Induction of T-cell immunity against leukemia by dendritic cells pulsed with total RNA isolated from leukemia cells.

abstract：BACKGROUND:Transradial coronary intervention has been widely used because of its effects in lowering the incidence of complications in vascular access site and improving patient satisfaction compared to the femoral approach. This study aimed to investigate the safety and feasibility of transradial approach for primary ...

journal_title：Chinese medical journal

authors： Yan ZX,Zhou YJ,Zhao YX,Liu YY,Shi DM,Guo YH,Cheng WJ

更新日期：2008-05-05 00:00:00

abstract：BACKGROUND:To avoid the irritation of tendons and soft tissues as well as hardware-related problems, we designed an intramedullary fixation with bioabsorbable rods for the treatment of the metacarpal shaft fractures. METHODS:Five patients with nine shaft fractures of the fourth and fifth metacarpi were treated with in...

journal_title：Chinese medical journal

authors： Xiong G,Xiao ZR,Guo SG,Zheng W,Dai LF

更新日期：2015-11-05 00:00:00

abstract：BACKGROUND:O(6)-methylguanine-DNA-methyltransferase (MGMT) is a specific DNA revising enzyme transferring alkylated groups from DNA to its cysteine residue to avoid the abnormal twisting of DNA. Therefore, it is one of the drug resistant genes targeted in the treatment of cancer. This study explored the protective effe...

journal_title：Chinese medical journal

authors： Li DB,Wang JS,Fang Q,Sun HY,Xu W,Li WD

更新日期：2007-04-20 00:00:00

abstract：BACKGROUND:Cholesterol-lowering therapy with statins has been reported to reduce the morbidity and mortality of cardiovascular diseases. This study aimed to investigate the effects of combined application of extended-release niacin and atorvastatin on lipid profile modification and the risks of adverse events in patien...

journal_title：Chinese medical journal

authors： Sang ZC,Wang F,Zhou Q,Li YH,Li YG,Wang HP,Chen SY

更新日期：2009-07-20 00:00:00

abstract：BACKGROUND:MicroRNAs (miRNAs) are highly conserved small non-coding RNAs of 18 - 25 nucleotides (nt) that mediate post-transcriptional gene regulation. Hepatitis B virus (HBV) can cause either acute or chronic hepatitis B, and is a high risk factor for liver cirrhosis and hepatocellular carcinoma. Some mammalian viruse...

journal_title：Chinese medical journal

authors： Liu Y,Zhao JJ,Wang CM,Li MY,Han P,Wang L,Cheng YQ,Zoulim F,Ma X,Xu DP

更新日期：2009-01-05 00:00:00

abstract：:Osteoarthritis (OA) models in bipedal rats were used to study the immune response, including the changes of IgG, antibody dependent cytotoxicity tests toward articular chondrocytes and the matrix. The results revealed significant difference between the bipedal and the quadruped rats. Immunological studies have proved ...

journal_title：Chinese medical journal

authors： Chen YP,Yang Y,Chen BX

更新日期：1991-03-01 00:00:00

abstract：BACKGROUND:Vascular endothelial growth factor (VEGF) is well known as a hypoxia-induced protein. That it markedly increased expression of VEGF and improvement of rat motor function after spinal cord injury suggested that VEGF could play a neuroprotective role in ischaemic tolerance. This study investigated whether vasc...

journal_title：Chinese medical journal

authors： Ding XM,Mao BY,Jiang S,Li SF,Deng YL

更新日期：2005-10-05 00:00:00

abstract：Background:Technical aspects of the correct placement of medial support locking screws in the locking plate for proximal humerus fractures remain incompletely understood. This study was to evaluate the clinical relationship between the number of medial support screws and the maintenance of fracture reduction after lock...

journal_title：Chinese medical journal

authors： Zeng LQ,Zeng LL,Jiang YW,Wei HF,Zhang W,Chen YF

更新日期：2018-08-05 00:00:00

abstract：BACKGROUND:Pancreatic beta-cell apoptosis induced by lipotoxicity, to a large extent, contributes to the progression of type 2 diabetes. To investigate the mechanism of free fatty acid induced apoptosis, we aimed to study the effects of palmitic acid (PA) on the apoptosis and peroxisome proliferator-activated receptor ...

journal_title：Chinese medical journal

authors： He TT,Cao XP,Chen RZ,Zhu XN,Wang XL,Li YB,Xiao HP

更新日期：2011-11-01 00:00:00

abstract：BACKGROUND:Obesity has an adverse effect on iron status. Hepcidin-mediated inhibition of iron absorption in the duodenum is a potential mechanism. Iron-deficient obese patients have diminished response to oral iron therapy. This study was designed to assess whether acupuncture could promote the efficacy of oral iron su...

