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Obstacles and options in the quest for drug candidates against vascular disease.

Abstract：

:The difficulties in cardiovascular drug development have been exposed by recent clinical trials, which have uncovered various limitations of promising drug candidates. Yet, the imperative to improve medical treatment of atherosclerosis in aging populations afflicted by metabolic disease remains unbroken. Herein alternatives to metabolically active compounds such as glitazones and torcetrapib are introduced and discussed, namely CC chemokine receptor 5 (CCR5) antagonists recently approved for treatment of patients with human immunodeficiency virus-1, interceptors of proatherogenic chemokine interactions, and actively protective pathways. A combination of different strategies may yield improved safety profiles of these therapeutics.

journal_name

Thromb Haemost

journal_title

Thrombosis and haemostasis

authors

Weber C

doi

10.1160/TH10-04-0256

subject

Has Abstract

pub_date

2010-07-01 00:00:00

pages

1-3

issue

1

eissn

0340-6245

issn

2567-689X

pii

10-04-0256

journal_volume

104

pub_type

社论

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