Metabolomic Response of Skeletal Muscle to Aerobic Exercise Training in Insulin Resistant Type 1 Diabetic Rats.

abstract：:The nonbiodegradability nature of heavy metals renders them resident in food chain and subsequently, destructing the entire ecosystem. Therefore, this study aimed to employ nitrate reduction-driven calcium carbonate precipitation in remediation of lead and mercury aerobically and anaerobically by Proteus mirabilis 10B...

journal_title：Scientific reports

authors： Eltarahony M,Zaki S,Abd-El-Haleem D

更新日期：2020-03-04 00:00:00

abstract：:We present a new general facile strategy for the preparation of protein-functionalized QDs in a single step at ambient conditions. We demonstrated that highly luminescent red to near-infrared (NIR) protein-functionalized QDs could be synthesized at room temperature in one second through a one-pot reaction that proceed...

journal_title：Scientific reports

authors： He X,Gao L,Ma N

更新日期：2013-10-02 00:00:00

abstract：:Er(3+) doped oxyfluoride tellurite glasses have been prepared. Three Judd-Ofelt parameters Ωt (t=2, 4, 6) and radiative properties are calculated for prepared glasses. Emission characteristics are analyzed and it is found that prepared glasses possess larger calculated predicted spontaneous transition probability (39....

journal_title：Scientific reports

authors： Chen F,Wei T,Jing X,Tian Y,Zhang J,Xu S

更新日期：2015-06-02 00:00:00

abstract：:Current diagnostic tests for tuberculosis (TB) are not able to predict reactivation disease progression from latent TB infection (LTBI). The main barrier to predicting reactivation disease is the lack of our understanding of host biomarkers associated with progression from latent infection to active disease. Here, we ...

journal_title：Scientific reports

authors： Petrilli JD,Araújo LE,da Silva LS,Laus AC,Müller I,Reis RM,Netto EM,Riley LW,Arruda S,Queiroz A

更新日期：2020-12-16 00:00:00

abstract：:ATP depletion and succinate accumulation during ischemia lead to oxidative damage to mammalian organs upon reperfusion. In contrast, freshwater turtles survive weeks of anoxia at low temperatures without suffering from oxidative damage upon reoxygenation, but the mechanisms are unclear. To determine how turtles surviv...

journal_title：Scientific reports

authors： Bundgaard A,James AM,Gruszczyk AV,Martin J,Murphy MP,Fago A

更新日期：2019-02-26 00:00:00

abstract：:CD4+latency-associated peptide (LAP)+ T cells are a newly discovered T cell subset with suppressive function on immune responses. In this study, we investigate the role of CD4+LAP+ T cells on mice corneal allograft survival by down-regulating their expression using anti-LAP mAb. We show that a blockage of LAP leads to...

journal_title：Scientific reports

authors： Li S,Lu H,Sella R,Zhang W,Dong H,Guo C,Afshari NA,Pan Z,Jie Y

更新日期：2018-05-22 00:00:00

abstract：:Neutrophil gelatinase-associated lipocalin (NGAL) is involved in cardiovascular and renal diseases. Gene inactivation of NGAL blunts the pathophysiological consequences of cardiovascular and renal damage. We aimed to design chemical NGAL inhibitors and investigate its effects in experimental models of myocardial infar...

journal_title：Scientific reports

authors： Bonnard B,Martínez-Martínez E,Fernández-Celis A,Pieronne-Deperrois M,Do QT,Ramos I,Rossignol P,Zannad F,Mulder P,Ouvrard-Pascaud A,López-Andrés N,Jaisser F

更新日期：2021-01-28 00:00:00

abstract：:Bats are the only mammals capable of true, powered flight, which drives an extremely high metabolic rate. The "Free Radical Theory of Ageing" (FTRA) posits that a high metabolic rate causes mitochondrial heteroplasmy and the progressive ageing phenotype. Contrary to this, bats are the longest-lived order of mammals gi...

journal_title：Scientific reports

authors： Jebb D,Foley NM,Whelan CV,Touzalin F,Puechmaille SJ,Teeling EC

更新日期：2018-09-11 00:00:00

abstract：:Orexins are originally characterized as orexigenic hypothalamic neuropeptides in mammals. Subsequent studies found orexin to be expressed and perform pleiotropic functions in multiple tissues in mammals. In avian (non-mammalian) species, however, orexin seemed to not affect feeding behavior and its physiological roles...

journal_title：Scientific reports

authors： Greene ES,Zampiga M,Sirri F,Ohkubo T,Dridi S

更新日期：2020-11-05 00:00:00

abstract：:Assessment of intraventricular pressure gradients (IVPG) using color Doppler M-mode echocardiography has gained increasing interest in the evaluation of cardiac function. However, standardized analysis tools for IVPG quantification are missing. We aimed to evaluate the feasibility, the test-retest observer reproducibi...

journal_title：Scientific reports

authors： Hodzic A,Bonnefous O,Langet H,Hamiche W,Chaufourier L,Tournoux F,Milliez P,Normand H,Saloux E

