Induction of islet transplantation tolerance with anti-CD4, anti-CD8 immunotoxins and donor soluble antigen.

abstract：OBJECTIVE:To investigate the relationship between the presence of the TNF2 allele and plasma concentrations of tumor necrosis factor-alpha (TNF alpha) and soluble TNF receptor (sTNF-R) with the development of acute severe pancreatitis (ASP) and severe sepsis. METHODS:Genomic DNA was prepared from peripheral blood leuk...

journal_title：Chinese medical journal

authors： Zhang D,Li J,Jiang Z,Yu B,Tang X,Li W

更新日期：2003-11-01 00:00:00

abstract：OBJECTIVE:To observe the long-term follow-up of 72 patients with transient ischemic attack (TIA) and evaluate the clinical significance of neurovascular surgical indication. METHODS:Seventy-two patients with TIA collected from years 1959 to 1977 were followed up by means of face-to-face communication with the patients...

journal_title：Chinese medical journal

authors： Gong T,Wang X

更新日期：2001-12-01 00:00:00

abstract：BACKGROUND:Ophthalmic gel has been developed to increase the drug concentration in aqueous humor and to retard the loss of drug from the conjunctival sac. The research was to compare the drug concentration in aqueous humor of cataract patients administered 0.3% gatifloxacin ophthalmic gel with that in patients administ...

journal_title：Chinese medical journal

authors： Liu X,Wang NL,Wang YL,Ma C,Ma L,Gao LX,Huang YX,Xiong SH,Wang K

更新日期：2010-08-05 00:00:00

abstract：BACKGROUND:Urolithiasis in pediatric population is a serious problem with the incidence increased these years. In the management of larger stones (diameters >2 cm), percutaneous nephrolithotomy (PCNL) is considered to be the gold standard. This study aimed to investigate the efficacy and safety of mini-PCNL under total...

journal_title：Chinese medical journal

authors： Xiao B,Zhang X,Hu WG,Chen S,Li YH,Tang YZ,Liu YB,Li JX

更新日期：2015-06-20 00:00:00

abstract：BACKGROUND:Expression of murine calcium-activated chloride channel family member 3 (mCLCA3) has been reported to be increased in the airway epithelium of asthmatic mice challenged with ovalbumin (OVA). However, its role in asthmatic airway inflammation under no OVA exposure has not yet been clarified. METHODS:mCLCA3 p...

journal_title：Chinese medical journal

authors： Mei L,He L,Wu SS,Zhang B,Xu YJ,Zhang ZX,Zhao JP,Zhang HL

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:The CYP2C19 G681A single polymorphism has been proven to affect clopidogrel responsiveness. However, the effect of coexisting polymorphisms of other genes has not yet been reported in the Chinese population. This study investigated the effect of coexisting polymorphisms of CYP2C19 and P2Y12 on clopidogrel re...

journal_title：Chinese medical journal

authors： Tang XF,Zhang JH,Wang J,Han YL,Xu B,Qiao SB,Wu YJ,Chen J,Wu Y,Chen JL,Gao RL,Yang YJ,Yuan JQ

更新日期：2013-03-01 00:00:00

abstract：BACKGROUND:Early diagnosis and accurate staging are important to improve the cure rate and prognosis for pancreatic cancer. This study was performed to develop an automatic and accurate imaging processing technique system, allowing this system to read computed tomography (CT) images correctly and make diagnosis of panc...

journal_title：Chinese medical journal

authors： Liu SL,Li S,Guo YT,Zhou YP,Zhang ZD,Li S,Lu Y

更新日期：2019-12-05 00:00:00

abstract：:An ovarian gynandroblastoma was found in a 59-year-old woman. The tumor consisting of mixed Sertoli-Leydig cells and granulosa-theca cells demonstrated no malignant features. Bisexual cells in gynandroblastoma derived from a common gonadal mesenchyme precursor or indifferent cell. The excision of appendages with tumor...

journal_title：Chinese medical journal

authors： Zhang SQ

更新日期：1991-01-01 00:00:00

abstract：BACKGROUND:P53 is one of the most studied tumor suppressors in the cancer research, and over 50% of human tumors carry P53 mutations. MDM-2 is amplified and/or overexpressed in a variety of human tumors of diverse tissue origin. The aim of this study was to examine the expression of P53 protein and MDM-2 protein in gli...

journal_title：Chinese medical journal

authors： Wang AL,Liu ZX,Li G,Zhang LW

更新日期：2011-08-01 00:00:00

abstract：OBJECTIVE:To determine antiganglioside antibodies (AGA) in cerebrospinal fluid (CSF) of children with neuropsychiatric lupus erythematosus (NPLE), and to investigate their association with clinical manifestations and other laboratory tests. METHODS:An enzyme linked immunoabsorbent assay was used to detect AGA in 22 CS...

