Protective effect of O6-methylguanine-DNA-methyltransferase on mammalian cells.

abstract：:Diabetes mellitus and pancreatic ductal adenocarcinoma are two common diseases worldwidely which are both derived from different components of pancreas. The pancreatic and duodenal homeobox-1 (PDX1) is an essential transcription factor for the early development of pancreas that is required for the differentiation of a...

journal_title：Chinese medical journal

authors： Tang ZC,Chu Y,Tan YY,Li J,Gao S

更新日期：2020-02-05 00:00:00

abstract：OBJECTIVE:To determine the feasibility and accuracy of high-frequency ultrasound in evaluating the left ventricular (LV) structure and function in normal and pressure overload rats and to examine the changes of the left ventricle during its transition from hypertrophy to heart failure. METHODS:Thirty-eight female rats...

journal_title：Chinese medical journal

authors： Xu F,Wang J,Bai X,Yang J,Bai S

更新日期：2002-04-01 00:00:00

abstract：OBJECTIVE:To isolate and clone the tumor suppressor gene on chromosomal region 7q32 correlated with the carcinogenesis of human nasopharyngeal carcinoma (NPC). METHODS:The genotypes of polymorphic microsatellite markers on 7q32 in DNA from 24 biopsies of nasopharyngeal carcinoma and matched normal blood cells were ide...

journal_title：Chinese medical journal

authors： Jiang N,Zhan F,Tan G,Deng L,Zhou M,Cao L,Qiu Y,Xie Y,Li G

更新日期：2000-07-01 00:00:00

abstract：Background:Ischemia preconditioning (IPC) remains the most powerful intervention of protection against myocardial ischemia/reperfusion injury (IRI), but diabetes can weaken or eliminate its cardioprotective effect and detailed mechanisms remain unclear. In this study, we aimed to explore whether changes of autophagy in...

journal_title：Chinese medical journal

authors： Liu YY,Sun C,Xue FS,Yang GZ,Li HX,Liu Q,Liao X

更新日期：2018-07-20 00:00:00

abstract：OBJECTIVE:To reveal the sequence of events of osteoclastic resorption taking place in the cortical bone of the femoral neck in aged women. MATERIAL AND METHODS:The cross sections of cortical bones of the femoral neck from 7 aged women who underwent endoprosthetic replacement for intracapsular hip fracture, were proces...

journal_title：Chinese medical journal

authors： Chai B,Tang X,Li H

更新日期：1996-09-01 00:00:00

abstract：BACKGROUND:Mitochondrial diseases are a group of energy metabolic disorders with multisystem involvements. Variable clinical features present a major challenge in pediatric diagnoses. We summarized the clinical spectrum of m.3243A>G mutation in Chinese pediatric patients, to define the common clinical manifestations an...

journal_title：Chinese medical journal

authors： Xia CY,Liu Y,Liu H,Zhang YC,Ma YN,Qi Y

更新日期：2016-08-20 00:00:00

abstract：:In present study, we examined the effects of NG-nitro-L-arginine (LNNA), an inhibitor of nitric oxide synthase (NOS), and/or methylene blue (MB), a blocker of guanylate cyclase on the vasodilator response of isolated rat arteries including aorta and mesenteric artery to calcitonin gene-related peptide (CGRP) by in vit...

journal_title：Chinese medical journal

authors： Tan DY,Zhang LZ,Zhao YT,Zhao D,Tang J

更新日期：1994-10-01 00:00:00

abstract：:Aluminium citrate (Al-cit) was shown to be biologically effective in preventing silicosis. A total of 917 cases selected from both engineering corps of railway and coalmines with stage 0 or 0+ by radiographs were studied. Cases were randomly divided into Al-cit treatment group and control group with continuing dust ex...

journal_title：Chinese medical journal

authors： Zou SQ,Liu H,Zhou YY,Su KQ,Qi KY,Guan SM,Liu SJ

更新日期：1990-02-01 00:00:00

abstract：BACKGROUND:The best age for the arterial switch operation (ASO) in complete transposition of great arteries with ventricular septal defect is usually considered to be within six months. This is because of severe pulmonary arterial hypertension and pulmonary arterial obstructive pathological changes. There are few repor...

journal_title：Chinese medical journal

authors： Liu CH,Su JW,Li ZQ,Fan XM,Chen Y,He Y,Liu YL

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Studies on selected patients undergoing off-pump versus on-pump coronary artery bypass surgery have produced inconsistent results, especially in patients with multiple coronary artery disease. This study compared the clinical results of on-pump and off-pump coronary bypass surgery in patients with triple-ves...

journal_title：Chinese medical journal

authors： Chen X,Xu M,Shi HW,Mu XW,Chen ZQ,Qiu ZB

更新日期：2004-03-01 00:00:00

abstract：BACKGROUND:Pancreatic cancer is one of the most lethal human cancers with a very low survival rate of 5 years. Conventional cancer treatments including surgery, radiation, chemotherapy or combinations of these show little effect on this disease. Several proteins have been proved critical to the development and the prog...

