Incorporation of the factor IX Padua mutation into FIX-Triple improves clotting activity in vitro and in vivo.

abstract：:To find if there is a relation between levels of haemostatic variables at low and high hormonal levels (oestradiol and progesterone) in an individual, blood samples were drawn from 12 women repeatedly during one menstrual cycle (Study I) and from 14 women undergoing in vitro fertilization, before hormonal stimulation ...

journal_title：Thrombosis and haemostasis

authors： Andersson O,Blombäck M,Bremme K,Wramsby H

更新日期：1997-05-01 00:00:00

abstract：:Elderly patients have previously been shown to have an increased plasma concentration of tissue plasminogen activator (t-PA) antigen (t-PA Ag). Since the concentration of t-PA Ag depends on both free t-PA and t-PA complexed with inhibitors, mainly plasminogen activator inhibitor (PA inhibitor), we have investigated th...

journal_title：Thrombosis and haemostasis

authors： Aillaud MF,Pignol F,Alessi MC,Harle JR,Escande M,Mongin M,Juhan-Vague I

更新日期：1986-06-30 00:00:00

abstract：:The characterization of mutations in von Willebrand disease provides useful insight into the synthesis, structure, and function of von Willebrand factor. This growing body of information has prompted a reclassification of vWD types that is intended to reflect distinct pathophysiologic mechanisms. Despite this apparent...

journal_title：Thrombosis and haemostasis

authors： Sadler JE,Matsushita T,Dong Z,Tuley EA,Westfield LA

更新日期：1995-07-01 00:00:00

abstract：:Oral anticoagulants used for the primary treatment of venous thromboembolism (VTE) include warfarin and the more recently introduced direct oral anticoagulants (DOACs), including rivaroxaban, apixaban, dabigatran and edoxaban. Information on the comparative safety of these medications in routine clinical practice is l...

journal_title：Thrombosis and haemostasis

authors： Roetker NS,Lutsey PL,Zakai NA,Alonso A,Adam TJ,MacLehose RF

更新日期：2018-09-01 00:00:00

abstract：:Glu-plasminogen binds to platelets; the monocytoid line, U937, and the human fetal fibroblast line, GM1380 bind both plasminogen and its activator, urokinase. This study assesses the interaction of these fibrinolytic proteins with circulating human blood cells. Plasminogen bound minimally to red cells but bound satura...

journal_title：Thrombosis and haemostasis

authors： Miles LA,Plow EF

更新日期：1987-10-28 00:00:00

abstract：:Congenital amegakaryocytic thrombocytopaenia (CAMT) is a disorder caused by c-MPL mutations that impair thrombopoietin (TPO) signalling, resulting in a near absence of megakaryocytes (MKs). While this phenotype is consistent in adults, neonates with CAMT can present with severe thrombocytopaenia despite normal MK numb...

journal_title：Thrombosis and haemostasis

authors： Lorenz V,Ramsey H,Liu ZJ,Italiano J Jr,Hoffmeister K,Bihorel S,Mager D,Hu Z,Slayton WB,Kile BT,Sola-Visner M,Ferrer-Marin F

更新日期：2017-12-01 00:00:00

abstract：:The biologically active components from Viperidae venoms specifically affect cell-matrix interactions, and have been utilized for developing anti-adhesive therapy as anti-thrombotic and anti-angiogenic agents. Utilizing platelet aggregometry coupled with flow cytometry, we found that a metalloproteinase isolated from ...

journal_title：Thrombosis and haemostasis

authors： Tseng YL,Lee CJ,Huang TF

更新日期：2004-02-01 00:00:00

abstract：:The PAI-1 gene promoter 4G/5G polymorphism was found to be associated with plasma PAI-1 activity in Northern and Central Europe populations, but no data are available on the association between this polymorphism and PAI-1 levels in Southern Europe countries (such as Italy) where the incidence of ischemic disorders is ...

journal_title：Thrombosis and haemostasis

authors： Burzotta F,Di Castelnuovo A,Amore C,D'Orazio A,Di Bitondo R,Donati MB,Iacoviello L

更新日期：1998-02-01 00:00:00

abstract：:Compelling evidence suggests that the risk of pulmonary embolism (PE) and deep-vein thrombosis (DVT) persists after hospital discharge in acutely-ill medical patients. However, no studies consistently supported the routine use of extended-duration thromboprophylaxis (ET) in this setting. We performed a meta-analysis t...

journal_title：Thrombosis and haemostasis

authors： Dentali F,Mumoli N,Prisco D,Fontanella A,Di Minno MN

更新日期：2017-02-28 00:00:00

abstract：:Alpha 2-macroglobulin (alpha 2 M) in vitro inhibits numerous proteinases that are generated during inflammatory reactions and therefore, probably plays an important role in diseases such as sepsis. To monitor the state of alpha 2 M in sepsis, we developed novel assays for functional and inactive alpha 2M. Functional a...

journal_title：Thrombosis and haemostasis

authors： Abbink JJ,Nuijens JH,Eerenberg AJ,Huijbregts CC,Strack van Schijndel RJ,Thijs LG,Hack CE

