potentiate thrombin inhibition by the second heparin cofactor (HC II), the principle of this assay was to measure the formation of covalent complexes between HC II and the thrombin generated in plasma after ...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:

    authors: Dol F,Sié P,Dupouy D,Boneu B

    更新日期:1986-12-15 00:00:00

  • Akt protects the heart against ischaemia-reperfusion injury by modulating mitochondrial morphology.

    abstract::The mechanism through which the protein kinase Akt (also called PKB), protects the heart against acute ischaemia-reperfusion injury (IRI) is not clear. Here, we investigate whether Akt mediates its cardioprotective effect by modulating mitochondrial morphology. Transfection of HL-1 cardiac cells with constitutively ac...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:10.1160/TH14-07-0592

    authors: Ong SB,Hall AR,Dongworth RK,Kalkhoran S,Pyakurel A,Scorrano L,Hausenloy DJ

    更新日期:2015-03-01 00:00:00

  • Venous antithrombotic and anticoagulant activities of a fucoïdan fraction.

    abstract::Fucoïdans catalyse thrombin inhibition by antithrombin (AT) and heparin cofactor II (HCII); their affinity for each serpin varies according to the seaweed species from which they are extracted, as well as their chemical composition and molecular weight. We extracted a homogeneous fucoïdan fraction from Ascophyllum nod...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:

    authors: Mauray S,Sternberg C,Theveniaux J,Millet J,Sinquin C,Tapon-Bretaudière J,Fischer AM

    更新日期:1995-11-01 00:00:00

  • Effects of etamsylate on platelet functions and arachidonic acid metabolism.

    abstract::The effects of etamsylate on human platelet aggregation and ATP release as well as on the arachidonate metabolism by the platelet have been studied. Etamsylate enhanced these platelet functions induced by arachidonic acid (AA), thromboxane A2, collagen and calcium ionophore A23187 but not those induced by ADP and epin...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:

    authors: Okuma M,Takayama H,Sugiyama T,Sensaki S,Uchino H

    更新日期:1982-12-27 00:00:00

  • Evaluation of frozen plasma calibrants for enhanced standardization of the international normalized ratio (INR): a multi-center study.

    abstract::Local ISI calibration has been proposed to improve INR accuracy and inter-laboratory precision. We evaluated the affect of local PT calibration on INR precision and accuracy using six levels of frozen plasma calibrants prepared and pooled from normal donors and patients stabilized on sodium warfarin (coumarin) based o...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:

    authors: Adcock DM,Johnston M

    更新日期:2002-01-01 00:00:00

  • Thrombin generation measured ex vivo following microvascular injury is increased in SLE patients with antiphospholipid-protein antibodies.

    abstract::Antiphospholipid-protein antibodies (APA) include lupus-type anticoagulant (LA) and antibodies recognizing complexes of anionic phospholipids (e.g. cardiolipin) and proteins (e.g. prothrombin and beta2-glycoprotein I). The presence of APA is associated with an increased risk of both arterial and venous thrombosis. How...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:

    authors: Musiał J,Swadźba J,Jankowski M,Grzywacz M,Bazan-Socha S,Szczeklik A

    更新日期:1997-10-01 00:00:00

  • Investigation of the interaction of blood platelets with the coagulation system at the site of plug formation in vivo in man--effect of low-dose aspirin.

    abstract::In 7 healthy volunteers, formation of thrombin (represented by fibrinopeptide A (FPA) generation, alpha-granule release (represented by beta-thromboglobulin [beta TG] release) and the generation of thromboxane B2 (TxB2) were measured in vivo in blood emerging from a template bleeding time incision. At the site of plug...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:

    authors: Kyrle PA,Westwick J,Scully MF,Kakkar VV,Lewis GP

    更新日期:1987-02-03 00:00:00

  • Effect of heparin and/or antithrombin III on the generation of endotoxin-induced plasminogen activator inhibitor.

    abstract::It has been experimentally shown that endotoxin induces a significant increase in the blood levels of a plasminogen activator inhibitor (PAI). We evaluated the effect of different doses of heparin (5 to 20 IU kg-1 h-1), antithrombin III (10 to 40 U kg-1 h-1 and 240 U/kg as bolus) and of a combination of the two on: 1)...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:

    authors: Gómez C,Páramo JA,Colucci M,Rocha E

    更新日期:1989-09-29 00:00:00

  • Regulation of urokinase receptor function and pericellular proteolysis by the integrin alpha(5)beta(1).

    abstract::Interactions between the uPA receptor (uPAR) and various integrins, including alpha(5)beta(1), are known to modulate integrin-dependent cell adhesion, and we have shown that the integrin-associated tetraspanin protein CD82 down-regulates uPAR-dependent plasminogen activation by affecting alpha(5)beta(1) cellular local...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:

    authors: Bass R,Ellis V

    更新日期:2009-05-01 00:00:00

  • International collaborative study for the establishment of the second International Reference Preparation of plasmin.

    abstract::An international collaborative study involving seven laboratories was undertaken to assess the suitability of a freeze-dried preparation of human plasmin to replace the current International Reference Preparation (IRP) for plasmin. Chromogenic and fibrinolytic assays were used by all participating laboratories to asse...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:

    authors: Gaffney PJ,Mussett MV

    更新日期:1983-10-31 00:00:00

  • Measurement of thrombin generation in whole blood--the effect of heparin and aspirin.

    abstract::A technique has been developed to monitor the development of thrombin in freshly collected whole blood in the absence of anticoagulants. It is based on the centrifugal separation of the cellular components from subsamples of blood drawn from non-anticoagulated clotting whole blood which are diluted in buffer containin...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:

    authors: Kessels H,Béguin S,Andree H,Hemker HC

    更新日期:1994-07-01 00:00:00

  • Impaired prothrombin consumption in Bernard-Soulier syndrome is corrected in vitro by human factor VIII.

