当前位置： SCI文献检索 > THROMBOSIS AND HAEMOSTASIS期刊下所有文献 > Effects of DX-9065a, an orally active, newly synthesized and specific inhibitor of factor Xa, against experimental disseminated intravascular coagulation in rats.

Effects of DX-9065a, an orally active, newly synthesized and specific inhibitor of factor Xa, against experimental disseminated intravascular coagulation in rats.

Abstract：

:We investigated the protective effects of DX-9065a, an orally active, newly synthesized and specific inhibitor of factor Xa, against two kinds of experimental disseminated intravascular coagulation (DIC) in rats. Endotoxin-induced experimental DIC was induced by a 4-h sustained infusion of endotoxin at a dose of 100 mg/kg. Thromboplastin-induced experimental DIC was induced by a bolus injection of thromboplastin at a dose of 150 mg/kg. The rats were orally administered DX-9065a at 10, 30 or 100 mg/kg 30 min before endotoxin or thromboplastin injection. In both DIC models, DX-9065a showed a protective effect against DIC, at all doses and in all parameters, including fibrin/fibrinogen degradation products (FDP), fibrinogen level, prothrombin time, activated partial thromboplastin time, platelet count and the number of renal glomeruli with fibrin thrombi. When DX-9065a was orally administrated at 100 mg/kg without endotoxin or thromboplastin, no significant changes were seen in hemostatic parameters except PT and APTT, and no fibrin thrombi or abnormal bleeding were seen in renal specimens. These findings suggest that the new oral anti-Xa drug, DX-9065a, has an effect in reducing the severity of DIC. However, further dose-finding and safety studies of this drug have still to be assessed.

journal_name

Thromb Haemost

journal_title

Thrombosis and haemostasis

authors

Yamazaki M,Asakura H,Aoshima K,Saito M,Jokaji H,Uotani C,Kumabashiri I,Morishita E,Ikeda T,Matsuda T

subject

Has Abstract

pub_date

1994-09-01 00:00:00

pages

392-6

issue

3

eissn

0340-6245

issn

2567-689X

journal_volume

72

pub_type

杂志文章

相关文献

THROMBOSIS AND HAEMOSTASIS文献大全
  • Temporal variability in the antiplatelet effects of clopidogrel and aspirin after elective drug-eluting stent implantation. An ADAPT-DES substudy.

    abstract：:Given conflicting data on temporal variability in pharmacodynamic platelet responses to clopidogrel, we investigated platelet reactivity on clopidogrel and aspirin for up to six months after elective percutaneous coronary intervention (PCI) with drug-eluting stents. Platelet reactivity was determined in 102 patients b...

    journal_title：Thrombosis and haemostasis

    pub_type： 临床试验,杂志文章

    doi：10.1160/TH15-03-0257

    authors： Nührenberg TG,Stratz C,Leggewie S,Hochholzer W,Valina CM,Gick M,Kirtane AJ,Stone GW,Neumann FJ,Trenk D

    更新日期：2015-11-01 00:00:00

  • Improvement of walking distance by defibrotide in patients with intermittent claudication--results of a randomized, placebo-controlled study (the DICLIS study). Defibrotide Intermittent CLaudication Italian Study.

    abstract：:Defibrotide is an antithrombotic drug which enhances prostacyclin production and activates fibrinolytic system. The aim of this study was to investigate the improvement of walking distance in patients with intermittent claudication treated with defibrotide. DICLIS was a double blind, placebo-controlled study which inc...

    journal_title：Thrombosis and haemostasis

    pub_type： 临床试验,杂志文章,多中心研究,随机对照试验

    doi：

    authors： Violi F,Marubini E,Coccheri S,Nenci GG

    更新日期：2000-05-01 00:00:00

  • Human leukocyte elastase and cathepsin G inactivate factor VII by limited proteolysis.

    abstract：:The effect of supernatant from phorbol myristate acetate (PMA) stimulated human polymorphonuclear granulocytes (PMN) on human factor VII was studied in vitro. The supernatant caused a rapid loss in factor VII coagulant activity by the action of human leukocyte elastase (HLE) and cathepsin G in the supernatant, as demo...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：

    authors： Anderssen T,Halvorsen H,Bajaj SP,Osterud B

    更新日期：1993-09-01 00:00:00

  • Inflammatory profile of oxidized phospholipids.

