Abstract：
:Regenerative medicine strategies rely on exogenous cell transplantation and/or endogenous cell stimulation. Biomaterials can help to increase the regenerative potential of cells and biomolecules by controlling transplanted cell fate and provide a local, sustained release of biomolecules. In this review, we describe the use of a hyaluronan/methylcellulose (HAMC)-based hydrogel as a delivery vehicle to the brain, spinal cord, and retina to promote cellular survival and tissue repair. We discuss various controlled release strategies to prolong the delivery of factors for neuroprotection. The versatility of this hydrogel for a diversity of applications highlights its potential to enhance cell- and biomolecule-based treatment strategies.
journal_name
Brain Res Bulljournal_title
Brain research bulletinauthors
Ho MT,Teal CJ,Shoichet MSdoi
10.1016/j.brainresbull.2019.03.005subject
Has Abstractpub_date
2019-05-01 00:00:00pages
46-54eissn
0361-9230issn
1873-2747pii
S0361-9230(19)30023-1journal_volume
148pub_type
杂志文章,评审abstract：:Sleepiness and driving is a dangerous combination that causes thousands of crashes each year resulting in injury and death. In the last few years, driving simulators have been used to study the performance decrements associated with drowsiness. We correlated performances of a driving simulation task in healthy volunte...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/j.brainresbull.2003.12.015
更新日期：2004-06-30 00:00:00
abstract：:In female rats, stimulation of the uterine cervix during mating induces two daily surges of prolactin. Inhibition of hypothalamic dopamine release and stimulation of oxytocin neurons in the paraventricular nucleus (PVN) are required for prolactin secretion. We aim to better understand how stimulation of the uterine ce...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/j.brainresbull.2012.06.004
更新日期：2012-09-01 00:00:00
abstract：:The labelling of hypothalamic binding sites by [125I]-FK, a specific mu-opioid receptor ligand, was studied in female C57BL/6J mice to test whether removal of ovarian steroids affected the density of distribution of receptor binding. Labelling densities in the forebrain of normally cycling (intact) females (N = 12), w...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/0361-9230(93)90093-q
更新日期：1993-01-01 00:00:00
abstract：:Neuronal nitric oxide synthase (nNOS) has been reported to be up-regulated in the hypothalamic supraoptic nucleus (SON) during dehydration which in turn could increase nitric oxide (NO) production and consequently affect arginine vasopressin (AVP) secretion. The anteroventral third ventricle (AV3V) region has strong a...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/j.brainresbull.2011.07.020
更新日期：2011-10-10 00:00:00
abstract：:We have studied the molecular and cellular mechanisms underlying the acute and chronic effects of opiate on neurons of the rat locus coeruleus (LC). Acutely, opiates inhibit LC neurons by activating K+ channels and inhibiting a novel sodium-dependent inward current. Both of these actions are mediated via pertussis tox...
journal_title：Brain research bulletin
pub_type： 杂志文章,评审
doi：10.1016/0361-9230(94)90166-x
更新日期：1994-01-01 00:00:00
abstract：:Preprodynorphin and preproenkephalin are protein precursors from which are derived two classes of opioid neurotransmitter peptides. Dynorphin A((1-17)) is produced by proteolytic processing of prodynorphin, and processing of proenkephalin yields the enkephalin peptides. We report here on the isolation and sequencing o...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/j.brainresbull.2004.01.008
更新日期：2004-03-15 00:00:00
abstract：:Massively obese males often show symptoms of hypogonadism, but the mechanism for this is unclear. Increased endogenous opioid inhibition of the hypothalamic GnRH pulse generator resulting in insufficient stimulation of the pituitary gonadotroph has been proposed as a possible mechanism. If this hypothesis is correct, ...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/0361-9230(94)90142-2
更新日期：1994-01-01 00:00:00
abstract：:Methylphenidate (MPD) is a widely prescribed psychostimulants used for the treatment of attention deficit hyperactive disorder (ADHD). Unlike the psychostimulants cocaine and amphetamine, MPD does not exhibit direct actions on the serotonin transporter, however there is evidence suggesting that the therapeutic effects...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/j.brainresbull.2016.10.011
更新日期：2017-01-01 00:00:00
abstract：:Cerebral malaria (CM) is the severe neurological complication associated with Plasmodium falciparum infection. In clinical settings CM is predominantly characterized by fever, epileptic seizures, and asexual forms of parasite on blood smears, coma and even death. Cognitive impairment in the children and adults even af...
