Antipsychotic and antidepressant drug use in the elderly and the risk of venous thromboembolism.

abstract：:The structural and functional properties of plasma and platelet vWF were studied in 8 patients (5 unrelated families) with vWD demonstrating a mutation at position 611 (R611C or R611H). Following reduction, electrophoresis and immunoblotting with a polyclonal anti-reduced vWF antibody, abnormal proteolysis of vWF was ...

journal_title：Thrombosis and haemostasis

authors： Nishikubo T,Christophe O,Lavergne JM,Obert B,Nonami K,Takahashi Y,Yoshioka A,Meyer D,Girma JP

更新日期：1997-01-01 00:00:00

abstract：:Tissue plasminogen activator (tPA) activity in blood and blood plasma has been difficult to determine because it is unstable, especially in subjects with high levels of plasminogen activator inhibitor type 1 (PAI-1). We have attempted to stabilize the tPA activity by collecting 9 volumes of blood in 1 volume acidic ci...

journal_title：Thrombosis and haemostasis

authors： Rånby M,Sundell IB,Nilsson TK

更新日期：1989-11-24 00:00:00

abstract：:Activated protein C resistance is in almost all cases caused by the factor V Leiden mutation (FV:R506Q). Due to the high prevalence and clinical significance of the mutation reliable methods suited for processing large sets of samples are in demand. We here present the oligonucleotide ligation assay (OLA) with lanthan...

journal_title：Thrombosis and haemostasis

authors： Chakravarty A,Hansen TS,Hørder M,Kristensen SR

更新日期：1997-10-01 00:00:00

abstract：:FPA level, fibrinogen turnover rate, and fibrinolytic activity were studied on 18 patients with malignant disease. It was found that the FPA levels were significantly elevated and were correlated with fibrinogen turnover rate (r = 0.74, p less than 0.001) and FDP (r - 0.58, p less than 0.02). Estimated FPA turnover ra...

journal_title：Thrombosis and haemostasis

authors： Yoda Y,Abe T

更新日期：1981-12-23 00:00:00

abstract：:Platelet-leukocyte interactions are recognised to have pro-inflammatory effects, which may be important in the pathophysiology of ischaemic heart disease. Clopidogrel and the novel intravenous antithrombotic agent AR-C69931MX act at the level of the platelet P2Y12 receptor, which is known to amplify platelet activatio...

journal_title：Thrombosis and haemostasis

authors： Storey RF,Judge HM,Wilcox RG,Heptinstall S

更新日期：2002-09-01 00:00:00

abstract：:Hemorrhagic diathesis was observed in patients with renal insufficiency after carbenicillin at serum levels greater than 300 mug/ml. Normal coagulation factors (F. I, II, V, VII, VIII, X), normal PTT, normal platelet counts, negative ethanol gelation test (fibrin monomers) were found as well as a prolongation of throm...

journal_title：Thrombosis and haemostasis

authors： Andrassy K,Weischedel E,Ritz E,Andrassy T

更新日期：1976-08-31 00:00:00

abstract：:The A4070G polymorphism in exon 13 of the factor V (FV) gene, which replaces His by Arg at position 1299 of the B domain, was recently shown to influence circulating FV levels and to contribute to the activated protein C (APC) resistance phenotype. We examined the impact of this polymorphism in a population of unselec...

journal_title：Thrombosis and haemostasis

authors： Alhenc-Gelas M,Nicaud V,Gandrille S,van Dreden P,Amiral J,Aubry ML,Fiessinger JN,Emmerich J,Aiach M

更新日期：1999-02-01 00:00:00

abstract：:Growing evidence indicates that rheumatoid arthritis (RA) is associated with an increased risk for thromboembolic cardiovascular events. We investigated thrombin generation profiles in RA patients and their dependence on plasma factor/inhibitor composition. Plasma factor (F) compositions (II, V, VII, VIII, IX, X), ant...

journal_title：Thrombosis and haemostasis

authors： Undas A,Gissel M,Kwasny-Krochin B,Gluszko P,Mann KG,Brummel-Ziedins KE

更新日期：2010-08-01 00:00:00

abstract：:Hemin is a heme oxygenase-1 (HO-1) inducer which provides endogenous carbon monoxide known for playing roles in cell proliferation, inflammation or aggregation process. The objective of the current study was to examine the effect of prophylactic treatment with hemin in a thrombosis vascular model. Three groups of Wist...

journal_title：Thrombosis and haemostasis

authors： Desbuards N,Rochefort GY,Schlecht D,Machet MC,Halimi JM,Eder V,Hyvelin JM,Antier D

更新日期：2007-09-01 00:00:00

abstract：:[This corrects the article DOI: 10.1160/TH14-06-0547.]. ...

journal_title：Thrombosis and haemostasis

authors：

更新日期：2017-04-03 00:00:00

abstract：:Following the initial report of the clinical use of plasminogen activators (PAs) in cerebrovascular thrombosis in 1958, interest in the efficacy of this approach accelerated only when the need for acute intervention in stroke was recognized. The use of PAs in acute ischemic stroke is based on the observation that appr...

