Identification of dense granule specific membrane proteins in bovine platelets that are absent in the Chediak-Higashi syndrome.

abstract：:The influence of ionic and non-ionic contrast media (CM) on platelet and leukocyte activation and platelet-leukocyte crosstalk was investigated in hirudinized whole blood. The blood was incubated with and without the ionic CM ioxaglate and the nonionic CM iodixanol at 37 degrees C for 5 min, without or with stirring. ...

journal_title：Thrombosis and haemostasis

authors： Ji Q,Ghaly M,Hjemdahl P,Tornvall P,Li N

更新日期：2005-05-01 00:00:00

abstract：:Thrombin regulation in newborns remains incompletely understood. We studied tissue factor-initiated thrombin formation in cord plasma in vitro, and the effects of Factor V(Leiden) (FVL) heterozygosity on thrombin regulation both in vitro and in vivo in newborns. Pregnant women with known thrombophilia (n=27) were enro...

journal_title：Thrombosis and haemostasis

authors： Hyytiäinen S,Wartiovaara-Kautto U,Ulander VM,Kaaja R,Heikinheimo M,Petäjä J

更新日期：2006-03-01 00:00:00

abstract：:Adhesion of rat blood platelets to native rat tail collagen fibrils was studied in the electron microscope under conditions that preserved collagen-associated proteoglycans (CAPG). The CAPG molecules were aligned in chain-like configurations that encircled the fibrils with a 65 nm period; they appeared to coat the fib...

journal_title：Thrombosis and haemostasis

authors： Behnke O

更新日期：1987-08-04 00:00:00

abstract：:The major plasmin inhibitors namely alpha2-plasmin inhibitor and alpha2-macroglobulin were compared for their effects on lysis of fibrin clot. Plasmin fibrinolytic activity was immediately inhibited by alpha2-plasmin inhibitor, whereas alpha2-macroglobulin inhibited plasmin progressively. Urokinase(plasminogen activat...

journal_title：Thrombosis and haemostasis

authors： Aoki N,Moroi M,Tachiya K

更新日期：1978-02-28 00:00:00

abstract：:Excessive leukocyte infiltration causes severe tissue damage in a variety of inflammatory diseases. The initial step in leukocyte extravasation is mediated by selectins and oligosaccharides on their glycoconjugate ligands. Human milk is a rich source of lactose-derived oligosaccharides that are partly absorbed in the ...

journal_title：Thrombosis and haemostasis

authors： Bode L,Kunz C,Muhly-Reinholz M,Mayer K,Seeger W,Rudloff S

更新日期：2004-12-01 00:00:00

abstract：:We previously reported that antithrombin (AT) reduced ischemia/reperfusion (I/R)-induced liver injury in rats by increasing endothelial production of prostacyclin (PGI2). However, the mechanism(s) underlying this phenomenon remains to be fully elucidated. We also demonstrated that activation of capsaicin-sensitive sen...

journal_title：Thrombosis and haemostasis

authors： Harada N,Okajima K,Yuksel M,Isobe H

更新日期：2005-01-01 00:00:00

abstract：:Dilated cardiomyopathy is associated with thromboembolic complications, which correlate poorly, however, with a visible left ventricular thrombus. Therefore, this study was performed to assess whether an abnormality of platelet function in vivo can be detected in patients with dilated cardiomyopathy. Platelet survival...

journal_title：Thrombosis and haemostasis

authors： Weidinger F,Glogar D,Sochor H,Sinzinger H

更新日期：1991-10-01 00:00:00

abstract：:During treatment with vitamin K antagonists, International Normalized Ratios (INR) are determined periodically to maintain a therapeutic level of anticoagulation. We evaluated two existing methods for therapeutic quality control (linear interpolation and equidivision), with regard to their validity and reproducibility...

journal_title：Thrombosis and haemostasis

authors： Hutten BA,Prins MH,Redekop WK,Tijssen JG,Heisterkamp SH,Büller HR

更新日期：1999-10-01 00:00:00

abstract：:Dabigatran is an oral, reversible thrombin inhibitor that has shown promising results in large clinical trials. Laboratory monitoring is not needed but the effects on common coagulation assays are incompletely known. Dabigatran was added to plasma from healthy subjects in the concentration range 0-1,000 μg/l and analy...

journal_title：Thrombosis and haemostasis

authors： Lindahl TL,Baghaei F,Blixter IF,Gustafsson KM,Stigendal L,Sten-Linder M,Strandberg K,Hillarp A,Expert Group on Coagulation of the External Quality Assurance in Laboratory Medicine in Sweden.

