Human tissue factor pathway inhibitor fused to CD4 binds both FXa and TF/FVIIa at the cell surface.

abstract：INTRODUCTION: Bleeds such as intra-ventricular (IVH) and pulmonary haemorrhage (PH) are life-threatening events in extremely low birth weight (ELBW) infants. Serial coagulation monitoring by measuring the international normalized ratio (INR) with small volume samples might facilitate early diagnosis and possibly preven...

journal_title：Thrombosis and haemostasis

authors： Thanhaeuser M,Binder C,Derhaschnig U,Jilma B,Kornsteiner-Krenn M,Huber-Dangl M,Repa A,Kreissl A,Berger A,Haiden N

更新日期：2018-07-01 00:00:00

abstract：:Urokinase plasminogen activator (uPA) system regulates extracellular matrix remodelling by activating ubiquitous protease plasmin in many important physiological processes. The system components include uPA, plasminogen activator inhibitors (PAIs) and uPA receptor (uPAR). Besides its role in physiological processes, u...

journal_title：Thrombosis and haemostasis

authors： Madunić J

更新日期：2018-12-01 00:00:00

abstract：:Platelet aggregation and thromboxane A2 have been implicated in the pathogenesis of several forms of vascular disease. The aim of this study was to determine the effect of a wide range of adrenoceptor antagonists on platelet aggregation, and thromboxane A2 production, from normal human platelet rich plasma in vitro. L...

journal_title：Thrombosis and haemostasis

authors： Greer IA,Walker JJ,McLaren M,Calder AA,Forbes CD

更新日期：1985-08-30 00:00:00

abstract：:Fibrin(ogen) is the major matrix ligand for beta3 integrins. If alpha(v)beta3 is the major receptor for fibrin(ogen) on intimal smooth muscle cells, we might expect to see this integrin associated with fibrin(ogen). Eighty-four specimens obtained from endarterectomies of 14 patients were studied. Fibrin was frequently...

journal_title：Thrombosis and haemostasis

authors： Ikari Y,Yee KO,Hatsukami TS,Schwartz SM

更新日期：2000-08-01 00:00:00

abstract：:Haemorrhagic metalloproteinases from Bothrops jararaca and other venoms degrade vessel-wall and plasma proteins involved in platelet plug and fibrin clot formation. These enzymes also cause proteolytic digestion of fibrinogen which has been suggested to cause defective platelet function. Fibrinogen degradation by jara...

journal_title：Thrombosis and haemostasis

authors： Kamiguti AS,Slupsky JR,Zuzel M,Hay CR

更新日期：1994-08-01 00:00:00

abstract：:The walls of rabbit mesenteric arterioles and venules (diameter 20 to 40 microns) were punctured with glass micropipets (tip diameter 6 to 8 microns). Thromboembolic reactions resulting from this standardized, small mechanical vessel wall injury could be quantified in vivo with the use of intravital video-microscopy. ...

journal_title：Thrombosis and haemostasis

authors： oude Egbrink MG,Tangelder GJ,Slaaf DW,Reneman RS

更新日期：1988-02-25 00:00:00

abstract：:Our initial finding that CD40- and CD40 ligand (CD40L)-deficient mice displayed prolonged tail bleeding and platelet function analyzer (PFA-100) closure times prompted us to further investigate the role of the CD40-CD40L dyad in primary hemostasis and platelet function. Recombinant human soluble CD40L (rhsCD40L), chem...

journal_title：Thrombosis and haemostasis

authors： Langer F,Ingersoll SB,Amirkhosravi A,Meyer T,Siddiqui FA,Ahmad S,Walker JM,Amaya M,Desai H,Francis JL

更新日期：2005-06-01 00:00:00

abstract：:A pulmonary embolism model in hamsters was used for the quantitative evaluation of the thrombolytic and pharmacokinetic properties of variants of tissue-type plasminogen activator (t-PA). A 25 microliters 125I-fibrin labeled human plasma clot was made in vitro and injected into the jugular vein of heparinized hamsters...

journal_title：Thrombosis and haemostasis

authors： Collen D,Lijnen HR,Vanlinthout I,Kieckens L,Nelles L,Stassen JM

更新日期：1991-02-12 00:00:00

abstract：:Plasminogen activator that is associated with the development of hypersensitivity granulomas (gPA) was partially purified from a saline soluble fraction of murine lepromas elicited in "resistant" mice, C57BL/6N. The gPA was shown to consist of two subspecies (23,000 and 48,000 in molecular weight) with essentially ide...

journal_title：Thrombosis and haemostasis

authors： Izaki S,Hibino T,Isozaki Y,Hsu PS,Izaki M,Matsuo O

更新日期：1984-12-29 00:00:00

abstract：:Patients treated with high doses of interleukin-2 (IL-2) because of cancer, develop hemodynamic and vasopermeability changes, that resemble those observed in sepsis. These patients thus provide a unique opportunity to study the early events in the development of septic shock. We analysed the changes that occurred in t...

