Establishment of multidrug-resistance cell line C(6)/adr and reversal of drug-resistance.

abstract：:Recombinant DNA Yeast-Derived Hepatitis B Vaccine (RYHB vaccine) is comparable to and can replace Plasma-Derived Hepatitis B Vaccine (PHB vaccine) for the prevention of mother-infant transmission of hepatitis B virus (HBV), but the duration of immune efficacy of RYHB vaccine is not clear. This study indicates the long...

journal_title：Chinese medical journal

authors： Zhu QR,Gu XH,Duan SC,Xu HF

更新日期：1994-12-01 00:00:00

abstract：BACKGROUND:Prostate specific membrane antigen (PSMA) can facilitate the growth, migration, and invasion of the LNCaP prostate cancer cell lines, but the underlying molecular mechanisms have not yet been clearly defined. Here, we investigated whether PSMA serves as a novel regulator of the phosphatidylinositol 3-kinase ...

journal_title：Chinese medical journal

authors： Guo Z,Lai Y,Du T,Zhang Y,Chen J,Bi L,Lin T,Liu H,Wang W,Xu K,Jiang C,Han J,Zhang C,Dong W,Huang J,Huang H

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:In 2012, the working group on abdominal problems of the European Society of Intensive Care Medicine (ESICM) proposed a definition and also guidelines for the grading system and treatment of acute gastrointestinal injury (AGI). Until now, clinical reports on this topic have not been available, and the practic...

journal_title：Chinese medical journal

authors： Zhang D,Li N,Dong L,Fu Y,Liu Z,Wang Y

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:A satisfactory animal model of breast cancer metastasizing to bone is unavailable. In this study, we used human breast cancer stem-like cells and human bone to build a novel "human-source" model of human breast cancer skeletal metastasis. METHODS:Human breast cancer stem-like cells, the CD44+/CD24-/lower su...

journal_title：Chinese medical journal

authors： Ling LJ,Wang S,Liu XA,Shen EC,Ding Q,Lu C,Xu J,Cao QH,Zhu HQ,Wang F

更新日期：2008-10-20 00:00:00

abstract：:Microencapsules for pituitary transplantation was successfully developed with sodium alginate and poly-L-lysine (average molecular weight MW 70,000). The permeability of the capsular membrane (CM) was tested. The results showed that 60% of growth hormone (GH), thyroid stimulating hormone (TSH), prolactin (PRL) have pa...

journal_title：Chinese medical journal

authors： Chen ZP,Bao YD

更新日期：1994-03-01 00:00:00

abstract：BACKGROUND:The usual transbronchial coagulation techniques include microwave, argon plasma coagulation (APC), electrocautery and cryotherapy. However, there are serious clinical problems in the safety of each. By analyzing the experimental data and clinical observations, we observed the variable effects of different co...

journal_title：Chinese medical journal

authors： Bai C,Dong YC,Song XL,Huang Y,Shi H,Hu ZL,Li Q

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Smoking is the major cause of airway inflammation in chronic obstructive pulmonary disease (COPD), and smoking cessation is regarded as one of the important strategies for prevention and treatment of the inflammation. The inflammation of the chronic airway may be present and deteriorated even if the COPD pat...

journal_title：Chinese medical journal

authors： Li QY,Huang SG,Wan HY,Wu HC,Zhou T,Li M,Deng WW

更新日期：2007-09-05 00:00:00

abstract：OBJECTIVE:To study the severe acute respiratory syndrome (SARS)-associated coronavirus genotype and its characteristics. METHODS:A SARS-associated coronavirus isolate named ZJ01 was obtained from throat swab samples taken from a patient in Hangzhou, Zhejing province. The complete genome sequence of ZJ01 consisted of 2...

journal_title：Chinese medical journal

authors： Li L,Wang Z,Lu Y,Bao Q,Chen S,Wu N,Cheng S,Weng J,Zhang Y,Yan J,Mei L,Wang X,Zhu H,Yu Y,Zhang M,Li M,Yao J,Lu Q,Yao P,Bo X,Wo J,Wang S,Hu S

更新日期：2003-09-01 00:00:00

abstract：OBJECTIVE:To determine antiganglioside antibodies (AGA) in cerebrospinal fluid (CSF) of children with neuropsychiatric lupus erythematosus (NPLE), and to investigate their association with clinical manifestations and other laboratory tests. METHODS:An enzyme linked immunoabsorbent assay was used to detect AGA in 22 CS...

journal_title：Chinese medical journal

authors： Chen Y,Wu F,Hou L,Ma S,He X

更新日期：1997-08-01 00:00:00

abstract：BACKGROUND:Therapeutic angiogenesis has been shown to promote blood vessel growth and improve tissue perfusion. Vascular endothelial growth factor (VEGF) plays an important role in angiogenesis. However, it has side effects that limit its therapeutic utility in vivo, especially at high concentrations. This study aimed ...