更新日期：2020-04-28 00:00:00

abstract：:In biological tissues, radiation causes the formation of reactive oxygen species (ROS), some of which lead to sequential oxidation of certain protein cysteine residues. Resultant cysteinyl radicals are subject to post-translational modification through S-glutathionylation. The present clinical trial was designed to de...

journal_title：Scientific reports

authors： Zhang L,Zhang J,Ye Z,Manevich Y,Townsend DM,Marshall DT,Tew KD

更新日期：2019-09-24 00:00:00

abstract：:Natural biochemical systems are ubiquitously organized both in space and time. Engineering the spatial organization of biochemistry has emerged as a key theme of synthetic biology, with numerous technologies promising improved biosynthetic pathway performance. One strategy, however, may produce disparate results for d...

journal_title：Scientific reports

authors： Jakobson CM,Tullman-Ercek D,Mangan NM

更新日期：2018-05-29 00:00:00

abstract：:Term preeclampsia (tPE), ≥37 weeks, is the most common form of PE and the most difficult to predict. Little is known about its pathogenesis. This study aims to elucidate the pathogenesis and assess early prediction of tPE using serial integrated metabolomic and proteomic systems biology approaches. Serial first- (11-1...

journal_title：Scientific reports

authors： Bahado-Singh R,Poon LC,Yilmaz A,Syngelaki A,Turkoglu O,Kumar P,Kirma J,Allos M,Accurti V,Li J,Zhao P,Graham SF,Cool DR,Nicolaides K

更新日期：2017-11-23 00:00:00

abstract：:Climatic fluctuations largely affects species turnover and cause major shifts of terrestrial ecosystem. In the present study the five decade old herbarium specimens of lichens were compared with recent collection from Darjeeling district with respect to elements, PAHs accumulation and carbon isotope composition (δ(13)...

journal_title：Scientific reports

authors： Bajpai R,Mishra S,Dwivedi S,Upreti DK

更新日期：2016-08-09 00:00:00

abstract：:Hydrogen sulfide is the third and most recently discovered gaseous signaling molecule following nitric oxide and carbon monoxide, playing important roles both in normal physiological conditions and disease progression. The trimethylsulfonium ion (TMS) can result from successive methylation reactions of hydrogen sulfid...

journal_title：Scientific reports

authors： Lajin B,Francesconi KA

更新日期：2016-06-01 00:00:00

abstract：:A novel label-free electrochemiluminescence (ECL) immunosensor based on luminol functional-Au NPs@polypyrrole has been developed for the detection of carcinoembryonic antigen (CEA). In this work, polypyrrole prepared by chemical polymerization provided a large surface area to load amounts of gold nanoparticles (Au NPs...

journal_title：Scientific reports

authors： Zhu W,Wang Q,Ma H,Lv X,Wu D,Sun X,Du B,Wei Q

更新日期：2016-04-19 00:00:00

abstract：:Ovarian cancer (OC) is the most lethal gynecological carcinoma due to the lack of diagnostic markers and effective drug targets. Discovery of new therapeutic targets in OC to improve the treatment outcome is urgently needed. We performed proteomic analysis of OC specimens and the paired normal tissues and revealed tha...

journal_title：Scientific reports

authors： Guo J,Li X,Zhang W,Chen Y,Zhu S,Chen L,Xu R,Lv Y,Wu D,Guo M,Liu X,Lu W,Deng H

更新日期：2019-09-02 00:00:00

abstract：:Telomeres, the protective, terminal parts of the chromosomes erode during cell division and as a result of oxidative damage by reactive oxygen species (ROS). Ectotherms rely on the ambient temperature for maintaining temperature-dependent metabolic rate, regulated through behavioural thermoregulation. Their temperatur...

journal_title：Scientific reports

authors： Axelsson J,Wapstra E,Miller E,Rollings N,Olsson M

更新日期：2020-01-13 00:00:00

abstract：:Bisacylphosphane oxides (BAPOs) are established as photoinitiators for industrial applications. Light irradiation leads to their photolysis, producing radicals. Radical species induce oxidative stress in cells and may cause cell death. Hence, BAPOs may be suitable as photolatent cytotoxic agents, but such applications...

journal_title：Scientific reports

authors： Beil A,Steudel FA,Bräuchle C,Grützmacher H,Möckl L

更新日期：2019-04-12 00:00:00

abstract：:Chromatin remodeling has been newly established as an important cancer genome characterization and recent exome and whole-genome sequencing studies of hepatocellular carcinoma (HCC) showed that recurrent inactivating mutations in SWI/SNF subunits involved in the molecular basis of hepatocarcinogenesis. To test the hyp...

journal_title：Scientific reports

authors： Zhong R,Liu L,Tian Y,Wang Y,Tian J,Zhu BB,Chen W,Qian JM,Zou L,Xiao M,Shen N,Yang H,Lou J,Qiu Q,Ke JT,Lu XH,Wang ZL,Song W,Zhang T,Li H,Wang L,Miao XP

更新日期：2014-02-21 00:00:00

abstract：:Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease worldwide, ranging from steatosis to non-alcoholic steatohepatitis (NASH). Recently, cerium oxide nanoparticles (CeO2NPs) have emerged as a new antioxidant agent with hepatoprotective properties in experimental liver disease. T...

