Current Nondopaminergic Therapeutic Options for Motor Symptoms of Parkinson's Disease.

abstract：BACKGROUND:Alpha 2A adrenergic receptor (AR) is a subtype of α2 AR belonging to G protein-coupled receptors, and exerts a variety of biological effects. Recent studies have demonstrated that the α2A AR activation was closely related with inflammatory reaction. The present study aimed to investigate the influence of α2A...

journal_title：Chinese medical journal

authors： Lin Y,Zhu X,Yao WZ,Yang YL,A LT,Chen L

更新日期：2011-04-01 00:00:00

abstract：:Twenty-seven samples of pleomorphic salivary adenoma (PSA) were examined for expression and structure of c-myc, c-Ha-ras, c-erbB-2, c-sis oncogenes by RNA dot blot, DNA dot blot and Southern blot hybridization. Eighteen of 25 PSA showed 5.02 +/- 4.74 fold overexpression of c-myc oncogene, 6 of 19 PSA had 4.91 +/- 3.87...

journal_title：Chinese medical journal

authors： Xue H,Situ ZQ,Wang CJ,Wu JZ

更新日期：1993-01-01 00:00:00

abstract：BACKGROUND:Double plate osteosynthesis is the standard treatment for intra-articular fractures of the distal humerus. However, there is still controversy concerning dual plate positions in terms of providing optimal stability. The purpose of this retrospective study was to compare the clinical outcomes in patients with...

journal_title：Chinese medical journal

authors： Lan X,Zhang LH,Tao S,Zhang Q,Liang XD,Yuan BT,Xu WP,Yin P,Tang PF

更新日期：2013-06-01 00:00:00

abstract：OBJECTIVE:To determine the effects and toxicity of interstitial brachytherapy using iridium-192 on brain malignant gliomas. METHODS:Between January 1992 and January 1995, 56 patients with anaplastic astrocytoma and glioblastoma multiforme were treated with stereotactic brachytherapy using temporary high-activity iridi...

journal_title：Chinese medical journal

authors： Liu Z,Yu X,Guo Y,Li S,Cui Y,Yu X,Yuan Z,Kang J

更新日期：1999-02-01 00:00:00

abstract：BACKGROUND:Psoriasis is a chronic inflammatory skin disease, affecting about 0.6% of the Chinese population. Many patients are not well controlled by conventional treatments, thus there is need for new treatment regimens. In this study, we assessed the efficacy and safety of secukinumab in Chinese patients with moderat...

journal_title：Chinese medical journal

authors： Cai L,Zhang JZ,Yao X,Gu J,Liu QZ,Zheng M,Zhang SF,Xu JH,Li CX,Cheng H,Guo Q,Pan WL,Li SQ,Li RY,Guo ZP,Song ZQ,Li SS,Dong XQ,Wang L,Fu R,Regnault P,Charef P,Mazur R,Patekar M

更新日期：2020-11-20 00:00:00

abstract：OBJECTIVE:Secreted modular calcium-binding proteins (SMOCs) are extracellular glycoproteins of the secreted protein, acidic, and rich in cysteine-related modular calcium-binding protein family and include two isoforms, SMOC1 and SMOC2, in humans. Functionally, SMOCs bind to calcium for various cell functions. In this r...

journal_title：Chinese medical journal

authors： Gao Q,Mok HP,Zhuang J

更新日期：2019-10-20 00:00:00

abstract：:This review of recent literature presents new concepts to evaluate radiation hormesis in cancer mortality. Using these interpretations cancer mortality rates were found to be significantly reduced following whole body exposure to low doses of either acute or chronic irradiation. The threshold dose, the zero equivalent...

journal_title：Chinese medical journal

authors： Lukey TD

更新日期：1994-08-01 00:00:00

abstract：:Using the electrophoretic method, the changes in the catalytic activities of three CK-MM isoforms in multiple sequential serum samples of 12 patients with acute myocardial infarction (AMI) were monitored for 3 days after the onset of chest pain. In post-AMI period, MM3 reached a peak (518.6 U/L) first, on the average ...

journal_title：Chinese medical journal

authors： Yang XS,Meng QY

更新日期：1993-06-01 00:00:00

abstract：OBJECTIVE:To explore the mechanism of autoimmune hemolysis and establish a more sensitive test for autoimmune hemolytic anemia (AIHA). METHODS:IgG subclasses were tested in 40 patients with idiopathic or secondary AIHA by Coombs test with monoclonal antibodies. Hb, TBil, RC and FHb, as hemolytic parameters, were used ...

journal_title：Chinese medical journal

authors： Li Z,Shao Z,Xu Y,Shen L,Chen G,Zhang Y,Chu Y

更新日期：1999-09-01 00:00:00

abstract：BACKGROUND:After establishing a murine model of aminoglycoside antibiotic (AmAn) induced ototoxicity, the sensitivity of AmAn induced ototoxicity in three murine strains and the effect of kanamycin on the expression of Na-K-2Cl cotransporter-1 (NKCC1) in stria vascularis were investigated. METHODS:C57BL/6J, CBA/CaJ, N...

