Abstract:
:Using the electrophoretic method, the changes in the catalytic activities of three CK-MM isoforms in multiple sequential serum samples of 12 patients with acute myocardial infarction (AMI) were monitored for 3 days after the onset of chest pain. In post-AMI period, MM3 reached a peak (518.6 U/L) first, on the average 14.0 hours after AMI, followed by MM2 (19.8 h, 640.5 U/L) and MM1 (28.7 h, 641.3 U/L). According to their faster decay from circulation, MM3 had higher fractional disappearance and appearance rates, followed by MM2 and MM1. The MM3/MM1 activity ratio rose beyond the upper limit, found in health subjects, about 3.5 hours after onset of symptom and peaked on an average 10.6 hours after AMI, even earlier than the peaks of all isoforms, CK and CK-MB. On the other hand, our findings indicated these changes in isoform composition can be of value in estimating the time elapsed since the onset of tissue damage; MM3 is the predominant isoform when the tissue necrosis is of relatively recent origin (5-15 h); MM2 is the dominant subband between 15 and 24 hours after AMI, whereas a predominant MM1 band would indicate a significantly longer time period since the injury occurred (24 hours or more). Thus, these characteristics make CK-MM isoforms an earlier and more sensitive indicator of acute release from necrotic myocardium and an effective mean of predicting the time of the onset of AMI.
journal_name
Chin Med J (Engl)journal_title
Chinese medical journalauthors
Yang XS,Meng QYsubject
Has Abstractpub_date
1993-06-01 00:00:00pages
410-4issue
6eissn
0366-6999issn
2542-5641journal_volume
106pub_type
杂志文章abstract::Lectin binding patterns in psoriasis, lichen planus and seborrheic keratosis lesions were studied using 14 different biotinyl lectins and avidin-horseradish peroxidase. Compared with normal epidermis, there were significant quantitative and qualitative differences, some of which were characteristic. ...
journal_title:Chinese medical journal
pub_type: 杂志文章
doi:
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abstract:Background:Facing the increasing prevalence of gestational diabetes mellitus (GDM), this study aimed to evaluate the management of GDM and its association with adverse pregnancy outcomes. Methods:The data of 996 inpatients with GDM who terminated pregnancies in our hospital from January 2011 to December 2015 were coll...
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journal_title:Chinese medical journal
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doi:
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abstract:BACKGROUND:Peripheral nerve injury causes a high rate of disability and a huge economic burden, and is currently one of the serious health problems in the world. The use of nerve grafts plays a vital role in repairing nerve defects. Acellular nerve grafts have been widely used in many experimental models as a periphera...
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journal_title:Chinese medical journal
pub_type: 杂志文章
doi:
更新日期:1992-05-01 00:00:00
abstract:OBJECTIVE:To explore the mechanism of cisplatin resistance and its reversion in human ovarian cancer. MATERIALS AND METHODS:A cisplatin resistant cell subline of SKOV3, SKOV3/cp, was established, and a xenograft mice model of human ovarian cancer was established by microencapsulation technology. Various biochemical ch...
journal_title:Chinese medical journal
pub_type: 杂志文章
doi:
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pub_type: 杂志文章
doi:
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doi:
更新日期:2011-03-01 00:00:00
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更新日期:2003-11-01 00:00:00
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journal_title:Chinese medical journal
pub_type: 杂志文章
doi:
更新日期:1991-01-01 00:00:00
abstract:BACKGROUND:Von Hippel-Lindau (VHL) disease is a hereditary tumor disorder caused by mutations or deletions of the VHL gene. Few studies have documented the clinical phenotype and genetic basis of the occurrence of VHL disease in China. This study armed to present clinical and genetic analyses of VHL within a five-gener...
journal_title:Chinese medical journal
pub_type: 杂志文章
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更新日期:2015-01-05 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2015-04-20 00:00:00
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journal_title:Chinese medical journal
pub_type: 杂志文章
doi:
更新日期:2005-10-05 00:00:00
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journal_title:Chinese medical journal
pub_type: 杂志文章
doi:
更新日期:2012-06-01 00:00:00
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journal_title:Chinese medical journal
pub_type: 杂志文章,多中心研究
doi:
更新日期:1995-04-01 00:00:00
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journal_title:Chinese medical journal
pub_type: 杂志文章
doi:
更新日期:2009-08-05 00:00:00
abstract:BACKGROUND:The effects of near-road pollution on lung function in China have not been well studied. We aimed to investigate the effects of long-term exposure to traffic-related air pollution on lung function, airway inflammation, and respiratory symptoms. METHODS:We enrolled 1003 residents aged 57.96 ± 8.99 years livi...
journal_title:Chinese medical journal
pub_type: 杂志文章
doi:10.4103/0366-6999.189923
更新日期:2016-09-20 00:00:00
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journal_title:Chinese medical journal
pub_type: 杂志文章
doi:
更新日期:2008-11-20 00:00:00
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journal_title:Chinese medical journal
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:
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abstract:BACKGROUND:Acute kidney injury (AKI) is a severe disease in critically ill patients. Neutrophil infiltration into kidney was associated with the development of AKI, and P-selectin may be involved in the process of neutrophil recruitment in kidney. This study aimed to explore the potential effect of platelet-derived P-s...
journal_title:Chinese medical journal
pub_type: 杂志文章
doi:10.4103/0366-6999.209889
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abstract::Aluminium citrate (Al-cit) was shown to be biologically effective in preventing silicosis. A total of 917 cases selected from both engineering corps of railway and coalmines with stage 0 or 0+ by radiographs were studied. Cases were randomly divided into Al-cit treatment group and control group with continuing dust ex...
journal_title:Chinese medical journal
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1990-02-01 00:00:00
abstract::Myocardial revascularization by Nd: YAG laser used in rats with myocardial infarction was studied. The left coronary artery was ligated and the laser channels with a diameter of 300 microns were made immediately by 2.5-4.2 W lasersonics YAG unit. After 24 hours, the rats were killed. Evaluation included hemodynamics, ...
journal_title:Chinese medical journal
pub_type: 杂志文章
doi:
更新日期:1993-09-01 00:00:00
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journal_title:Chinese medical journal
pub_type: 杂志文章
doi:
更新日期:2009-08-20 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2017-04-20 00:00:00
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pub_type: 杂志文章,多中心研究
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更新日期:2016-07-20 00:00:00
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journal_title:Chinese medical journal
pub_type: 杂志文章
doi:
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journal_title:Chinese medical journal
pub_type: 杂志文章,meta分析
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journal_title:Chinese medical journal
pub_type: 杂志文章
doi:
更新日期:2005-11-20 00:00:00