The more, the less: age and chemotherapy load are predictive of poor stem cell mobilization in patients with hematologic malignancies.

Abstract:

BACKGROUND:Intensive treatment such as autologous peripheral blood stem cell (PBSC) transplantation is an important therapeutic strategy in many hematologic malignancies. A number of factors have been reported to impact PBSC mobilization, but the predictive factors varied from one study to another. This retrospective study assessed our current mobilization and collection protocols, and explored the factors predictive of PBSC mobilization in patients with hematologic malignancies. METHODS:Data of 64 consecutive patients with hematologic malignancies (multiple myeloma, n = 22; acute leukemia, n = 27; lymphoma, n = 15) who underwent PBSC mobilization for over 1 year were analyzed. Four patients with response to treatment of near complete remission or better were administered granulocyte colony-stimulating factor (G-CSF) to mobilize PBSCs. Sixty patients received G-CSF followed by chemotherapy mobilizing regimens. Poor mobilization (PM) was defined as when ≤ 2.0'10(6) CD34(+) cells/kg body weight were collected within three leukapheresis procedures. RESULTS:The incidence of PM at the first mobilization attempt was 19% (12/64). The PM group was older than the non-PM group (median age, 51 vs. 40 years; P = 0.013). In univariate analysis, there were no significant differences in gender, diagnosis, and body weight between the PM and non-PM groups. A combination of chemotherapy and G-CSF was more effective than G-CSF alone as a mobilizing regimen (P = 0.019). Grade III or IV hematopoietic toxicity of chemotherapy had no significant effect on the mobilization efficacy. Supportive care and the incidence of febrile neutropenia were not significantly different between the two groups. In multivariate analysis, age (odds ratio (OR), 9.536; P = 0.002) and number of previous chemotherapy courses (OR 3.132; P = 0.024) were two independent negative predictive factors for CD34(+) cell yield. PM patients could be managed well by remobilization. CONCLUSION:Older age and a heavy load of previous chemotherapy are the negative risk factors for PBSC mobilization.

journal_name

Chin Med J (Engl)

journal_title

Chinese medical journal

authors

Yang SM,Chen H,Chen YH,Zhu HH,Zhao T,Liu KY

subject

Has Abstract

pub_date

2012-02-01 00:00:00

pages

593-8

issue

4

eissn

0366-6999

issn

2542-5641

journal_volume

125

pub_type

杂志文章
  • Altered regional homogeneity in spontaneous cluster headache attacks: a resting-state functional magnetic resonance imaging study.

    abstract:BACKGROUND:Functional neuroimaging study has opened an avenue for exploring the pathophysiology of cluster headache (CH). The aim of our study was to assess the changes in brain activity in CH patients by the regional homogeneity method using resting-state functional magnetic resonance imaging technique. METHODS:The f...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Qiu EC,Yu SY,Liu RZ,Wang Y,Ma L,Tian LX

    更新日期:2012-02-01 00:00:00

  • Two Different Total Hip Arthroplasties for Hartofilakidis Type C1 Developmental Dysplasia of Hip in Adults.

    abstract:BACKGROUND:Total hip arthroplasty (THA) in developmental dysplasia of the hip (DDH) is more complex than the normal hip, with large replacement risks and many complications. Although nonosteotomy THA is convenient to perform, femoral osteotomy shortening can avoid blood vessel and nerve traction injuries. This study ai...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:10.4103/0366-6999.174507

    authors: Chu YM,Zhou YX,Han N,Yang DJ

    更新日期:2016-02-05 00:00:00

  • Determination of drug concentration in aqueous humor of cataract patients administered gatifloxacin ophthalmic gel.

    abstract:BACKGROUND:Ophthalmic gel has been developed to increase the drug concentration in aqueous humor and to retard the loss of drug from the conjunctival sac. The research was to compare the drug concentration in aqueous humor of cataract patients administered 0.3% gatifloxacin ophthalmic gel with that in patients administ...