journal_title：Chinese medical journal

authors： Chu HQ,Xiong H,Zhou XQ,Han F,Wu ZG,Zhang P,Huang XW,Cui YH

更新日期：2006-06-20 00:00:00

abstract：BACKGROUND:Duchenne muscular dystrophy (DMD) and Becker muscular dystrophy (BMD) are X-linked recessive neuromuscular diseases resulting from dystrophin (DMD) gene mutations. It has been known that the carrier of DMD mutations may also have symptoms of the disease. While de novo mutation is quite common in BMD/DMD pati...

journal_title：Chinese medical journal

authors： Yu H,Chen YC,Liu GL,Wu ZY

更新日期：2017-10-05 00:00:00

abstract：BACKGROUND:Osteoarthritis (OA) is the most common form of human polyarthritis. Many genetic factors have been implicated in OA. It was reported that a polymorphism in the gene of interleukin-6 (IL-6) was associated with OA of knee. The aim of this study was to determine whether functional IL-6 promoter -174G/C (rs18007...

journal_title：Chinese medical journal

authors： Ai Z,Ning X,Shou T,Tang W,Luo Y,Zhang J

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Roundabout 5 (R5) is a monoclonal antibody which can neutralize the binding of Roundabout 1 (Robo1) to Slit2. Oral squamous cell carcinoma angiogenesis was significantly inhibited when R5 blocked slit-robo signaling pathway. However, the effect of R5 on the invasion of tongue cancer cells has not been invest...

journal_title：Chinese medical journal

authors： Xiao R,Zhao Y,Wang LJ,Li WP

更新日期：2011-08-01 00:00:00

abstract：BACKGROUND:Inner retinal oxygenation response (ΔPO(2)) is a worldwide study focus. However, the relevant reports on its radiological measurements are limited. In this study, magnetic resonance imaging (MRI), employing T1 weighted image (T1WI), was used to detect changes in ΔPO(2) following 100% oxygen inhalation in hum...

journal_title：Chinese medical journal

authors： Xu QG,Chen QH,Xian JF,Wang ZC

更新日期：2010-11-01 00:00:00

abstract：BACKGROUND:Fractional flow reserve (FFR) has become an increasingly important index when making decisions with respect to revascularization of coronary artery stenosis. However, the pressure guidewire used in obtaining FFR measurements is difficult to control and manipulate in certain complex coronary artery lesions, r...

journal_title：Chinese medical journal

authors： He WM,Li CL,Sun Y,Zhou Z,Mai YF

更新日期：2015-03-20 00:00:00

abstract：BACKGROUND:Although breast-conserving surgery is one of the standard treatments for breast cancer, few studies have assessed its recent implementation in China. We aimed to clarify the current real-world status of breast-conserving surgery in China. METHODS:This cross-sectional survey relied on data collected by the C...

journal_title：Chinese medical journal

authors： Yu LX,Shi P,Tian XS,Yu ZG,Chinese Society of Breast Surgery.

更新日期：2020-11-20 00:00:00

abstract：BACKGROUND:Urine output (UO) is an essential criterion of the Kidney Disease Improving Global Outcomes (KDIGO) definition and classification system for acute kidney injury (AKI), of which the diagnostic value has not been extensively studied. We aimed to determine whether AKI based on KDIGO UO criteria (KDIGOUO) could ...

journal_title：Chinese medical journal

authors： Qin JP,Yu XY,Qian CY,Li SS,Qin TH,Chen EZ,Lin JD,Ai YH,Wu DW,Liu DX,Sun RH,Hu ZJ,Cao XY,Zhou FC,He ZY,Zhou LH,An YZ,Kang Y,Ma XC,Zhao MY,Jiang L,Xu Y,Du B,China Critical Care Clinical Trial Group (CCCCTG).

更新日期：2016-09-05 00:00:00

abstract：OBJECTIVE:To elucidate the transmission dynamic and epidemic trend of bancroftian filariasis occurred under the condition with no control measure taken 5 years after elimination of filariasis. METHODS:A 10-year longitudinal observation (from 1984 to 1994) was made in Huayuan Village in Shengli Township of Tancheng Cou...

journal_title：Chinese medical journal

authors： Wang P,Wang F,Sun Y,Wang J,Kou J,Huang Y,Kang X,Wan G,Liang Y,Wang Q

更新日期：1998-03-01 00:00:00

abstract：BACKGROUND:The Ras/Raf/ERK1/2 signaling pathway controls many cellular responses such as cell proliferation, migration, differentiation, and death. In the nervous system, emerging evidence also points to a death-promoting role for ERK1/2 in both in vitro and in vivo models of neuronal death. To further investigate how ...

journal_title：Chinese medical journal

authors： Cao FJ,Zhang X,Liu T,Li XW,Malik M,Feng SQ

更新日期：2013-10-01 00:00:00

abstract：BACKGROUND:Studies have shown that abnormal activation of the sonic hedgehog pathway is closely related to tumorigenesis in central nervous system. This study aimed to investigate the role of the sonic hedgehog signaling pathway in the occurrence of brainstem and supratentorial glioma. METHODS:Real-time quantitative r...

