Increase in plasma concentration of plasminogen activator inhibitor, fibrinogen, von Willebrand factor, factor VIII:C and in erythrocyte sedimentation rate with age.

abstract：:Microparticles (MPs) are formed from platelets (PMPs), endothelial cells (EMPs) and monocytes (MMPs), and in acute myocardial infarction (MI), there is an increase of MPs in the culprit artery. In this study MPs were evaluated in whole blood in 105 patients with MI at five time-points during a two-year follow-up (FU)....

journal_title：Thrombosis and haemostasis

authors： Christersson C,Thulin Å,Siegbahn A

更新日期：2017-07-26 00:00:00

abstract：:This study explores the effects on some hematological parameters of a low-dose aspirin regimen (50 mg/day) versus a conventional aspirin treatment with reported antithrombotic efficacy (324 mg/day), in patients with acute myocardial infarction. Fifteen patients were randomized into 3 equal groups receiving 50 mg or 32...

journal_title：Thrombosis and haemostasis

authors： De Caterina R,Giannessi D,Boem A,Bernini W,Battaglia D,Michelassi C,Dell'Amico F,L'Abbate A,Patrignani P,Patrono C

更新日期：1985-08-30 00:00:00

abstract：:Experimental studies have suggested that TNF alpha, a pro-inflammatory cytokine, may contribute to the deterioration of cardiovascular function through various mechanisms, including the generation of reactive oxygen species. It has not yet been demonstrated whether TNF alpha has prooxidant activity in patients with he...

journal_title：Thrombosis and haemostasis

authors： De Biase L,Pignatelli P,Lenti L,Tocci G,Piccioni F,Riondino S,Pulcinelli FM,Rubattu S,Volpe M,Violi F

更新日期：2003-08-01 00:00:00

abstract：:Lipid oxidation products and in particular oxidized phospholipids (OxPL) are increasingly recognized as inducers of chronic inflammation characteristic of atherosclerosis. OxPL stimulate production of chemokines and adhesion of monocytes to endothelial cells. However, accumulating data suggest that, in addition to the...

journal_title：Thrombosis and haemostasis

authors： Bochkov VN

更新日期：2007-03-01 00:00:00

abstract：:Using an in vitro model of clot lysis, the individual response to a pharmacological concentration of recombinant tissue plasminogen activator (rt-PA) and the influence on this response of the physiological variations of blood parameters known to interfere with the fibrinolytic/thrombolytic process were investigated in...

journal_title：Thrombosis and haemostasis

authors： Colucci M,Scopece S,Gelato AV,Dimonte D,Semeraro N

更新日期：1997-04-01 00:00:00

abstract：:Plasminogen activator inhibitor type-1 (PAI-1) is a physiologic modulator of the fibrinolytic system. We have shown previously that PAI-1 biosynthesis in cultured cells depends on several factors in serum. Because platelets are richly endowed with specific growth factors and because the release reaction is an integral...

journal_title：Thrombosis and haemostasis

authors： Hopkins WE,Westerhausen DR,Fujii S,Billadello JJ,Sobel BE

更新日期：1991-08-01 00:00:00

abstract：:Monitoring of anti-factor Xa activity is often performed during treatment with low-molecular-weight heparins (LMWHs) in pregnancy because the anticoagulant effect may decrease as pregnancy progresses, but assays for anti-factor Xa activity are unavailable in many clinical institutions caring for pregnant women. Heptes...

journal_title：Thrombosis and haemostasis

authors： Dempfle CE,Zharkowa U,Elmas E,Ahmad-Nejad P,Neumaier M,Borggrefe M

更新日期：2009-11-01 00:00:00

abstract：:The effects on platelet function of a 5-day course of Ticlopidine (Tcl) have been studied in two groups of volunteers receiving different dosage schedules. Tcl had a relatively greater inhibitory effect on aggregation induced by ADP than by other agonists, and a greater effect, in contrast to that of an ADP receptor a...

journal_title：Thrombosis and haemostasis

authors： Hardisty RM,Powling MJ,Nokes TJ

更新日期：1990-08-13 00:00:00

abstract：:Previous studies have demonstrated that cell-permeable cytoplasmic tail (CT) alpha(II)beta peptides can modulate the activation of alpha(IIb)b(3). As alpha(V) CT contains an alpha(II)beta homologous region, a series of cell-permeable alpha(V) and alpha(IIb) peptides were generated to determine if alpha(V) CT can modul...

journal_title：Thrombosis and haemostasis

authors： Haas TA

更新日期：2008-01-01 00:00:00

abstract：:In the AMPLIFY clinical trial, apixaban was non-inferior to warfarin plus subcutaneous enoxaparin bridge therapy in the treatment of acute venous thromboembolism (VTE) and was associated with significantly less bleeding. This study evaluated their comparative effectiveness and safety in routine clinical practice. A ma...

