Endothelial perturbation in cystic fibrosis.

abstract：:Both the HEPTEST and amidolytic anti factor Xa assays are currently being used for heparin activity detection in plasma from patients receiving standard heparin or low molecular weight heparin (LMWH). In this study we have investigated the influence of recombinant and endogenous Tissue Factor Pathway Inhibitor (TFPI) ...

journal_title：Thrombosis and haemostasis

authors： Kristensen HI,Ostergaard PB,Nordfang O,Abildgaard U,Lindahl AK

更新日期：1992-09-07 00:00:00

abstract：:Human platelets were separated into subpopulations using continuous flow electrophoresis, which uses electrophoretic mobility as the separative parameter. The platelets with the greatest electrophoretic mobility showed higher amounts of total sialic acid than the less electrophoretically mobile subpopulation (74.3 +/-...

journal_title：Thrombosis and haemostasis

authors： Crook M,Crawford N

更新日期：1993-01-11 00:00:00

abstract：:Platelet activation as a result of vascular injury provokes endothelial cells to respond in a manner which limits or reverses the occlusive consequences of platelet accumulation. If the agonistic forces are strong, platelet accumulation is irreversible. In vitro data from our laboratory have repeatedly demonstrated th...

journal_title：Thrombosis and haemostasis

authors： Marcus AJ,Safier LB,Broekman MJ,Islam N,Fliessbach JH,Hajjar KA,Kaminski WE,Jendraschak E,Silverstein RL,von Schacky C

更新日期：1995-07-01 00:00:00

abstract：:Haemophilia A and B are X-linked disorders which are due to a reduced activity of coagulation factor VIII or IX, respectively. Female carriers have a wide range of plasma concentration of factor VIII or factor IX, and may in rare cases have an affected phenotype. In order to investigate if this variation is related to...

journal_title：Thrombosis and haemostasis

authors： Orstavik KH,Scheibel E,Ingerslev J,Schwartz M

更新日期：2000-03-01 00:00:00

abstract：:Human fibrinogen was subjected to limited proteolytic attack by thrombin, batroxobin or Agkistrodon contortrix thrombin-like enzyme, yielding desAB-, desA- or desB-fibrin monomers, respectively. Turbidity curves demonstrated that, with all three enzymes, the polymerization process was strongly accelerated by increasin...

journal_title：Thrombosis and haemostasis

authors： Furlan M,Rupp C,Beck EA,Svendsen L

更新日期：1982-04-30 00:00:00

abstract：:Antiphospholipid antibodies (aPL) have been reported to activate platelets. This is considered to be one of the pathogenic properties of aPL. Even though aPL heterogeneity is quite well established, little is known, if the ability to activate platelets is common to all aPL or depends on antigen specificity. To further...

journal_title：Thrombosis and haemostasis

authors： Hollerbach A,Müller-Calleja N,Ritter S,Häuser F,Canisius A,Orning C,Jurk K,Lackner KJ

更新日期：2019-07-01 00:00:00

abstract：:Defibrotide is an antithrombotic drug which enhances prostacyclin production and activates fibrinolytic system. The aim of this study was to investigate the improvement of walking distance in patients with intermittent claudication treated with defibrotide. DICLIS was a double blind, placebo-controlled study which inc...

journal_title：Thrombosis and haemostasis

authors： Violi F,Marubini E,Coccheri S,Nenci GG

更新日期：2000-05-01 00:00:00

abstract：:This study assessed the frequency and factors associated with failure to correct international normalised ratio (INR) in patients administered fresh frozen plasma (FFP) for warfarin-related major bleeding. This retrospective database analysis used electronic health records from an integrated health system. Patients wh...

journal_title：Thrombosis and haemostasis

authors： Menzin J,White LA,Friedman M,Nichols C,Menzin J,Hoesche J,Bergman GE,Jones C