journal_title：Thrombosis and haemostasis

authors： del Zoppo GJ

更新日期：1997-07-01 00:00:00

abstract：:Today, direct oral anticoagulants (DOAC) are widely used alternatives to Vitamin-K antagonists (VKA). Women of reproductive age may become pregnant during anticoagulation and, while VKA carry an embryotoxic potential, the risk of DOAC embryopathy is unknown. As a result, some patients elect to terminate pregnancy for ...

journal_title：Thrombosis and haemostasis

authors： Beyer-Westendorf J,Michalski F,Tittl L,Middeldorp S,Cohen H,Abdul Kadir R,Arachchillage DJ,Arya R,Ay C,Marten S

更新日期：2016-09-27 00:00:00

abstract：:Tissue factor pathway inhibitor (TFPI) plays a crucial role in haemostasis by regulating TF-induced initiation of coagulation. Since it is expressed by endothelial and trophoblastic cells, TFPI is of particular importance at the placental level and might be involved in the occurrence of gestational vascular complicati...

journal_title：Thrombosis and haemostasis

authors： Ittel A,Bretelle F,Gris JC,Chau C,Sébahoun G,Boubli L,Arnoux D

更新日期：2011-01-01 00:00:00

abstract：:Isolated rat hepatocytes possess per cell 4,500 high-affinity binding sites for thrombin with a Kd of 30-40 pM, and 2.8 X 10(5) low-affinity sites with a Kd of 30 nM. These binding sites are highly specific for thrombin. Half-maximal binding of 125I-labelled thrombin is achieved after 3 min at 37 degrees C and 7 min a...

journal_title：Thrombosis and haemostasis

authors： Weyer B,Petersen TE,Sonne O

更新日期：1988-12-22 00:00:00

abstract：:Despite years of research and efforts to translate stroke research to clinical therapy, ischaemic stroke remains a major cause of death, disability, and diminished quality of life. Primary and secondary preventive measures combined with improved quality of care have made significant progress. However, no novel drug fo...

journal_title：Thrombosis and haemostasis

authors： Mosnier LO,Zlokovic BV,Griffin JH

更新日期：2014-11-01 00:00:00

abstract：:Tridegin is a potent inhibitor of factor XIIIa from the leech, Haementeria ghilianii, which inhibits protein cross-linking. It modifies plasmin-mediated fibrin degradation as shown by the absence of D-dimer and approximately halves the time for fibrinolysis. Plasma clots formed in the presence of Tridegin lyse more ra...

journal_title：Thrombosis and haemostasis

authors： Seale L,Finney S,Sawyer RT,Wallis RB

更新日期：1997-05-01 00:00:00

abstract：:The carboxy-terminal region of hirudin (residues 54-65) has previously been shown to inhibit thrombin clotting activity without binding to the catalytic site of the enzyme. In the present study, the effect of hirudin 54-65 on thrombin interaction with specified platelet proteins has been investigated. Hirudin 54-65 wa...

journal_title：Thrombosis and haemostasis

authors： Jandrot-Perrus M,Huisse MG,Krstenansky JL,Bezeaud A,Guillin MC

更新日期：1991-09-02 00:00:00

abstract：:When compared to normal megakaryocytes, those from a patient with the giant platelet syndrome exhibited numerous cytochemical abnormalities. These reflected disturbances in the metabolism of RNA, glycogen, arginine-rich histone, and various glycolytic enzymes. Ultrastructural studies of the abnormal megakaryocytes als...

journal_title：Thrombosis and haemostasis

authors： Kass L,Leichtman DA,Beals TF,Schnitzer B

更新日期：1977-10-31 00:00:00

abstract：:MYH9-related disease ( MYH9-RD) is an autosomal dominant thrombocytopenia with giant platelets variably associated with young-adult onset of progressive sensorineural hearing loss, presenile cataract, and renal damage. MYH9-RD is caused by mutations of MYH9 , the gene encoding for non-muscle heavy-chain myosin-9. Wild...

journal_title：Thrombosis and haemostasis

authors： Savoia A,De Rocco D,Panza E,Bozzi V,Scandellari R,Loffredo G,Mumford A,Heller PG,Noris P,De Groot MR,Giani M,Freddi P,Scognamiglio F,Riondino S,Pujol-Moix N,Fabris F,Seri M,Balduini CL,Pecci A

更新日期：2010-04-01 00:00:00

abstract：:The pathogenesis of abdominal aortic aneurysm (AAA) involves a central component of chronic inflammation which is predominantly mediated by myeloid cells. We hypothesized that the local inflammatory activity may be reflected in systemic alterations of neutrophil and monocyte populations as well as in soluble factors o...

journal_title：Thrombosis and haemostasis

authors： Zagrapan B,Eilenberg W,Prausmueller S,Nawrozi P,Muench K,Hetzer S,Elleder V,Rajic R,Juster F,Martelanz L,Hayden H,Klopf J,Inan C,Teubenbacher P,Weigl MP,Kirchweger P,Beitzke D,Jilma B,Wojta J,Bailey MA,Scott DJA,