    journal_title:Chinese medical journal

    pub_type: 杂志文章,随机对照试验

    doi:

    authors: Liu X,Wang NL,Wang YL,Ma C,Ma L,Gao LX,Huang YX,Xiong SH,Wang K

    更新日期:2010-08-05 00:00:00

  • Arthroscopic reduction and fixation for isolated greater tuberosity fractures.

    abstract:BACKGROUND:Traditionally, displaced greater tuberosity fractures are treated with open reduction and internal fixation. Arthroscopic treatment and outcome of greater tuberosity fractures is far from comprehensive. The objective of the current study was to assess the surgical procedure and outcome of an arthroscopic met...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Wang YP,Zhao JZ,Huangfu XQ,Liu WX,Jiang Y,Zhou XH,He YH

    更新日期:2012-04-01 00:00:00

  • Stress-induced growth-differentiation factor 15 plays an intriguing role in cardiovascular diseases.

    abstract:OBJECTIVE:To provide an overview of the current knowledge of growth-differentiation factor 15 (GDF-15) in heart disease. DATA SOURCES:To identify relevant publications, we searched PubMED database combining the textual terms of heart, cardiac, cardiovascular disease with GDF-15. STUDY SELECTION:Well-controlled, relat...

    journal_title:Chinese medical journal

    pub_type: 杂志文章,评审

    doi:

    authors: Liu HT,Wang HC,Tao L,Li CX,Li F,Zhang YY,Liu BW

    更新日期:2013-04-01 00:00:00

  • Genomics-based Approach and Prognostic Stratification Significance of Gene Mutations in Intermediate-risk Acute Myeloid Leukemia.

    abstract:OBJECTIVE:Intermediate-risk acute myeloid leukemia (IR-AML), which accounts for a substantial number of AML cases, is highly heterogeneous. We systematically summarize the latest research progress on the significance of gene mutations for prognostic stratification of IR-AML. DATA SOURCES:We conducted a systemic search...

    journal_title:Chinese medical journal

    pub_type: 杂志文章,评审

    doi:10.4103/0366-6999.163400

    authors: Wang BH,Li YH,Yu L

    更新日期:2015-09-05 00:00:00

  • Role of plasma C-reactive protein in predicting in-stent restenosis in patients with stable angina after coronary stenting.

    abstract:BACKGROUND:The role of plasma high sensitivity C-reactive protein (hs-CRP) in in-stent restenosis (ISR) remains controversial. We investigated plasma hs-CRP level at both admission and follow-up in patients with stable angina (SA) after successful coronary stenting in order to clarify the predictive value of hs-CRP for...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Xu YL,Li JJ,Xu B,Zhu CG,Yang YJ,Chen JL,Qiao SB,Yuan JQ,Qin XW,Ma WH,Yao M,Liu HB,Wu YJ,Chen J,You SJ,Dai J,Xia R,Gao RL

    更新日期:2011-03-01 00:00:00

  • Pathologic changes, mechanisms and diagnosis in renal bone disease.

    abstract:OBJECTIVE:To investigate the incidence rate, pathologic changes, mechanisms and diagnostic methods in renal bone disease. METHODS:The blood levels of carboxyterminal parpthyriod hormone (C-PTH), 1,25(OH)2D3, calcium and phosphate, aluminum in serum and bone tissue were measured. The bone biopsy and bone scan with 99m ...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Zhu P,Wang G,Yu Y,Lou D,Wang S,Jia J,Dong D

    更新日期:1998-09-01 00:00:00

  • Flow-dependent regulation of vascular function and gene expression in rat superior mesenteric artery.

    abstract:BACKGROUND:Mesenteric artery thrombosis is prone to occur at specific arterial regions with different fluid flow patterns, yet mechanistic links between blood flow and vascular function remain unclear. This study aimd to investigate the role of blood flow in regulation of vascular function and gene expression in rats. ...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Xia S,Deng CS

    更新日期:2009-05-20 00:00:00

  • The role of GRH mediated AC-cAMP system in the pathogenesis of human pituitary GH-secreting adenomas.