更新日期：2012-04-01 00:00:00

abstract：:Heparin-associated thrombocytopenia (HAT) is a severe complication of heparin therapy. Its diagnosis is difficult. Conventional assays employ platelet aggregometry (PAA) and/or 14C-serotonin release (SRA) which are either insensitive (PAA) or require radioactive tracers (SRA). We here describe a newly developed sensit...

journal_title：Thrombosis and haemostasis

authors： Greinacher A,Michels I,Kiefel V,Mueller-Eckhardt C

更新日期：1991-12-02 00:00:00

abstract：:The spleen is a crucial organ in humans. However, little is known about the association of venous thromboembolism (VTE) with splenic injury and splenectomy in trauma patients. The aim of this study was to determine the subsequent risk of VTE following splenic injury and splenectomy. A nationwide retrospective cohort s...

journal_title：Thrombosis and haemostasis

authors： Lin JN,Chen HJ,Lin MC,Lai CH,Lin HH,Yang CH,Kao CH

更新日期：2016-01-01 00:00:00

abstract：:Congenital afibrinogenemia and severe hypofibrinogenemia are severe bleeding disorders characterized by either undetectable or very low levels of fibrinogen in patients' plasma and platelets. A majority of the reported cases are caused by mutations in the fibrinogen Aalpha chain. In this study, we identified a genetic...

journal_title：Thrombosis and haemostasis

authors： Xu X,Wu J,Zhai Z,Zhou R,Wang X,Wang H,Ding K,Sun Z,Ni H

更新日期：2006-06-01 00:00:00

abstract：:This epidemiological study was undertaken to explore possible relationships among various haematological indices, prevalent ischaemic heart disease and platelet "function" as measured by two rather different methods. ADP-induced platelet impedance changes in whole blood were strongly associated with prevalent ischaemi...

journal_title：Thrombosis and haemostasis

authors： Sharp DS,Beswick AD,O'Brien JR,Renaud S,Yarnell JW,Elwood PC

更新日期：1990-10-22 00:00:00

abstract：:Our initial finding that CD40- and CD40 ligand (CD40L)-deficient mice displayed prolonged tail bleeding and platelet function analyzer (PFA-100) closure times prompted us to further investigate the role of the CD40-CD40L dyad in primary hemostasis and platelet function. Recombinant human soluble CD40L (rhsCD40L), chem...

journal_title：Thrombosis and haemostasis

authors： Langer F,Ingersoll SB,Amirkhosravi A,Meyer T,Siddiqui FA,Ahmad S,Walker JM,Amaya M,Desai H,Francis JL

更新日期：2005-06-01 00:00:00

abstract：:We report genetic abnormalities of protein C gene in a male infant who developed neonatal purpura fulminans. DNA-sequence analysis of all exons in protein C gene in this family revealed two mutations. The first abnormality, derived from the mother, was a deletion of one of four consecutive G at nucleotide number 10758...

journal_title：Thrombosis and haemostasis

authors： Ido M,Ohiwa M,Hayashi T,Nishioka J,Hatada T,Watanabe Y,Wada H,Shirakawa S,Suzuki K

更新日期：1993-10-18 00:00:00

abstract：:Data on the in vivo function of platelets induced by the thrombopoietin receptor agonist eltrombopag are scarce. To assess a possible influence of eltrombopag we compared platelet function of eltrombopag-treated immune thrombocytopenia (ITP) patients (group 1; n=10) after treatment response to that from control ITP pa...

journal_title：Thrombosis and haemostasis

authors： Haselboeck J,Kaider A,Pabinger I,Panzer S

更新日期：2013-04-01 00:00:00

abstract：:The significance of platelet beta-adrenoceptors for platelet responses to adrenergic stimuli in vivo and in vitro was studied in healthy volunteers. Low dose infusion of the beta-adrenoceptor agonist isoprenaline decreased platelet aggregability in vivo as measured by ex vivo filtragometry. Infusion of adrenaline, a m...

