Polymorphisms of the plasminogen activator inhibitor-1 gene in type 1 and type 2 diabetes, and in patients with diabetic retinopathy.

abstract：:Biosynthesis of the adhesive glycoprotein von Willebrand factor (vWf) by endothelial cells results in constitutive secretion of small multimers and storage of the largest multimers in rod-shaped granules called Weibel-Palade bodies. This pattern is reproduced by expression of pro-vWf in heterologous cells with a regul...

journal_title：Thrombosis and haemostasis

authors： Journet AM,Saffaripour S,Wagner DD

更新日期：1993-12-20 00:00:00

abstract：:Retinal vein occlusion (RVO) is the most common retinal vascular disorder second to diabetic retinopathy. The main risk factors in patients with RVO are hypertension, diabetes, hyperlipidemia, increased blood viscosity and glaucoma. The pathogenesis of RVO has not yet been clarified. In these events platelets could pl...

journal_title：Thrombosis and haemostasis

authors： Leoncini G,Bruzzese D,Signorello MG,Armani U,Piana A,Ghiglione D,Camicione P

更新日期：2007-02-01 00:00:00

abstract：:Computer-assisted oral anticoagulant dosage is being increasingly used to meet growing demands for oral anticoagulation. The DAWN AC is one of the most widely used computer-dosage programs. Evidence of its value and that of other computer programs has been based previously only on laboratory evidence of "time in targe...

journal_title：Thrombosis and haemostasis

authors： Poller L,Keown M,Ibrahim S,Lowe G,Moia M,Turpie AG,Roberts C,van den Besselaar AM,van der Meer FJ,Tripodi A,Palareti G,Shiach C,Bryan S,Samama M,Burgess-Wilson M,Heagerty A,Maccallum P,Wright D,Jespersen J,European

更新日期：2009-03-01 00:00:00

abstract：:Recent investigations have revealed the crucial role of von Willebrand factor (vWF) in platelet thrombus formation under flow conditions. The plasma concentrations of vWF were measured together with various hemodynamic and hemostatic parameters in 51 cases of acute myocardial infarction. In 10 randomly selected cases,...

journal_title：Thrombosis and haemostasis

authors： Sakai H,Goto S,Kim JY,Aoki N,Abe S,Ichikawa N,Yoshida M,Nagaoka Y,Handa S

更新日期：2000-08-01 00:00:00

abstract：:The molecular basis of Factor V deficiency has been defined in few patients only. We report a homozygous nucleotide change (G6395A) in two Tunisian probands with Factor V deficiency and bleeding episodes. This substitution results in the replacement of an arginine (R) by a histidine (H) in amino acid position 2074, lo...

journal_title：Thrombosis and haemostasis

authors： Schrijver I,Houissa-Kastally R,Jones CD,Garcia KC,Zehnder JL

更新日期：2002-02-01 00:00:00

abstract：:The content of free-catecholamines in blood platelets is much higher than in plasma and platelet catecholamines must be taken up from plasma, since platelets lack the enzymes for catecholamine synthesis. There is some evidence that platelet catecholamine content under certain circumstances may be an integrated measure...

journal_title：Thrombosis and haemostasis

authors： Kjeldsen SE,Gjesdal K,Leren P,Eide IK

更新日期：1988-10-31 00:00:00

abstract：:Excessive leukocyte infiltration causes severe tissue damage in a variety of inflammatory diseases. The initial step in leukocyte extravasation is mediated by selectins and oligosaccharides on their glycoconjugate ligands. Human milk is a rich source of lactose-derived oligosaccharides that are partly absorbed in the ...

journal_title：Thrombosis and haemostasis

authors： Bode L,Kunz C,Muhly-Reinholz M,Mayer K,Seeger W,Rudloff S

更新日期：2004-12-01 00:00:00

abstract：:Monocytes play a central role in the inflammatory disease atherosclerosis. CD14+CD16+ monocytes are considered proinflammatory monocytes, as they have an increased capacity to produce proinflammatory cytokines, such as TNF-alpha, and are elevated in various inflammatory diseases. We hypothesized that patients with cor...