    abstract：:Lipid oxidation products and in particular oxidized phospholipids (OxPL) are increasingly recognized as inducers of chronic inflammation characteristic of atherosclerosis. OxPL stimulate production of chemokines and adhesion of monocytes to endothelial cells. However, accumulating data suggest that, in addition to the...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章,评审

    doi：

    authors： Bochkov VN

    更新日期：2007-03-01 00:00:00

  • Antithrombotic activity of a novel C-terminal hirudin analog in experimental animals.

    abstract：:A synthetic hirudin55-65 C-terminal fragment analog was evaluated for anticoagulant activity and in models of experimental thrombosis in mice and rats. Intravenous injection caused dose-related inhibition of thrombin and anticoagulation in rat blood samples, protection from thromboembolism in mice and inhibition of st...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：

    authors： Broersma RJ,Kutcher LW,Heminger EF,Krstenansky JL,Marshall FN

    更新日期：1991-04-08 00:00:00

  • The effects of metal ions on esterase activities of urokinase.

    abstract：:The esterase activity of highly purified human urokinase on Nalpha-acetylglycl-L-lysine methyl ester is strongly inhibited by 1 X 10(-5) to 1 X 10(-2)M Cu++, Hg++, Ni++, Co++, Fe+++, and Mn++ solutions, whereas Na+, K+, Ca++, and Mg++ are weakly effective. This inhibition is parallel with the inhibition of activation ...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：

    authors： Sumi H,Takada Y,Takada A

    更新日期：1978-02-28 00:00:00

  • Standardisation of factor VIII--V. Calibration of the 2nd International Standard for Factor VIII and von Willebrand factor activities in plasma.

    abstract：:The proposed 2nd International Standard for Factor VIII and von Willebrand Factor activities in plasma, NIBSC code 87/718, was assayed against the 1st IRP, 80/511, and against fresh normal plasma, in 21 laboratories. There were no significant differences between the various assay methods for factor VIII antigen, von W...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：

    authors： Heath AB,Barrowcliffe TW

    更新日期：1992-08-03 00:00:00

  • Beneficial Effects of High-Density Lipoproteins on Acquired von Willebrand Syndrome in Aortic Valve Stenosis.

    abstract：BACKGROUND:Infusions of apolipoprotein A-I (apoA-I), the major protein component of high-density lipoproteins (HDL), result in aortic valve stenosis (AVS) regression in experimental models. Severe AVS can be complicated by acquired von Willebrand syndrome, a haemorrhagic disorder associated with loss of high-molecular-...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：10.1160/TH17-10-0729

    authors： Gebhard C,Maafi F,Stähli BE,Bonnefoy A,Gebhard CE,Nachar W,de Oliveira Moraes AB,Mecteau M,Mihalache-Avram T,Lavoie V,Kernaleguen AE,Shi Y,Busseuil D,Chabot-Blanchet M,Perrault LP,Rhainds D,Rhéaume E,Tardif JC

    更新日期：2018-02-01 00:00:00

  • Ultrasound thrombolysis.

    abstract：:Cardiovascular diseases are a major cause of mortality in the developed world. Efficacy of thrombolysis plays an important role in the management of acute myocardial infarction and cerebral insult both in the acute event and in the long-term outcome of these patients. New adjunctive strategies have been tested, theref...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章,评审

    doi：10.1160/TH04-12-0818

    authors： Pfaffenberger S,Devcic-Kuhar B,Kastl SP,Huber K,Maurer G,Wojta J,Gottsauner-Wolf M

    更新日期：2005-07-01 00:00:00

  • Recombinant Human Soluble Thrombomodulin in Sepsis-Induced Coagulopathy: An Updated Systematic Review and Meta-Analysis.

    abstract：BACKGROUND: Clinical effectiveness of recombinant human soluble thrombomodulin (rhTM) in sepsis or sepsis-induced coagulopathy remains a matter of dispute. Recently, the Sepsis Coagulopathy Asahi Recombinant LEThrombomodulin (SCARLET) trial, the latest multinational multi-centre phase III randomized controlled trial, w...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章,meta分析

    doi：10.1055/s-0038-1676345

    authors： Yamakawa K,Murao S,Aihara M

    更新日期：2019-01-01 00:00:00

  • Risk stratification and heparin prophylaxis to prevent venous thromboembolism in pregnant women.