journal_title：Chinese medical journal

authors： Diao Y,Lian L,Guo L,Chen H,Chen Y,Song X,Li Y

更新日期：2014-01-01 00:00:00

abstract：OBJECTIVE:To compare the effect of ouabain on the blood pressure of rats with that of digoxin to find the evidences of the relationship between endogenous ouabain (EO) and development of hypertension. METHODS:Sprague-Dawley rats, which were divided into 3 groups, were infused with ouabain (23 x 75 micrograms.kg-1/day,...

journal_title：Chinese medical journal

authors： Wang H,Lu Z,Yuan W

更新日期：1997-12-01 00:00:00

abstract：BACKGROUND:Severe valgus deformity often has bone defect and laxity of the medial ligamentous, and total knee arthroplasty in severe valgus knee is, in most cases, more challenging for surgeons. The usefulness of a computer assisted navigation system in reestablishing the mechanical axis has been well established. Henc...

journal_title：Chinese medical journal

authors： Shao JJ,Zhang XL,Wang Q,Chen YS,Shen H,Jiang Y

更新日期：2010-10-01 00:00:00

abstract：BACKGROUND:Successful antiretroviral therapy (ART) has been demonstrated to be effective in reducing the infectivity of human immunodeficiency virus (HIV). We conducted a study to predict the potential effect of ART on the spread of HIV in Chaoyang District, Beijing, China, using the Asian Epidemic Model (AEM). METHOD...

journal_title：Chinese medical journal

authors： Tao LL,Liu M,Li SM,Liu J,Jiang SL,Wang LJ,Luo FJ,Wang N

更新日期：2017-01-01 00:00:00

abstract：OBJECTIVE:A human promyelocytic leukemia (APL) cell line NB4 was used to demonstrate the synergistic effects between all-trans retinoic acid (ATRA) and prostaglandin E2 (PGE2) on growth inhibition and cytodifferentiation induction. METHODS:NB4 cells were cultured in the presence of either ATRA or PGE2 as a single agen...

journal_title：Chinese medical journal

authors： Chen Z,Breitman TR

更新日期：1997-10-01 00:00:00

abstract：BACKGROUND:Sacroiliac (SI) screw fixation is a demanding technique, with a high rate of screw malposition due to the complex pelvic anatomy. TiRobot™ is an orthopedic surgery robot which can be used for SI screw fixation. This study aimed to evaluate the accuracy of robot-assisted placement of SI screws compared with a...

journal_title：Chinese medical journal

authors： Wang JQ,Wang Y,Feng Y,Han W,Su YG,Liu WY,Zhang WJ,Wu XB,Wang MY,Fan YB

更新日期：2017-11-05 00:00:00

abstract：BACKGROUND:The duration of viral shedding and the transmission of 2009 H1N1 influenza among individuals, especially among the younger population with mild illness, are not well understood now. The aim of this study was to determine the viral shedding of the young adult patients with mild 2009 H1N1 influenza in China. ...

journal_title：Chinese medical journal

authors： Jia N,Gao Y,Suo JJ,Xie LJ,Yan ZQ,Xing YB,He L,Liu YX

更新日期：2011-05-01 00:00:00

abstract：BACKGROUND:The Notch-regulated ankyrin repeat protein (NRARP) is recently found to promote proliferation of breast cancer cells. The role of NRARP in carcinogenesis deserves extensive investigations. This study attempted to investigate the expression of NRARP in thyroid cancer tissues and assess the influence of NRARP ...

journal_title：Chinese medical journal

authors： Chu BF,Qin YY,Zhang SL,Quan ZW,Zhang MD,Bi JW

更新日期：2016-07-05 00:00:00

abstract：Objective:Endothelial cells (ECs) are important metabolic and endocrinal organs which play a significant role in regulating vascular function. Vascular ECs, located between the blood and vascular tissues, can not only complete the metabolism of blood and interstitial fluid but also synthesize and secrete a variety of b...

journal_title：Chinese medical journal

authors： Meng LB,Chen K,Zhang YM,Gong T

更新日期：2018-10-05 00:00:00

abstract：OBJECTIVE:To investigate the significance of telomerase activity in urine in the diagnosis and recurrence surveillance of urothelial carcinoma. METHODS:Telomerase activity in urine of 54 cases of urothelial carcinoma (urothelial carcinoma group) was estimated by polymerase chain reaction-enzyme-linked immunosorbent as...

journal_title：Chinese medical journal

authors： Li Z,Kong C,Wang P,Liu X,Liu T

更新日期：2002-11-01 00:00:00

abstract：BACKGROUND:Alzheimer disease (AD) is a neurodegenerative disease related to aging. At present, its pathological mechanisms remain unclear. Family members of the renin-angiotensin system (RAS) play a role in neuronal plasticity, as well as formation of learning and memory. In this study, we explore the effects of altere...

