Abstract：
BACKGROUND:Stenting a bifurcation lesion is technically challenging. No study has reported the clinical outcome of a dedicated bifurcation stent in China. We aimed to analyze the safety and clinical outcome of a novel side branch ostial stent (BIGUARD) stent in treating coronary bifurcation lesions. METHODS:Forty-seven patients were enrolled in this first-in-man study, with 61.7% true bifurcation lesions (0,1,1 and 1,1,1) and 26.7% diabetes. A two-stent technique was used in 27.6% of the patients, and 64.7% of patients crossed from the one-stent technique to the two-stent arm. Clinical and angiographic follow-up data at 12 months were available in all the 47 patients and in 43 patients (91.9%), respectively. The study endpoint was the occurrence of major adverse cardiac events (MACE) at 12 months. RESULTS:Only one patient had a non-ST segment elevation myocardial infarction, which led to 2% of the in-hospital composite MACE. Notably, the target lesion revascularization at 12 months was 8.6%, with a 10.6% composite MACE at 12 months. Neither cardiac death nor stent thrombosis was seen during the follow-up. By quantitative coronary analysis, the restenosis rate at the main vessel and ostium of the side branch was 9.4% and 2.1%, respectively. Four of 12 patients (33.3%) treated with one-stent and kissing balloon inflation had restenosis in the main vessel. CONCLUSION:BIGUARD stent was safe and feasible in treatment of bifurcation lesions.
journal_name
Chin Med J (Engl)journal_title
Chinese medical journalauthors
Chen SL,Zhang JJ,Ye Fsubject
Has Abstractpub_date
2009-09-20 00:00:00pages
2092-6issue
18eissn
0366-6999issn
2542-5641journal_volume
122pub_type
临床试验,杂志文章abstract：BACKGROUND:Image-guided radiation therapy (IGRT) is the preferred method for curative treatment of localized prostate cancer, which could improve disease outcome and reduce normal tissue toxicity reaction. IGRT using cone-beam computed tomography (CBCT) in combination with volumetric-modulated arc therapy (VMAT) potent...
journal_title：Chinese medical journal
pub_type： 杂志文章
doi：10.4103/0366-6999.183429
更新日期：2016-06-20 00:00:00
abstract：OBJECTIVE:To study the cellular mechanism of the effect of Ang II on ICa,L in single guinea-pig ventricular cells by using losartan and 1-(5-lsoquinolinylsulfonyl)-2-Methyl-Piperazine (H-7) as the Ang II type 1 receptor (AT1) inhibitor and protein kinase C inhibitor, respectively. METHODS:Patch clamp techniques were u...
journal_title：Chinese medical journal
pub_type： 杂志文章
doi：
更新日期：2001-06-01 00:00:00
abstract：BACKGROUND:Tumor necrosis factor-α is a key mediator in the pathogenesis of psoriasis. Infliximab is a monoclonal antibody that specifically binds to tumor necrosis factor-α. The purpose of this study was to validate the efficacy and safety of 5 mg/kg infliximab therapy in Chinese patients with moderate to severe plaqu...
journal_title：Chinese medical journal
pub_type： 杂志文章,多中心研究,随机对照试验
doi：
更新日期：2012-06-01 00:00:00
abstract：OBJECTIVE:To investigate the correlation among retinal fluorescein angiography, blood viscosity, and other factors in patients with open angle glaucoma (POAG). METHODS:Multiple step regression analysis was made to investigate the correlation between each of the following blood vessel filling times: the arm-choroid (A-...
journal_title：Chinese medical journal
pub_type： 杂志文章
doi：
更新日期：1997-09-01 00:00:00
abstract：OBJECTIVE:To explore the characteristics of Helicobacter pylori (H. pylori) antigen in serum and to evaluate its clinical diagnostic value. METHODS:Enzyme-linked immunosorbant assay (ELISA) was developed to detect the soluble H. pylori antigen (S-Hp) and circulatory specific H. pylori antigen immunocomplexes (Hp-IC) i...
journal_title：Chinese medical journal
pub_type： 杂志文章
doi：
更新日期：2002-03-01 00:00:00
abstract：: ...
journal_title：Chinese medical journal
pub_type： 社论
doi：10.4103/0366-6999.247217
更新日期：2018-12-20 00:00:00
abstract：:Forty-four infertile women in 44 cycles were stimulated by CC/hMG/hCG (39 cycles) and by CC/hCG (5 cycles) for the purpose of in vitro fertilization (IVF, 37 cases with 35 transfers) and gamete intrafallopian transfer (GIFT, 7 cases). Intraoperative ovum pick-up was performed 32-36 hours after hCG injection. Blood E2 ...
journal_title：Chinese medical journal
pub_type： 杂志文章
doi：
更新日期：1990-03-01 00:00:00
abstract：Background:Type 2 diabetes (T2DM) patients are susceptible to Helicobacter pylori (HP), and it has been reported that the occurrence of proteinuria is associated with HP infection in T2DM patients; however, this view remains controversial. This meta-analysis aimed to explore the association between HP infection and the...