    abstract:OBJECTIVE:To investigate the role of AC-cAMP system in the transmission of the action of the growth hormone releasing hormone (GRH) on growth hormone (GH) release in pituitary GH-secreting adenomas. METHODS:The effects of GRH (10(-7) mol/L) on intracellular cAMP levels and GH release and the effects of AC-cAMP stimula...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Shi Y,Deng J,Yin J

    更新日期:1996-08-01 00:00:00

  • Intracoronary stent implantation under intracoronary ultrasound guidance with aspirin and ticlopidine therapy.

    abstract:OBJECTIVE:To observe the immediate angiographic and intravascular ultrasound (IVUS) results and their effects on one month clinical outcomes in forty-one patients who submitted to coronary stent deployment with IVUS guidance. METHODS:All patients were allocated to coronary stent implantation with high inflation pressu...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Zhang D,Cai X,Shen W,Schiele F,Bassand JP

    更新日期:2001-03-01 00:00:00

  • Dexamethasone increases susceptibility of Aspergillus fumigatus to hydrogen peroxide via down-regulation of Afyap1 gene expression in vitro.

    abstract:BACKGROUND:Glucocorticoid is speculated to be able to have Aspergillus fumigatus (A. fumigatus) being more susceptible to reactive oxygen species (ROS) by inhibiting Afyap1, the transcription factor activating protein-1 (AP-1) homologue in A. fumigatus, which may provide a clue to expand the clinical use of glucocortic...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Xu H,Li LJ,Wan Z,Li RY,Liu W

    更新日期:2011-11-01 00:00:00

  • Common Injuries and Repair Mechanisms in the Endothelial Lining.

    abstract:Objective:Endothelial cells (ECs) are important metabolic and endocrinal organs which play a significant role in regulating vascular function. Vascular ECs, located between the blood and vascular tissues, can not only complete the metabolism of blood and interstitial fluid but also synthesize and secrete a variety of b...

    journal_title:Chinese medical journal

    pub_type: 杂志文章,评审

    doi:10.4103/0366-6999.241805

    authors: Meng LB,Chen K,Zhang YM,Gong T

    更新日期:2018-10-05 00:00:00

  • Is obstructive sleep apnea syndrome a risk factor for pulmonary thromboembolism?

    abstract:BACKGROUND:In many studies, obstructive sleep apnea (OSA) has been shown to be an independent risk factor for cardiovascular disease. Conversely, there are few reports establishing possible relation between OSA and venous thromboembolism (VTE). In this study, the aim is to evaluate OSA via polysomnography in patients w...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Kezban OS,Ali NA,Umran T,Talha D,Ege GB,Peri A,Leyla YA,Hasan S

    更新日期:2012-10-01 00:00:00

  • A live birth of activated one-day-old unfertilized oocyte for a patient who experienced repeatedly near-total fertilization failure after intracytoplasmic sperm injection.

    abstract::Total or near-total fertilization failure after intracytoplasmic sperm injection (ICSI) is a rare event, but it occurs repeatedly because of sperm defects in activating oocyte. The case presents a successful pregnancy and live birth after calcium ionophore A23187 (A23187) activation on one-day-old unfertilized oocytes...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Lu Q,Chen X,Li Y,Zhang XH,Liang R,Zhao YP,Wei LH,Shen H

    更新日期:2012-02-01 00:00:00

  • Regulatory action of Astragalus saponins and buzhong yiqi compound on synthesis of nicotinic acetylcholine receptor antibody in vitro for myasthenia gravis.

    abstract::With overall analysis of symptoms and signs of myasthenia gravis (MG) basing on "Pi (Spleen) Deficiency" [symbol: see text] theory and with years of our clinical experience in treating MG, we performed a pharmacological study of Astragalus saponins and Buzhong Yiqi Compound (Tonic granulae invigorating vital energy) i...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Tu LH,Huang DR,Zhang RQ,Shen Q,Yu YY,Hong YF,Li GH

    更新日期:1994-04-01 00:00:00

  • Molecular cloning and characterization of NAG-7: a novel gene downregulated in human nasopharyngeal carcinoma.