更新日期：2011-02-01 00:00:00

abstract：:Fibrinogen Matsumoto V (M-V) is a dysfibrinogen identified in a 52-year-old woman with systemic lupus erythematous. The triplet AGG encoding the amino acid residue Aalpha19 was replaced by GGG, resulting in the substitution of Arg-->Gly. Residue Aalpha19 has been shown to be one of the most important amino acids in th...

journal_title：Thrombosis and haemostasis

authors： Tanaka H,Terasawa F,Ito T,Tokunaga S,Ishida F,Kitano K,Kiyosawa K,Okumura N

更新日期：2001-01-01 00:00:00

abstract：:The vast majority of thrombin (>95%) is generated after clotting is completed, suggesting that thrombin formation serves purposes beyond coagulation, such as tissue repair after vessel injury. Two types of vascular thrombin binding sites exist: protease-activated receptors (PARs) and thrombomodulin (TM). Their express...

journal_title：Thrombosis and haemostasis

authors： Schrör K,Bretschneider E,Fischer K,Fischer JW,Pape R,Rauch BH,Rosenkranz AC,Weber AA

更新日期：2010-05-01 00:00:00

abstract：:In a recent study, we purified and cloned a newly identified bioactive factor that stimulates prostacyclin (PGI2) production by vascular endothelial cells (ECs) using conditioned medium (CM) from cultured human diploid fibroblast cells. The present study was undertaken to clarify whether PSF is expressed in ECs and va...

journal_title：Thrombosis and haemostasis

authors： Masakado M,Umeda F,Takei A,Hashimoto T,Sueishi K,Nawata H

更新日期：1995-12-01 00:00:00

abstract：:Our aim was to demonstrate that the sequential use of the Verigene® rapid CYP2C19 test for genetic profiling and the VerifyNowTM bedside test for platelet function measurement in ACS patients may optimise P2Y12 inhibition. "Rapid" (CYP2C19*1/*1 or CYP2C19*17 carriers, n=211) and "slow" metabolisers (CYP2C19*2 carriers...

journal_title：Thrombosis and haemostasis

authors： Collet JP,Kerneis M,Hulot JS,O'Connor SA,Silvain J,Mansencal N,Brugier D,Abtan J,Barthélémy O,Vignalou JB,Payot L,Rousseau H,Vicaut E,Montalescot G,GAMMA Investigators.

更新日期：2016-01-01 00:00:00

abstract：:The multimeric plasma glycoprotein von Willebrand factor (VWF) is best known for recruiting platelets to sites of injury during primary hemostasis. Generally, mutations in the VWF gene lead to loss of hemostatic activity and thus the bleeding disorder von Willebrand Disease. By employing cone and platelet aggregometry...

journal_title：Thrombosis and haemostasis

authors： Huck V,Chen PC,Xu ER,Tischer A,Klemm U,Aponte-Santamaría C,Mess C,Obser T,Kutzki F,König G,Denis C,Gräter F,Wilmanns M,Auton M,Schneider SW,Schneppenheim R,Hennig J,Brehm MA

更新日期：2020-12-31 00:00:00

abstract：:The fibrin-specificity and procoagulant effects of recombinant staphylokinase (Sak42D) were compared with those of recombinant tissue-type plasminogen activator (rt-PA) in patients with acute myocardial infarction. Plasma samples were obtained at baseline and at 25 and 90 min, from 24 patients who were randomly assign...