journal_title：Thrombosis and haemostasis

authors： Weycker D,Li X,Wygant GD,Lee T,Hamilton M,Luo X,Vo L,Mardekian J,Pan X,Burns L,Atwood M,Hanau A,Cohen AT

更新日期：2018-11-01 00:00:00

abstract：:A complex of heparin and a quaternary ammonium compound dissolved in an organic solvent was investigated for its potential ability to prevent clotting on the surface of plastic catheters. Despite the complexing of heparin to ammonium, anticoagulant activity remained on in vitro testing. Both the heparin complex and it...

journal_title：Thrombosis and haemostasis

authors： Evans RW,Pasmantier MW,Coleman M,Wagner FS,Flair RC

更新日期：1979-05-25 00:00:00

abstract：:Helicobacter pylori (H. pylori) infection is associated with peptic ulcer disease and gastric cancer. The eradication of H. pylori is of special interest in patients with congenital bleeding disorders, for whom treatment of gastrointestinal hemorrhage with factor concentrates is costly. The prevalence of H. pylori var...

journal_title：Thrombosis and haemostasis

authors： Schulman S,Rehnberg AS,Hein M,Hegedus O,Lindmarker P,Hellström PM

更新日期：2003-04-01 00:00:00

abstract：:The gel-chromatography of the beta-alanine precipitate of human plasma and of purified fibrinogen shows the presence of different classes of fibrinogen complexes. A first class of complexes is detectable in correspondence with the ascending branch of the fibrinogen peak ("shoulder" complexes or high molecular weight f...

journal_title：Thrombosis and haemostasis

authors： Serneri GGE,Gensini GF,Abbate R,Favilla S

更新日期：1979-07-01 00:00:00

abstract：:We have previously suggested that the human homologue of the Drosophila transient receptor potential protein, TRPC1, is involved in conducting store-operated Ca2+ entry (SOCE) in human platelets since an antibody raised against the pore-forming region of TRPC1 inhibited SOCE. Here we have investigated plasma membrane ...

journal_title：Thrombosis and haemostasis

authors： Brownlow SL,Sage SO

更新日期：2005-10-01 00:00:00

abstract：:A preliminary clinical trial was conducted to determine the feasibility of achieving and regulating therapeutic anticoagulation with heparin given by continuous subcutaneous infusion. Five patients with deep venous thrombosis confirmed by impedance plethysmography and/or venography were studied. All patients received ...

journal_title：Thrombosis and haemostasis

authors： Parrilla N,Ansell J

更新日期：1982-02-26 00:00:00

abstract：:Activated protein C resistance (APCR) is a major risk factor for venous thromboembolism (VTE). Although the factor V (FV) Leiden mutation accounts for the vast majority of APCR cases, other polymorphisms may contribute to the APCR phenotype. Genetic components of APCR and thrombophilia were investigated by two dinucle...

journal_title：Thrombosis and haemostasis

authors： Mingozzi F,Legnani C,Lunghi B,Scanavini D,Castoldi E,Palareti G,Marchetti G,Bernardi F

更新日期：2003-06-01 00:00:00

abstract：:A four-decade clinical experience and recent evidence from randomised controlled studies definitively recognised primary prophylaxis, i.e. the regular infusion of factor concentrates started after the first haemarthrosis and/or before the age of two years, as the first-choice treatment in children with severe haemophi...

journal_title：Thrombosis and haemostasis

authors： Coppola A,Franchini M,Tagliaferri A

更新日期：2009-04-01 00:00:00

abstract：:We have established a new analytical method which allows the characterization of von Willebrand factor (vWF) degradation fragments in minute amounts (10 microliters) of plasma, without the need for immunopurification of vWF. Plasma vWF was hydrolysed by S aureus V-8 protease (V-8 protease) and the cleaved fragments se...

journal_title：Thrombosis and haemostasis

authors： Takahashi Y,Kalafatis M,Girma JP,Meyer D

更新日期：1988-12-22 00:00:00

abstract：:In an international collaborative study three candidate reference and the local APTT reagent have been tested with lyophilized plasmas containing heparin added in vitro and fresh plasmas from heparinized patients to determine whether it was possible to standardize APTT heparin monitoring. The APTT responses of patient...

journal_title：Thrombosis and haemostasis

authors： Van der Velde EA,Poller L

更新日期：1995-01-01 00:00:00

abstract：:Nitric oxide (NO) is a signaling molecule of major importance modulating not only the function of the vascular wall but also that of blood cells, such as platelets and leukocytes. The synthesis of NO in the circulation has been attributed mainly to the vascular endothelium. Red blood cells (RBC) have been demonstrated...

journal_title：Thrombosis and haemostasis

authors： Kleinbongard P,Keymel S,Kelm M

更新日期：2007-11-01 00:00:00

abstract：:Hot water extracts of Mo-er (1 gm by 15 ml of water), an oriental food (Auricularia auricula), inhibit strongly both human and rat platelet ADP-induced aggregation. HPLC analysis of two varieties of Mo-er, A. auricula and A. polytricha (a black tree fungus), shows that they contain adenosine (Ado), 133 and 154 microgr...