journal_title：Chinese medical journal

authors： Chen Y,Wu F,Hou L,Ma S,He X

更新日期：1997-08-01 00:00:00

abstract：BACKGROUND:With the progress of perinatal medicine and neonatal technology, more and more extremely low birth weight (ELBW) survived all over the world. This study was designed to investigate the short-term outcomes of ELBW infants during their Neonatal Intensive Care Unit (NICU) stay in the mainland of China. METHODS...

journal_title：Chinese medical journal

authors： Lin HJ,Du LZ,Ma XL,Shi LP,Pan JH,Tong XM,Li QP,Zhou JG,Yi B,Liu L,Chen YB,Wei QF,Wu HQ,Li M,Liu CQ,Gao XR,Xia SW,Li WB,Yan CY,He L,Liang K,Zhou XY,Han SP,Lyu Q,Qiu YP,Li W,Chen DM,Lu HR,Liu XH,Li

更新日期：2015-10-20 00:00:00

abstract：OBJECTIVE:To explore the involvement of calcium in the mechanism of hypoxic/hypoglycemic insults and nerve growth factor (NGF) protection. METHODS:Neuron viability and lactate dehydrogenase (LDH) efflux in the bathing medium in cerebral cortex cultures from fetal rats were measured. Calcium fluorescent indicator Fura-...

journal_title：Chinese medical journal

authors： Wu J,Zhang J

更新日期：1998-11-01 00:00:00

abstract：OBJECTIVE:To study the expression of vascular endothelial growth factor (VEGF) in different parts of heart during early acute myocardial ischemia. METHODS:The expression of VEGF in control and study group in rats was performed with the Strept Avidin-Biotin-Peroxidase Complex (SABC) method. RESULTS:A rapid expression ...

journal_title：Chinese medical journal

authors： Chen J,Xu X,Wu X,Zhu J

更新日期：1999-08-01 00:00:00

abstract：OBJECTIVE:To study the ultrastructural damages of brain tissues dynamically after middle cerebral artery obstruction (MCAO). METHODS:A middle cerebral artery obstruction (MCAO) model was reproduced in renal vascular hypertensive rats (RHR). Brain tissues in different locations were collected for eight times in row, fr...

journal_title：Chinese medical journal

authors： Fang Y,Huang R,Su Z,Lin J,Li J

更新日期：2000-06-01 00:00:00

abstract：BACKGROUND:An inflammatory response leading to organ dysfunction and failure continues to be a major problem after injury in many clinical conditions such as sepsis, severe burns, and trauma. It is increasingly recognized that atrial natriuretic peptide (ANP) possesses a broad range of biological activities, including ...

journal_title：Chinese medical journal

authors： Zhu YB,Zhang YB,Liu DH,Li XF,Liu AJ,Fan XM,Qiao CH,Ling F,Liu YL

更新日期：2013-02-01 00:00:00

abstract：BACKGROUND:The primary reasons for local recurrence and therapeutic failure in the treatment of malignant gliomas are the invasion and interactions of tumor cells with surrounding normal brain cells. However, these tumor cells are hard to be visualized directly in histopathological preparations, or in experimental glio...

journal_title：Chinese medical journal

authors： Dong J,Dai XL,Lu ZH,Fei XF,Chen H,Zhang QB,Zhao YD,Wang ZM,Wang AD,Lan Q,Huang Q

更新日期：2012-12-01 00:00:00

abstract：BACKGROUND:A number of studies have demonstrated the rates of overall and aneurysm-related mortality and morbidity in Western populations. The cardiovascular risk factors influencing postoperative outcome have been also reported. Until recently, little has been known about the prognosis in this patient cohort in the Ch...

journal_title：Chinese medical journal

authors： Sun T,Zhang H,Cheng Y,Wang S,Tao Y,Zhang D,Huang J,Zhang J,Li Z

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Combination paclitaxel and carboplatin is currently a first-line regimen for ovarian cancer. However, many patients develop tumor recurrence or drug resistance to this regimen. The study aims to investigate the effectiveness and safety of an oxaliplatin + epirubicin + ifosfamide regimen for the treatment of ...

journal_title：Chinese medical journal

authors： Zhang G,Li XP,Liu BJ,Wang JL,Wang SJ,Cui H,Wei LH

更新日期：2013-12-01 00:00:00

abstract：BACKGROUND:For patients with severe endometriosis, the spontaneous pregnancy rates have been reported to be near 0 due to extreme distortion of normal pelvic anatomy. Surgery is one of the treatment options; however, if patients failed to conceive after surgery, in vitro fertilization (IVF) is effective. The objective ...

journal_title：Chinese medical journal

authors： Huang XW,Qiao J,Xia EL,Ma YM,Wang Y

更新日期：2010-08-01 00:00:00

abstract：:Eighteen patients with acute hemorrhagic necrotizing pancreatitis who survived from operation were followed up for 12 to 43 months. Late complications including pancreatic external fistula, pseudocyst, hyperglycemia, etc were reviewed. The pancreatic juice was collected through endoscopic cannulation. The volume and H...

