Experimental study on the mechanism of cisplatin resistance and its reversion in human ovarian cancer.

abstract：BACKGROUND:It is the first multicenter clinical study in China to investigate zanamivir use among Chinese adolescents and adults with influenza-like illness (ILI) since 2009, when inhaled zanamivir (RELENZA(®)) was marketed in China. METHODS:An uncontrolled open-label, multicentre study to evaluate the antiviral activ...

journal_title：Chinese medical journal

authors： Cao B,Wang DY,Yu XM,Wei LQ,Pu ZH,Gao Y,Wang J,Dong JP,Li XL,Xu Q,Hu K,Chen BY,Yu YS,Song SF,Shu YL,Wang C

更新日期：2012-09-01 00:00:00

abstract：BACKGROUND:The purpose of this study was to investigate the feasibility of avoiding axillary lymph node dissection (ALND) for patients with only one sentinel lymph node (SLN) metastasis. The characteristics and predictive factors for non-sentinel lymph node (NSLN) metastasis of patients with single positive SLN were al...

journal_title：Chinese medical journal

authors： Yang B,Yang L,Zuo WS,Ge WK,Zheng G,Zheng MZ,Yu ZY,Wang YS

更新日期：2013-02-01 00:00:00

abstract：BACKGROUND:Among HIV-infected patients initiating antiretroviral therapy (ART), early changes in CD4+ T-cell subsets are well described. However, HIV-infected late presenters initiating treatment present with a suboptimal CD4+ T-cell reconstitution and remain at a higher risk for AIDS and non-AIDS events. Therefore, fa...

journal_title：Chinese medical journal

authors： Guo FP,Li YJ,Qiu ZF,Lv W,Han Y,Xie J,Li YL,Song XJ,Du SS,Mehraj V,Li TS,Routy JP

更新日期：2016-11-20 00:00:00

abstract：OBJECTIVE:To determine the in vitro expression of interleukin-12 (IL-12) and its effect on signal transducers and activators of transcription (STAT) signaling molecules in peripheral blood mononuclear cells (PBMCs) in patients with systemic lupus erythematosus (SLE). METHODS:Peripheral blood mononuclear cells in 39 pa...

journal_title：Chinese medical journal

authors： Li Z,Li Y,Huang L,Xu H,Yu X,Ye R

更新日期：2002-06-01 00:00:00

abstract：Objective:Since the advent of induced pluripotent stem cell (iPSC) technology a decade ago, enormous progress has been made in stem cell biology and regenerative medicine. Human iPSCs have been widely used for disease modeling, drug discovery, and cell therapy development. In this review, we discuss the progress in app...

journal_title：Chinese medical journal

authors： Wang F,Kong J,Cui YY,Liu P,Wen JY

更新日期：2018-04-05 00:00:00

abstract：BACKGROUND:Neutrophil/lymphocyte ratio (NLR) has been proposed as a novel marker of systemic inflammation and oxidative stress. The objective of this study was to ascertain the relationship between levels of NLR and recurrence of lone atrial fibrillation (AF) after catheter ablation. METHODS:A total of 379 lone AF pat...

journal_title：Chinese medical journal

authors： Guo X,Zhang S,Yan X,Chen Y,Yu R,Long D,Sang C,Du X,Dong J,Ma C

更新日期：2014-01-01 00:00:00

abstract：OBJECTIVE:To evaluate the roles of folic acid and beta-carotene in the chemoprevention of gastric and other gastrointestinal (GI) cancers. METHODS:In a randomized, double-blind, placebo-controlled trial, a total of 216 patients with atrophic gastritis were randomly assigned to one of the four groups: (1) folate (FA, 2...

journal_title：Chinese medical journal

authors： Zhu S,Mason J,Shi Y,Hu Y,Li R,Wahg M,Zhou Y,Jin G,Xie Y,Wu G,Xia D,Qian Z,Sohg H,Zhang L,Russell R,Xiao S

更新日期：2003-01-01 00:00:00

abstract：OBJECTIVE:To explore the immune promotion mechanism of retinoic acid (RA). METHODS:Reverse Transcription-Polymerase chain reaction (RT-PCR) was used to detect the gene expression of insulin like growth factor I (IGF-I) and IGF receptors (IGF-IR and IGF-IIR) in vitro, and their regulation by RA in human cord blood lymp...

journal_title：Chinese medical journal

authors： Yang Y,Wang W,Su Y

更新日期：2001-02-01 00:00:00

abstract：BACKGROUND:Transcatheter bronchial artery embolization (BAE) is widely used for the treatment of hemoptysis and the immediate success rate is high, but there are still some hemorrhage recurrences. One of the common reasons for failure of BAE is collateral branches as blood supply. The inferior phrenic artery (IPA) is o...