journal_title：Thrombosis and haemostasis

authors： Okada K,Lijnen HR,Moreau H,Vanderschueren S,Collen D

更新日期：1996-12-01 00:00:00

abstract：:Although there is evidence that altitude increases the platelet count, its effect on the platelet precursor stimulating factor, thrombopoietin (TPO), is unclear. Unlike erythropoietin, TPO appears largely unresponsive to exogenous signals. In a study in 16 healthy volunteers, we report the effects of altitude exposure...

journal_title：Thrombosis and haemostasis

authors： Hartmann S,Krafft A,Huch R,Breymann C

更新日期：2005-01-01 00:00:00

abstract：:We investigated plasma activated factor VII (FVIIa) levels in uremic patients (nondialysis group: n = 38; dialysis group: n = 36) and healthy controls (n = 32). We also measured the plasma levels of thrombomodulin (an indicator of endothelial cell injury) and tissue factor. Plasma FVIIa showed a marked increase in the...

journal_title：Thrombosis and haemostasis

authors： Kario K,Matsuo T,Matsuo M,Koide M,Yamada T,Nakamura S,Sakata T,Kato H,Miyata T

更新日期：1995-05-01 00:00:00

abstract：:Platelet-rich clots are inefficiently lysed by current fibrinolytic agents. Platelets contain a great deal of plasminogen activator inhibitor 1 (PAI-1), the principal endogenous inhibitor of tissue-type plasminogen activator (t-PA). We have tested whether PAI-1 resistant t-PAs would be more effective thrombolytic agen...

journal_title：Thrombosis and haemostasis

authors： Shohet RV,Spitzer S,Madison EL,Bassel-Duby R,Gething MJ,Sambrook JF

更新日期：1994-01-01 00:00:00

abstract：:We investigated the influence of low molecular weight dextran sulfate (LMWdxs) and low molecular weight heparins (LMWH: dalteparin, enoxaparin and nadroparin) on the inhibition of FXIa by C1-inhibitor, alpha1-antitrypsin, alpha2-antiplasmin and antithrombin in a purified system and in plasma. The second order rate con...

journal_title：Thrombosis and haemostasis

authors： Mauron T,Lämmle B,Wuillemin WA

更新日期：1998-07-01 00:00:00

abstract：:Antithrombin (AT) is a serine protease inhibitor that regulates the activity of coagulation proteases of both intrinsic and extrinsic pathways. We identified an AT-deficient patient with a heterozygous Thr90Ser (T90S) mutation who experiences recurrent venous thrombosis. To understand the molecular basis of the clotti...

journal_title：Thrombosis and haemostasis

authors： Lu Y,Villoutreix BO,Biswas I,Ding Q,Wang X,Rezaie AR

更新日期：2020-07-01 00:00:00

abstract：:Transplant-associated thrombotic microangiopathy (TA-TMA) is a life-threatening complication of allogeneic hematopoietic cell transplantation (HCT). We hypothesized that pretransplant genetic susceptibility is evident in adult TA-TMA and further investigated the association of TMA-associated variants with clinical out...

journal_title：Thrombosis and haemostasis

authors： Gavriilaki E,Touloumenidou T,Sakellari I,Batsis I,Mallouri D,Psomopoulos F,Tsagiopoulou M,Koutra M,Yannaki E,Papalexandri A,Taylor P,Nikolousis E,Stamouli M,Holbro A,Baltadakis I,Liga M,Spyridonidis A,Tsirigotis P,Cha

更新日期：2020-04-01 00:00:00

abstract：:The aim of the present study was to evaluate the relative performance of five screening methods for APC resistance caused by the factor V:Q506 mutation: the original method Coatest APC Resistance Chromogenix, a modified method using the same reagents but a predilution 1+4 of the plasma in a factor V deficient plasma f...

journal_title：Thrombosis and haemostasis

authors： Freyburger G,Javorschi S,Labrouche S,Bernard P

更新日期：1997-11-01 00:00:00

abstract：:Tecarfarin is a novel vitamin K antagonist that is metabolised by carboxyl estererase, thereby eliminating the variability associated with cytochrome-mediated metabolism. EmbraceAC was designed to compare the quality of anticoagulation with tecarfarin and warfarin as determined by time in therapeutic range (TTR). In t...