    abstract::The Bernard-Soulier syndrome (BSS) is characterized by thrombocytopenia with giant platelets, a prolonged bleeding time with defective platelet adhesion to the subendothelium related to a defect in platelet membrane glycoprotein Ib (GPIb) and a decreased prothrombin consumption. The mechanism of the latter abnormality...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:

    authors: Bellucci S,Girma JP,Lozano M,Meyer D,Caen JP

    更新日期:1997-02-01 00:00:00

  • Treatment with the CC chemokine-binding protein Evasin-4 improves post-infarction myocardial injury and survival in mice.

    abstract::Chemokines trigger leukocyte trafficking and are implicated in cardiovascular disease pathophysiology. Chemokine-binding proteins, called "Evasins" have been shown to inhibit both CC and CXC chemokine-mediated bioactivities. Here, we investigated whether treatment with Evasin-3 (CXC chemokine inhibitor) and Evasin-4 (...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:10.1160/TH13-04-0297

    authors: Braunersreuther V,Montecucco F,Pelli G,Galan K,Proudfoot AE,Belin A,Vuilleumier N,Burger F,Lenglet S,Caffa I,Soncini D,Nencioni A,Vallée JP,Mach F

    更新日期:2013-10-01 00:00:00

  • Chewing versus Swallowing Ticagrelor to Accelerate Platelet Inhibition in Acute Coronary Syndrome - the CHEERS study. For The PLATIS (Platelets and Thrombosis in Sheba) Study Group.

    abstract::It was the study objective to evaluate whether chewing a 180 mg loading dose of ticagrelor versus an equal dose of traditional oral administration, enhances inhibition of platelet aggregation 1 hour (h) after administering a ticagrelor loading dose in non-ST elevation myocardial infarction (NSTEMI) patients. Dual anti...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章,随机对照试验

    doi:10.1160/TH16-09-0728

    authors: Asher E,Frydman S,Katz M,Regev E,Sabbag A,Mazin I,Abu-Much A,Kukuy A,Mazo A,Erez A,Berkovitch A,Narodistky M,Barbash I,Segev A,Beigel R,Matetzky S

    更新日期:2017-04-03 00:00:00

  • Stroke and Thromboembolism in Warfarin-Treated Patients with Atrial Fibrillation: Comparing the CHA2DS2-VASc and GARFIELD-AF Risk Scores.

    abstract:BACKGROUND: Evaluation of thromboembolic risk is essential in anticoagulated atrial fibrillation (AF) patients. The CHA2DS2-VASc score is largely validated and recommended by most guidelines. The GARFIELD-AF Stroke score has been proposed as an alternative risk score. METHODS: We analyzed warfarin-treated patients fro...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:10.1055/a-1333-4448

    authors: Proietti M,Rivera-Caravaca JM,Esteve-Pastor MA,Marín F,Lip GYH

    更新日期:2020-12-09 00:00:00

  • HMGB1 binds to activated platelets via the receptor for advanced glycation end products and is present in platelet rich human coronary artery thrombi.

    abstract::High mobility group box 1 (HMGB1) acts as both a nuclear protein that regulates gene expression, as well as a pro-inflammatory alarmin that is released from necrotic or activated cells. Recently, HMGB1-expression in human atherosclerotic plaques was identified. Therapeutic blockade of HMGB1 reduced the development of ...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:10.1160/TH14-12-1073

    authors: Ahrens I,Chen YC,Topcic D,Bode M,Haenel D,Hagemeyer CE,Seeba H,Duerschmied D,Bassler N,Jandeleit-Dahm KA,Sweet MJ,Agrotis A,Bobik A,Peter K

    更新日期:2015-11-01 00:00:00

  • Characterisation and validity of inflammatory biomarkers in the prediction of post-operative atrial fibrillation in coronary artery disease patients.

    abstract::Atrial fibrillation (AF) is a common complication of coronary artery bypass grafting (CABG). We sought to determine the diagnostic validity of plasma biomarkers of i) inflammation (marked by interleukin-6 [IL-6] and high-sensitivity C-reactive protein [hs-CRP]), ii) extracellular matrix remodelling (matrix metalloprot...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:10.1160/TH09-12-0837

    authors: Kaireviciute D,Blann AD,Balakrishnan B,Lane DA,Patel JV,Uzdavinys G,Norkunas G,Kalinauskas G,Sirvydis V,Aidietis A,Lip GY

    更新日期:2010-07-01 00:00:00

  • Vascular thrombogenicity induced by progressive LDL oxidation: protection by antioxidants.

    abstract::Oxidative modification of LDL, which dysregulates the homeostasis between blood and vascular cells, and alterations of endothelial function are considered among the early events in the pathogenesis of atherosclerosis. This study was designed to evaluate the impact of progressive LDL oxidation on the thrombotic respons...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:

    authors: Banfi C,Camera M,Giandomenico G,Toschi V,Arpaia M,Mussoni L,Tremoli E,Colli S

    更新日期:2003-03-01 00:00:00

  • Monitoring of heparin therapy with the activated partial thromboplastin time and chromogenic substrate assays.

    abstract::Heparin therapy was monitored with the activated partial thromboplastin time (APTT) and with chromogenic substrate assays (factor Xa and factor IIa inhibition) in 100 plasma samples from 47 patients. Heparin concentrations were classified as being below, within or above a defined therapeutic range (TR; 0.2-0.55 units ...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:

    authors: Fey MF,Lang M,Furlan M,Beck EA

    更新日期:1987-10-28 00:00:00