journal_title：Thrombosis and haemostasis

authors： Larsson PT,Wallén NH,Martinsson A,Egberg N,Hjemdahl P

更新日期：1992-12-07 00:00:00

abstract：:The risk of acute cardiovascular events is highest during morning hours, and platelet activity peaks during morning hours. The effect of timing of aspirin intake on circadian rhythm and morning peak of platelet reactivity is not known. It was our objective to evaluate the effect of timing of aspirin intake on circadia...

journal_title：Thrombosis and haemostasis

authors： Bonten TN,Saris A,van Oostrom MJ,Snoep JD,Rosendaal FR,Zwaginga J,Eikenboom J,van der Meer PF,van der Bom JG

更新日期：2014-12-01 00:00:00

abstract：BACKGROUND: Anticoagulant therapy has seldom been achieved in randomized trials targeting nonspecific overall sepsis patients. Although the key components to identify the appropriate target in sepsis may be disseminated intravascular coagulation (DIC) and high disease severity, the interaction and relation of these two...

journal_title：Thrombosis and haemostasis

authors： Yamakawa K,Gando S,Ogura H,Umemura Y,Kabata D,Shintani A,Shiraishi A,Saitoh D,Fujishima S,Mayumi T,Kushimoto S,Abe T,Shiino Y,Nakada TA,Tarui T,Hifumi T,Otomo Y,Okamoto K,Kotani J,Sakamoto Y,Sasaki J,Shiraishi S

更新日期：2019-11-01 00:00:00

abstract：:Desmopressin acetate administration markedly stimulates release of tissue plasminogen activator (t-PA) from vascular endothelial cells. The mechanism for this effect is unknown. Because infusion of epinephrine has been shown to increase t-PA levels, we examined the role of endogenous catecholamine mediation of t-PA re...

journal_title：Thrombosis and haemostasis

authors： Grant MB,Guay C,Lottenberg R

更新日期：1988-04-08 00:00:00

abstract：:Outcomes of acute coronary syndrome (ACS) patients undergoing percutaneous coronary intervention (PCI) have been significantly improved with the use of potent P2Y12 receptor inhibitors like prasugrel. While most of the ischaemic risk reduction for prasugrel versus clopidogrel was demonstrated in the early treatment pe...

journal_title：Thrombosis and haemostasis

authors： Sibbing D,Aradi D,Jacobshagen C,Gross L,Trenk D,Geisler T,Orban M,Gori T,Hadamitzky M,Merkely B,Kiss RG,Komócsi A,Dézsi CA,Thalmeier A,Löw A,Holdt L,Teupser D,Ince H,Felix SB,Parma R,Malek L,Horstkotte J,Bayla

更新日期：2017-01-05 00:00:00

abstract：:Tissue-type plasminogen activator (t-PA) is a fibrin-specific agent which is used to treat acute myocardial infarction. Pharmacokinetically, t-PA is characterized by a rapid clearance from the circulation. In a previous study, we constructed variant forms of t-PA with genetic modifications at the fibronectin finger-li...

journal_title：Thrombosis and haemostasis

authors： Yahara H,Matsumoto K,Maruyama H,Nagaoka T,Ikenaka Y,Yajima K,Fukao H,Ueshima S,Matsuo O

更新日期：1994-12-01 00:00:00

abstract：:Haemorrhagic metalloproteinases from Bothrops jararaca and other venoms degrade vessel-wall and plasma proteins involved in platelet plug and fibrin clot formation. These enzymes also cause proteolytic digestion of fibrinogen which has been suggested to cause defective platelet function. Fibrinogen degradation by jara...

journal_title：Thrombosis and haemostasis

authors： Kamiguti AS,Slupsky JR,Zuzel M,Hay CR

更新日期：1994-08-01 00:00:00

abstract：:To find if there is a relation between levels of haemostatic variables at low and high hormonal levels (oestradiol and progesterone) in an individual, blood samples were drawn from 12 women repeatedly during one menstrual cycle (Study I) and from 14 women undergoing in vitro fertilization, before hormonal stimulation ...