journal_title：Thrombosis and haemostasis

authors： Schlitt A,Heine GH,Blankenberg S,Espinola-Klein C,Dopheide JF,Bickel C,Lackner KJ,Iz M,Meyer J,Darius H,Rupprecht HJ

更新日期：2004-08-01 00:00:00

abstract：:Lupus anticoagulants (LA) are immunoglobulins directed to either prothrombin or Beta-2-glycoprotein 1(beta1GPI) bound to phospholipids. Most patients with LA have both beta2GPI- and prothrombin-dependent antibodies. Several recent reports have shown that LA is more strongly associated with thrombosis than anticardioli...

journal_title：Thrombosis and haemostasis

authors： Arnout J,Meijer P,Vermylen J

更新日期：1999-06-01 00:00:00

abstract：:East Asian patients have reduced anti-ischemic benefits and increased bleeding risk during antithrombotic therapies compared with Caucasian patients. As potent P2Y12 receptor inhibitors (e.g., ticagrelor and prasugrel) and direct oral anticoagulants are commonly used in current daily practice, the unique risk-benefit ...

journal_title：Thrombosis and haemostasis

authors： Kim HK,Tantry US,Smith SC Jr,Jeong MH,Park SJ,Kim MH,Lim DS,Shin ES,Park DW,Huo Y,Chen SL,Bo Z,Goto S,Kimura T,Yasuda S,Chen WJ,Chan M,Aradi D,Geisler T,Gorog DA,Sibbing D,Lip GYH,Angiolillo DJ,Gurbel PA,J

更新日期：2020-11-10 00:00:00

abstract：:Microparticles (MPs) are formed from platelets (PMPs), endothelial cells (EMPs) and monocytes (MMPs), and in acute myocardial infarction (MI), there is an increase of MPs in the culprit artery. In this study MPs were evaluated in whole blood in 105 patients with MI at five time-points during a two-year follow-up (FU)....

journal_title：Thrombosis and haemostasis

authors： Christersson C,Thulin Å,Siegbahn A

更新日期：2017-07-26 00:00:00

abstract：:Accumulation of the newly formed 14C-cyclic adenosine 3',5'-monophosphate (cyclic AMP) was found in the P1 (1.0) fraction, i.e. a platelet plasma membrane fraction which was obtained from 14C-adenine-labeled platelets. On the other hand, total cyclic AMP as determined simultaneously was located mainly in the platelet ...

journal_title：Thrombosis and haemostasis

authors： Hashimoto S

更新日期：1983-02-28 00:00:00

abstract：:Advanced electronic alerts (eAlerts) and computerised physician order entry (CPOE) increase adequate thromboprophylaxis orders among hospitalised medical patients. It remains unclear whether eAlerts maintain their efficacy over time, after withdrawal of continuing medical education (CME) on eAlerts and on thromboproph...

journal_title：Thrombosis and haemostasis

authors： Beeler PE,Kucher N,Blaser J

更新日期：2011-10-01 00:00:00

abstract：:Acute myocardial infarction (AMI) is associated with activation of various cells, including platelets that form monocyte-platelet complexes (MPCs). Here, we analysed MPC in vivo and in vitro and investigated the abilities of different monocyte subclasses to form MPC, the characteristics of the cells involved in MPC fo...

journal_title：Thrombosis and haemostasis

authors： Loguinova M,Pinegina N,Kogan V,Vagida M,Arakelyan A,Shpektor A,Margolis L,Vasilieva E

更新日期：2018-11-01 00:00:00

abstract：:A significant proportion of patients with Essential Thrombocythaemia (ET) have thrombotic complications which have an important impact upon the quality, and duration of their life. We performed a retrospective cross sectional study of the prevalence of antiphospholipid antibodies (APA) in 68 ET patients. Compared to 2...