journal_title：Chinese medical journal

authors： Xie XC,Cao YQ,Gao Q,Wang C,Li M,Wei SG

更新日期：2017-03-05 00:00:00

abstract：OBJECTIVE:To summarize the recent findings on the epidemiology of medically important, opportunistic invasive fungal infections (IFIs) in China and discuss the relevant social, economical reasons and medical factors. DATA SOURCES:We performed a comprehensive search of both English and Chinese literatures of opportunis...

journal_title：Chinese medical journal

authors： Liao Y,Chen M,Hartmann T,Yang RY,Liao WQ

更新日期：2013-01-01 00:00:00

abstract：OBJECTIVE:To investigate the role of AC-cAMP system in the transmission of the action of the growth hormone releasing hormone (GRH) on growth hormone (GH) release in pituitary GH-secreting adenomas. METHODS:The effects of GRH (10(-7) mol/L) on intracellular cAMP levels and GH release and the effects of AC-cAMP stimula...

journal_title：Chinese medical journal

authors： Shi Y,Deng J,Yin J

更新日期：1996-08-01 00:00:00

abstract：BACKGROUND:Dendritic cells (DCs) are the most important professional antigen presenting cells that play a key role in initiating adaptive immune responses. The depletion and dysfunction of DCs contribute to the development of immunodeficiency or immunoparalysis in some lung diseases. In the present study, we investigat...

journal_title：Chinese medical journal

authors： Wang HW,Lu JY,Wang L,Tian G

更新日期：2012-07-01 00:00:00

abstract：BACKGROUND:Coronary heart diseases (CHD) have been identified as one of topmost diseases affecting the Chinese population. However, depression in CHD has not been reported and there are limited high quality empirical studies in China focused on the prevalence of the comorbidity. This study aimed to estimate the pooled ...

journal_title：Chinese medical journal

authors： Ren Y,Yang H,Browning C,Thomas S,Liu M

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Tbx1 is the major candidate gene for DiGeorge syndrome (DGS). Similar to defects observed in DGS patients, the structures disrupted in Tbx1(-/-) animal models are derived from the neural crest cells during development. Although the morphological phenotypes of some Tbx1 knock-down animal models have been well...

journal_title：Chinese medical journal

authors： Zhang LF,Gui YH,Wang YX,Jiang Q,Song HY

更新日期：2010-05-05 00:00:00

abstract：BACKGROUND:Excessive expression of thymic stromal lymphopoietin (TSLP) has been demonstrated in asthmatic airway epithelia and in nasal epithelia from animal models of allergic rhinitis (AR), but the evidence of expression of TSLP in nasal epithelial cells (NECs) of patients with AR is lacking. We aimed to investigate ...

journal_title：Chinese medical journal

authors： Zhu DD,Zhu XW,Jiang XD,Dong Z

更新日期：2009-10-05 00:00:00

abstract：OBJECTIVE:To investigate the expression of Toll-like receptor 2 (TLR2) and Toll-like receptor 4 (TLR4) and the effect of lipopolysaccharide (LPS) on their expression in cultured endothelial cells. METHODS:Total RNA was extracted from ECV304 cells and isolated human umbilical vein endothelial cells (HUVECs) exposed to ...

journal_title：Chinese medical journal

authors： Yang Q,Zhu P,Wang Z,Jiang J

更新日期：2002-02-01 00:00:00

abstract：OBJECTIVE:To investigate the effect of active immunotherapy with anti-idiotypic vaccine in patients with nasopharyngeal carcinoma (NPC). METHODS:Anti-idiotypic antibodies (2H4/5D3) bearing the internal image of the NPC antigen were used in active immunotherapy in NPC patients receiving radiotherapy. Antibodies and cyt...

journal_title：Chinese medical journal

authors： Li G,Xie L,Zhou G,Fu H,Zhou J,Sun Q

更新日期：2002-04-01 00:00:00

abstract：: ...

journal_title：Chinese medical journal

authors： Du J,Yang XW,Wen ZJ,Xue C,Wu YM,Wu MC,Zhang LL

更新日期：2018-10-20 00:00:00

abstract：Background:Signal transducer and activator of transcription 3 (STAT3) was strongly expressed and activated in psoriatic keratinocytes (KCs) and correlated with the severity of psoriasis. The study aimed to investigate the effects of STAT3 small interfering RNA (siRNA) combined with ultrasonic irradiation and SonoVue mi...

journal_title：Chinese medical journal

authors： Ran LW,Wang H,Lan D,Jia HX,Yu SS

更新日期：2018-09-05 00:00:00

abstract：BACKGROUND:Diffusion weighted imaging with background suppression (DWIBS) is potentially useful in detecting metastatic lymph nodes. This study aimed to evaluate the efficacy of DWIBS at 3T magnetic resonance (MR) for diagnosing metastatic lymph nodes in cervical cancer. METHODS:This retrospective study included 25 pa...

