Abstract：
:Basal-like breast cancer (BLBC) is associated with a poor clinical outcome due to the few treatment options and absence of effective targeted agents. Here, we show that malic enzyme 1 (ME1) is dramatically upregulated in BLBC due to ME1 copy number amplification. ME1 expression increases glucose uptake and lactate production, and reduces oxygen consumption, leading to aerobic glycolysis. ME1 expression promotes, whereas knockdown of ME1 expression suppresses tumorigenicity. In breast cancer patients, ME1 expression is positively correlated with large tumor size, high grade, poor survival, and chemotherapy resistance. Our study not only contributes to a new understanding of how metabolic reprogramming contributes to BLBC progression, but also provides a potential prognostic marker and therapeutic target for this challenging disease.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Liao R,Ren G,Liu H,Chen X,Cao Q,Wu X,Li J,Dong Cdoi
10.1038/s41598-018-35106-ysubject
Has Abstractpub_date
2018-11-13 00:00:00pages
16743issue
1issn
2045-2322pii
10.1038/s41598-018-35106-yjournal_volume
8pub_type
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pub_type： 杂志文章
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pub_type： 杂志文章
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pub_type： 杂志文章
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pub_type： 杂志文章
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pub_type： 杂志文章
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pub_type： 已发布勘误
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更新日期：2020-02-18 00:00:00
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journal_title：Scientific reports
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journal_title：Scientific reports
pub_type： 杂志文章
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journal_title：Scientific reports
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