    abstract：:Women with a history of venous thromboembolism (VTE), thrombophilia or both may be at increased risk of thrombosis during pregnancy, but the optimal management strategy is not well defined in clinical guidelines because of limited trial data. A strategy of risk assessment and heparin prophylaxis was evaluated in pregn...

    journal_title：Thrombosis and haemostasis

    pub_type： 临床试验,杂志文章,多中心研究

    doi：10.1160/th07-05-0329

    authors： Bauersachs RM,Dudenhausen J,Faridi A,Fischer T,Fung S,Geisen U,Harenberg J,Herchenhan E,Keller F,Kemkes-Matthes B,Schinzel H,Spannagl M,Thaler CJ,EThIG Investigators.

    更新日期：2007-12-01 00:00:00

  • Linking Complement Activation, Coagulation, and Neutrophils in Transplant-Associated Thrombotic Microangiopathy.

    abstract：:Transplant-associated thrombotic microangiopathy (TA-TMA) is a severe and life-threatening complication of hematopoietic cell transplantation (HCT) that often coincides with graft-versus-host-disease (GVHD). Although endothelial damage seems to be the common denominator for both disorders, the role of complement syste...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：10.1055/s-0039-1692721

    authors： Gavriilaki E,Chrysanthopoulou A,Sakellari I,Batsis I,Mallouri D,Touloumenidou T,Papalexandri A,Mitsios A,Arampatzioglou A,Ritis K,Brodsky RA,Mitroulis I,Anagnostopoulos A

    更新日期：2019-09-01 00:00:00

  • Increased level of oxidized LDL-dependent monocyte-derived microparticles in acute coronary syndrome.

    abstract：:We measured and compared the levels of plasma soluble (s) P-selectin, sCD40L, platelet-derived microparticles (PDMP), monocyte-derived microparticles (MDMP), and anti-oxidized LDL antibody, to obtain a better understanding of their potential contribution to vascular complications in acute coronary syndrome (ACS). The ...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：10.1160/TH03-04-0247

    authors： Matsumoto N,Nomura S,Kamihata H,Kimura Y,Iwasaka T

    更新日期：2004-01-01 00:00:00

  • Thrombin receptors in vascular smooth muscle cells - function and regulation by vasodilatory prostaglandins.

    abstract：:The vast majority of thrombin (>95%) is generated after clotting is completed, suggesting that thrombin formation serves purposes beyond coagulation, such as tissue repair after vessel injury. Two types of vascular thrombin binding sites exist: protease-activated receptors (PARs) and thrombomodulin (TM). Their express...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章,评审

    doi：10.1160/TH09-09-0627

    authors： Schrör K,Bretschneider E,Fischer K,Fischer JW,Pape R,Rauch BH,Rosenkranz AC,Weber AA

    更新日期：2010-05-01 00:00:00

  • Contraceptive pills induce an improvement in congenital hypoplasminogenemia in two unrelated patients with ligneous conjunctivitis.

    abstract：:Severe type I plasminogen deficiency is the underlying cause of ligneous conjunctivitis, a rare disease characterized by wood-like pseudomembranes developing on the ocular and extraocular mucosa. Two unrelated female patients with ligneous conjunctivitis and moderate hypoplasminogenemia are described. Being of fertile...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：

    authors： Teresa Sartori M,Saggiorato G,Pellati D,Casonato A,Spiezia L,Pontara E,Gavasso S,Girolami A

    更新日期：2003-07-01 00:00:00

  • Inhibition of human and rat platelet aggregation by extracts of Mo-er (Auricularia auricula).

    abstract：:Hot water extracts of Mo-er (1 gm by 15 ml of water), an oriental food (Auricularia auricula), inhibit strongly both human and rat platelet ADP-induced aggregation. HPLC analysis of two varieties of Mo-er, A. auricula and A. polytricha (a black tree fungus), shows that they contain adenosine (Ado), 133 and 154 microgr...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：

    authors： Agarwal KC,Russo FX,Parks RE Jr

    更新日期：1982-10-29 00:00:00

  • Effect of pentosan polysulphate administration in man on the formation of covalent complexes between heparin cofactor II and thrombin generated in plasma by contact activation.