journal_title：Brain research bulletin
pub_type： 杂志文章,评审
doi：10.1016/j.brainresbull.2020.01.020
更新日期：2020-04-01 00:00:00
abstract：:Windup, the frequency dependent build-up of spinal neuronal responses is an electrophysiological model of the development of the central sensitization in the chronic pain states. NR2B subunit containing NMDA-type glutamate receptors are implicated in the windup of dorsal horn neurons, while their role at the motoneuro...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/j.brainresbull.2004.06.002
更新日期：2004-08-30 00:00:00
abstract：:The direct monosynaptic pathway which exists between vasoactive intestinal peptide (VIP) and GnRH neurons in the hypothalamic preoptic area provides a neuroanatomical background for the modulatory effects of VIP exerted on GnRH neurons activity. Though central microinjection of VIP revealed its involvement in the modu...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/j.brainresbull.2005.07.007
更新日期：2005-10-30 00:00:00
abstract：:Astrocytes are key active elements of the brain that contribute to information processing. They not only provide neurons with metabolic and structural support, but also regulate neurogenesis and brain wiring. Furthermore, astrocytes modulate synaptic activity and plasticity in part by controlling the extracellular spa...
journal_title：Brain research bulletin
pub_type： 杂志文章,评审
doi：10.1016/j.brainresbull.2017.02.001
更新日期：2018-01-01 00:00:00
abstract：:Intra-arterial administration of papaverine has been revealed to cause an increase in the blood-brain tumor barrier (BTB) permeability. The exact mechanism of papaverine opening the BTB in chemotherapy of malignant cerebral tumors, however, has not been well described. We used a rat brain glioma (C6) model for studyin...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/j.brainresbull.2010.08.009
更新日期：2010-11-20 00:00:00
abstract：:The antidepressant desipramine has been shown to decrease synaptic membrane concentrations of the norepinephrine re-uptake transporter (NET) in vivo and in vitro, on both an acute and a chronic basis. The possible contribution of decreased NET synthesis to the chronic downregulation of the NETs has not been definitive...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/s0361-9230(99)00063-5
更新日期：1999-07-01 00:00:00
abstract：:The present study examined the changes of extracellular concentration of dopamine and its metabolite homovanillic acid in the striatum, the periaqueductal gray and the dorsal horn of lumbar spinal cord following intraplantar injection of carrageenan. In vivo microdialysis and high-performance liquid chromatography wit...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/s0361-9230(00)00460-3
更新日期：2001-03-01 00:00:00
abstract：:Klotho, which is a life extension factor, and erythropoietin (EPO) have been introduced as effective neuroprotective factors in several neurological disorders. The present study is an attempt to examine the potential role of klotho and EPO in therapeutic effect of curcumin-loaded nanoparticles (NPs) in pentylenetetraz...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/j.brainresbull.2018.08.010
更新日期：2018-09-01 00:00:00
abstract：:Nicotinic acetylcholine (ACh) and dopamine (DA) receptor activation has been found to be important for working memory. The regional distribution of these receptors in the brain has been well characterized. However, the relationship of the region-specific nicotinic ACh and DA binding density to memory performance has n...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/s0361-9230(97)00009-9
更新日期：1997-01-01 00:00:00
abstract：:Ouabain, tetrodotoxin, and calcium selective ionophore (A23187) were administered bilaterally into the hypothalamus of the unrestrained, fully conscious cat, while body temperature and other indicators of thermoregulatory responses were monitored continuously. Posterior hypothalamic microinjection of 2.0 to 10.0 ng or...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/0361-9230(80)90286-5
更新日期：1980-01-01 00:00:00
abstract：:We carried out a study to establish ribonucleic acid (RNA) content in the nucleus and cytoplasm of single neuronal cells from the dorsal lateral geniculate nucleus (dLGN) of 3-30 month-old rats. Mean RNA content was calculated as the product of RNA concentration and nuclear or cytoplasmic surface. The analysis of neur...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/s0361-9230(98)00015-x
更新日期：1998-06-01 00:00:00
