Different expression of proteins in platelets from aspirin-resistant and aspirin-sensitive patients.

abstract：:We studied the recovery pattern of platelet malondialdehyde (MDA) formation after a single intake of various doses of aspirin (ASA). In normal subjects, there were striking differences in the recovery pattern between large doses (1,000 or 500 mg) and small doses (100 or 50 mg) of oral ASA. The 2 day lag phase was pres...

journal_title：Thrombosis and haemostasis

authors： Takayama H,Okuma M,Uchino H

更新日期：1982-08-24 00:00:00

abstract：:Normal adults have very few circulating endothelial cells (CECs) in their blood, but increased levels have been shown in association with conditions associated with endothelial damage such as myocardial infarction and stroke. As atrial fibrillation (AF) is associated with a hypercoagulable state and abnormalities of p...

journal_title：Thrombosis and haemostasis

authors： Freestone B,Lip GY,Chong AY,Nadar S,Lee KW,Blann AD

更新日期：2005-10-01 00:00:00

abstract：:The strong effect of protein adsorption on blood and tissue compatibility is well known. Little is presently known about the mechanisms which control the composition of the adsorbed protein layer which forms upon exposure of surfaces to mixtures of proteins. Reexamination of the ability of hemoglobin to inhibit the ad...

journal_title：Thrombosis and haemostasis

authors： Horbett TA

更新日期：1984-04-30 00:00:00

abstract：:There is no patient-reported medication adherence measure that has been validated in Singapore. This study aimed to validate the 8-item Morisky Medication Adherence Scale (MMAS) in patients taking warfarin in Singapore. A cross-sectional survey was conducted in a convenience sample of 151 patients taking warfarin at a...

journal_title：Thrombosis and haemostasis

authors： Wang Y,Kong MC,Ko Y

更新日期：2012-10-01 00:00:00

abstract：:An alternative method of uniting small diameter vessels to obtain tissue union while limiting the thrombogenic effect of suture placement at a vessel anastomosis involves the use of a thrombin based fibrin glue as a surgical sealant. This investigation addresses whether the in vitro application of a thrombin based glu...

journal_title：Thrombosis and haemostasis

authors： Dascombe WH,Dumanian G,Hong C,Heil BV,Labadie K,Hessel B,Blombäck B,Johnson PC

更新日期：1997-08-01 00:00:00

abstract：:A fibrinolysis inhibitor was purified in serum from post-traumatic patients by the use of flat bed electrofocusing of serum desalted by gel chromatography followed by affinity chromatography on a column of matrix-linked plasminogen. Disc gel electrophoresis yielded one protein band. The inhibitor protein was also foun...

journal_title：Thrombosis and haemostasis

authors： Bagge L,Björk I,Saldeen T,Wallin R

更新日期：1978-02-28 00:00:00

abstract：:Idarucizumab, a Fab fragment directed against dabigatran, produced rapid and complete reversal of the anticoagulation effect of dabigatran in animals and in healthy volunteers. The Study of the REVERSal Effects of Idarucizumab in Patients on Active Dabigatran (RE-VERSE AD™) is a global phase 3 prospective cohort study...

journal_title：Thrombosis and haemostasis

authors： Pollack CV Jr,Reilly PA,Bernstein R,Dubiel R,Eikelboom J,Glund S,Huisman MV,Hylek E,Kam CW,Kamphuisen PW,Kreuzer J,Levy JH,Sellke F,Stangier J,Steiner T,Wang B,Weitz JI

更新日期：2015-07-01 00:00:00

abstract：:Coumarin and homologous compounds are the most widely used anticoagulant drugs worldwide. They function as antagonists of vitamin K, an essential cofactor for the posttranslational gamma-glutamyl carboxylation of the so-called vitamin K-dependent proteins. As vitamin K hydroquinone is converted to vitamin K epoxide (V...

journal_title：Thrombosis and haemostasis

authors： Rost S,Fregin A,Hünerberg M,Bevans CG,Müller CR,Oldenburg J

更新日期：2005-10-01 00:00:00

abstract：:Chemokines trigger leukocyte trafficking and are implicated in cardiovascular disease pathophysiology. Chemokine-binding proteins, called "Evasins" have been shown to inhibit both CC and CXC chemokine-mediated bioactivities. Here, we investigated whether treatment with Evasin-3 (CXC chemokine inhibitor) and Evasin-4 (...

journal_title：Thrombosis and haemostasis

authors： Braunersreuther V,Montecucco F,Pelli G,Galan K,Proudfoot AE,Belin A,Vuilleumier N,Burger F,Lenglet S,Caffa I,Soncini D,Nencioni A,Vallée JP,Mach F

更新日期：2013-10-01 00:00:00

abstract：:Excessive leukocyte infiltration causes severe tissue damage in a variety of inflammatory diseases. The initial step in leukocyte extravasation is mediated by selectins and oligosaccharides on their glycoconjugate ligands. Human milk is a rich source of lactose-derived oligosaccharides that are partly absorbed in the ...

