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Sensitivity of lateral hypothalamic neurons to glycemic level: possible involvement of an indirect adrenergic mechanism.

Abstract：

:Most of the lateral hypothalamic neurons responding to moderate changes in blood glucose fail to be affected by direct glucose applications. Therefore their sensitivity to glycemic level must be mediated by an indirect mechanism. In order to test whether adrenergic afferents might be involved, the activity of lateral hypothalamic neurons was recorded during hyperglycemia and local glucose and epinephrine microiontophoresis. A majority of the recorded cells sensitive to local epinephrine responded to this substance with a decrease in activity. While no consistent correspondence was found between the responses of the same cells to local glucose and epinephrine ejections, almost all the neurons sensitive to glycemic alterations responded in the same direction to hyperglycemia and iontophorised epinephrine. These results support the view that the activity of lateral hypothalamic cells can be modulated in relation to changes in glycemic level through adrenergic signals released by some neurons which are sensitive to the blood glucose. The possible localization in the solitary tract area of such neurons projecting to the lateral hypothalamus is discussed.

journal_name

Brain Res Bull

journal_title

Brain research bulletin

authors

Orsini JC,Wiser AK,Himmi T,Boyer A,Perrin J

doi

10.1016/0361-9230(91)90086-y

subject

Has Abstract

pub_date

1991-04-01 00:00:00

pages

473-8

issue

4

eissn

0361-9230

issn

1873-2747

pii

0361-9230(91)90086-Y

journal_volume

26

pub_type

杂志文章

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