    abstract：:An assay for the quantification of pentosan polysulphate (PPS) in plasma is described. As PPS has been shown to potentiate thrombin inhibition by the second heparin cofactor (HC II), the principle of this assay was to measure the formation of covalent complexes between HC II and the thrombin generated in plasma after ...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：

    authors： Dol F,Sié P,Dupouy D,Boneu B

    更新日期：1986-12-15 00:00:00

  • Akt protects the heart against ischaemia-reperfusion injury by modulating mitochondrial morphology.

    abstract：:The mechanism through which the protein kinase Akt (also called PKB), protects the heart against acute ischaemia-reperfusion injury (IRI) is not clear. Here, we investigate whether Akt mediates its cardioprotective effect by modulating mitochondrial morphology. Transfection of HL-1 cardiac cells with constitutively ac...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：10.1160/TH14-07-0592

    authors： Ong SB,Hall AR,Dongworth RK,Kalkhoran S,Pyakurel A,Scorrano L,Hausenloy DJ

    更新日期：2015-03-01 00:00:00

  • Platelet-bound prekallikrein promotes pro-urokinase-induced clot lysis: a mechanism for targeting the factor XII dependent intrinsic pathway of fibrinolysis.

    abstract：:Clots formed from platelet rich plasma were found to be lysed more readily by low concentrations of pro-urokinase (pro-UK) than clots formed from platelet poor plasma. This was not a non-specific effect since the reverse occurred with tissue plasminogen activator. A mechanical explanation due to platelet-mediated clot...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：

    authors： Loza JP,Gurewich V,Johnstone M,Pannell R

    更新日期：1994-03-01 00:00:00

  • Low molecular weight heparin for the out-of-hospital treatment of venous thrombosis: rationale and clinical results.

    abstract：:LMWH preparations have been proven to be safe and effective in the out-patient management of acute DVT. Although LMWHs are more expensive than unfractionated heparin, the lack of need for laboratory monitoring of LMWHs and their potential for out-patient treatment more than offsets the drug related cost difference and...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章,评审

    doi：

    authors： Hirsh J,Crowther M

    更新日期：1997-07-01 00:00:00

  • Increased plasma thrombomodulin in cancer patients.

    abstract：:Plasma samples from 35 patients with colorectal cancer, 16 patients with pancreatic cancer and 46 patients with various cancers in the terminal stage were analysed for soluble plasma thrombomodulin with an ELISA method. At time of diagnosis and before primary treatment, the patients with colorectal cancer had normal p...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：

    authors： Lindahl AK,Boffa MC,Abildgaard U

    更新日期：1993-02-01 00:00:00

  • Monocytes of Different Subsets in Complexes with Platelets in Patients with Myocardial Infarction.

    abstract：:Acute myocardial infarction (AMI) is associated with activation of various cells, including platelets that form monocyte-platelet complexes (MPCs). Here, we analysed MPC in vivo and in vitro and investigated the abilities of different monocyte subclasses to form MPC, the characteristics of the cells involved in MPC fo...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：10.1055/s-0038-1673342

    authors： Loguinova M,Pinegina N,Kogan V,Vagida M,Arakelyan A,Shpektor A,Margolis L,Vasilieva E

    更新日期：2018-11-01 00:00:00

  • Alteration of von Willebrand Factor after Transcatheter Aortic Valve Replacement in the Absence of Paravalvular Regurgitation.

    abstract：:Moderate or severe paravalvular regurgitation after transcatheter aortic valve implantation (TAVI) is frequently associated with a loss of high-molecular-weight multimers of von Willebrand factor (VWF) and a reduced VWF collagen-binding capacity. It is unclear whether this phenomenon can also be observed in patients w...

    journal_title：Thrombosis and haemostasis

    pub_type： 临床试验,杂志文章

    doi：10.1160/17-07-0506

    authors： Pawlitschek F,Keyl C,Zieger B,Budde U,Beyersdorf F,Neumann FJ,Stratz C,Nührenberg TG,Trenk D

    更新日期：2018-01-01 00:00:00

  • Prasugrel inhibits platelet-leukocyte interaction and reduces inflammatory markers in a model of endotoxic shock in the mouse.