journal_title：Thrombosis and haemostasis

authors： Agarwal KC,Russo FX,Parks RE Jr

更新日期：1982-10-29 00:00:00

abstract：:The Bernard-Soulier syndrome (BSS) is characterized by thrombocytopenia with giant platelets, a prolonged bleeding time with defective platelet adhesion to the subendothelium related to a defect in platelet membrane glycoprotein Ib (GPIb) and a decreased prothrombin consumption. The mechanism of the latter abnormality...

journal_title：Thrombosis and haemostasis

authors： Bellucci S,Girma JP,Lozano M,Meyer D,Caen JP

更新日期：1997-02-01 00:00:00

abstract：:A suggestive locus on chromosome 8 could be shown to be associated with familial high factor VIII (FVIII) levels in venous thromboembolism. The ADAMDEC 1 gene is a candidate expressing an ectodomain sheddase. However, the ectodomain of the clearance receptor for FVIII, the low-density lipoprotein receptor-related prot...

journal_title：Thrombosis and haemostasis

authors： Berger M,Moscatelli H,Kulle B,Luxembourg B,Blouin K,Spannagl M,Lindhoff-Last E,Schambeck CM

更新日期：2008-05-01 00:00:00

abstract：:Thrombolytic therapy has become the mainstay of treatment for acute transmural myocardial infarction. Present fibrinolytic regimens have a number of shortcomings, including the failure to induce early and sustained reperfusion in as many as 40-50% of the patients, and to prevent reocclusion in another 10-20% of the pa...

journal_title：Thrombosis and haemostasis

authors： Pislaru SV,Van de Werf F

更新日期：1999-09-01 00:00:00

abstract：:We investigated the influence of low molecular weight dextran sulfate (LMWdxs) and low molecular weight heparins (LMWH: dalteparin, enoxaparin and nadroparin) on the inhibition of FXIa by C1-inhibitor, alpha1-antitrypsin, alpha2-antiplasmin and antithrombin in a purified system and in plasma. The second order rate con...

journal_title：Thrombosis and haemostasis

authors： Mauron T,Lämmle B,Wuillemin WA

更新日期：1998-07-01 00:00:00

abstract：:Wide variations in procoagulant properties, lipid composition and ultrastructure of five commonly used APTT methods have been demonstrated. Performance of the methods with a range of coagulation abnormalities has been ranked. Most of the reagents obtained a high score with one or more defects, but a low score with oth...

journal_title：Thrombosis and haemostasis

authors： Stevenson KJ,Easton AC,Curry A,Thomson JM,Poller L

更新日期：1986-04-30 00:00:00

abstract：:Hemorrhagic diathesis was observed in patients with renal insufficiency after carbenicillin at serum levels greater than 300 mug/ml. Normal coagulation factors (F. I, II, V, VII, VIII, X), normal PTT, normal platelet counts, negative ethanol gelation test (fibrin monomers) were found as well as a prolongation of throm...

journal_title：Thrombosis and haemostasis

authors： Andrassy K,Weischedel E,Ritz E,Andrassy T

更新日期：1976-08-31 00:00:00

abstract：:Extracellular RNA (eRNA), released from cells under conditions of injury or vascular disease, acts as potent prothrombotic factor and promotes vascular hyperpermeability related to oedema formation in vivo. In this study, we aimed to investigate the mechanism by which eRNA triggers inflammatory processes, particularl...

journal_title：Thrombosis and haemostasis

authors： Fischer S,Grantzow T,Pagel JI,Tschernatsch M,Sperandio M,Preissner KT,Deindl E

更新日期：2012-10-01 00:00:00

abstract：:The effect of selective activation of platelet prostaglandin (PG) E2 receptor subtype EP2 or EP4 on platelet aggregation remains to be determined. In platelets prepared from wild-type mice (WT platelets), high concentrations of PGE2 inhibited platelet aggregation induced by U-46619, a thromboxane receptor agonist. How...

journal_title：Thrombosis and haemostasis

authors： Kuriyama S,Kashiwagi H,Yuhki K,Kojima F,Yamada T,Fujino T,Hara A,Takayama K,Maruyama T,Yoshida A,Narumiya S,Ushikubi F

更新日期：2010-10-01 00:00:00

abstract：:We developed an ELISA test to measure the binding of plasma von Willebrand factor (vWF) to arterial microfibrils and compared this interaction to the binding of vWF to collagen under the same conditions. We found that vWF binds to microfibrils in a similar manner as it binds to collagen: the binding was independent of...

journal_title：Thrombosis and haemostasis

authors： Fauvel-Lafève F,Legrand YJ

更新日期：1990-08-13 00:00:00