journal_title：Thrombosis and haemostasis

authors： Hack CE,Wagstaff J,Strack van Schijndel RJ,Eerenberg AJ,Pinedo HM,Thijs LG,Nuijens JH

更新日期：1991-05-06 00:00:00

abstract：:Outcomes of acute coronary syndrome (ACS) patients undergoing percutaneous coronary intervention (PCI) have been significantly improved with the use of potent P2Y12 receptor inhibitors like prasugrel. While most of the ischaemic risk reduction for prasugrel versus clopidogrel was demonstrated in the early treatment pe...

journal_title：Thrombosis and haemostasis

authors： Sibbing D,Aradi D,Jacobshagen C,Gross L,Trenk D,Geisler T,Orban M,Gori T,Hadamitzky M,Merkely B,Kiss RG,Komócsi A,Dézsi CA,Thalmeier A,Löw A,Holdt L,Teupser D,Ince H,Felix SB,Parma R,Malek L,Horstkotte J,Bayla

更新日期：2017-01-05 00:00:00

abstract：:Normal adults have very few circulating endothelial cells (CECs) in their blood, but increased levels have been shown in association with conditions associated with endothelial damage such as myocardial infarction and stroke. As atrial fibrillation (AF) is associated with a hypercoagulable state and abnormalities of p...

journal_title：Thrombosis and haemostasis

authors： Freestone B,Lip GY,Chong AY,Nadar S,Lee KW,Blann AD

更新日期：2005-10-01 00:00:00

abstract：:The plasma protein beta2-glycoprotein I (beta2-GPI) is a major target of autoantibodies in patients with the antiphospholipid syndrome. To understand the physiological function of beta2-GPI and its potential role in the pathophysiology of the antiphospholipid syndrome, the binding of beta2-GPI to phospholipid membrane...

journal_title：Thrombosis and haemostasis

authors： Harper MF,Hayes PM,Lentz BR,Roubey RA

更新日期：1998-10-01 00:00:00

abstract：:We studied exercise-induced changes in coagulation and fibrinolytic factors and activation products in different age categories. Thirty-eight sedentary males, divided in three age categories (cats I-III; 20-30, 35-45 and 50-60 y) were subjected to a standardized exercise test. Pre-exercise levels (cats I-III resp) of ...

journal_title：Thrombosis and haemostasis

authors： van den Burg PJ,Hospers JE,van Vliet M,Mosterd WL,Bouma BN,Huisveld IA

更新日期：1995-12-01 00:00:00

abstract：:Mature circulating endothelial cells (CECs) are novel cellular markers of endothelial damage/dysfunction. The two main techniques of CEC enumeration are flow cytometry (FC) and immunomagnetic bead (IB) isolation. Both quantify CECs accurately, but a direct comparison of both methods has not been reported. We sought to...

journal_title：Thrombosis and haemostasis

authors： Goon PK,Boos CJ,Stonelake PS,Blann AD,Lip GY

更新日期：2006-07-01 00:00:00

abstract：:A genetically-transmissible factor (F) XII-inactivated allele has been produced in mice by targeted replacement of exons 3-8 of the FXII gene with the neomycin resistance gene. Interbreeding of these mice provided offspring homozygous for two inactivated FXII alleles (FXII(-/-)). Male and female FXII-deficient mice br...

journal_title：Thrombosis and haemostasis

authors： Iwaki T,Castellino FJ

更新日期：2006-06-01 00:00:00

abstract：:Clotting factor VIII (fVIII)-inhibitory antibodies represent a major problem in the treatment of haemophilia A. To understand the inactivation mechanisms and to pave the way towards modifications of recombinant clotting factors that reduce their immunogenicity, the exact localization of immunodominant epitopes is requ...

journal_title：Thrombosis and haemostasis

authors： Mühle C,Schulz-Drost S,Khrenov AV,Saenko EL,Klinge J,Schneider H

更新日期：2004-03-01 00:00:00

abstract：:It was our aim to assess whether factor V Leiden (FVL) and G20210A prothrombin (FII) mutation are associated with the presence of residual vein obstruction (RVO) after a standard course of anticoagulation for a first episode of idiopathic proximal deep-vein thrombosis (DVT) of the lower limbs, with or without symptoma...

journal_title：Thrombosis and haemostasis

authors： Cosmi B,Legnani C,Pengo V,Ghirarduzzi A,Testa S,Poli D,Prisco D,Tripodi A,Palareti G,PROLONG Investigators (on behalf of FCSA, Italian Federation of Anticoagulation Clinics).