更新日期：1991-01-23 00:00:00

abstract：:CD36, also known as GPIIIb or GPIV, is a main protein of the platelet membrane. Accumulating evidence implicates CD36 in the pathogenesis of atherosclerosis. CD36 binds to cholesteryl-hemisuccinate coupled to agarose. This binding may be of physiologic relevance since CD36 has a long extracellular hydrophobic region a...

journal_title：Thrombosis and haemostasis

authors： Kronenberg A,Grahl H,Kehrel B

更新日期：1998-05-01 00:00:00

abstract：:To understand the role of the factor X (fX) activation peptide (AP), a deletion mutagenesis approach was employed. Two single-chain, variant enzymes were generated in which 41 residues were deleted from the AP: fX (des-137-183) and fX(des-137-183;N191A), which lacks a carbohydrate moiety at Asn191 due to an alanine su...

journal_title：Thrombosis and haemostasis

authors： Rudolph AE,Mullane MP,Porche-Sorbet R,Daust HA,Miletich JP

更新日期：2002-11-01 00:00:00

abstract：:Platelets are not only centrally involved in haemostasis, but also in antimicrobial defence and inflammation. Since evaluation of platelet physiology in the particular patient group of preterm and term neonatal infants is highly restricted for ethical reasons, there are hardly any data available in healthy and much le...

journal_title：Thrombosis and haemostasis

authors： Andres O,Schulze H,Speer CP

更新日期：2015-01-01 00:00:00

abstract：:Platelets from cattle with the Chediak-Higashi syndrome (CHS) have a platelet dense granule deficiency. One hypothesis for the platelet dense granule deficiency is that the granule is simply not formed in CHS megakaryocytes (MK). Alternative hypotheses include that the granule is assembled in CHS MK but a functional a...

journal_title：Thrombosis and haemostasis

authors： Meyers K,Seachord C

更新日期：1990-10-22 00:00:00

abstract：:Treatment with the direct thrombin inhibitor argatroban (ARG) is often followed by vitamin K-antagonist treatment (VKA). Phenprocoumon (PC) and acenocoumarol (AC) are frequently used in Europe. The standard monitoring test for VKA, pro-thrombin time (PT), is prolonged by direct thrombin inhibitors. Therefore the Inter...

journal_title：Thrombosis and haemostasis

authors： Harder S,Graff J,Klinkhardt U,von Hentig N,Walenga JM,Watanabe H,Osakabe M,Breddin HK

更新日期：2004-06-01 00:00:00

abstract：:Vitamin K antagonists (VKAs) remain as the most prescribed drug for treatment and prevention of thrombotic disorders in many countries, despite the recent approval of the new oral anticoagulants (NOACs). Although effectiveness and safety of VKAs are tightly associated to maintaining the patient within the internationa...

journal_title：Thrombosis and haemostasis

authors： Jiménez-Varo E,Cañadas-Garre M,Henriques CI,Pinheiro AM,Gutiérrez-Pimentel MJ,Calleja-Hernández MÁ

更新日期：2014-09-02 00:00:00

abstract：:We investigated the presence of the gene mutation of factor V, FV R506Q or factor V Leiden, responsible for activated protein C resistance, in DNA samples of 127 probands and 188 relatives from 128 families with antithrombin deficiency. The factor V mutation was identified in 18 families. Nine families were available ...

journal_title：Thrombosis and haemostasis

authors： van Boven HH,Reitsma PH,Rosendaal FR,Bayston TA,Chowdhury V,Bauer KA,Scharrer I,Conard J,Lane DA

更新日期：1996-03-01 00:00:00

abstract：:In two randomized double-blind studies perioperative bleeding complications and thromboembolic events were assessed in 189 patients (pts) undergoing elective visceral surgery after subcutaneous administration of a low molecular weight (LMW) heparin fragment (KABI fragment 2165) or unfractionated (UF) heparin. The firs...

journal_title：Thrombosis and haemostasis

authors： Koller M,Schoch U,Buchmann P,Largiadèr F,von Felten A,Frick PG

更新日期：1986-12-15 00:00:00

abstract：:Extensive contact between blood and artificial surfaces causes platelet activation and depletion. The aim of the present study was to test the efficacy of Ro 44-9883, a potent and selective peptidomimetic GPIIb-IIIa antagonist, in preventing platelet loss in guinea pigs undergoing extracorporeal circulation (ECC) with...

journal_title：Thrombosis and haemostasis

authors： Carteaux JP,Steiner B,Roux S

更新日期：1993-11-15 00:00:00

abstract：:Hematological parameters including platelet counts, etc. were determined in 1,140 healthy subjects living in four cities: Suzhou (Jiangsu Province), Chengdu (Sichuan Province) and Harbin (Heilongjang Province) in China, and Kobe in Japan. Then, the reference intervals for platelet counts were calculated and compared. ...

journal_title：Thrombosis and haemostasis

authors： Ruan C,Wu Y,Okada T,Motoi S,Kondo T,Jiang M,Xin X,Peng L,Ichihara K,Ikeda Y

