Effects of Prior Antiplatelet Therapy on the Prognosis of Primary Intracerebral Hemorrhage: A Meta-analysis.

Abstract:

BACKGROUND:Antiplatelet therapy (APT) was prevalently being used in the prevention of vascular disease, but the influence of prior APT on the prognosis of patients with intracerebral hemorrhage (ICH) remains controversial. This meta-analysis was to explore the effects of prior APT on the prognosis of patients with primary ICH. METHODS:PubMed and Embase were searched to identify the eligible studies. The studies comparing the mortality of ICH patients with or without prior APT were included. The quality of these studies was evaluated by the Newcastle-Ottawa quality assessment scale. The adjusted or unadjusted odds ratio (OR) for mortality between ICH patients with and without prior APT were pooled with 95% confidence interval (95% CI) as the effect of this meta-analysis. RESULTS:Twenty-two studies fulfilled the inclusion criteria and exhibited high qualities. The pooled OR was 1.37 (95% CI: 1.13-1.66, P = 0.001) for univariate analysis and 1.41 (95% CI: 1.05-1.90, P = 0.024) for multivariate analysis. The meta-regression indicated that for each 1-day increase in the time of assessment, the adjusted OR for the mortality of APT patients decreased by 0.0049 (95% CI: 0.0006-0.0091, P = 0.026) as compared to non-APT patients. CONCLUSION:Prior APT was associated with high mortality in patients with ICH that might be attributed primarily to its strong effect on early time.

journal_name

Chin Med J (Engl)

journal_title

Chinese medical journal

authors

Yu HH,Pan C,Tang YX,Liu N,Zhang P,Hu Y,Zhang Y,Wu Q,Deng H,Li GG,Li YY,Nie H,Tang ZP

doi

10.4103/0366-6999.220302

subject

Has Abstract

pub_date

2017-12-20 00:00:00

pages

2969-2977

issue

24

eissn

0366-6999

issn

2542-5641

pii

ChinMedJ_2017_130_24_2969_220302

journal_volume

130

pub_type

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