更新日期：2019-05-01 00:00:00

abstract：BACKGROUND:Prospective studies on the incidence of thrombosis in asymptomatic individuals with hereditary protein C- or protein S deficiency have not been performed so far. OBJECTIVE:We have carried out a prospective cohort study in 44 asymptomatic protein C- and protein S deficient subjects and in 49 asymptomatic non...

journal_title：Thrombosis and haemostasis

authors： Pabinger I,Kyrle PA,Heistinger M,Eichinger S,Wittmann E,Lechner K

更新日期：1994-04-01 00:00:00

abstract：:We investigated the presence of the gene mutation of factor V, FV R506Q or factor V Leiden, responsible for activated protein C resistance, in DNA samples of 127 probands and 188 relatives from 128 families with antithrombin deficiency. The factor V mutation was identified in 18 families. Nine families were available ...

journal_title：Thrombosis and haemostasis

authors： van Boven HH,Reitsma PH,Rosendaal FR,Bayston TA,Chowdhury V,Bauer KA,Scharrer I,Conard J,Lane DA

更新日期：1996-03-01 00:00:00

abstract：:In order to investigate the reported heterogeneity of commercial heparin injections, lung and mucous preparations were fractionated by gel chromatography according to molecular size. Eluent pools were characterized by measuring electrophoretic mobility, anticoagulant activity using a reactivation assay and an anti-Xa ...

journal_title：Thrombosis and haemostasis

authors： Graham DT,Pomeroy AR

更新日期：1980-02-29 00:00:00

abstract：:Undoubtedly, platelets are key elements in the regulation of thrombosis and haemostasis. Along with their primary task to prevent blood loss from injured vessels, platelets have emerged as regulators of a variety of processes in the vasculature. Multiple challenges, from the contact and adhesion to subendothelial matr...

journal_title：Thrombosis and haemostasis

authors： von Hundelshausen P,Petersen F,Brandt E

更新日期：2007-05-01 00:00:00

abstract：:An assay of human antiplasmins has been developed utilizing radial diffusion of plasma from wells cut in plasmin-enriched, fibrinogen-agarose plates. After diffusion the fibrinogen is clotted. Zones of fibrin protected from background fibrinolysis develop as the result of plasma antiplasmin activity. A pooled plasma s...

journal_title：Thrombosis and haemostasis

authors： Andes WA

更新日期：1978-04-30 00:00:00

abstract：:The antithrombotic effect of MCI-9042, (+-)-2-(dimethyl-amino)-1-((o-(m- methoxyphenethyl)phenoxyl]methyl]ethyl hydrogen succinate hydrochloride was investigated in three different experimental thrombosis models in animals. Simultaneous injection of serotonin and collagen into the tail vein in mice induced acute pulmo...

journal_title：Thrombosis and haemostasis

authors： Hara H,Kitajima A,Shimada H,Tamao Y

更新日期：1991-10-01 00:00:00

abstract：:A preliminary clinical trial was conducted to determine the feasibility of achieving and regulating therapeutic anticoagulation with heparin given by continuous subcutaneous infusion. Five patients with deep venous thrombosis confirmed by impedance plethysmography and/or venography were studied. All patients received ...

journal_title：Thrombosis and haemostasis

authors： Parrilla N,Ansell J

更新日期：1982-02-26 00:00:00

abstract：:In a placebo-controlled trial healthy volunteers and patients with hyperlipoproteinemias types II and IV received orally vitamin E at doses of 300 mg and 600 mg daily for 2 weeks. Serum tocopherol levels increased two-fold, but serum concentrations of total lipids, cholesterol, triglycerides, ceruloplasmin and transfe...

journal_title：Thrombosis and haemostasis

authors： Szczeklik A,Gryglewski RJ,Domagala B,Dworski R,Basista M

更新日期：1985-08-30 00:00:00

abstract：:Peripheral vascular disease (PVD) is an indicator of diffuse atherosclerosis and is associated with a greatly increased incidence of coronary heart and cerebrovascular disease. Although several studies have assessed whether in vivo platelet activation takes place in patients with PVD, no data are available comparing d...

journal_title：Thrombosis and haemostasis

authors： Gresele P,Catalano M,Giammarresi C,Volpato R,Termini R,Ciabattoni G,Nenci GG,Davì G

更新日期：1997-12-01 00:00:00

abstract：:In a group of 705 healthy middle-aged men, we have examined the relationship between plasma levels of Factor VII (FVII) c and Factor VII antigen (FVIIag) and two polymorphisms in the FVII gene. One polymorphism alters arginine at position 353 to glutamine (R/Q), and the other is the result of a 10 base pair (bp) inser...

journal_title：Thrombosis and haemostasis

authors： Humphries S,Temple A,Lane A,Green F,Cooper J,Miller G

更新日期：1996-04-01 00:00:00