journal_title：Chinese medical journal

authors： Zhou JH,Cheng HY,Yu ZQ,He DW,Pan Z,Yang DT

更新日期：2011-06-01 00:00:00

abstract：OBJECTIVE:To elucidate the transmission dynamic and epidemic trend of bancroftian filariasis occurred under the condition with no control measure taken 5 years after elimination of filariasis. METHODS:A 10-year longitudinal observation (from 1984 to 1994) was made in Huayuan Village in Shengli Township of Tancheng Cou...

journal_title：Chinese medical journal

authors： Wang P,Wang F,Sun Y,Wang J,Kou J,Huang Y,Kang X,Wan G,Liang Y,Wang Q

更新日期：1998-03-01 00:00:00

abstract：:Dot-ELISA assay was compared with standard Sandwich ELISA in detecting parasite antigen in sera from patients with bancroftian filariasis. The same monoclonal antibody and the same serum samples were used in both assays. With Dot-ELISA, 67 of 70 serum samples from microfilaremic patients were positive at a dilution of...

journal_title：Chinese medical journal

authors： Zheng HJ,Fuhrman JA,Xu M,Cheng WF,Reddy MV,Piessens WF

更新日期：1990-09-01 00:00:00

abstract：BACKGROUND:Asthma is a heterogeneous disease for which a strong genetic basis has been firmly established. Until now no studies have been undertaken to systemically explore the network of asthma-related genes using an internally developed literature-based discovery approach. This study was to explore asthma-related gen...

journal_title：Chinese medical journal

authors： Liang R,Wang L,Wang G

更新日期：2013-07-01 00:00:00

abstract：BACKGROUND:Pulsed radiofrequency (PRF), as a non-invasive treatment of neuropathic pain (NP), has been widely administered clinically. Previous studies have shown that PRF has the potential to improve hyperalgesia in animal models of NP. However, there have been few reports to clarify whether the mechanism of PRF treat...

journal_title：Chinese medical journal

authors： Wang JA,Niu SN,Luo F

更新日期：2020-01-20 00:00:00

abstract：BACKGROUND:Connective tissue growth factor (CTGF) contributes greatly to renal tubulointerstitial fibrosis, which is the final event leading to end-stage renal failure. This study was designed to investigate the effects of CTGF antisense oligodeoxynucleotides (ODNs) on the expressions of plasminogen activator inhibitor...

journal_title：Chinese medical journal

authors： Zhang C,Meng XF,Zhu ZH,Yang X,Deng AG

更新日期：2004-07-01 00:00:00

abstract：OBJECTIVE:To explore the relationship between interleukin-8 (IL-8) and airway hyper-responsiveness (AHR) of asthma in guinea pigs. METHODS:IL-8 at a dose of 0.5 microgram/kg or 5.0 micrograms/kg was administered intranasally to guinea pigs twice a week for 3 weeks. 24 hours after the last administration, airway respon...

journal_title：Chinese medical journal

authors： Qi H,Lu K,Wang W

更新日期：1999-11-01 00:00:00

abstract：OBJECTIVE:To study the ultrastructural damages of brain tissues dynamically after middle cerebral artery obstruction (MCAO). METHODS:A middle cerebral artery obstruction (MCAO) model was reproduced in renal vascular hypertensive rats (RHR). Brain tissues in different locations were collected for eight times in row, fr...

journal_title：Chinese medical journal

authors： Fang Y,Huang R,Su Z,Lin J,Li J

更新日期：2000-06-01 00:00:00

abstract：BACKGROUND:Renal artery stenosis (RAS) is always associated with abnormalities in renal microvascular perfusion (RMP). However, few imaging methods can simultaneously evaluate the degree of luminal stenosis and RMP. Thus, this study will aim to evaluate the feasibility of using contrast-enhanced ultrasound (CEUS) for a...

journal_title：Chinese medical journal

authors： Ren JH,Ma N,Wang SY,Sun YJ,Zhang YW,Guo FJ,Li YJ,Li TH,Ai H,Zhang WD,Li P,Ma WH

更新日期：2019-01-05 00:00:00

abstract：:This is China's pilot study in the assessment of the diagnostic value of serum soluble IL-2 receptor (sIL-2R) in gastric cancer. We measured its level by ELISA method in 45 patients with gastric cancer (without metastasis: 32; with metastasis: 5; recurrence: 8) 27 gastric ulcer, 27 superficial gastritis and 44 healthy...