journal_title：Chinese medical journal

authors： Xin Y,Hao SY,Tian YJ,Zhang JT,Wu Z,Wan H,Li JH,Jiang J,Zhang LW

更新日期：2011-11-01 00:00:00

abstract：:Somatosensory evoked potentials (SEP) arising from median nerve stimulation were recorded in 102 patients with unilateral cerebral hemorrhage or infarct located in basal ganglion, internal capsule, thalamus or cerebral lobe. Of them 42 cases were followed up and reexamined with SEPs. Three types of SEPs were observed:...

journal_title：Chinese medical journal

authors： Lu ZN,Yu SZ

更新日期：1993-01-01 00:00:00

abstract：OBJECTIVE:To analyse the relationship between age and treatment with captopril after acute myocardial infarction (AMI). METHODS:In a randomized trial, 822 patients with a first AMI received conventional medical treatment, including intravenous thrombolytic therapy and oral aspirin or metoprolol, and then were randomly...

journal_title：Chinese medical journal

authors： Cai X,Shen W,Gong L

更新日期：2001-07-01 00:00:00

abstract：:Apolipoprotein (a) [Lp(a)] phenotypes of 69 myocardial infarction survivor and 56 stroke patients were reported and compared to those of 190 healthy Chinese. The results revealed that the distributions of apo(a) phenotype frequency in patients with cardio-cerebrovascular disease (CCVD) were different from those of con...

journal_title：Chinese medical journal

authors： Zhuang YY,Li JJ,Wang JJ

更新日期：1994-02-01 00:00:00

abstract：BACKGROUND:There is no detailed report about the angiographic leakage of polypoidal choroidal vasculopathy (PCV) lesions on indocyanine green (ICG) angiography. This study aimed to investigate the angiographic leakage of polypoidal lesions in PCV on ICG angiography. METHODS:One hundred and forty-four eyes of 137 patie...

journal_title：Chinese medical journal

authors： Zuo CG,Wen F,Huang SZ,Luo GW,Yan H,Wu WJ,Wu DZ

更新日期：2010-06-01 00:00:00

abstract：BACKGROUND:Chronic liver disease causes aberrant formation of fibrous tissue that impedes normal liver function, ultimately resulting in liver cirrhosis. Iron uptake can occur within the hepatic parenchyma or within the various nodules that form in a cirrhotic liver, termed siderotic nodules (SN). We aimed to investiga...

journal_title：Chinese medical journal

authors： Tao R,You ZL,Zhang JQ,Dai YM,Zhou DQ,Cai P,Fan Y,Cui JG,Wang J

更新日期：2012-09-01 00:00:00

abstract：BACKGROUND:The acute abdomen remains a challenge for all obstetricians and physicians who take part in the care of women in pregnancy. To add substantially to our understanding of acute pancreatitis (AP) in pregnancy, in particular affirming the increased risks for mother and fetus associated with AP, we explored featu...

journal_title：Chinese medical journal

authors： Li HP,Huang YJ,Chen X

更新日期：2011-09-01 00:00:00

abstract：BACKGROUND:The endovascular treatment of abdominal aortic aneurysm (AAA) has improved greatly in the last 15 years. The present study aimed to evaluate the endografting experience for the treatment of unfavorable abdominal aortic aneurysm (uAAA). METHODS:During December 2001 and December 2007, 41 patients with uAAA we...

journal_title：Chinese medical journal

authors： Hu ZJ,Chang GQ,Li XX,Huang XL,Yin HH,Wang SM

更新日期：2009-04-05 00:00:00

abstract：:Total or near-total fertilization failure after intracytoplasmic sperm injection (ICSI) is a rare event, but it occurs repeatedly because of sperm defects in activating oocyte. The case presents a successful pregnancy and live birth after calcium ionophore A23187 (A23187) activation on one-day-old unfertilized oocytes...

journal_title：Chinese medical journal

authors： Lu Q,Chen X,Li Y,Zhang XH,Liang R,Zhao YP,Wei LH,Shen H

更新日期：2012-02-01 00:00:00

abstract：OBJECTIVE:To investigate the relationship between the presence of the TNF2 allele and plasma concentrations of tumor necrosis factor-alpha (TNF alpha) and soluble TNF receptor (sTNF-R) with the development of acute severe pancreatitis (ASP) and severe sepsis. METHODS:Genomic DNA was prepared from peripheral blood leuk...

journal_title：Chinese medical journal

authors： Zhang D,Li J,Jiang Z,Yu B,Tang X,Li W

更新日期：2003-11-01 00:00:00

abstract：OBJECTIVE:To study the analgesic mechanism of gabapentin, an anticonvulsant, during antinociceptive clinical treatment. METHODS:Whole-cell voltage-clamp recordings were taken from adult rat spinal cord slices to investigate the effect of gabapentin on primary afferent A delta-fiber evoked excitatory postsynaptic curre...

journal_title：Chinese medical journal

authors： Liu Z,Xu R,Yang K

更新日期：2003-06-01 00:00:00