[Changes after dynamic observation of ultrastructural cerebral infarction in renovascular hypertensive rats].

abstract：BACKGROUND:Exposure of adult mice to more than 95% O(2) produces a lethal injury by 72 hours. Nitric oxide synthase (NOS) is thought to contribute to the pathophysiology of murine hyperoxia-induced acute lung injury (ALI). Osteopontin (OPN) is a phosphorylated glycoprotein produced principally by macrophages. OPN inhib...

journal_title：Chinese medical journal

authors： Zhang XF,Liu S,Zhou YJ,Zhu GF,Foda HD

更新日期：2010-04-05 00:00:00

abstract：BACKGROUND:Trichosporon asahii (T. asahii) is one of the most important pathogenic fungus in the genus of trichosporon. Although the species identification of T. asahii was based upon the complicated results of morphologic, biochemical and biologic examination, the morphology characteristic is still the first clue to t...

journal_title：Chinese medical journal

authors： Wang WL,Yang RY,Ao JH

更新日期：2009-08-05 00:00:00

abstract：OBJECTIVE:To review the development of T follicular helper (TFH) cells and their role in systemic lupus erythematosus (SLE) pathogenesis, the effect of dendritic cells (DCs) on TFH cells in SLE, as well as the potential use of TFH cells as a new therapeutic target in clinical practice. DATA SOURCES:The data used in th...

journal_title：Chinese medical journal

authors： Ma H,Wan S,Xia C

更新日期：2014-01-01 00:00:00

abstract：OBJECTIVES:To assess the feasibility and efficacy of eliciting leukemia-specific T-cell responses in syngeneic mice in vitro and in vivo using dendritic cells (DCs) pulsed with total RNA from leukemia cells. METHODS:DCs generated from bone marrow culture in vitro in the presence of combined cytokines were pulsed with ...

journal_title：Chinese medical journal

authors： Li M,You S,Ge W,Ma S,Ma N,Zhao C

更新日期：2003-11-01 00:00:00

abstract：BACKGROUND:Preeclampsia, characterized by hypertension and proteinuria, is a multifactorial disease associated with shallow invasion of trophoblast cells and inadequate spiral artery remodeling. Trophoblast and tumor cells have similar invasion mechanism. Prostasin is closely related to tumor development, invasion and ...

journal_title：Chinese medical journal

authors： Luo D,Zhang Y,Bai Y,Liu X,Gong Y,Zhou B,Zhang L,Luo L,Zhou R

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Alpha 2A adrenergic receptor (AR) is a subtype of α2 AR belonging to G protein-coupled receptors, and exerts a variety of biological effects. Recent studies have demonstrated that the α2A AR activation was closely related with inflammatory reaction. The present study aimed to investigate the influence of α2A...

journal_title：Chinese medical journal

authors： Lin Y,Zhu X,Yao WZ,Yang YL,A LT,Chen L

更新日期：2011-04-01 00:00:00

abstract：BACKGROUND:Premature ventricular contractions (PVCs) are common in the general population, and frequent PVCs may result in the poor quality of life or even the damage of cardiac function. We examined the efficacy and safety of a traditional Chinese medicine Wenxin Keli for the treatment of frequent PVCs among a relativ...

journal_title：Chinese medical journal

authors： Hua W,Gao RL,Zhao BC,Wang J,Chen XH,Cai C,Zhang S

更新日期：2015-10-05 00:00:00

abstract：OBJECTIVE:To evaluate the effect of gynostemma pentaphyllum mak (GP) on carcinomatous conversions of leukoplasia of the golden hamster cheek pouch induced by dimethylbenzanthracene (DMBA). METHODS:284 golden hamsters, ranging from 4 to 8 weeks of age, 80 to 100 grams in weight were randomly divided into three groups: ...

journal_title：Chinese medical journal

authors： Zhou Z,Wang Y,Zhou Y,Zhang S

更新日期：1998-09-01 00:00:00

abstract：OBJECTIVES:To get a more comprehensive recognition about carpal tunnel syndrome (CTS), especially the manual housework as its risk factor, and to facilitate early diagnosis and proper treatment. METHODS:262 CTS patients (396 CTS hands) were analyzed retrospectively. A 1:1 matched case-control study of 61 woman pairs i...

journal_title：Chinese medical journal

authors： Tang X,Zhuang L,Lu Z

更新日期：1999-01-01 00:00:00

abstract：:The solid pseudopapillary tumors of the pancreas (SPTP) are rare tumors, which are commonly found in adolescent women. Radical surgical resection of the primary tumor or metastases is the standard treatment for SPTP and could achieve long-term survival. We reported a case of a 20-year-old female with multiple liver me...

journal_title：Chinese medical journal

authors： Li JX,Wu H,Huang JW,Prasoon P,Zeng Y

更新日期：2012-05-01 00:00:00

abstract：BACKGROUND:Some research groups have hypothesized that human rhinoviruses (HRVs) delayed the circulation of the 2009 pandemic influenza A(H1N1) virus (A(H1N1)pdm09) at the beginning of Autumn 2009 in France. This study aimed to evaluate the relationship between HRV and A(H1N1)pdm09 in pediatric patients with influenza-...