journal_title：Thrombosis and haemostasis

authors： Bode L,Kunz C,Muhly-Reinholz M,Mayer K,Seeger W,Rudloff S

更新日期：2004-12-01 00:00:00

abstract：:The cellular phospholipid, lysophosphatidic acid (LPA), released by activated platelets and fibroblasts or, at high levels, from ovarian and cervical carcinomas is a powerful serum mitogen that may modulate several signaling pathways in endothelial cells (EC). Hence, LPA could function in a paracrine manner during EC-...

journal_title：Thrombosis and haemostasis

authors： Palmetshofer A,Robson SC,Nehls V

更新日期：1999-11-01 00:00:00

abstract：:A preliminary clinical trial was conducted to determine the feasibility of achieving and regulating therapeutic anticoagulation with heparin given by continuous subcutaneous infusion. Five patients with deep venous thrombosis confirmed by impedance plethysmography and/or venography were studied. All patients received ...

journal_title：Thrombosis and haemostasis

authors： Parrilla N,Ansell J

更新日期：1982-02-26 00:00:00

abstract：:Activation of coagulation was studied during the peri-operative period in patients undergoing cardiopulmonary bypass (CPB) surgery using activation markers which have recently become available: prothrombin fragment F1 + 2 (F1 + 2), which is a measure of total thrombin generation, and thrombin-antithrombin complex, whi...

journal_title：Thrombosis and haemostasis

authors： Boisclair MD,Lane DA,Philippou H,Sheikh S,Hunt B

更新日期：1993-08-02 00:00:00

abstract：:Using the Northern blot technique, we screened 6 human hepatoma cell lines to investigate the regulation mechanism of heparin cofactor II (HC II) biosynthesis. We found that HuH-7 and Hep G2 cells constitutively expressed the HC II gene. In conditioned medium, HuH-7 cells constantly produced HC II that was functionall...

journal_title：Thrombosis and haemostasis

authors： Koike C,Hayakawa Y,Niiya K,Sakuragawa N,Sasaki H

更新日期：1996-02-01 00:00:00

abstract：:Deep-vein thrombosis (DVT) is a common condition that often leads to pulmonary thromboembolism (VTE) and death. The role of prostaglandin-endoperoxide synthase (PTGS)2 in arterial thrombosis has been well established, whereas its impact in venous thrombosis remains unclear. Here, we showed that PTGS2 deletion predispo...

journal_title：Thrombosis and haemostasis

authors： Amadio P,Tarantino E,Sandrini L,Tremoli E,Barbieri SS

更新日期：2017-07-26 00:00:00

abstract：:Severe postpartum haemorrhages (PPH) are responsible for maternal morbidity/mortality. Their complex management sometimes requires haemostatic supplementation, and therapeutic trials on fibrinogen or activated factor VII, which may add to the thrombotic risk, are currently being considered. Furthermore, there is a ris...

journal_title：Thrombosis and haemostasis

authors： Chauleur C,Cochery-Nouvellon E,Mercier E,Aya G,Marès P,Mismetti P,Lissalde-Lavigne G,Gris JC

更新日期：2008-11-01 00:00:00

abstract：:Hyperglycaemia impairs fibrinolytic activity on the surface of endothelial cells, but the underlying mechanisms are not fully understood. In this study, we tested the hypothesis that hyperglycaemia causes dysfunction of the endothelial membrane protein annexin A2, thereby leading to an overall reduction of fibrinolyti...

journal_title：Thrombosis and haemostasis

authors： Dai H,Yu Z,Fan X,Liu N,Yan M,Chen Z,Lo EH,Hajjar KA,Wang X

更新日期：2013-06-01 00:00:00

abstract：:Unstimulated human platelets from normal volunteers adhere to sulfatides (galactosylceramide-I3-sulfate) as single cells but do not adhere appreciably to other lipids including gangliosides, neutral glycolipids, phospholipids or cholesterol-3-SO4. Platelet adhesion to sulfatide is saturable and dose-dependent, reaches...

journal_title：Thrombosis and haemostasis

authors： Data RE,Williams SB,Roberts DD,Gralnick HR

更新日期：1991-05-06 00:00:00

abstract：:The acidic mucopolysaccharide extracted from sea cucumber (Stichopus japonicus Selenka) (SJAMP) has been shown to cause platelets to aggregate. Using citrated platelet-rich plasma (PRP), washed platelets and formaldehyde-fixed platelets from humans, we investigated the effects of platelet inhibitors and various plasma...

journal_title：Thrombosis and haemostasis

authors： Li JZ,Lian EC

更新日期：1988-06-16 00:00:00

abstract：:The amino acid sequence of the subunit of human platelet factor 4 has been determined. Human platelet factor 4 consists of identical subunits containing 70 amino acids, each with a molecular weight of 7,756. The molecule contains no methionine, phenylalanine or tryptophan. The proposed amino acid sequence of PF4 is: G...