    abstract:OBJECTIVE:To identify novel tumor suppressor genes at chromosome 3p24-26 in human nasopharyngeal carcinoma (NPC). METHODS:Twenty epithelial-derived expressed sequence tags (EST) were selected from chromosome 3p24-26. RT-PCR and Northern blot were used to detect the expression of the ESTs in NPC cell line, HNE-1, and p...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Xie Y,Bin L,Yang J,Li Z,Yu Y,Zhang X,Cao L,Li G

    更新日期:2001-05-01 00:00:00

  • Endothelial progenitor cells with Alzheimer's disease.

    abstract:BACKGROUND:Endothelial dysfunction is thought to be critical events in the pathogenesis of Alzheimer's disease (AD). Endothelial progenitor cells (EPCs) have provided insight into maintaining and repairing endothelial function. To study the relation between EPCs and AD, we explored the number of circulating EPCs in pat...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Kong XD,Zhang Y,Liu L,Sun N,Zhang MY,Zhang JN

    更新日期:2011-03-01 00:00:00

  • An uncontrolled open-label, multicenter study to monitor the antiviral activity and safety of inhaled zanamivir (as Rotadisk via Diskhaler device) among Chinese adolescents and adults with influenza-like illness.

    abstract:BACKGROUND:It is the first multicenter clinical study in China to investigate zanamivir use among Chinese adolescents and adults with influenza-like illness (ILI) since 2009, when inhaled zanamivir (RELENZA(®)) was marketed in China. METHODS:An uncontrolled open-label, multicentre study to evaluate the antiviral activ...

    journal_title:Chinese medical journal

    pub_type: 杂志文章,多中心研究

    doi:

    authors: Cao B,Wang DY,Yu XM,Wei LQ,Pu ZH,Gao Y,Wang J,Dong JP,Li XL,Xu Q,Hu K,Chen BY,Yu YS,Song SF,Shu YL,Wang C

    更新日期:2012-09-01 00:00:00

  • Up-regulation of visfatin expression in subjects with hyperthyroidism and hypothyroidism is partially relevant to a nonlinear regulation mechanism between visfatin and tri-iodothyronine with various concentrations.

    abstract:BACKGROUND:Visfatin, a visceral fat-derived adipocytokine, plays a significant physiological function in lipid metabolism. However, the precise function of visfatin and its regulation by thyroid hormones are still unknown. This study observed the plasma visfatin concentrations in subjects with hyperthyroidism and hypot...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Han J,Zhang TO,Xiao WH,Chang CQ,Ai H

    更新日期:2012-03-01 00:00:00

  • Lactadherin and procoagulant activities of red blood cells in cyclosporine induced thrombosis.

    abstract:BACKGROUND:The side effects of cyclosporine therapy include thromboembolic complications. However, the mechanisms underlying the hypercoagulable state induced by cyclosporine are not fully understood. Cyclosporine binds to red blood cells (RBCs) with a high affinity in circulation and alters the membranes of RBCs. Ther...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Zheng YN,Yu HJ,Hou JX,Lu CF,Zhou J

    更新日期:2009-07-20 00:00:00

  • Risk assessment and genomic characterization of Zika virus in China and its surrounding areas.

    abstract:BACKGROUND:Zika virus (ZIKV) has emerged as a global pathogen causing significant public health concerns. China has reported several imported cases where ZIKV were carried by travelers who frequently travel between China and ZIKV-endemic regions. To fully characterize the ZIKV strains isolated from the cases reported i...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:10.1097/CM9.0000000000000317

    authors: Liu RF,He ZJ,Mei P,Xi JC,Cao XD,Yuan LH,Lu JH

    更新日期:2019-07-20 00:00:00

  • Efficacy of hepatitis B immunoglobulin in relation to the gene polymorphisms of human leukocyte Fcgamma receptor III (CD16) in Chinese liver transplant patients.

