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Common Injuries and Repair Mechanisms in the Endothelial Lining.

Abstract：

Objective:Endothelial cells (ECs) are important metabolic and endocrinal organs which play a significant role in regulating vascular function. Vascular ECs, located between the blood and vascular tissues, can not only complete the metabolism of blood and interstitial fluid but also synthesize and secrete a variety of biologically active substances to maintain vascular tension and keep a normal flow of blood and long-term patency. Therefore, this article presents a systematic review of common injuries and healing mechanisms for the vascular endothelium. Data Sources:An extensive search in the PubMed database was undertaken, focusing on research published after 2003 with keywords including endothelium, vascular, wounds and injuries, and wound healing. Study Selection:Several types of articles, including original studies and literature reviews, were identified and reviewed to summarize common injury and repair processes of the endothelial lining. Results:Endothelial injury is closely related to the development of multiple cardiovascular and cerebrovascular diseases. However, the mechanism of vascular endothelial injury is not fully understood. Numerous studies have shown that the mechanisms of EC injury mainly involve inflammatory reactions, physical stimulation, chemical poisons, concurrency of related diseases, and molecular changes. Endothelial progenitor cells play an important role during the process of endothelial repair after such injuries. What's more, a variety of restorative cells, changes in cytokines and molecules, chemical drugs, certain RNAs, regulation of blood pressure, and physical fitness training protect the endothelial lining by reducing the inducing factors, inhibiting inflammation and oxidative stress reactions, and delaying endothelial caducity. Conclusions:ECs are always in the process of being damaged. Several therapeutic targets and drugs were seeked to protect the endothelium and promote repair. :血管内皮细胞的普遍状态：修复与损伤的抗衡摘要目的：内皮细胞是重要的代谢和内分泌器官，在调节血管功能方面起着重要的作用。血管内皮细胞位于血液和血管组织之间，不仅可以完成血液和组织液的新陈代谢，而且可以合成和分泌多种生物活性物质，以保持血管紧张度，维持正常的血液流动和长期通畅。因此，本文系统地综述了血管内皮细胞的普遍状态：修复与损伤的抗衡。方法：通过计算机检索Pubmed数据库，搜索了2003年以后发表的相关研究论文，文章关键词包括”内皮细胞“、”血管“、”损伤“、”修复“。结果：多种心脑血管疾病的发生发展与内皮细胞的损伤密切相关。然而，血管内皮细胞损伤的机制尚不完全清楚。大量研究表明，内皮细胞损伤的机制主要涉及炎症反应、物理刺激、化学毒物和分子改变。内皮祖细胞在损伤后的内皮细胞修复过程中起着重要作用。此外，多种具有修复功能的细胞、细胞因子和分子的变化、药物、某些RNA、血压调节和体能训练都对内皮细胞有保护作用，其作用是通过减弱诱发因素、抑制炎症和氧化应激反应、延缓内皮细胞衰老来实现的。结论：内皮细胞一直处于损伤和抗损伤的过程中。鉴于内皮细胞在脑血管病发展中的重要作用，人们正在寻找保护内皮细胞和促进内皮细胞修复的治疗靶点和药物。.

journal_name

Chin Med J (Engl)

journal_title

Chinese medical journal

authors

Meng LB,Chen K,Zhang YM,Gong T

doi

10.4103/0366-6999.241805

subject

Has Abstract

pub_date

2018-10-05 00:00:00

pages

2338-2345

issue

eissn

0366-6999

issn

2542-5641

pii

ChinMedJ_2018_131_19_2338_241805

journal_volume

131

pub_type

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Common Injuries and Repair Mechanisms in the Endothelial Lining.