journal_title：Thrombosis and haemostasis

authors： Harrison CN,Donohoe S,Carr P,Dave M,Mackie I,Machin SJ

更新日期：2002-05-01 00:00:00

abstract：:Platelet-monocyte aggregates are increasingly being used to quantify platelet activation. The variables that influence platelet-monocyte aggregates have not been well defined. We sought to determine the effect of blood collection, handling and processing techniques on detected levels of platelet-monocyte aggregates us...

journal_title：Thrombosis and haemostasis

authors： Harding SA,Din JN,Sarma J,Jessop A,Weatherall M,Fox KA,Newby DE

更新日期：2007-08-01 00:00:00

abstract：:The preparation of antithrombin concentrate for clinical use requires a viral inactivation step. In most commercial preparations this is achieved by heat pasteurisation. This process would be expected to alter the conformation of antithrombin from the active native species to an inactive latent (L-form) state (1, 2). ...

journal_title：Thrombosis and haemostasis

authors： Chang WS,Harper PL

更新日期：1997-02-01 00:00:00

abstract：:The terms glycoprotein IV (GPIV) and glycoprotein IIIb (GPIIIb) have been used interchangeably and reports in the literature have indicated this glycoprotein as having a molecular weight variously described as either 88,000 or 97,000, a fast anodal mobility on crossed electrophoresis and either 13 or less than 1 methi...

journal_title：Thrombosis and haemostasis

authors： Yamamoto N,de Romeuf C,Tandon NN,Jamieson GA

更新日期：1990-02-19 00:00:00

abstract：BACKGROUND:Infusions of apolipoprotein A-I (apoA-I), the major protein component of high-density lipoproteins (HDL), result in aortic valve stenosis (AVS) regression in experimental models. Severe AVS can be complicated by acquired von Willebrand syndrome, a haemorrhagic disorder associated with loss of high-molecular-...

journal_title：Thrombosis and haemostasis

authors： Gebhard C,Maafi F,Stähli BE,Bonnefoy A,Gebhard CE,Nachar W,de Oliveira Moraes AB,Mecteau M,Mihalache-Avram T,Lavoie V,Kernaleguen AE,Shi Y,Busseuil D,Chabot-Blanchet M,Perrault LP,Rhainds D,Rhéaume E,Tardif JC

更新日期：2018-02-01 00:00:00

abstract：:To understand the role of the factor X (fX) activation peptide (AP), a deletion mutagenesis approach was employed. Two single-chain, variant enzymes were generated in which 41 residues were deleted from the AP: fX (des-137-183) and fX(des-137-183;N191A), which lacks a carbohydrate moiety at Asn191 due to an alanine su...

journal_title：Thrombosis and haemostasis

authors： Rudolph AE,Mullane MP,Porche-Sorbet R,Daust HA,Miletich JP

更新日期：2002-11-01 00:00:00

abstract：:An analysis was made of 346 cases of disseminated intravascular coagulation (DIC) diagnosed by utilizing a combination of laboratory tests which reflect the pathophysiology of the syndrome. The goals of the study were three fold: 1) to compare our clinical disease categories with those of other investigators, 2) to re...

journal_title：Thrombosis and haemostasis

authors： Spero JA,Lewis JH,Hasiba U

更新日期：1980-02-29 00:00:00

abstract：:The fibrinolytic system was studied in 96 patients with type I diabetes mellitus. Patients were grouped according to their degree of retinopathy; 38 patients with no evidence of retinopathy, 28 patients with background retinopathy and 30 patients with proliferative retinopathy. Thirty healthy individuals served as con...

journal_title：Thrombosis and haemostasis

authors： Ostermann H,Tschöpe D,Greber W,Meyer-Rüsenberg HW,van de Loo J

更新日期：1992-10-05 00:00:00

abstract：:After the demonstration that moderate hyperhomocysteinemia is associated with thrombosis, many hematological labs are becoming interested in total homocysteine (tHcy) measurement. This prompted us to organize a collaborative study to investigate the performance of methods used in this setting and to assess the between...