journal_title：Thrombosis and haemostasis

authors： Whitlock RP,Fordyce CB,Midei MG,Ellis D,Garcia D,Weitz JI,Canafax DM,Albrecht D,Milner PG

更新日期：2016-08-01 00:00:00

abstract：:Patients with inflammatory bowel disease (IBD) are at higher risk of venous thromboembolism and coronary artery disease despite having a lower burden of traditional risk factors. Platelets from IBD patients release more soluble CD40 ligand (CD40L), and this has been implicated in IBD platelet hyper-activation. We here...

journal_title：Thrombosis and haemostasis

authors： Di Sabatino A,Santilli F,Guerci M,Simeone P,Ardizzone S,Massari A,Giuffrida P,Tripaldi R,Malara A,Liani R,Gurini E,Aronico N,Balduini A,Corazza GR,Davì G

更新日期：2016-08-30 00:00:00

abstract：:Findings from a recent study suggest that earlier start of treatment with factor VIII in patients with severe hemophilia is associated with a higher risk to develop inhibitors. We set out to assess the association between age of first administration of clotting factor VIII and the risk to develop inhibitors in infants...

journal_title：Thrombosis and haemostasis

authors： van der Bom JG,Mauser-Bunschoten EP,Fischer K,van den Berg HM

更新日期：2003-03-01 00:00:00

abstract：:Oxidative modification of LDL, which dysregulates the homeostasis between blood and vascular cells, and alterations of endothelial function are considered among the early events in the pathogenesis of atherosclerosis. This study was designed to evaluate the impact of progressive LDL oxidation on the thrombotic respons...

journal_title：Thrombosis and haemostasis

authors： Banfi C,Camera M,Giandomenico G,Toschi V,Arpaia M,Mussoni L,Tremoli E,Colli S

更新日期：2003-03-01 00:00:00

abstract：:A complex of heparin and a quaternary ammonium compound dissolved in an organic solvent was investigated for its potential ability to prevent clotting on the surface of plastic catheters. Despite the complexing of heparin to ammonium, anticoagulant activity remained on in vitro testing. Both the heparin complex and it...

journal_title：Thrombosis and haemostasis

authors： Evans RW,Pasmantier MW,Coleman M,Wagner FS,Flair RC

更新日期：1979-05-25 00:00:00

abstract：:Transplant-associated thrombotic microangiopathy (TA-TMA) is a severe and life-threatening complication of hematopoietic cell transplantation (HCT) that often coincides with graft-versus-host-disease (GVHD). Although endothelial damage seems to be the common denominator for both disorders, the role of complement syste...

journal_title：Thrombosis and haemostasis

authors： Gavriilaki E,Chrysanthopoulou A,Sakellari I,Batsis I,Mallouri D,Touloumenidou T,Papalexandri A,Mitsios A,Arampatzioglou A,Ritis K,Brodsky RA,Mitroulis I,Anagnostopoulos A

更新日期：2019-09-01 00:00:00

abstract：:The recombinant plasminogen activator BM 06.022 consists of the kringle 2 and the protease domains of human t-PA and is unglycosylated because of the expression in Escherichia coli. The thrombolytic and pharmacokinetic properties as well as the hemostasis effects of BM 06.022 were investigated in the rabbit model of j...

journal_title：Thrombosis and haemostasis

authors： Martin U,Fischer S,Kohnert U,Opitz U,Rudolph R,Sponer G,Stern A,Strein K

更新日期：1991-05-06 00:00:00

abstract：:Nipah virus (NiV) is a highly pathogenic paramyxovirus that was first isolated in 1999 during an outbreak in Malaysia. In contrast to other paramyxoviruses NiV infects many mammalian species. Because of its zoonotic potential, the high pathogenicity and the lack of therapeutic treatment, NiV was classified as a biosaf...

journal_title：Thrombosis and haemostasis

authors： Maisner A,Neufeld J,Weingartl H

更新日期：2009-12-01 00:00:00