journal_title：Chinese medical journal

authors： Sun Y,Zhu R,Zhao L,Deng J,Wang F,Ding Y,Yuan Y,Qu D,Qian Y

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:One of the major causes of death in severe acute pancreatitis (SAP) is severe infection owing to bacterial translocation. Some clinical studies suggested that ecoimmunonutrition (EIN) as a new strategy had better treatment effect on SAP patients. But the experiment studies on the precise mechanism of the eff...

journal_title：Chinese medical journal

authors： Xu GF,Lu Z,Gao J,Li ZS,Gong YF

更新日期：2006-04-20 00:00:00

abstract：OBJECTIVE:Sepsis remains a leading cause of death in many Intensive Care Units worldwide. Immunosuppression has been a primary focus of sepsis research as a key pathophysiological mechanism. Given the important role of the negative costimulatory molecules programmed cell death-1 (PD-1) and programmed death-ligand 1 (PD...

journal_title：Chinese medical journal

authors： Liu Q,Li CS

更新日期：2017-04-20 00:00:00

abstract：BACKGROUND:Alzheimer disease (AD) is a neurodegenerative disease related to aging. At present, its pathological mechanisms remain unclear. Family members of the renin-angiotensin system (RAS) play a role in neuronal plasticity, as well as formation of learning and memory. In this study, we explore the effects of altere...

journal_title：Chinese medical journal

authors： Hou DR,Wang Y,Zhou L,Chen K,Tian Y,Song Z,Bao J,Yang QD

更新日期：2008-11-20 00:00:00

abstract：BACKGROUND:Acinetobacter baumannii is one of the main gram-negative bacilli in clinical practice. Nosocomial infections caused by multi-drug resistance Acinetobacter baumannii is very difficult to treat. This study was designed to investigate the antimicrobial resistance characteristics and four resistant gene expressi...

journal_title：Chinese medical journal

authors： Shi WF,Jiang JP,Mi ZH

更新日期：2005-01-20 00:00:00

abstract：BACKGROUND:Total hip arthroplasty (THA) in developmental dysplasia of the hip (DDH) is more complex than the normal hip, with large replacement risks and many complications. Although nonosteotomy THA is convenient to perform, femoral osteotomy shortening can avoid blood vessel and nerve traction injuries. This study ai...

journal_title：Chinese medical journal

authors： Chu YM,Zhou YX,Han N,Yang DJ

更新日期：2016-02-05 00:00:00

abstract：OBJECTIVE:To investigate the role of a potential diabetes-related mitochondrial region, which includes two previously reported mutations, 3243A-->G and 3316G-->A, in Chinese patients with adult-onset type 2 diabetes. METHODS:A total of 277 patients and 241 normal subjects were recruited for the study. Mitochondrial nt...

journal_title：Chinese medical journal

authors： Yang T,Lam CW,Tsang MW,Tong SF,Kam GY,Chan LY,Poon PM,Wu X,Pang CP

更新日期：2002-05-01 00:00:00

abstract：BACKGROUND:Intravertebral and general anesthesia (GA) are two main anesthesia approaches but both have defects. This study was aimed to evaluate the effect of subarachnoid anesthesia combined with propofol target-controlled infusion (TCI) on blood loss and transfusion for total hip arthroplasty (THA) in elderly patient...

journal_title：Chinese medical journal

authors： Xu CS,Qu XD,Qu ZJ,Wang G,Wang HJ

更新日期：2020-03-20 00:00:00

abstract：OBJECTIVE:To study the analgesic mechanism of gabapentin, an anticonvulsant, during antinociceptive clinical treatment. METHODS:Whole-cell voltage-clamp recordings were taken from adult rat spinal cord slices to investigate the effect of gabapentin on primary afferent A delta-fiber evoked excitatory postsynaptic curre...

journal_title：Chinese medical journal

authors： Liu Z,Xu R,Yang K

更新日期：2003-06-01 00:00:00

abstract：BACKGROUND:Psoriasis is a chronic inflammatory skin disease, affecting about 0.6% of the Chinese population. Many patients are not well controlled by conventional treatments, thus there is need for new treatment regimens. In this study, we assessed the efficacy and safety of secukinumab in Chinese patients with moderat...

journal_title：Chinese medical journal

authors： Cai L,Zhang JZ,Yao X,Gu J,Liu QZ,Zheng M,Zhang SF,Xu JH,Li CX,Cheng H,Guo Q,Pan WL,Li SQ,Li RY,Guo ZP,Song ZQ,Li SS,Dong XQ,Wang L,Fu R,Regnault P,Charef P,Mazur R,Patekar M

