Evaluation of recently described tests for detection of the lupus anticoagulant.

Abstract:

:It is known that lupus anticoagulants (LA) are antibodies which interfere with phospholipid-dependent coagulation tests, but due to the heterogeneity of LA and the differences in sensitivity of reagents and tests, the diagnosis of LA remains difficult. Recently, Triplett et al. (26) have proposed a new test based on two venoms, Textarin (T) and Ecarin (E), that activate prothrombin but differ in their phospholipid requirements. By testing this new assay we have evaluated 36 patient plasmas containing LA according to standard tests (activated partial thromboplastin time, dilute Russell viper venom time and platelet neutralization procedure) and our results confirm a high sensitivity for LA of the T/E test. In addition, we observed a greater sensitivity of the tissue thromboplastin inhibition test using a recombinant thromboplastin instead of a human placenta thromboplastin. Our study also showed that the T/E test seems to be a useful assay in confirming the diagnosis of LA in patients with an unexplained prolonged APTT.

journal_name

Thromb Haemost

authors

Forastiero RR,Cerrato GS,Carreras LO

subject

Has Abstract

pub_date

1994-11-01 00:00:00

pages

728-33

issue

5

eissn

0340-6245

issn

2567-689X

journal_volume

72

pub_type

杂志文章
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    pub_type: 杂志文章

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    authors: Hourdillé P,Fialon P,Belloc F,Namur M,Boisseau MR,Nurden AT

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  • Flow cytometric analysis of circulating platelet-monocyte aggregates in whole blood: methodological considerations.

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    journal_title:Thrombosis and haemostasis

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    authors: Harding SA,Din JN,Sarma J,Jessop A,Weatherall M,Fox KA,Newby DE

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  • All-Cause Mortality Risk with Direct Oral Anticoagulants and Warfarin in the Primary Treatment of Venous Thromboembolism.

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    pub_type: 杂志文章

    doi:

    authors: Chediak J,Eldridge J,Bergmann F,Sobel D,Baron J,Maxey B,Telfer MC

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  • Clinical use of a rapid collagen binding assay for von Willebrand factor cleaving protease in patients with thrombotic thrombocytopenic purpura.

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    authors: Rick ME,Moll S,Taylor MA,Krizek DM,White GC 2nd,Aronson DL

    更新日期:2002-10-01 00:00:00

  • The frequency of type I heterozygous protein S and protein C deficiency in 141 unrelated young patients with venous thrombosis.

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    authors: Gladson CL,Scharrer I,Hach V,Beck KH,Griffin JH

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  • Molecular mechanism and classification of von Willebrand disease.

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    journal_title:Thrombosis and haemostasis

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    doi:

    authors: Sadler JE,Matsushita T,Dong Z,Tuley EA,Westfield LA

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  • Effect of Additional Treatments Combined with Conventional Therapies in Pregnant Patients with High-Risk Antiphospholipid Syndrome: A Multicentre Study.

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    pub_type: 杂志文章,多中心研究

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    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

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    authors: Balleisen L,Assmann G,Bailey J,Epping PH,Schulte H,van de Loo J

    更新日期:1985-10-30 00:00:00

  • Low levels of the anticoagulant activity of protein C in patients with chronic renal insufficiency: an inhibitor of protein C is present in uremic plasma.

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    doi:

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    doi:

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    更新日期:2018-12-01 00:00:00

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    doi:

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    doi:

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    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

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    doi:

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