journal_title：Chinese medical journal

authors： Wang YF,Wu XN,Zhou YH,Chen XF,Shen J,Wang HJ

更新日期：1994-04-01 00:00:00

abstract：BACKGROUND:Stenting a bifurcation lesion is technically challenging. No study has reported the clinical outcome of a dedicated bifurcation stent in China. We aimed to analyze the safety and clinical outcome of a novel side branch ostial stent (BIGUARD) stent in treating coronary bifurcation lesions. METHODS:Forty-seve...

journal_title：Chinese medical journal

authors： Chen SL,Zhang JJ,Ye F

更新日期：2009-09-20 00:00:00

abstract：OBJECTIVE:To evaluate the feasibility, safety and diagnostic accuracy of pharmacologic stress of (99m)Technetium-MIBI single-photon emission computed tomography (SPECT) with intravenous adenosine triphosphate (ATP) in patients with suspected coronary artery disease. METHODS:The study group included 263 patients who we...

journal_title：Chinese medical journal

authors： He Q,Yao Z,Yu X,Qu W,Sun F,Ji F,Xu F,Qian Y

更新日期：2002-11-01 00:00:00

abstract：BACKGROUND:During the last 3 decades, China has dramatic changes of the dietary pattern among its citizens, particularly in urban cities. This study aimed to determine the nutrient intake status and factors associated with nutrient intakes of urban Chinese pregnant women now-a-day. METHODS:The multistage stratified ra...

journal_title：Chinese medical journal

authors： Liu FL,Zhang YM,Parés GV,Reidy KC,Zhao WZ,Zhao A,Chen C,Ning CY,Zheng YD,Wang PY

更新日期：2015-07-05 00:00:00

abstract：BACKGROUND:With the significant improvement in the survival of patients with nasopharyngeal carcinoma (NPC) undergoing radiotherapy and the growing availability of the sophisticated imaging modalities, the number of radiation encephalopathy (RE) cases relating to NPC radiotherapy is increasing. In this study, we invest...

journal_title：Chinese medical journal

authors： Wang XL,Yin JL,Li H,Li XD,Quan JT

更新日期：2007-03-20 00:00:00

abstract：BACKGROUND:It is unclear whether a history of paroxysmal atrial fibrillation (PAF) would impact the effect of catheter ablation on persistent atrial fibrillation (AF). This study aimed to compare the effect of catheter ablation on persistent AF with and without a history of PAF. METHODS:One hundred and eighty-three pa...

journal_title：Chinese medical journal

authors： Miao CL,Yin XD,Dong JZ,Liu XP,Yu RH,Long DY,Tang RB,Sang CH,Ma CS

更新日期：2012-03-01 00:00:00

abstract：BACKGROUND:This retrospective study aimed to investigate the difference of the intra-dural reserving space for spinal cord in magnetic resonance imaging (MRI) between patients with and without developmental cervical stenosis and its clinical significance. METHODS:A total of 264 patients with cervical spondylotic myelo...

journal_title：Chinese medical journal

authors： Tang Y,Yu M,Liu Z,Sun Y,Liu X

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Interferon-gamma release assay (IGRA) has been used in latent tuberculosis (TB) infection and TB diagnosis, but the results from different high TB-endemic countries are different. The aim of this study was to investigate the value of IGRA in the diagnosis of active pulmonary TB (PTB) in China. METHODS:We co...

journal_title：Chinese medical journal

authors： Kang WL,Wang GR,Wu MY,Yang KY,Er-Tai A,Wu SC,Geng SJ,Li ZH,Li MW,Li L,Tang SJ

更新日期：2018-02-05 00:00:00

abstract：BACKGROUND:One of the reasons for poor neuroregeneration after central nervous system injury is the presence of inhibitory factors such as Nogo. Here, we tested the inhibition of Nogo by RNA interference both in vitro and in vivo, using recombinant adenovirus-mediated transfection of short hairpin RNAs, to explore a ne...

journal_title：Chinese medical journal

authors： Sun HH,Gao F,Liu B,Yu HT,Kong N,Liu GM

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND:It is a surgical dilemma when patients present with both severe heart disease and neoplasms. The best surgical treatment remains controversial. This study aimed to analyze the early and long-term results of simultaneous surgical treatment of severe heart disease and neoplasms. METHODS:We reviewed the clinic...

journal_title：Chinese medical journal

authors： Fu Q,Li QZ,Liang DG,Ruan XH,Wang ZX,Wei MX

更新日期：2011-07-05 00:00:00

abstract：BACKGROUND:The rapid transmission and high mortality rate made severe acute respiratory syndrome (SARS) a global threat for which no efficacious therapy is available now. Without sufficient knowledge about the SARS coronavirus (SARS-CoV), it is impossible to define the candidate for the anti-SARS targets. The putative ...

journal_title：Chinese medical journal

authors： Lu JH,Zhang DM,Wang GL,Guo ZM,Zhang CH,Tan BY,Ouyang LP,Lin L,Liu YM,Chen WQ,Ling WH,Yu XB,Zhong NS

更新日期：2005-05-05 00:00:00