journal_title：Thrombosis and haemostasis

authors： Andersson O,Blombäck M,Bremme K,Wramsby H

更新日期：1997-05-01 00:00:00

abstract：:Noninvasive diagnosis of deep vein thrombosis (DVT) is based on ultrasound examination of the leg veins, usually restricted to only compression of the proximal veins (CUS). Patients with negative CUS findings require a second examination or a combination with other tests, which impairs clinical efficiency. In this pro...

journal_title：Thrombosis and haemostasis

authors： Schellong SM,Schwarz T,Halbritter K,Beyer J,Siegert G,Oettler W,Schmidt B,Schroeder HE

更新日期：2003-02-01 00:00:00

abstract：:Heme oxygenase-1 (HO-1) decreases apoptosis, inflammation and oxidative stress. The aim of the study was to investigate the effects of intracoronary infusion of allogenic bone marrow cells (BMC) overexpressing HO-1 in the porcine model of myocardial infarction (MI). MI was produced by balloon occlusion of a coronary a...

journal_title：Thrombosis and haemostasis

authors： Wojakowski W,Tendera M,Cybulski W,Zuba-Surma EK,Szade K,Florczyk U,Kozakowska M,Szymula A,Krzych L,Paslawska U,Paslawski R,Milewski K,Buszman PP,Nabialek E,Kuczmik W,Janiszewski A,Dziegiel P,Buszman PE,Józkowicz A,D

更新日期：2012-09-01 00:00:00

abstract：:The development of antibodies against infused factor VIII (FVIII) in patients with haemophilia A is a serious complication leading to poorly controlled bleeding and increased morbidity. No treatment has been proven to reduce high titre antibodies in patients who fail immune tolerance induction or are not candidates fo...

journal_title：Thrombosis and haemostasis

authors： Leissinger C,Josephson CD,Granger S,Konkle BA,Kruse-Jarres R,Ragni MV,Journeycake JM,Valentino L,Key NS,Gill JC,McCrae KR,Neufeld EJ,Manno C,Raffini L,Saxena K,Torres M,Marder V,Bennett CM,Assmann SF

更新日期：2014-09-02 00:00:00

abstract：:Platelets are critically involved in atherosclerosis and acute thrombosis. The platelet phenotype shows a wide variability documented by the inherited difference of platelet reactivity, platelet volume and count and function of platelet surface receptors. Several candidate genes have been put into focus and investigat...

journal_title：Thrombosis and haemostasis

authors： Geisler T,Schaeffeler E,Gawaz M,Schwab M

更新日期：2013-11-01 00:00:00

abstract：:It is known that thrombosis is a leading cause of vascular access failure and that the formation of thrombus requires platelets. The activation of platelets induces the increase in intracellular Ca 2(+) levels ([Ca(2+)](i)) leading to aggregation and thrombosis. We compared the platelet [Ca(2+)](i) before and after st...

journal_title：Thrombosis and haemostasis

authors： Chou KJ,Jan CR,Lee PT,Chen CL,Chung HM,Hwang YY,Chou JD,Fang HC

更新日期：2004-09-01 00:00:00

abstract：:Expression of isolated beta integrin cytoplasmic domains in cultured endothelial cells was reported to induce cell detachment and death. To test whether cell death was the cause or the consequence of cell detachment, we expressed isolated integrin beta1 cytoplasmic and transmembrane domains (CH1) in cultured human umb...

journal_title：Thrombosis and haemostasis

authors： Hasmim M,Vassalli G,Alghisi GC,Bamat J,Ponsonnet L,Bieler G,Bonnard C,Paroz C,Oguey D,Rüegg C

更新日期：2005-11-01 00:00:00

abstract：:In order to assess the value of I.P.G. for the diagnosis of D.V.T. in general practice, an I.P.G. was carried out by a skilled technician in 255 consecutive patients with suspected D.V.T. at home. Ascending venography was carried out in 185 of these patients. In addition, blood for assay of AT III, platelet count, fib...

journal_title：Thrombosis and haemostasis

authors： Peters SH,Jonker JJ,de Boer AC,den Ottolander GJ

更新日期：1982-12-27 00:00:00