journal_title：Chinese medical journal
pub_type： 杂志文章,meta分析,评审
doi：10.4103/0366-6999.245269
更新日期：2018-11-20 00:00:00
abstract：BACKGROUND:A number of studies have demonstrated the rates of overall and aneurysm-related mortality and morbidity in Western populations. The cardiovascular risk factors influencing postoperative outcome have been also reported. Until recently, little has been known about the prognosis in this patient cohort in the Ch...
journal_title：Chinese medical journal
pub_type： 杂志文章
doi：
更新日期：2014-01-01 00:00:00
abstract：OBJECTIVE:To investigate the effects of gypenosides (Gs) on cellular immunocompetence in the gamma-ray-irradiated mice. MATERIALS AND METHODS:Tested mice of ICR strain were treated continuously with Gs for 10 days before or after 4 Gy gamma-irradiation. Body weight and splenic weight of mice were measured. The blastog...
journal_title：Chinese medical journal
pub_type： 杂志文章
doi：
更新日期：1996-02-01 00:00:00
abstract：BACKGROUND:Drug treatment for secondary hyperparathyroidism caused by chronic renal failure may be available at the early stage of the disease, but it is not as effective for serious patients. The aim of the study was to evaluate the effect of total parathyroidectomy combined with forearm autotransplantation in the ure...
journal_title：Chinese medical journal
pub_type： 杂志文章
doi：
更新日期：2007-10-20 00:00:00
abstract：BACKGROUND:Recombinant human-erythropoietin (rh-EPO) has therapeutic efficacy for premature infants with brain damage during the active rehabilitation and anti-inflammation. In the present study, we found that the rh-EPO was related to the promotion of neovascularization. Our aim was to investigate whether rh-EPO augme...
journal_title：Chinese medical journal
pub_type： 杂志文章
doi：10.4103/0366-6999.202744
更新日期：2017-04-05 00:00:00
abstract：BACKGROUND:Endothelial dysfunction is thought to be critical events in the pathogenesis of Alzheimer's disease (AD). Endothelial progenitor cells (EPCs) have provided insight into maintaining and repairing endothelial function. To study the relation between EPCs and AD, we explored the number of circulating EPCs in pat...
journal_title：Chinese medical journal
pub_type： 杂志文章
doi：
更新日期：2011-03-01 00:00:00
abstract：:This review of recent literature presents new concepts to evaluate radiation hormesis in cancer mortality. Using these interpretations cancer mortality rates were found to be significantly reduced following whole body exposure to low doses of either acute or chronic irradiation. The threshold dose, the zero equivalent...
journal_title：Chinese medical journal
pub_type： 杂志文章,评审
doi：
更新日期：1994-08-01 00:00:00
abstract：BACKGROUND:It is still controversial as to the implementation of higher positive end-expiratory pressure (PEEP) in patients with acute respiratory distress syndrome (ARDS). This study was conducted to compare the lower and higher PEEP in patients with ARDS ventilated with low tidal volume, to investigate the relationsh...
journal_title：Chinese medical journal
pub_type： 临床试验,杂志文章
doi：
更新日期：2008-11-20 00:00:00
abstract：OBJECTIVE:To report our experiences in retroperitoneoscopic renal pedicle lymphatic stripping for chyluria. METHODS:Six cases of filarial chyluria were admitted to our hospital from November 2001 to June 2002. Of these cases, 4 were men and 2 women, with age ranging from 34 to 52 years (mean, 42 years). Diagnosis was ...
journal_title：Chinese medical journal
pub_type： 杂志文章
doi：
更新日期：2003-11-01 00:00:00
abstract：BACKGROUND:In county-level tuberculosis (TB) dispensaries in China, the accurate diagnosis of sputum smear-negative pulmonary tuberculosis (SNPT) needs to be improved by developing and validating clinical and radiographic predictors. METHODS:The study was conducted simultaneously in three counties per province in Chon...
journal_title：Chinese medical journal
pub_type： 杂志文章
doi：
更新日期：2013-01-01 00:00:00
abstract：OBJECTIVE:To investigate the incidence rate, pathologic changes, mechanisms and diagnostic methods in renal bone disease. METHODS:The blood levels of carboxyterminal parpthyriod hormone (C-PTH), 1,25(OH)2D3, calcium and phosphate, aluminum in serum and bone tissue were measured. The bone biopsy and bone scan with 99m ...
journal_title：Chinese medical journal
pub_type： 杂志文章
doi：
更新日期：1998-09-01 00:00:00
abstract：OBJECTIVE:The aim of this study was to summarize recent studies on nondopaminergic options for the treatment of motor symptoms in Parkinson's disease (PD). DATA SOURCES:Papers in English published in PubMed, Cochrane, and Ovid Nursing databases between January 1988 and November 2016 were searched using the following k...