更新日期：2002-07-01 00:00:00

abstract：:Accumulating evidence indicates that accelerated formation of fibrin clots composed of compact, highly-branched networks with thin fibres which are relatively resistant to plasmin-mediated lysis can be commonly observed in patients with venous or arterial thrombosis. This review discusses characteristics of fibrin clo...

journal_title：Thrombosis and haemostasis

authors： Undas A

更新日期：2014-07-03 00:00:00

abstract：:Venous thromboembolism, which encompasses deep-vein thrombosis and acute pulmonary embolism (PE), represents a major contributor to global disease burden worldwide. For patients who present with cardiogenic shock or persistent hypotension (acute high-risk PE), there is consensus that immediate reperfusion treatment ap...

journal_title：Thrombosis and haemostasis

authors： Konstantinides SV,Wärntges S

更新日期：2015-06-01 00:00:00

abstract：:Recent prospective studies indicate endothelial dysfunction and increased risk for cardiovascular events in patients with serological evidence of multiple infections. Soluble CD14 (sCD 14) plays a key role in the neutralization of lipopolysaccharide (LPS), a well-established bacterial product inducing endothelial dysf...

journal_title：Thrombosis and haemostasis

authors： Fernández-Real JM,López-Bermejo A,Castro A,Broch M,Peñarroja G,Vendrell J,Vázquez G,Ricart W

更新日期：2005-09-01 00:00:00

abstract：:Several studies have highlighted a specific role for membrane cholesterol domains in platelet signalling. Upon adhesion to von Willebrand factor (VWF) or collagen, cholesterol-rich domains (CRDs) accumulate in filopodial extensions and selectively harbour counterpart receptors (GPIb and GPVI) and associated signalling...

journal_title：Thrombosis and haemostasis

authors： van Lier M,Verhoef S,Cauwenberghs S,Heemskerk JW,Akkerman JW,Heijnen HF

更新日期：2008-06-01 00:00:00

abstract：:One of the most severe and important complication in the treatment of haemophilia A (HA) patients is the formation of inhibitors. The mechanism that leads to factor (F)VIII inhibitor formation is complicated. Both genetic and environmental factors have been mentioned to play decisive roles. Recently, polymorphisms in ...

journal_title：Thrombosis and haemostasis

authors： Lu Y,Ding Q,Dai J,Wang H,Wang X

更新日期：2012-01-01 00:00:00

abstract：:In patients with atrial fibrillation (AF) who require interruption of dabigatran or warfarin for an elective surgery/procedure, the risks and benefits of perioperative bridging anticoagulation is uncertain.We accessed the database from RE-LY, a randomised trial comparing dabigatran with warfarin for stroke prevention ...

journal_title：Thrombosis and haemostasis

authors： Douketis JD,Healey JS,Brueckmann M,Eikelboom JW,Ezekowitz MD,Fraessdorf M,Noack H,Oldgren J,Reilly P,Spyropoulos AC,Wallentin L,Connolly SJ

更新日期：2015-03-01 00:00:00

abstract：:The synthetic peptide SFLLRNPNDKYEPF, identical in sequence to the new amino-terminus of the thrombin receptor generated following cleavage of thrombin, acts a thrombin receptor agonist/activating peptide (TRAP). In this study, Northern blot analysis showed that cultured human vascular smooth muscle cells (HVSMC) expr...

journal_title：Thrombosis and haemostasis

authors： Kanthou C,Benzakour O,Patel G,Deadman J,Kakkar VV,Lupu F

更新日期：1995-11-01 00:00:00

abstract：:Direct oral factor inhibitors (DOFIs) are an attractive alternative to vitamin K antagonists (VKA) for the treatment of patients with antiphospholipid syndrome (APS). In the absence of prospective, randomised trial data, reports of therapeutic failures in clinical practice alert clinicians to potential limitations of ...

journal_title：Thrombosis and haemostasis

authors： Schaefer JK,McBane RD,Black DF,Williams LN,Moder KG,Wysokinski WE

更新日期：2014-11-01 00:00:00

abstract：:Residual venous obstruction (RVO) in patients with previous deep vein thrombosis (DVT) of the lower limbs has been suggested as an independent risk factor for recurrent venous thromboembolism (VTE). RVO could be a marker of a persistent prothrombotic state. We have compared the rate of RVO in patients with DVT and a p...

journal_title：Thrombosis and haemostasis

authors： Galli M,Ageno W,Squizzato A,Dentali F,Manfredi E,Steidl L,Venco A

更新日期：2005-07-01 00:00:00

abstract：:An analysis was made of 346 cases of disseminated intravascular coagulation (DIC) diagnosed by utilizing a combination of laboratory tests which reflect the pathophysiology of the syndrome. The goals of the study were three fold: 1) to compare our clinical disease categories with those of other investigators, 2) to re...

journal_title：Thrombosis and haemostasis

authors： Spero JA,Lewis JH,Hasiba U

更新日期：1980-02-29 00:00:00