Abstract:
:The role of gamma-aminobutyric acid (GABA) in the regulation of gonadotropin hormone-releasing hormone (GnRH) release was studied using rat hypothalamic slices in vitro. Perifusion with GABA (10(-8)-10(-4) M) caused a dose-dependent increase in GnRH release. The GABAA receptor agonist isoguvacine (10(-5) M) also stimulated GnRH release, whereas the GABAB agonist baclofen (10(-6) M) had no effect. The specific GABAA antagonist SR95103 (10(-6) M) caused a reduction of basal GnRH release and completely blocked that induced by GABA (10(-4) M). When nerve transmission was blocked with tetrodotoxin (TTX, 10(-6) M), GnRH release was slightly reduced but the stimulatory effects of both GABA and isoguvacine were abolished. The GABA-induced stimulation of GnRH release was also prevented when the hypothalamic slices were treated with a corticotropin releasing hormone (CRH) antagonist (alpha-helical CRF9-41, 10(-6) M) or the opioid antagonist naloxone (10(-6) M). Treatment with CRH (10(-8) M) resulted in a decrease in GnRH release and this effect was not reversed in the presence of GABA. Finally, GABA was found to stimulate the release of the opioid peptides beta-endorphin, dynorphin and met-enkephalin. These results lead us to conclude that GABA exerts two opposing effects upon GnRH neuronal activity: it acts in an inhibitory fashion at GnRH nerve terminals and in a stimulatory fashion at GnRH perikarya; the latter might occur through GABAergic inhibition of CRH release and, therefore, of opioid peptide release. Lastly, all the effects of GABA upon GnRH release appear to be mediated through GABAA receptors.
journal_name
Brain Res Bulljournal_title
Brain research bulletinauthors
Nikolarakis KE,Loeffler JP,Almeida OF,Herz Adoi
10.1016/0361-9230(88)90208-0subject
Has Abstractpub_date
1988-10-01 00:00:00pages
677-83issue
4eissn
0361-9230issn
1873-2747pii
0361-9230(88)90208-0journal_volume
21pub_type
杂志文章abstract::The expression of dopamine by primary sensory neurons and their peripheral projections was studied in the chick dorsal root ganglion by means of immunocytochemical procedures. Within the sensory neurons, dopamine immunoreactivity is first expressed by 0.8% of cells at E10 and reaches a percentage of 5.6% before hatchi...
journal_title:Brain research bulletin
pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Brain research bulletin
pub_type: 杂志文章
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更新日期:1987-09-01 00:00:00
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更新日期:1984-01-01 00:00:00
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更新日期:2007-03-15 00:00:00
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pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1997-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:1995-01-01 00:00:00
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更新日期:1988-10-01 00:00:00
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更新日期:1983-03-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(88)90133-5
更新日期:1988-04-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
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更新日期:1988-06-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
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更新日期:1997-01-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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