更新日期：2013-03-01 00:00:00

abstract：:Thromboelastography (TEG) has been shown to be a valuable point-of-care device for the rapid diagnosis of various bleeding disorders. However, TEG has thus far not been used for the screening for von Willebrand disease (VWD). We evaluated the performance of a modified TEG assay for the laboratory screening of VWD. Thr...

journal_title：Thrombosis and haemostasis

authors： Topf HG,Weiss D,Lischetzki G,Strasser E,Rascher W,Rauh M

更新日期：2011-06-01 00:00:00

abstract：:Platelet function is dependent upon membrane receptors and their interaction with other proteins. Platelet activation appears to cause a structural change of the glycoprotein IIb/IIIa complex that exposes the fibrinogen binding site, which subsequently binds fibrinogen. Fluorescence-activated flow cytometry (FACS) is ...

journal_title：Thrombosis and haemostasis

authors： Lindahl TL,Festin R,Larsson A

更新日期：1992-08-03 00:00:00

abstract：:The 50 laboratories of the Netherlands Federation of Thrombosis Services, covering a population of 9 million and responsible for the laboratory control of approximately 150,000 patients under oral anticoagulation, have participated since 1974 in a voluntary external and internal quality control program. The external p...

journal_title：Thrombosis and haemostasis

authors： van Dijk-Wierda CA,Hermans J,Loeliger EA,Roos J

更新日期：1977-06-30 00:00:00

abstract：:The effects on the haemoglobin level of low dose aspirin and of low intensity oral anticoagulation with warfarin separately and in combination have been established in men aged between 45 and 69 at high risk of ischaemic heart disease. The findings confirm that combined treatment with warfarin and aspirin (WA) leads t...

journal_title：Thrombosis and haemostasis

authors： Meade TW,Howarth DJ,Brennan PJ

更新日期：1994-03-01 00:00:00

abstract：:Dilated cardiomyopathy is associated with thromboembolic complications, which correlate poorly, however, with a visible left ventricular thrombus. Therefore, this study was performed to assess whether an abnormality of platelet function in vivo can be detected in patients with dilated cardiomyopathy. Platelet survival...

journal_title：Thrombosis and haemostasis

authors： Weidinger F,Glogar D,Sochor H,Sinzinger H

更新日期：1991-10-01 00:00:00

abstract：:The release of microvesicles ('platelet microparticles', PMPs) by activated platelets has been shown to be an integral part of the thrombotic process. PMPs are believed to mediate many biological processes as they possess various platelet membrane proteins and bioactive lipids. Of note, there is a growing body of evid...

journal_title：Thrombosis and haemostasis

authors： Tan KT,Lip GY

更新日期：2005-09-01 00:00:00

abstract：:Imaging methods based on time-lapse microscopy are important tools for studying the dynamic events that shape thrombus formation upon vascular injury. However, there is a lack of methods to translate the vast amount of visual data generated in such experiments into quantitative variables describing platelet movements ...

journal_title：Thrombosis and haemostasis

authors： Tunströmer K,Faxälv L,Boknäs N,Lindahl TL

更新日期：2018-09-01 00:00:00

abstract：:Recent progress in the understanding of thrombus formation has suggested an important role of glycoprotein (GP)VI. In contrast to its pivotal role in collagen-induced platelet activation, it has been suggested that its blockade does not induce massive bleeding tendency. To demonstrate the dissociation between inhibito...

journal_title：Thrombosis and haemostasis

authors： Matsumoto Y,Takizawa H,Nakama K,Gong X,Yamada Y,Tandon NN,Kambayashi J

更新日期：2006-08-01 00:00:00

abstract：:Factor VIII procoagulant activity (F VIII:C) and factor VIII related antigen (F VIII R: Ag) were investigated in 35 patients with Argentine hemorrhagic fever. Since the results obtained in the three clinical forms of the disease were not significantly different, they were tabulated altogether. F VIII:C was low in earl...

journal_title：Thrombosis and haemostasis

authors： Molinas FC,Maiztegui JI

更新日期：1981-08-28 00:00:00

abstract：:Analysis of platelet membrane proteins and glycoproteins by SDS polyacrylamide gel electrophoresis was carried out before and after treatment with thrombin. Extended incubation with thrombin (in the presence of EDTA or adenosine, which inhibit aggregation) produced extensive changes in the bands observed. With incuba...

journal_title：Thrombosis and haemostasis

authors： Podolsak B

更新日期：1977-06-30 00:00:00

abstract：:Inherited thrombophilia has been shown to be linked with fetal loss. We performed a case-control study on the association between thrombosis-related polymorphisms in the factor V (FV) gene (Leiden, Cambridge, Hong Kong; HR2 haplotype) and idiopathic recurrent pregnancy loss (RPL) in Tunisian women. A total of 348 wome...

journal_title：Thrombosis and haemostasis

authors： Zammiti W,Mtiraoui N,Mercier E,Abboud N,Saidi S,Mahjoub T,Almawi WY,Gris JC

更新日期：2006-04-01 00:00:00

abstract：:Assembly of fibronectin into the provisional fibrillar matrix of embryonic tissues and wounds is a complicated process by which the intracellular cytoskeleton determines the pattern of assembly of extracellular matrix and vice versa. Assembly is restricted to dimeric fibronectin molecules with intact N-terminal module...

journal_title：Thrombosis and haemostasis

authors： Mosher DF

更新日期：1995-07-01 00:00:00