Abstract：
OBJECTIVE:To investigate whether pretreatment with repeated electroacupuncture (EA) at the Baihui acupoint could induce ischemic tolerance against transient focal cerebral ischemic injury in rats. METHODS:Thirty male Sprague-Dawley (SD) rats were randomly divided into 3 groups (n=10 for each): the control group consisted of animals receiving no treatment, the isoflurane (ISO) group had animals that inhaled 1.5% isoflurane for 30 min a day for 5 days, and animals in the EA group received electroacupuncture at the Baihui acupoint for 30 min a day for 5 days under 1.5% isoflurane anesthesia. Twenty-four hours after the last treatment, the middle cerebral artery was occluded with No. 3 nylon monofilament for 120 min. The neurological outcomes were evaluated 24 h after reperfusion. The infarct volumes were then assessed using 2% triphenyltetrazolium chloride staining after the neurological outcome evaluation. RESULTS:The neurological deficit score (NDS) of the EA group [1 (0-2)] was lower than that of the ISO group [2 (1-3)] and the control group [2 (1-4)], P < 0.05. The infarct volume of the EA group (38.3 +/- 25.4 mm(3)) was significantly smaller than that of the control group (220.5 +/- 66.0 mm(3)) and the ISO group (168.6 +/- 57.6 mm(3)) 24 h after reperfusion. CONCLUSION:Electroacupuncture at the Baihui acupoint 30 min a day for 5 days significantly reduces neurological injury induced by transient middle cerebral artery occlusion.
journal_name
Chin Med J (Engl)journal_title
Chinese medical journalauthors
Xiong L,Lu Z,Hou L,Zheng H,Zhu Z,Wang Q,Chen Skeywords:
subject
Has Abstractpub_date
2003-01-01 00:00:00pages
108-11issue
1eissn
0366-6999issn
2542-5641journal_volume
116pub_type
杂志文章abstract：BACKGROUND:Acute kidney injury (AKI) is a severe disease in critically ill patients. Neutrophil infiltration into kidney was associated with the development of AKI, and P-selectin may be involved in the process of neutrophil recruitment in kidney. This study aimed to explore the potential effect of platelet-derived P-s...
journal_title：Chinese medical journal
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journal_title：Chinese medical journal
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journal_title：Chinese medical journal
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doi：
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更新日期：2010-11-01 00:00:00
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pub_type： 临床试验,杂志文章
doi：10.4103/0366-6999.164927
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journal_title：Chinese medical journal
pub_type： 杂志文章
doi：
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