    abstract：:Prasugrel, through its active metabolite, reduces atherothrombosis and its clinical manifestations by inhibiting platelet activation and aggregation. Platelets also contribute to inflammation through interaction with different classes of leukocytes. We investigated whether the inhibitory effect of prasugrel on platele...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：10.1160/TH11-12-0867

    authors： Totani L,Dell'Elba G,Martelli N,Di Santo A,Piccoli A,Amore C,Evangelista V

    更新日期：2012-06-01 00:00:00

  • Pregnancy outcome in patients exposed to direct oral anticoagulants - and the challenge of event reporting.

    abstract：:Today, direct oral anticoagulants (DOAC) are widely used alternatives to Vitamin-K antagonists (VKA). Women of reproductive age may become pregnant during anticoagulation and, while VKA carry an embryotoxic potential, the risk of DOAC embryopathy is unknown. As a result, some patients elect to terminate pregnancy for ...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：10.1160/TH16-04-0305

    authors： Beyer-Westendorf J,Michalski F,Tittl L,Middeldorp S,Cohen H,Abdul Kadir R,Arachchillage DJ,Arya R,Ay C,Marten S

    更新日期：2016-09-27 00:00:00

  • Homozygous variant of antithrombin III that lacks affinity for heparin, AT III Kumamoto.

    abstract：:Abnormal antithrombin III (AT III) was found in the plasma of a 31-year-old female who suffered from recurrent thrombotic episodes. Heparin cofactor activity was 28% of normal and undetectable when measured by inhibition of thrombin and factor Xa (F.Xa), while both progressive antithrombin and antifactor Xa activities...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：

    authors： Okajima K,Ueyama H,Hashimoto Y,Sasaki Y,Matsumoto K,Okabe H,Inoue M,Araki S,Takatsuki K

    更新日期：1989-02-28 00:00:00

  • Biphasic myosin II light chain activation during clot retraction.

    abstract：:Clot retraction is an essential step during primary haemostasis, thereby promoting thrombus stability and wound healing. Integrin αIIbβ3 plays a critical role in clot retraction, by inducing acto-myosin interactions that allow platelet cytoskeleton reorganisation. However, the signalling pathways that lead to clot ret...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：10.1160/TH13-04-0335

    authors： Egot M,Kauskot A,Lasne D,Gaussem P,Bachelot-Loza C

    更新日期：2013-12-01 00:00:00

  • Relationship of coagulation test abnormalities to tumour burden and postoperative DVT in resected colorectal cancer.

    abstract：:In a prospective study, coagulation test results were compared in 137 patients with colorectal cancer (CRC) and 39 subjects with benign colorectal diseases. Prothrombin fragment 1+2 (F1+2), thrombin-antithrombin complex (TAT), and soluble fibrin (SF) were measured in plasma before and after surgery. CRC patients prese...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：

    authors： Iversen LH,Thorlacius-Ussing O

    更新日期：2002-03-01 00:00:00

  • Immunoglobulin fractions isolated from patients with antiphospholipid antibodies prevent the inactivation of factor Va by activated protein C on human endothelial cells.

    abstract：:We studied the effect of purified immunoglobulins (Ig) from 21 patients with antiphospholipid antibodies (aPL) on factor Va degradation by activated protein C (aPC) on cultured human umbilical vein endothelial cells (HUVEC). Sera from patients were tested on an ELISA aPL assay to determine the isotype with aPL activit...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：

    authors： Borrell M,Sala N,de Castellarnau C,Lopez S,Gari M,Fontcuberta J

    更新日期：1992-09-07 00:00:00

  • The TF-603A/G gene promoter polymorphism and circulating monocyte tissue factor gene expression in healthy volunteers.

    abstract：:Three single nucleotide polymorphisms (-603A/G, -1322C/T, -1812C/T) and one deletion/insertion polymorphism (-1208D/I) are present in the tissue factor (TF) gene promoter sequence. These polymorphisms are in complete linkage disequilibrium, determining two haplotypes with almost equal frequency. The -603A/-1208D/-1322...

    journal_title：Thrombosis and haemostasis

    pub_type： 杂志文章

    doi：10.1160/TH03-09-0566

    authors： Reny JL,Laurendeau I,Fontana P,Bièche I,Dupont A,Remones V,Emmerich J,Vidaud M,Aiach M,Gaussem P

    更新日期：2004-02-01 00:00:00