journal_title：Chinese medical journal
pub_type： 杂志文章,评审
doi：10.4103/0366-6999.211555
更新日期：2017-08-05 00:00:00
abstract：OBJECTIVE:To determine the relationships of Met416Val and XbaI polymorphism of muscle glycogen synthase (GYS1) gene and Trg64Arg variant of the beta(3)-adrenergic-receptor (beta(3)-AR) gene with type 2 diabetes mellitus (DM) and its intermediate phenotypes in the Chinese population. METHODS:Polymerase chain reaction-o...
journal_title：Chinese medical journal
pub_type： 杂志文章
doi：
更新日期：2002-09-01 00:00:00
abstract：BACKGROUND:It remains controversial whether patients with Stage II colorectal cancer would benefit from adjuvant chemotherapy after radical resection. The aim of this study was to establish two mathematical models to identify the suitable patients for adjuvant chemotherapy. METHODS:The current study comprised of two s...
journal_title：Chinese medical journal
pub_type： 杂志文章
doi：10.4103/0366-6999.213432
更新日期：2017-09-05 00:00:00
abstract：BACKGROUND:Atypical meningioma is one of the rare subtypes of meningioma, which is lacking of optimal consensus on treatment strategies. This study aimed to investigate the radical treatment strategies to improve the long-term outcome of recurrent atypical meningiomas. METHODS:The prognostic factors including the age ...
journal_title：Chinese medical journal
pub_type： 杂志文章
doi：
更新日期：2011-08-01 00:00:00
abstract：BACKGROUND:Peroxisome proliferator-activated receptor (PPAR) alpha is one of the subtypes of PPARs. It regulates metabolism of lipid and lipoprotein, as well as glucose homeostasis. In addition, PPARalpha influences cellular proliferation, inflammation, differentiation and apoptosis, which plays a vital role in cardiov...
journal_title：Chinese medical journal
pub_type： 杂志文章
doi：
更新日期：2008-08-20 00:00:00
abstract：BACKGROUND:Septicemia and inflammation-mediated septic shock caused by Vibrio vulnificus (VV) is strongly associated with chronic liver disease. This study examined the effects of antimicrobial therapy on expression of hepatic toll-like receptors and inflammatory cytokines in rats with alcohol-induced liver disease com...
journal_title：Chinese medical journal
pub_type： 杂志文章
doi：
更新日期：2009-08-20 00:00:00
abstract：BACKGROUND:Pulmonary problems often occur in patients with early-onset scoliosis (EOS). However, lung function in patients with EOS after growing rod surgery has not been documented. The aim of this study was to investigate lung function after the treatment for EOS with growing rod and its possible correlative factors....
journal_title：Chinese medical journal
pub_type： 杂志文章
doi：
更新日期：2011-12-01 00:00:00
abstract：OBJECTIVES:To assess the feasibility and efficacy of eliciting leukemia-specific T-cell responses in syngeneic mice in vitro and in vivo using dendritic cells (DCs) pulsed with total RNA from leukemia cells. METHODS:DCs generated from bone marrow culture in vitro in the presence of combined cytokines were pulsed with ...
journal_title：Chinese medical journal
pub_type： 杂志文章
doi：
更新日期：2003-11-01 00:00:00
abstract：BACKGROUND:The development of the targeted signal transduction inhibitor STI571 has prompted us to treat chronic myeloid leukemia in different ways. Since STI571 may reverse multidrug-resistance of K562/MDR cells in vitro, we studied the effect of STI571 on multidrug-resistant K562 cells in vivo. METHODS:Multidrug-res...
journal_title：Chinese medical journal
pub_type： 杂志文章
doi：
更新日期：2006-06-05 00:00:00
abstract：:Metastases to the breast from extramammary neoplasms are very rare, constituting 2.7% of all malignant breast tumours. The most common primary tumor metastatic to the breast is primary breast cancer. Rectal cancer metastasizing to the breast is extremely rare. We report a case of aggressive rectal carcinoma with metas...
journal_title：Chinese medical journal
pub_type： 杂志文章
doi：
更新日期：2011-04-01 00:00:00
abstract：BACKGROUND:Preoperative incisional local anaesthesia with ropivacaine is a common method of providing post-laparoscopy pain relief. The pulmonary recruitment manoeuvre also provides pain relief, but the combined effect of these two methods on pain following laparoscopic procedures has not been reported. We investigated...
journal_title：Chinese medical journal
pub_type： 杂志文章,随机对照试验
doi：
更新日期：2014-01-01 00:00:00
abstract：BACKGROUND:Three randomised trials have demonstrated that combining bevacizumab with first-line chemotherapy significantly improves progression-free survival versus chemotherapy alone in HER2-negative locally recurrent/metastatic breast cancer (LR/mBC). However, data from Chinese populations are limited and possible di...
journal_title：Chinese medical journal
pub_type： 临床试验,杂志文章
doi：
更新日期：2012-03-01 00:00:00