    abstract:BACKGROUND:Although the use of hepatitis B immunoglobulin (HBIG) may lead to a significant reduction in recurrent hepatitis B virus (HBV) infection and improve the survival of patients who have undergone liver transplantation (LT) for hepatitis B-related diseases, the recurrence of the disease still remains at a lower ...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Wang WL,Zhang GL,Wu LH,Yao MY,Jin J,Jia CK,Xie HY,Zhou L,Jiang ZJ,Zheng SS

    更新日期:2007-09-20 00:00:00

  • Etiological role of Alternaria alternata in human esophageal cancer.

    abstract::In this paper, the mutagenicity and carcinogenicity of alternariol monomethyl ether (AME), alternariol (AOH), and their relevance to the etiology of human esophageal cancer were studied. These mycotoxins were produced by Alternaria alternata which was the main contaminating fungi isolated from the grain in Linxian Cou...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Liu GT,Qian YZ,Zhang P,Dong WH,Qi YM,Guo HT

    更新日期:1992-05-01 00:00:00

  • Apolipoprotein (a) phenotypes in cardio-cerebrovascular diseases.

    abstract::Apolipoprotein (a) [Lp(a)] phenotypes of 69 myocardial infarction survivor and 56 stroke patients were reported and compared to those of 190 healthy Chinese. The results revealed that the distributions of apo(a) phenotype frequency in patients with cardio-cerebrovascular disease (CCVD) were different from those of con...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Zhuang YY,Li JJ,Wang JJ

    更新日期:1994-02-01 00:00:00

  • Spermatozoal protein profiles in male infertility with asthenozoospermia.

    abstract:BACKGROUND:Infertility is a major medical and social problem, and elementary research on the spermatozoal proteins and their functions are relatively scarce and there are very few confirmed and effective options for the treatment of male infertility. Thus, it is essential to find candidate proteins that affect male inf...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Li HJ,Yu N,Zhang XY,Jin W,Li HZ

    更新日期:2010-10-01 00:00:00

  • DNA vaccine pCD-Sj32 and its efficacy of protective immunity against infection of Schistosoma japonicum.

    abstract:OBJECTIVE:To study protective immunity afforded by murine immunization with DNA vaccine of Schistosoma japonicum (S. japonicum) as measured by reduction in worm burden and host antibody, cytokines. METHODS:DNA vaccine pCD-Sj32 was constructed, identified and expressed. pCD-Sj32 could induce substantial protective immu...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Shi Y,Xie L,Li C,Han J

    更新日期:1999-08-01 00:00:00

  • Effects of exercise on pulmonary gas exchange and oxygen transport in chronic obstructive pulmonary diseases.

    abstract::The effect of exercise on pulmonary gas exchange, arterial oxygenation, oxygen transport and delivery, and hemodynamics are studied in 100 patients with chronic obstructive pulmonary diseases. According to the change of PaO2 or PaCO2 induced by exercise, patients were divided into two groups. Group A (n = 52) had sign...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Zeng GB,Zhang ZX,Xu YJ,Duan SF

    更新日期:1992-01-01 00:00:00

  • Uncommon characteristics of the structure and development of Trichosporon asahii.

    abstract:BACKGROUND:Trichosporon asahii (T. asahii) is one of the most important pathogenic fungus in the genus of trichosporon. Although the species identification of T. asahii was based upon the complicated results of morphologic, biochemical and biologic examination, the morphology characteristic is still the first clue to t...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Wang WL,Yang RY,Ao JH

    更新日期:2009-08-05 00:00:00

  • Outcomes of upper airway reconstructive surgery for obstructive sleep apnea syndrome based on polysomnography after nasopharyngeal tube insertion.

    abstract:BACKGROUND:The most common obstruction sites for obstructive sleep apnea hypopnea syndrome (OSAHS) are the oropharynx and the glossopharyx. The diagnosis of glossopharyngeal airway obstruction is difficult. The study aimed to assess the effect of upper airway reconstructive surgery for OSAHS based on polysomnography (P...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Li SH,Wu DH,Bao JM,Shi HJ

    更新日期:2013-01-01 00:00:00