journal_title：Chinese medical journal

authors： Liu FY,Wang MQ,Fan QS,Duan F,Wang ZJ,Song P

更新日期：2009-03-05 00:00:00

abstract：:Cogan’s syndrome (CS) is a rare inflammatory disorder characterized by interstitial keratitis and vestibuloauditory abnormalities often associated with various systemic manifestations. Involvement of cardiovascular system resembling systemic vasculitis may lead to severe complications and death. The present report des...

journal_title：Chinese medical journal

authors： Branislava I,Marijana T,Nemanja D,Dragan S,Maja Z

更新日期：2011-10-01 00:00:00

abstract：BACKGROUND:Restrictive cardiomyopathy (RCM) is the least common cardiomyopathy in which the walls are rigid and the heart is restricted from stretching and filling properly. Cardiac troponin I (cTnI) mutation-caused myofibril Ca2+ hypersensitivity has been shown to be associated with impaired diastolic function. This s...

journal_title：Chinese medical journal

authors： Ding WH,Han L,Xiao YY,Mo Y,Yang J,Wang XF,Jin M

更新日期：2017-12-05 00:00:00

abstract：BACKGROUND:Congenital uterine anomalies are associated with the highest incidence of reproductive failure and obstetric complications. This study aimed to summarize the clinical characteristics and prenatal outcome of pregnancy in women with congenital uterine malformations. METHODS:This retrospective study evaluated ...

journal_title：Chinese medical journal

authors： Zhang Y,Zhao YY,Qiao J

更新日期：2010-02-20 00:00:00

abstract：BACKGROUND:One of the major causes of death in severe acute pancreatitis (SAP) is severe infection owing to bacterial translocation. Some clinical studies suggested that ecoimmunonutrition (EIN) as a new strategy had better treatment effect on SAP patients. But the experiment studies on the precise mechanism of the eff...

journal_title：Chinese medical journal

authors： Xu GF,Lu Z,Gao J,Li ZS,Gong YF

更新日期：2006-04-20 00:00:00

abstract：BACKGROUND:Recent studies have suggested that cancer stem cells cause tumor recurrence based on their resistance to radiotherapy and chemotherapy. Although the highly invasive nature of glioblastoma cells is also implicated in the failure of current therapies, it is not clear whether cancer stem cells are involved in i...

journal_title：Chinese medical journal

authors： Yu SP,Yang XJ,Zhang B,Ming HL,Chen C,Ren BC,Liu ZF,Liu B

更新日期：2011-09-01 00:00:00

abstract：OBJECTIVE:To review articles aiming to present an overview of the principles, progress, uses and limitations of laser speckle flowgraphy (LSFG) in posterior fundus circulation research. DATA SOURCES:The data used in this review was obtained mainly from the studies reported in PubMed using the key terms "laser speckle"...

journal_title：Chinese medical journal

authors： Zhang W,Kogure A,Yamamoto K,Hori S

更新日期：2011-12-01 00:00:00

abstract：BACKGROUND:In county-level tuberculosis (TB) dispensaries in China, the accurate diagnosis of sputum smear-negative pulmonary tuberculosis (SNPT) needs to be improved by developing and validating clinical and radiographic predictors. METHODS:The study was conducted simultaneously in three counties per province in Chon...

journal_title：Chinese medical journal

authors： Li XX,Jiang SW,Zhang H,Jing KH,Wang L,Li WB,Liu XQ,Yao HY,Wang LX

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Patients with elevated admission glucose levels may be at increased risk of death after myocardial infarction, independent of other baseline risk factors and more severe coronary artery disease. However, data regarding admission glucose and epicardial and microvascular flow after primary angioplasty is limit...

journal_title：Chinese medical journal

authors： Shen XH,Jia SQ,Li HW

更新日期：2006-01-20 00:00:00

abstract：OBJECTIVE:Little information is available to guide treatment strategies regarding patients with unexpected positive cultures (UPC), including Propionibacterium acnes (PA), without overt signs of infection in revision shoulder arthroplasty (RSA). The purpose of our study was to analyze the prevalence, clinical meaning, ...

journal_title：Chinese medical journal

authors： Kim SJ,Kim JH

更新日期：2014-01-01 00:00:00

abstract：OBJECTIVE:To determine the relationship between remodeling and dysfunction of left ventricle (LV) and the expression of the angiotensin II AT1 receptor mRNA after myocardial infarction (MI) in rats. METHODS:Nine MI rats (Group A) and 8 sham-operated rats (Group B) were studied by both Doppler echocardiography and Dot ...

journal_title：Chinese medical journal

authors： Zhang G,Yang Y,Pu S,Shen X,Peng T,Chen H

更新日期：1999-07-01 00:00:00

abstract：:100 women ranging in age from 26-34 years were followed up for 4-21 months after undergoing sterilization by tubal occlusion using intraluminal threads and silver clips. The number of children/woman ranged from 1-5 with 80% having 2. 31 women underwent sterilization postmenstrually, 11 midmenstrually, 28 premenstrua...