journal_title：Thrombosis and haemostasis

authors： Morgan FJ,Begg GS,Chesterman CN

更新日期：1980-02-29 00:00:00

abstract：:It has been reported that lanosterol can sensitize isolated rat platelets to agonists such as ADP and thrombin (4). The purpose of this paper was to determine whether lanosterol had similar effects on human platelets and whether this was achieved by changes in membrane fluidity. Lanosterol did increase the sensitivity...

journal_title：Thrombosis and haemostasis

authors： Hassall DG,Bruckdorfer KR,Sulpice JC,Lutton C

更新日期：1985-12-17 00:00:00

abstract：:Heparin-induced thrombocytopenia (HIT), a relatively common complication of heparin therapy, results of platelet activation, via the receptor for the Fc domain of IgG (FcgammaRIIa), by heparin-dependent-antibodies, commonly directed against the heparin-platelet factor 4 (H-PF4) antigenic complex. Our strategy was to u...

journal_title：Thrombosis and haemostasis

authors： Khairy M,Lasne D,Brohard-Bohn B,Aiach M,Rendu F,Bachelot-Loza C

更新日期：2001-06-01 00:00:00

abstract：:Platelets contain, besides alpha- and delta-granules, lysosomes which store glycohydrolases able to degrade glycoproteins, glycolipids and glycosaminoglycans. While several studies have shown that alpha- and delta-granule secretion takes place "in vivo" in humans upon platelet activation, no data are available on the ...

journal_title：Thrombosis and haemostasis

authors： Ciferri S,Emiliani C,Guglielmini G,Orlacchio A,Nenci GG,Gresele P

更新日期：2000-01-01 00:00:00

abstract：:We have previously suggested that the human homologue of the Drosophila transient receptor potential protein, TRPC1, is involved in conducting store-operated Ca2+ entry (SOCE) in human platelets since an antibody raised against the pore-forming region of TRPC1 inhibited SOCE. Here we have investigated plasma membrane ...

journal_title：Thrombosis and haemostasis

authors： Brownlow SL,Sage SO

更新日期：2005-10-01 00:00:00

abstract：:Sepsis triggers a complex series of pathophysiologic events involving inflammatory responses and coagulation abnormalities. While circulating blood platelets are well-characterized for their contributions to coagulation, increasingly platelet-dependent effects on inflammation are being recognized. Here, we focus on th...

journal_title：Thrombosis and haemostasis

authors： Asfari A,Dent JA,Corken A,Herington D,Kaliki V,Sra N,Hefley G,Pasala S,Prodhan P,Ware J

更新日期：2019-03-01 00:00:00

abstract：:The methylenetetrahydrofolate reductase (MTHFR) 677 C→T polymorphism may be associated with elevated total homocysteine (tHcy) levels, an independent risk factor for cardiovascular disease. It was the study objective to evaluate in vivo lipid peroxidation and platelet activation in carriers of the MTHFR 677 C→T polymo...

journal_title：Thrombosis and haemostasis

authors： Dragani A,Falco A,Santilli F,Basili S,Rolandi G,Cerasa L,Lattanzio S,Ciabattoni G,Patrono C,Davì G

更新日期：2012-09-01 00:00:00

abstract：:Epidemiological studies suggest that hormone replacement therapy (HRT) decreases the risk of cardiovascular disease in postmenopausal women via several mechanisms, including modifications in the fibrinolytic system and lipoprotein(a) [Lp(a)] levels. The aim of this study was to examine the influence of the levels and ...

journal_title：Thrombosis and haemostasis

authors： Estellés A,Cano A,Falcó C,España F,Gilabert J,Grancha S,Aznar J

更新日期：1999-01-01 00:00:00

abstract：:Endotoxin (LPS) and interleukin-1 beta (IL-1 beta) increased in a dose-dependent manner the expression of tissue factor, an ubiquitous membrane-anchored glycoprotein that initiates blood coagulation at the surface of human umbilical vein endothelial cells (HUVEC and human peripheral blood mononuclear cells (PBMC). Ech...

journal_title：Thrombosis and haemostasis

authors： Herbert JM,Lalé A,Pereillo JM,Derocq JM,Casellas P

更新日期：1996-02-01 00:00:00

abstract：:In an international collaborative study three candidate reference and the local APTT reagent have been tested with lyophilized plasmas containing heparin added in vitro and fresh plasmas from heparinized patients to determine whether it was possible to standardize APTT heparin monitoring. The APTT responses of patient...

journal_title：Thrombosis and haemostasis

authors： Van der Velde EA,Poller L

更新日期：1995-01-01 00:00:00

abstract：:Noninvasive diagnosis of deep vein thrombosis (DVT) is based on ultrasound examination of the leg veins, usually restricted to only compression of the proximal veins (CUS). Patients with negative CUS findings require a second examination or a combination with other tests, which impairs clinical efficiency. In this pro...

journal_title：Thrombosis and haemostasis

authors： Schellong SM,Schwarz T,Halbritter K,Beyer J,Siegert G,Oettler W,Schmidt B,Schroeder HE

更新日期：2003-02-01 00:00:00