journal_title：Chinese medical journal

authors： Hou DR,Wang Y,Zhou L,Chen K,Tian Y,Song Z,Bao J,Yang QD

更新日期：2008-11-20 00:00:00

abstract：:The model was established in male rabbits with experimental atherosclerosis, which was induced by diet cholesterol (0.5 g per day for 8 weeks), by means of intravenous injection of one unit of pituitrin (P.P.). To evaluate the effects of aspirin, heparin and viper venom (VV) on this model, 26 male rabbits were divided...

journal_title：Chinese medical journal

authors： Zhang W,Wang P,Chen Z,Fan Y

更新日期：1995-05-01 00:00:00

abstract：BACKGROUND:Pulsed radiofrequency (PRF) application to the dorsal root ganglia can reduce neuropathic pain (NP) in animal models, but the effect of PRF on damaged peripheral nerves has not been examined. We investigated the effect of PRF to the rat sciatic nerve (SN) on pain-related behavior and SN ultrastructure follow...

journal_title：Chinese medical journal

authors： Li DY,Meng L,Ji N,Luo F

更新日期：2015-02-20 00:00:00

abstract：BACKGROUND:Intravascular ultrasound (IVUS) examination can provide useful information during endovascular stent graft repair. However, its actual clinical utility in thoracic endovascular aortic repair (TEVAR) for type B aortic dissection (type B-AD) remains unclear, especially in complicated aortic dissection. We eval...

journal_title：Chinese medical journal

authors： Guo BL,Shi ZY,Guo DQ,Wang LX,Tang X,Li WM,Fu WG

更新日期：2015-09-05 00:00:00

abstract：BACKGROUND:Interferon-gamma release assay (IGRA) has been used in latent tuberculosis (TB) infection and TB diagnosis, but the results from different high TB-endemic countries are different. The aim of this study was to investigate the value of IGRA in the diagnosis of active pulmonary TB (PTB) in China. METHODS:We co...

journal_title：Chinese medical journal

authors： Kang WL,Wang GR,Wu MY,Yang KY,Er-Tai A,Wu SC,Geng SJ,Li ZH,Li MW,Li L,Tang SJ

更新日期：2018-02-05 00:00:00

abstract：BACKGROUND:Chronic liver diseases are a major burden in China. Alanine aminotransferase (ALT) can be used as an indicator of hepatocyte damage. In this study, we determined the prevalence and etiologies of elevated ALT in an adult population in Jilin, China. METHODS:A total of 4072 individuals aged between 18 and 79 y...

journal_title：Chinese medical journal

authors： Zhang H,Jiang YF,He SM,Sun J,Gu Q,Feng XW,DU B,Wang W,Shi XD,Wang CY,Zhang SQ,Li WY,Niu JQ

更新日期：2011-09-01 00:00:00

abstract：OBJECTIVE:To investigate the relationship between vascular endothelial growth factor C (VEGF-C) expression, VEGFR-3 expression, lymphangiogenesis and angiogenesis in human non-small cell lung cancer (NSCLC). METHODS:Seventy-six NSCLC samples were stained for VEGF-C, VEGFR-3 and CD34 with immunohistochemical methods. A...

journal_title：Chinese medical journal

authors： Li Q,Dong X,Gu W,Qiu X,Wang E

更新日期：2003-05-01 00:00:00

abstract：BACKGROUND:It is important to determine prognostic factors for the outcome of amyotrophic lateral sclerosis (ALS) at an early stage. The time taken for symptoms to spread from spinal or bulbar regions to both (time to generalization; TTG) is considered a strong predictor of survival; however, this has rarely been studi...

journal_title：Chinese medical journal

authors： Sun QH,Li YR,Lan WJ,Yang F,Cui F,Huang XS

更新日期：2019-05-05 00:00:00

abstract：BACKGROUND:It is difficult and time-consuming for carrying out conventional hand-sewn bilioenteric anastomosis, especially for small bile duct anastomosis and laparoscopic procedure. In order to simplify it, we have developed a novel procedure of sutureless bilioenteric anastomosis with an intraluminal degradable stent...

journal_title：Chinese medical journal

authors： Zhu LH,Liang X,Lin H,Wang YF,Zhu YP,Cai XJ

更新日期：2011-07-05 00:00:00

abstract：BACKGROUND:Although obstructive sleep apnea (OSA) has been recognized as a major risk factor for cardiovascular complications and its clinical features are well characterized, it is difficult to replicate the OSA hypoxic model in humans. We aimed to establish an experimental rabbit model for chronic OSA and to explore ...

journal_title：Chinese medical journal

authors： Xu LF,Zhou XF,Hu K,Tang S,Luo YC,Lu W

更新日期：2017-02-20 00:00:00

abstract：:Apolipoprotein (a) [Lp(a)] phenotypes of 69 myocardial infarction survivor and 56 stroke patients were reported and compared to those of 190 healthy Chinese. The results revealed that the distributions of apo(a) phenotype frequency in patients with cardio-cerebrovascular disease (CCVD) were different from those of con...

journal_title：Chinese medical journal

authors： Zhuang YY,Li JJ,Wang JJ

更新日期：1994-02-01 00:00:00