Role of Whole-exome Sequencing in Phenotype Classification and Clinical Treatment of Pediatric Restrictive Cardiomyopathy.

abstract：:The unclear DNA content was measured with flow cytometry (FCM) in 167 specimens of normal nasopharyngeal epithelium (NE), adjacent tissue to carcinoma (ATC) and nasopharyngeal carcinoma (NPC). All 20 patients with NE showed diploid, whereas 38 (38%) of 101 patients with NPC, 7 (58%) of 12 patients with recurrent NPC, ...

journal_title：Chinese medical journal

authors： Zhao SP,Tao ZD,Xiao JY,Xiao PT,Peng YY

更新日期：1994-05-01 00:00:00

abstract：BACKGROUND:Some research groups have hypothesized that human rhinoviruses (HRVs) delayed the circulation of the 2009 pandemic influenza A(H1N1) virus (A(H1N1)pdm09) at the beginning of Autumn 2009 in France. This study aimed to evaluate the relationship between HRV and A(H1N1)pdm09 in pediatric patients with influenza-...

journal_title：Chinese medical journal

authors： Sun Y,Zhu R,Zhao L,Deng J,Wang F,Ding Y,Yuan Y,Qu D,Qian Y

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:The mechanisms underlying postoperative pain remain unclear. Neurotransmitters of excitatory and inhibitory amino acids play an important role in the transmission and modulation of pain in the spinal dorsal horn. This study aimed to investigate the changes of release of excitatory and inhibitory amino acids ...

journal_title：Chinese medical journal

authors： Wang Y,Yue Y,Shi L,Wu AS,Feng CS,Ni C

更新日期：2007-11-20 00:00:00

abstract：BACKGROUND:Some esophageal cancer patients complicated with depression exhibit cognitive impairments. Frontal electroencephalogram (EEG) may be used as a reliable biomarker for prefrontal-mediated cognitive functions. This study was to investigate alterations of EEG and frontal cognitive impairment in esophageal cancer...

journal_title：Chinese medical journal

authors： Cao Y,Chen X,Xie H,Zou L,Hu LJ,Zhou XJ

更新日期：2017-08-05 00:00:00

abstract：BACKGROUND:Balanced adjustment of the portal vein shunt volume during a transjugular intrahepatic portosystemic shunt (TIPS) is critical for maintaining liver perfusion and decreasing the incidence of liver insufficiency. A stent-graft is proved to be superior to a bare metal stent (BMS) for the construction of a TIPS....

journal_title：Chinese medical journal

authors： Wang CM,Li X,Fu J,Luan JY,Li TR,Zhao J,Dong GX

更新日期：2016-06-05 00:00:00

abstract：BACKGROUND:Accurate evaluation of coronary artery, aortic valve annulus diameter (AVAD), and cardiac function in patients with aortic valve disease is of great significance for surgical strategy. In this study, we explored the preoperative evaluation of low-dose sequence (MinDose sequence) scan of dual-source CT (DSCT)...

journal_title：Chinese medical journal

authors： Feng J,Wang XM,Ji XP,Li HO,Li Q,Guo WB,Wang ZJ

更新日期：2013-12-01 00:00:00

abstract：BACKGROUND:Antiplatelet therapy (APT) was prevalently being used in the prevention of vascular disease, but the influence of prior APT on the prognosis of patients with intracerebral hemorrhage (ICH) remains controversial. This meta-analysis was to explore the effects of prior APT on the prognosis of patients with prim...

journal_title：Chinese medical journal

authors： Yu HH,Pan C,Tang YX,Liu N,Zhang P,Hu Y,Zhang Y,Wu Q,Deng H,Li GG,Li YY,Nie H,Tang ZP

更新日期：2017-12-20 00:00:00

abstract：OBJECTIVE:To assess whether Angiotensin II (Ang II) and carbon tetrachloride (CCl(4)) used in combination could accelerate the process of fibrosis and whether Ang II play a role in exagerating hepatic fibrosis in rats. METHODS:Ang II was injected into the abdominal cavity of Sprague-Dawley (SD) rats together with subc...

journal_title：Chinese medical journal

authors： Zhou X,Li D,Li X,Lu H,Zhang W

更新日期：2003-01-01 00:00:00

abstract：BACKGROUND:Cubital tunnel syndrome is a well-recognized clinical condition and is the second most common peripheral compression neuropathy. This study was designed to investigate the causes of cubital tunnel syndrome by surgical means and to assess the clinical value of the neurophysiological diagnosis of cubital tunne...

journal_title：Chinese medical journal

authors： Jia ZR,Shi X,Sun XR

更新日期：2004-09-01 00:00:00

abstract：OBJECTIVE:This review focuses on the role of the large conductance calcium-activated potassium (BKCa) channels in diabetic vascular complications. DATA SOURCES:Relevant articles published in English or Chinese from 1981 to present were selected from PubMed. The search terms were "BKCa channels" and "diabetes". Importa...