abstract：:Dorsal lateral geniculate nucleus (dLGN) multiple-unit activity (MUA) and single visual evoked responses (VER) followed by afterdischarge (AD) were examined in lightly restrained albino rats. It was found that VER AD spike components are initially quite prominent, exceeding at times the amplitude of the broad surface ...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/0361-9230(81)90102-7
更新日期：1981-07-01 00:00:00
abstract：:Results using radial mazes suggest rats may have a greater short-term memory (STM) capacity than the human "magical number seven." We examined spatial STM in humans using a radial maze analog drawn on paper. Subjects were instructed to lift, in "random" order, each of 17 cardboard flaps arranged radially around a cent...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/0361-9230(93)90058-j
更新日期：1993-01-01 00:00:00
abstract：:The effects of intracerebroventricular (ICV) colchicine (70 micrograms per rat) on systolic pressures and levels of hexokinase activity in the hypothalamic paraventricular (PVH) and supraoptic (SON) nuclei were investigated in adult normotensive and spontaneously hypertensive rats (SHR). One day after colchicine injec...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/0361-9230(89)90162-7
更新日期：1989-07-01 00:00:00
abstract：:Vesicular glutamate transporter (VGLUT) 1 and VGLUT2 have been reported to distribute complementally in most brain regions and have been assumed to define distinct functional elements. Previous studies have shown the expression of VGLUT1 mRNA and VGLUT2 mRNA in the lateral reticular nucleus (LRN), a key precerebellar ...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/j.brainresbull.2020.06.008
更新日期：2020-09-01 00:00:00
abstract：:Previously we have shown that systemic injection of adenosine antagonists can significantly improve cold tolerance in both rats and humans. However, it is not clear whether systemic administration of adenosine antagonist acts peripherally or centrally at the thermoregulatory site. To resolve this, theophylline (nonsel...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/0361-9230(90)90094-g
更新日期：1990-03-01 00:00:00
abstract：:Medial preoptic axons were traced into the diagonal band of Broca and septum, particularly lateral septum. Other labeled fibers could be followed dorsally from medial preoptic area injections adjacent to the stria medullaris, and in the periventricular fiber system and the stria terminalis and its bed nucleus. The ant...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/0361-9230(80)90167-7
更新日期：1980-05-01 00:00:00
abstract：:A biotinylated oligonucleotide probe was used to demonstrate the presence in the heart of the portion of the proopiomelanocortin messenger RNA which contains the sequence for beta-endorphin. The probe indicated the presence of beta-endorphin messenger RNA in cardiac tissue and specifically in the cardiac muscle cell. ...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/0361-9230(92)90045-y
更新日期：1992-03-01 00:00:00
abstract：:Endogenous pyrogen (EP), injected systemically or intracerebrally, evokes fever and certain changes in plasma trace metal and glycoprotein levels which are characteristic of the acute-phase reaction. It is generally assumed that EP enters the brain from the blood, although it has not yet been demonstrated that EP cros...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/0361-9230(83)90124-7
更新日期：1983-11-01 00:00:00
abstract：:The effects of two indirect (dexfenfluramine and fluoxetine) and one direct (RU 24969) serotonergic agonists on diet selection over a 12-hr period were examined. Rats were habituated to eat, during the dark period, from two isoenergetic diets that differed in carbohydrate and protein content. Drugs were injected intra...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/0361-9230(90)90130-r
更新日期：1990-06-01 00:00:00
abstract：:The present study in piglets was designed to examine cerebrovascular effects of tumor necrosis factor-alpha (TNF alpha) and potential mechanisms involved. Anesthetized new-born pigs with closed cranial windows implanted were used. Effects of nitric oxide synthase (NOS) inhibitors, NG-nitro-L-arginine (L-NNA) and amino...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/0361-9230(95)02142-6
更新日期：1996-01-01 00:00:00
abstract：:An animal with an unimpaired "reference" memory can distinguish between alternatives that belong to a rewarded set and those that are unrewarded. An animal with an unimpaired "working" memory can distinguish between alternatives where it has been rewarded (e.g., food has been eaten and not replaced) and those where it...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/0361-9230(81)90086-1
更新日期：1981-08-01 00:00:00