journal_title：Chinese medical journal

authors： Huang YT,Liu Q,Zhang BS

更新日期：1993-07-01 00:00:00

abstract：:The depth and area-percentage of Alcian blue (AB) staining of glomeruli, the ability of RBC to bind AB and the onset of proteinuria in adriamycin nephrosis in rats were studied. The results showed that the negative charge (NC) on RBC and glomeruli decreased significantly after injection of adriamycin and there was a p...

journal_title：Chinese medical journal

authors： Chen ZY,Jiang XY

更新日期：1991-07-01 00:00:00

abstract：BACKGROUND:The Xpert MTB/RIF showed high sensitivity and specificity in previous studies carried out in different epidemiological and geographical settings and patient populations in high-burden tuberculosis (TB) countries. However, there were little data obtained by validation or demonstration study of the assay in Ch...

journal_title：Chinese medical journal

authors： Hu P,Bai L,Liu F,Ou X,Zhang Z,Yi S,Chen Z,Gong D,Liu B,Guo J,Tan Y

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:The side effects of cyclosporine therapy include thromboembolic complications. However, the mechanisms underlying the hypercoagulable state induced by cyclosporine are not fully understood. Cyclosporine binds to red blood cells (RBCs) with a high affinity in circulation and alters the membranes of RBCs. Ther...

journal_title：Chinese medical journal

authors： Zheng YN,Yu HJ,Hou JX,Lu CF,Zhou J

更新日期：2009-07-20 00:00:00

abstract：BACKGROUND:Survivin is an oncoprotein silenced in normal mature tissues but reactivated in serous ovarian cancer (SOC). Although transcriptional activation is assumed for its overexpression, the long 3'-untranslated region (3'-UTR) in survivin gene, which contains many alternate polyadenylation (APA) sites, implies a p...

journal_title：Chinese medical journal

authors： He XJ,Zhang Q,Ma LP,Li N,Chang XH,Zhang YJ

更新日期：2016-05-20 00:00:00

abstract：OBJECTIVE:To explore the relationship between apoptosis and spontaneous hypertension, and the effect of angiotensin converting enzyme (ACE) inhibitor on apoptosis. METHODS:Male spontaneously hypertensive rats (SHR) and normotensive control rats (WKY) at different ages were used, meanwhile, the treatment of SHR with ra...

journal_title：Chinese medical journal

authors： Peng L,Bradley CJ,Zulli A,Liu JJ

更新日期：1999-06-01 00:00:00

abstract：BACKGROUND:SIRT3 is an important regulator in cell metabolism, and recent studies have shown that it may be involved in the pharmacological effects of metformin. However, the molecular mechanisms underlying this process are unclear. METHODS:The effects of SIRT3 on the regulation of oxidative stress and insulin resista...

journal_title：Chinese medical journal

authors： Song Y,Shi J,Wu Y,Han C,Zou J,Shi Y,Liu Z

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Gastric cancer (GC) is one of the most globally prevalent cancers in the world. The pathogenesis of GC has not been fully elucidated, and there still lacks effective targeted therapeutics. The influence of altered kinesin superfamily protein 22 (KIF22) expression in GC progression is still unclearly. The aim...

journal_title：Chinese medical journal

authors： Yu ZY,Jiang XY,Zhao RR,Qin JJ,Luo CJ,Ren YX,Ren W,Ma ZJ,Jiao ZY

更新日期：2020-04-20 00:00:00

abstract：BACKGROUND:Renal artery stenosis (RAS) is always associated with abnormalities in renal microvascular perfusion (RMP). However, few imaging methods can simultaneously evaluate the degree of luminal stenosis and RMP. Thus, this study will aim to evaluate the feasibility of using contrast-enhanced ultrasound (CEUS) for a...

journal_title：Chinese medical journal

authors： Ren JH,Ma N,Wang SY,Sun YJ,Zhang YW,Guo FJ,Li YJ,Li TH,Ai H,Zhang WD,Li P,Ma WH

更新日期：2019-01-05 00:00:00

abstract：BACKGROUND:Current treatments for scoliosis have some defects and complications. To study spinal deformities and test novel scoliosis treatments, many animal models of scoliosis have been developed. These models applied a single load to the spine and could not precisely modulate the spinal growth in different dimension...

journal_title：Chinese medical journal

authors： Zhang HY,Li QY,Wu ZH,Zhao Y,Qiu GX

更新日期：2017-11-05 00:00:00

abstract：BACKGROUND:Glucocorticoid is speculated to be able to have Aspergillus fumigatus (A. fumigatus) being more susceptible to reactive oxygen species (ROS) by inhibiting Afyap1, the transcription factor activating protein-1 (AP-1) homologue in A. fumigatus, which may provide a clue to expand the clinical use of glucocortic...

journal_title：Chinese medical journal

authors： Xu H,Li LJ,Wan Z,Li RY,Liu W

更新日期：2011-11-01 00:00:00