journal_title：Chinese medical journal

authors： Qian L,Liu X,Wang R

更新日期：2014-01-01 00:00:00

abstract：:The phenotypes of mononuclear cells in 16 patients with mycosis fungoides (MF) (8 were in tumor stage and 8 in pretumor stage) were tested by ABC immunochemical technique. The results showed that the percentage of CD38 and Leu6(+) cells in tumor stage was higher than that in pretumor stage. CD38 was identified to be a...

journal_title：Chinese medical journal

authors： Liu JH,Zhang Q,Shi YF,Zeng XS,Wang XH,Li J,Chen Z,Shen DC

更新日期：1993-05-01 00:00:00

abstract：Background:The increasing frequency of explosive injuries has increased interest in blast-induced traumatic brain injury (bTBI). Various shock tube models have been used to study bTBI. Mild-to-moderate explosions are often overlooked because of the slow onset or mildness of the symptoms. However, heavy gas cylinders an...

journal_title：Chinese medical journal

authors： Zhou Y,Wen LL,Wang HD,Zhou XM,Fang J,Zhu JH,Ding K

更新日期：2018-10-20 00:00:00

abstract：BACKGROUND:The Toll-like receptors (TLRs) represent a group of single-pass transmembrane receptors expressed on sentinel cells that are central to innate immune responses.The aim of this study was to investigate the presence of soluble TLRs in pleural effusions, and the diagnostic values of TLRs for pleural effusion wi...

journal_title：Chinese medical journal

authors： Yang HB,Xie KQ,Deng JM,Qin SM

更新日期：2010-08-01 00:00:00

abstract：OBJECTIVE:To investigate the mechanism of multidrug resistance (MDR) in a human glioma cell and methods for overcoming multi-drug resistance. METHODS:MDR cell line C(6)/adr was established. The expression of the mdr-1 gene and its P-glycoprotein (P-gp) in the C(6)/adr cell line was observed by RT-PCR and flow cytometr...

journal_title：Chinese medical journal

authors： Liu F,Wang C,Zhang Q,Li J,Zhang Y

更新日期：2002-02-01 00:00:00

abstract：BACKGROUND:Epigallocatechin-3-gallate (EGCG) has exhibited antitumor properties in several types of cancers, including nasopharyngeal carcinoma (NPC), but the molecular mechanisms underlying this function remain incompletely understood. The aim of the present study was to characterize the global impact of EGCG on the e...

journal_title：Chinese medical journal

authors： Li BB,Huang GL,Li HH,Kong X,He ZW

更新日期：2017-01-05 00:00:00

abstract：Background:Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening clinical syndrome. Central nervous system (CNS) involvement is a severe complication, which can lead to rapid disease development and higher morality. However, this has not been given enough attention in adult HLH. Therefore, we carried out this ...

journal_title：Chinese medical journal

authors： Song Y,Pei RJ,Wang YN,Zhang J,Wang Z

更新日期：2018-04-05 00:00:00

abstract：BACKGROUND:The risk of clinical deterioration still exists in the acute phase despite the fact that patients with minor stroke may display less severe symptoms. The impact of this clinical deterioration on long-term outcomes is unknown. We characterized the clinical features of neurological deterioration (ND) in the ac...

journal_title：Chinese medical journal

authors： Ju Y,Zhao XQ,Wang CX,Wang YL,Liu GF,Wang YJ

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Early detection with screening mammography can potentially reduce breast cancer mortality rates. To achieve an efficient screening, a peer review system provides a compensatory double-check reviewing, will hopefully to prevent the omission of detectable lesions and reduce unnecessary recall. METHODS:In 2009...

journal_title：Chinese medical journal

authors： Pan HB,Hsu GC,Yang TL,Huang JS,Chou CP,Liang HL,Lee SK,Chou YH,Li HJ,Wong KF

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:It is still controversial as to the implementation of higher positive end-expiratory pressure (PEEP) in patients with acute respiratory distress syndrome (ARDS). This study was conducted to compare the lower and higher PEEP in patients with ARDS ventilated with low tidal volume, to investigate the relationsh...

journal_title：Chinese medical journal

authors： Guo FM,Ding JJ,Su X,Xu HY,Shi Y

更新日期：2008-11-20 00:00:00

abstract：BACKGROUND:Recent studies have demonstrated that the Lenke system is relatively efficient and consistent in classifying scoliosis curves. Basically, fusion should include the main curve and the structural minor curve. The criteria for defining the structural minor curve were established to help guide these decision-mak...