journal_title：Thrombosis and haemostasis

authors： Tripodi A,Chantarangkul V,Lombardi R,Lecchi A,Mannucci PM,Cattaneo M

更新日期：2001-02-01 00:00:00

abstract：:Magnesium (Mg) has shown the ability to inhibit arterial thrombus formation in some experimental animal studies. This effect may be due to an inhibition of platelet reactivity as in vitro studies have demonstrated that Mg inhibits platelet aggregation. In order to evaluate the in vivo effect of Mg in humans measuremen...

journal_title：Thrombosis and haemostasis

authors： Ravn HB,Vissinger H,Kristensen SD,Wennmalm A,Thygesen K,Husted SE

更新日期：1996-06-01 00:00:00

abstract：:In a preliminary study, we have demonstrated that tissue factor (TF) is immunohistochemically stained in monocytes from patients with disseminated intravascular coagulation (DIC) but not from healthy volunteers, and that leukocytes from DIC patients induce enhanced activated factor X (FXa) generation in the presence o...

journal_title：Thrombosis and haemostasis

authors： Sase T,Wada H,Nishioka J,Abe Y,Gabazza EC,Shiku H,Suzuki K,Nakamura S,Nobori T

更新日期：2003-04-01 00:00:00

abstract：:Alteplase is standard therapy for patients with acute, massive pulmonary embolism. The novel plasminogen activator desmoteplase displays high fibrin specificity and selectivity for fibrinbound plasminogen. In a preclinical model desmoteplase was twice as potent with a shorter lysis time and lower reocclusion rate. We ...

journal_title：Thrombosis and haemostasis

authors： Tebbe U,Bramlage P,Graf A,Lechleitner P,Bode C,Riess FC,Clemens N,Al-Rawi Y,Konstantinides S,Goldhaber SZ

更新日期：2009-03-01 00:00:00

abstract：BACKGROUND: Factor XI (FXI) deficiency is a rare autosomal bleeding disorder. The rarity of spontaneous bleeding and absence of optimal tools to predict the bleeding risk in FXI-deficient patients hamper the standardization of prophylactic treatment enabling them to undergo major surgeries without blood products. OBJE...

journal_title：Thrombosis and haemostasis

authors： Salomon O,Budnik I,Avishai E,Tamarin I,Bashari D,Dardik R,Livnat T

更新日期：2019-12-01 00:00:00

abstract：:Fibrin D-Dimer (D-Di), prothrombin activation fragment (F 1+2) and thrombin-antithrombin III complexes (TAT) were measured using ELISA procedures in the plasma of patients with an acute deep venous thrombosis (DVT), at presentation and on days 2, 6 and 10 after initiation of heparin treatment. Patients were randomly a...

journal_title：Thrombosis and haemostasis

authors：

更新日期：1993-12-20 00:00:00

abstract：:The effects of argatroban, a direct thrombin inhibitor, on the International Normalized Ratio (INR), activated partial thromboplastin time (aPTT) and functional factor X during warfarin co-administration were established to provide means to interpret INRs during argatroban/warfarin co-therapy. Twenty-four subjects rec...

journal_title：Thrombosis and haemostasis

authors： Sheth SB,DiCicco RA,Hursting MJ,Montague T,Jorkasky DK

更新日期：2001-03-01 00:00:00

abstract：:The surface of the platelet expresses procoagulant phospholipids that bind coagulation factors and contribute to the procoagulant activity of the cell. The evidence, however, also suggests that platelets may possess specific receptors for coagulation Factors V(a) and VIII(a). Examination of a limited set of the availa...

journal_title：Thrombosis and haemostasis

authors： Nesheim ME,Furmaniak-Kazmierczak E,Henin C,Côté G

更新日期：1993-07-01 00:00:00