journal_title：Chinese medical journal

authors： Yu SP,He L,Liu B,Zhuang XZ,Liu MJ,Hu XS

更新日期：2010-10-01 00:00:00

abstract：:The protective effect of improving the microcirculation on the retinal ganglion cells (RGC) and the ultrastructure of the optic nerve after intravenous (i.v.) use of Salviae miltiorrhiza (SMR) was studied in a chronic intraocular hypertension model in 36 rabbits. These rabbits were treated with topical 0.5% timolol, o...

journal_title：Chinese medical journal

authors： Zhu MD,Cai FY

更新日期：1993-12-01 00:00:00

abstract：:Type 2 diabetes mellitus and metabolic disorders have become an epidemic globally. However, the pathogenesis remains largely unclear and the prevention and treatment are still limited. In addition to environmental factors during adulthood, early life is the critical developmental window with high tissue plasticity, wh...

journal_title：Chinese medical journal

authors： Zhou LY,Deng MQ,Zhang Q,Xiao XH

更新日期：2020-08-20 00:00:00

abstract：BACKGROUND:Hippophae rhamnoides L. (HL) exerts antioxidant activities against various oxidative stress conditions. In this study, we investigated effects of extract from HL leaves (HLE) on cell proliferation and neuroblast differentiation in the subgranular zone (SGZ) of the dentate gyrus (DG) of aged gerbils. METHODS...

journal_title：Chinese medical journal

authors： Ahn JH,Chen BH,Park JH,Kim IH,Cho JH,Lee JC,Yan BC,Choi JH,Hwang IK,Park JH,Han SN,Lee YL,Kim MJ,Won MH

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:The mechanisms of endometriosis with infertility have not been fully studied. The present study aimed to assess the follicular fluid (FF) levels of prostaglandin E2 (PGE2), which plays a critical role within the ovary, and to investigate the effect of PGE2 on steroidogenesis in granulosa-lutein cells (GLCs) ...

journal_title：Chinese medical journal

authors： Wang J,Shen XX,Huang XH,Zhao ZM

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND:The coordinated change of haematopoietic supporting microenvironment in bone marrow (BM) is crucial for innate immunity and inflammation. As the precursors of marrow stroma, BM derived mesenchymal stem cells (MSCs) promote haematopoietic function, but their roles in innate immunity or inflammation have not b...

journal_title：Chinese medical journal

authors： Shi L,Wang JS,Liu XM,Hu XY,Fang Q

更新日期：2007-10-05 00:00:00

abstract：BACKGROUND:Porcine liver performing efficient physiological functions in the human body is prerequisite for successful liver xenotransplantation. However, the protein differences between pig and human remain largely unexplored. Therefore, we investigated the liver expression profile of a highly inbred minipig line. ME...

journal_title：Chinese medical journal

authors： Chen YN,Tan WD,Lu YR,Qin SF,Li SF,Zeng YZ,Bu H,Li YP,Cheng JQ

更新日期：2007-05-05 00:00:00

abstract：BACKGROUND:Drug treatment for secondary hyperparathyroidism caused by chronic renal failure may be available at the early stage of the disease, but it is not as effective for serious patients. The aim of the study was to evaluate the effect of total parathyroidectomy combined with forearm autotransplantation in the ure...

journal_title：Chinese medical journal

authors： Zou Q,Wang HY,Zhou J,Lao ZY,Xue J,Li MX,Li HM,Jin YT,Gu Y,Zhang YL

更新日期：2007-10-20 00:00:00

abstract：BACKGROUND:The aim of this research was to evaluate long-term pulmonary sequelae on paired inspiration-expiration thin-section computed tomography (CT) scans 3 years after influenza A (H1N1) virus-associated pneumonia, and to analyze the affecting factors on pulmonary fibrosis. METHODS:Twenty-four patients hospitalize...

journal_title：Chinese medical journal

authors： Xing ZH,Sun X,Xu L,Wu Q,Li L,Wu XJ,Shao XG,Zhao XQ,Wang JH,Ma LY,Wang K

更新日期：2015-04-05 00:00:00

abstract：BACKGROUND:L-shaped incision of pronator quadratus (PQ) muscle along its radial and distal borders was always taken for distal radius fractures reduction and internal fixation. Repair of the PQ muscle was always recommended at the end of operation for some instructive reasons. But repair of PQ is not satisfied because ...

journal_title：Chinese medical journal

authors： Fan J,Chen K,Zhu H,Jiang B,Yuan F,Zhu X,Mei J,Yu G

更新日期：2014-01-01 00:00:00