journal_title：Chinese medical journal

authors： Chen ZQ,Zhao YF,He SS,Wang CF,Zhang JT,Zhao YC,Yang CW,Li M

更新日期：2012-04-01 00:00:00

abstract：BACKGROUND:Drug-eluting stents represent a major advance in interventional cardiology. However, the current drug-eluting stents have significant limitations. One of the major problems is very late stent thrombosis, which is likely caused by inflammation and a hypersensitivity reaction related to a polymer on the stent....

journal_title：Chinese medical journal

authors： Chen M,Zheng B,Wu Z,Peng HY,Wang XG,Zhang B,Huo Y

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:The decreased degradation of extra-cellular matrix proteins plays an important role in the onset of diabetic nephropathy. Matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of metalloproteinase-1 (TIMP-1), which are members of the matrix metalloproteinase family, are associated with this process. Angiot...

journal_title：Chinese medical journal

authors： Ding HL,Guo Y,Xu MT,Li HY,Fu ZZ

更新日期：2007-11-05 00:00:00

abstract：OBJECTIVE:To investigate the expression of Toll-like receptor 2 (TLR2) and Toll-like receptor 4 (TLR4) and the effect of lipopolysaccharide (LPS) on their expression in cultured endothelial cells. METHODS:Total RNA was extracted from ECV304 cells and isolated human umbilical vein endothelial cells (HUVECs) exposed to ...

journal_title：Chinese medical journal

authors： Yang Q,Zhu P,Wang Z,Jiang J

更新日期：2002-02-01 00:00:00

abstract：OBJECTIVE:To investigate whether the decrease in expression of interleukin-2 (IL-2) after trauma is associated with changes in DNA binding activity of nuclear factor of activated T cells (NFAT) and activator protein-1 (AP-1). METHODS:Mice with closed impact injury with fracture in both hind limbs were adopted as the t...

journal_title：Chinese medical journal

authors： Luo Y,Liang H,Hu C,Xu X,Wang Z

更新日期：2002-09-01 00:00:00

abstract：BACKGROUND:An inflammatory response leading to organ dysfunction and failure continues to be a major problem after injury in many clinical conditions such as sepsis, severe burns, and trauma. It is increasingly recognized that atrial natriuretic peptide (ANP) possesses a broad range of biological activities, including ...

journal_title：Chinese medical journal

authors： Zhu YB,Zhang YB,Liu DH,Li XF,Liu AJ,Fan XM,Qiao CH,Ling F,Liu YL

更新日期：2013-02-01 00:00:00

abstract：Background:Signal transducer and activator of transcription 3 (STAT3) was strongly expressed and activated in psoriatic keratinocytes (KCs) and correlated with the severity of psoriasis. The study aimed to investigate the effects of STAT3 small interfering RNA (siRNA) combined with ultrasonic irradiation and SonoVue mi...

journal_title：Chinese medical journal

authors： Ran LW,Wang H,Lan D,Jia HX,Yu SS

更新日期：2018-09-05 00:00:00

abstract：OBJECTIVE:To study the analgesic mechanism of gabapentin, an anticonvulsant, during antinociceptive clinical treatment. METHODS:Whole-cell voltage-clamp recordings were taken from adult rat spinal cord slices to investigate the effect of gabapentin on primary afferent A delta-fiber evoked excitatory postsynaptic curre...

journal_title：Chinese medical journal

authors： Liu Z,Xu R,Yang K

更新日期：2003-06-01 00:00:00

abstract：:Dot-ELISA assay was compared with standard Sandwich ELISA in detecting parasite antigen in sera from patients with bancroftian filariasis. The same monoclonal antibody and the same serum samples were used in both assays. With Dot-ELISA, 67 of 70 serum samples from microfilaremic patients were positive at a dilution of...

journal_title：Chinese medical journal

authors： Zheng HJ,Fuhrman JA,Xu M,Cheng WF,Reddy MV,Piessens WF

更新日期：1990-09-01 00:00:00

abstract：BACKGROUND:Eating disorders (EDs) are serious illnesses associated with medical complications and have been increased, especially among societies with an excessive concern about weight, shape, or appearance. This study aimed to investigate the prevalence of EDs among the individuals attending weight management centers ...

journal_title：Chinese medical journal

authors： Eladawi N,Helal R,Niazy NA,Abdelsalam S

更新日期：2018-01-05 00:00:00

abstract：OBJECTIVE:To evaluate the safety and immunogenicity of lyophilized, live attenuated hepatitis A vaccine (H2 strain) in rhesus monkeys. METHODS:Nine adult rhesus monkeys were used as experimental animals. The rhesus monkeys without anti-HAV were divided randomly into the aqueous vaccination group (4 rhesus monkeys), th...

journal_title：Chinese medical journal

authors： Hu Y,Tan S,Shao C,Jin W,Ji Q,He J,Chen H,Yan J

更新日期：2000-04-01 00:00:00