journal_title：Chinese medical journal

authors： Ding SL

更新日期：1983-08-01 00:00:00

abstract：BACKGROUND:Peripheral nerve injury causes a high rate of disability and a huge economic burden, and is currently one of the serious health problems in the world. The use of nerve grafts plays a vital role in repairing nerve defects. Acellular nerve grafts have been widely used in many experimental models as a periphera...

journal_title：Chinese medical journal

authors： Ma XL,Sun XL,Yang Z,Li XL,Ma JX,Zhang Y,Yuan ZZ

更新日期：2011-12-01 00:00:00

abstract：: ...

journal_title：Chinese medical journal

authors： Zhang D,Han QX,Wu MH,Shen WJ,Yang XL,Guo J,Pan SK,Liu ZS,Tang L,Cai GY,Chen XM,Zhu HY

更新日期：2018-12-05 00:00:00

abstract：BACKGROUND:The treatment of spinal cord injury is still a challenge. This study aimed at evaluating the therapeutical effectiveness of neurons derived form mesenchymal stem cells (MSCs) for spinal cord injury. METHODS:In this study, rhesus MSCs were isolated and induced by cryptotanshinone in vitro and then a process ...

journal_title：Chinese medical journal

authors： Deng YB,Yuan QT,Liu XG,Liu XL,Liu Y,Liu ZG,Zhang C

更新日期：2005-09-20 00:00:00

abstract：:In present study, we examined the effects of NG-nitro-L-arginine (LNNA), an inhibitor of nitric oxide synthase (NOS), and/or methylene blue (MB), a blocker of guanylate cyclase on the vasodilator response of isolated rat arteries including aorta and mesenteric artery to calcitonin gene-related peptide (CGRP) by in vit...

journal_title：Chinese medical journal

authors： Tan DY,Zhang LZ,Zhao YT,Zhao D,Tang J

更新日期：1994-10-01 00:00:00

abstract：BACKGROUND:The usefulness of in-phase/opposed-phase imaging and diffusion weighted imaging (DWI) in differentiating benign and neoplastic vertebral fractures has been described. In this study, we aimed to evaluate the influence of the severity of vertebral damage on the diagnostic performance of these two technologies....

journal_title：Chinese medical journal

authors： Lin F,Lei Y,Li YB

更新日期：2009-06-05 00:00:00

abstract：BACKGROUND:A simple, safe and effective therapeutic strategy for traumatic instability of the subaxial cervical spine, as well as its prognostic assessment, is still controversial. METHODS:The therapeutic options for 83 patients of traumatic instability of the subaxial cervical spine, whose average age was 35 years, w...

journal_title：Chinese medical journal

authors： Cao P,Liang Y,Gong YC,Zheng T,Zhang XK,Wu WJ

更新日期：2008-08-05 00:00:00

abstract：BACKGROUND:The long-term safety and efficacy of drug-eluting stents (DES) versus bare metal stents (BMS) are unclear and controversial issues in patients with acute ST-elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI). The purpose of this study was to compare the long-t...

journal_title：Chinese medical journal

authors： Wang CH,Fang Q,Zhang SY,Shen ZJ,Fan ZJ,Jin XF,Zeng Y,Liu ZY,Xie HZ,Yang M

更新日期：2012-08-01 00:00:00

abstract：BACKGROUND:Despite the presigmoid transpetrosal approach has been used by different researchers in various ways, the surgical injury rate remains high. Applying a minimally invasive keyhole idea, we devised a presigmoid transpetrosal keyhole approach (PTKA), classified and quantitatively assessed their approach to the ...

journal_title：Chinese medical journal

authors： Wu CY,Lan Q

更新日期：2008-04-20 00:00:00

abstract：OBJECTIVE:To investigate the significance of telomerase activity in urine in the diagnosis and recurrence surveillance of urothelial carcinoma. METHODS:Telomerase activity in urine of 54 cases of urothelial carcinoma (urothelial carcinoma group) was estimated by polymerase chain reaction-enzyme-linked immunosorbent as...

journal_title：Chinese medical journal

authors： Li Z,Kong C,Wang P,Liu X,Liu T

更新日期：2002-11-01 00:00:00

abstract：OBJECTIVES:To study mitogen-activated protein kinase (MAPKs) activation in fibroblast-like synoviocytes (FLS) of rheumatoid arthritis (RA) under the stimulation of IL-1 beta, and to elucidate the role of protein tyrosine kinase (PTK) in the activation of MAPKs. METHODS:Primary cultures of RA FLS were used. Western blo...

journal_title：Chinese medical journal

authors： Lu H,Sun T,Yao L,Zhang Y

更新日期：2000-10-01 00:00:00