更新日期：2020-11-20 00:00:00

abstract：OBJECTIVE:To rapidly and economically obtain knowledge about adult stage Schistosoma japonicum (Chinese strain) expressed genes using expressed sequence tag (EST). METHODS:A directional cDNA library constructed from Schistosoma japonicum (Chinese strain) adult stage RNA was used to generate expressed sequence tags (ES...

journal_title：Chinese medical journal

authors： Bian G,Yu X,Wu Z

更新日期：2002-10-01 00:00:00

abstract：BACKGROUND:The mechanisms of endometriosis with infertility have not been fully studied. The present study aimed to assess the follicular fluid (FF) levels of prostaglandin E2 (PGE2), which plays a critical role within the ovary, and to investigate the effect of PGE2 on steroidogenesis in granulosa-lutein cells (GLCs) ...

journal_title：Chinese medical journal

authors： Wang J,Shen XX,Huang XH,Zhao ZM

更新日期：2012-11-01 00:00:00

abstract：OBJECTIVE:To explore the response of nasal mucosa epithelial cells to hypoxia in terms of formation of nasal polyps (NP). METHODS:Epithelial cells of NP and inferior turbinate (IT) were cultured serum-free under normal oxygen and hypoxic circumstances with stimulation of IL-1 beta and TNF alpha. The vascular endotheli...

journal_title：Chinese medical journal

authors： Jiang S,Dong Z,Zhu D,Yang Z

更新日期：2003-02-01 00:00:00

abstract：OBJECTIVE:Renal fibrosis is the most common manifestation of chronic kidney disease (CKD). Noting that existing treatments of renal fibrosis only slow disease progression but do not cure it, there is an urgent need to identify novel therapies. Hydrogen sulfide (H2S) is a newly discovered endogenous small gas signaling ...

journal_title：Chinese medical journal

authors： Wang Y,Xing QQ,Tu JK,Tang WB,Yuan XN,Xie YY,Wang W,Peng ZZ,Huang L,Xu H,Qin J,Xiao XC,Tao LJ,Yuan QJ

更新日期：2019-12-05 00:00:00

abstract：BACKGROUND:Connective tissue growth factor (CTGF) contributes greatly to renal tubulointerstitial fibrosis, which is the final event leading to end-stage renal failure. This study was designed to investigate the effects of CTGF antisense oligodeoxynucleotides (ODNs) on the expressions of plasminogen activator inhibitor...

journal_title：Chinese medical journal

authors： Zhang C,Meng XF,Zhu ZH,Yang X,Deng AG

更新日期：2004-07-01 00:00:00

abstract：PURPOSE:To review the current status of multimodality treatment and lymphadenectomy in the management of esophageal cancer. DATA SOURCES:Literature review. STUDY SELECTION:Multimodality treatment and lymphadenectomy in esophageal cancer. DATA EXTRACTION:Results in research papers published selected by literature sea...

journal_title：Chinese medical journal

authors： Law S,Wong J

更新日期：1997-11-01 00:00:00

abstract：:The effects of anisodamine on acetylcholine-induced endothelium-dependent relaxation were studied in organ chambers and under bioassay conditions. In organ chamber experiments, both acetylcholine and bradykinin induced an endothelium-dependent relaxation of norepinephrine-contracted canine femoral arteries in a concen...

journal_title：Chinese medical journal

authors： Guo HY,Loren RR,Vanhutte PM

更新日期：1992-08-01 00:00:00

abstract：BACKGROUND:A five-year follow-up study of intensive multifactorial intervention was undertaken to assess the changes of circulating serum amyloid A (SAA) levels and the incidence of atherosclerosis (AS) in patients with short-duration type 2 diabetes mellitus (T2DM) without macroangiopathy, and whether intensive multif...

journal_title：Chinese medical journal

authors： Du JL,Liu JF,Men LL,Yao JJ,Sun LP,Sun GH,Song GR,Yang Y,Bai R,Xing Q,Li CC,Sun CK

更新日期：2009-11-05 00:00:00

abstract：BACKGROUND:Anomalous origin of the left coronary artery from the pulmonary artery (ALCAPA) is a rare but potentially life-threatening congenital heart defect. A retrospective analysis was carried out to elucidate the surgical outcomes of ALCAPA in infants and children using follow-up echocardiography. METHODS:From Sep...

journal_title：Chinese medical journal

authors： Gao Y,Zhang J,Huang GY,Liang XC,Jia B,Ma XJ

更新日期：2017-10-05 00:00:00

abstract：BACKGROUND:Four single nucleotide polymorphisms (SNPs) in the modulator recognition factor 2/AT-rich interaction domain 5B (MRF2/ARID5B) gene located at chromosome 10q21.2 have been shown to be associated with both type 2 diabetes mellitus (T2DM) and coronary artery disease in a Japanese cohort. This study aimed to inv...

journal_title：Chinese medical journal

authors： Sun LL,Zhang SJ,Chen MJ,Elena K,Qiao H

更新日期：2017-05-05 00:00:00