journal_title：Scientific reports

authors： Carvajal S,Perramón M,Oró D,Casals E,Fernández-Varo G,Casals G,Parra M,González de la Presa B,Ribera J,Pastor Ó,Morales-Ruíz M,Puntes V,Jiménez W

更新日期：2019-09-06 00:00:00

abstract：:We tested the hypothesis that epigenetic mechanisms in the brain and the immune system are associated with chronic pain. Genome-wide DNA methylation assessed in 9 months post nerve-injury (SNI) and Sham rats, in the prefrontal cortex (PFC) as well as in T cells revealed a vast difference in the DNA methylation landsca...

journal_title：Scientific reports

authors： Massart R,Dymov S,Millecamps M,Suderman M,Gregoire S,Koenigs K,Alvarado S,Tajerian M,Stone LS,Szyf M

更新日期：2016-01-28 00:00:00

abstract：:The potential energy profile of an ideal binary switch is a symmetric double well. Switching between the wells without energy dissipation requires time-modulating the height of the potential barrier separating the wells and tilting the profile towards the desired well at the precise juncture when the barrier disappear...

journal_title：Scientific reports

authors： Fashami MS,Atulasimha J,Bandyopadhyay S

更新日期：2013-11-13 00:00:00

abstract：:An abrupt onset of the new tongue-shaped deformation of magnetic surface in magnetized plasmas, which was conjectured in since the 1960s but has not been observed, is experimentally identified just before an abrupt onset of a large-scale collapse event. Two novel properties of the event are identified. First, the tran...

journal_title：Scientific reports

authors： Ida K,Kobayashi T,Itoh K,Yoshinuma M,Tokuzawa T,Akiyama T,Moon C,Tsuchiya H,Inagaki S,Itoh SI

更新日期：2016-10-31 00:00:00

abstract：:Ultrasounds (US) has been used in the past decades as a non-invasive imaging modality. Although employed extensively in clinical applications for soft tissue imaging, the acoustic beams can also be used for sensing and actuation for biological implants. In this paper we present a unified three dimensional (3D) computa...

journal_title：Scientific reports

authors： Rosa BMG,Yang GZ

更新日期：2020-04-16 00:00:00

abstract：:A Maxwell fisheye lens using parallel plate index grading is presented in this study to develop a passive retrodirective antenna array. As a proof-of-concept a design frequency of 10 GHz was selected for fabrication and experiment. The design principals of the lens are discussed, which enables 85% energy flow at the d...

journal_title：Scientific reports

authors： Abbasi MAB,Fusco VF

更新日期：2019-11-07 00:00:00

abstract：:The effect of initial evenness on the temporal trajectory of synthetic communities in comprehensive, low-volume microcosm studies remains unknown. We used flow cytometric fingerprinting and 16S rRNA gene amplicon sequencing to assess the impact of time on community structure in one hundred synthetic ecosystems of fixe...

journal_title：Scientific reports

authors： Ehsani E,Hernandez-Sanabria E,Kerckhof FM,Props R,Vilchez-Vargas R,Vital M,Pieper DH,Boon N

更新日期：2018-01-10 00:00:00

abstract：:The immune checkpoint based therapy targeting the programmed death-1 (PD-1) receptor and its PD-L1 ligand has recently been approved for the therapy of different malignant conditions, but not yet for gastroenteropancreatic neuroendocrine tumors (GEP-NETs). In this context, we evaluated the expression of PD-1 and PD-L1...

journal_title：Scientific reports

authors： Sampedro-Núñez M,Serrano-Somavilla A,Adrados M,Cameselle-Teijeiro JM,Blanco-Carrera C,Cabezas-Agricola JM,Martínez-Hernández R,Martín-Pérez E,Muñoz de Nova JL,Díaz JÁ,García-Centeno R,Caneiro-Gómez J,Abdulkader I,González-Amaro

更新日期：2018-12-13 00:00:00

abstract：:Leber congenital amaurosis (LCA) is a genetically and clinically heterogeneous disease, and represents the most severe form of inherited retinal dystrophy (IRD). The present study reports the mutation spectra and frequency of known LCA and IRD-associated genes in 34 Japanese families with LCA (including three families...

journal_title：Scientific reports

authors： Hosono K,Nishina S,Yokoi T,Katagiri S,Saitsu H,Kurata K,Miyamichi D,Hikoya A,Mizobuchi K,Nakano T,Minoshima S,Fukami M,Kondo H,Sato M,Hayashi T,Azuma N,Hotta Y

更新日期：2018-05-29 00:00:00

abstract：:Phomopsis sp. XP-8, an endophytic fungus from the bark of Tu-Chung (Eucommia ulmoides Oliv) showed capability to biosynthesize pinoresinol (Pin) and pinoresinol diglucoside (PDG) from glucose (glu) and phenylalanine (Phe). To verify the mass flow in the biosynthesis pathway, [13C6]-labeled glu and [13C6]-labeled Phe w...

journal_title：Scientific reports

authors： Zhang Y,Shi J,Ni Y,Liu Y,Zhao Z,Zhao X,Gao Z

更新日期：2019-12-06 00:00:00