Abstract：
:ADAMTS13 dysfunction has been involved in the pathogenesis of Thrombotic Thrombocytopenic Purpura. This disorder occurs more frequently in women and, in 13% of them, is associated with pregnancy. However, there is little information on the protease behaviour in normal pregnancy. We studied von Willebrand factor and ADAMTS13 activity changes in normal non-pregnant, pregnant and post-delivery women. Fifty-five non-pregnant women, normal blood bank donors, who were not taking contraceptive pills were included as controls. A prospective cross-sectional study of 270 normal pregnant and post-delivery women was carried out. ADAMTS13 activity decreased progressively as from the period of 12-16 weeks up to the end of early puerperium (mean 52%, range 22-89, p < 0.0001), to increase slightly thereafter. Nulliparous presented mildly lower levels of ADAMTS13 activity than parous women (65% vs. 83 %, p = 0.0003), and primigravidae than multigravidae between 6-11 weeks up to 17-23 weeks of pregnancy (69% vs. 80%, p = 0.005). Although in all women the protease levels were the same by blood groups, the O blood group non-pregnant women showed a higher mean of ADAMTS13 activity than those non-O (78% vs. 69%, p = 0.064). Our results suggest that the changing levels of protease activity during pregnancy and puerperium, induced by unidentified mechanisms, could render the peripartum time more vulnerable to developed thrombotic microangiopathies.
journal_name
Thromb Haemostjournal_title
Thrombosis and haemostasisauthors
Sánchez-Luceros A,Farías CE,Amaral MM,Kempfer AC,Votta R,Marchese C,Salviú MJ,Woods AI,Meschengieser SS,Lazzari MAdoi
10.1160/TH03-11-0683keywords:
subject
Has Abstractpub_date
2004-12-01 00:00:00pages
1320-6issue
6eissn
0340-6245issn
2567-689Xpii
04121320journal_volume
92pub_type
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journal_title：Thrombosis and haemostasis
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journal_title：Thrombosis and haemostasis
pub_type： 杂志文章,评审
doi：
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journal_title：Thrombosis and haemostasis
pub_type： 杂志文章
doi：
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journal_title：Thrombosis and haemostasis
pub_type： 杂志文章
doi：
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journal_title：Thrombosis and haemostasis
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journal_title：Thrombosis and haemostasis
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journal_title：Thrombosis and haemostasis
pub_type： 杂志文章
doi：
更新日期：1980-10-31 00:00:00
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journal_title：Thrombosis and haemostasis
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journal_title：Thrombosis and haemostasis
pub_type： 杂志文章
doi：
更新日期：1985-08-30 00:00:00
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journal_title：Thrombosis and haemostasis
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doi：
更新日期：1996-11-01 00:00:00
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journal_title：Thrombosis and haemostasis
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journal_title：Thrombosis and haemostasis
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doi：
更新日期：1979-05-25 00:00:00
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journal_title：Thrombosis and haemostasis
pub_type： 杂志文章
doi：
更新日期：1977-08-31 00:00:00
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journal_title：Thrombosis and haemostasis
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更新日期：1988-10-31 00:00:00
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journal_title：Thrombosis and haemostasis
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更新日期：1996-09-01 00:00:00
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journal_title：Thrombosis and haemostasis
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journal_title：Thrombosis and haemostasis
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更新日期：1998-10-01 00:00:00
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journal_title：Thrombosis and haemostasis
pub_type： 杂志文章,多中心研究,随机对照试验
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journal_title：Thrombosis and haemostasis
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doi：
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