Therapeutic Effects of Sodium Hyaluronate on Ocular Surface Damage Induced by Benzalkonium Chloride Preserved Anti-glaucoma Medications.

Abstract:

BACKGROUND:Long-term use of benzalkonium chloride (BAC)-preserved drugs is often associated with ocular surface toxicity. Ocular surface symptoms had a substantial impact on the glaucoma patients' quality of life and compliance. This study aimed to investigate the effects of sodium hyaluronate (SH) on ocular surface toxicity induced by BAC-preserved anti-glaucoma medications treatment. METHODS:Fifty-eight patients (101 eyes), who received topical BAC-preserved anti-glaucoma medications treatment and met the severe dry eye criteria, were included in the analysis. All patients were maintained the original topical anti-glaucoma treatment. In the SH-treated group (56 eyes), unpreserved 0.3% SH eye drops were administered with 3 times daily for 90 days. In the control group (55 eyes), phosphate-buffered saline were administered with 3 times daily for 90 days. Ocular Surface Disease Index (OSDI) questionnaire, break-up time (BUT) test, corneal fluorescein staining, corneal and conjunctival rose Bengal staining, Schirmer test, and conjunctiva impression cytology were performed sequentially on days 0 and 91. RESULTS:Compared with the control group, SH-treated group showed decrease in OSDI scores (Kruskal-Wallis test: H = 38.668, P < 0.001), fluorescein and rose Bengal scores (Wilcoxon signed-ranks test: z = -3.843, P < 0.001, and z = -3.508, P < 0.001, respectively), increase in tear film BUT (t-test: t = -10.994, P < 0.001) and aqueous tear production (t-test: t = -10.328, P < 0.001) on day 91. The goblet cell density was increased (t-test: t = -9.981, P < 0.001), and the morphology of the conjunctival epithelium were also improved after SH treatment. CONCLUSIONS:SH significantly improved both symptoms and signs of ocular surface damage in patients with BAC-preserved anti-glaucoma medications treatment. SH could be proposed as a new attempt to reduce ocular surface toxicity, and alleviate symptoms of ocular surface damage in BAC-preserved anti-glaucoma medications treatment.

journal_name

Chin Med J (Engl)

journal_title

Chinese medical journal

authors

Liu X,Yu FF,Zhong YM,Guo XX,Mao Z

doi

10.4103/0366-6999.164927

subject

Has Abstract

pub_date

2015-09-20 00:00:00

pages

2444-9

issue

18

eissn

0366-6999

issn

2542-5641

pii

ChinMedJ_2015_128_18_2444_164927

journal_volume

128

pub_type

临床试验,杂志文章
  • Long-term effects of drug-eluting stents versus bare metal stents on patients with acute ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention: outcomes of 3-year clinical follow-up.

    abstract:BACKGROUND:The long-term safety and efficacy of drug-eluting stents (DES) versus bare metal stents (BMS) are unclear and controversial issues in patients with acute ST-elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI). The purpose of this study was to compare the long-t...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Wang CH,Fang Q,Zhang SY,Shen ZJ,Fan ZJ,Jin XF,Zeng Y,Liu ZY,Xie HZ,Yang M

    更新日期:2012-08-01 00:00:00

  • ESR spin trapping studies on the free radicals in gasphase of cigarette smoking.

    abstract::Free radicals in the gasphase of cigarette smoke were determined by spin trapping agent PBN (N-tert-butyl-2-phenyl nitrone) and DMPO (5,5-dimethyl-1-pyrroline-oxide) on electron spin resonance spectrometer. They were identified according to the spectrum parameters calculated from the spectra. The free radicals mainly ...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Zhao BL,Yan LJ,Hou JW,Xin WJ

    更新日期:1991-07-01 00:00:00

  • Comparative study of the effects of ouabain and digoxin on blood pressure of rats.

    abstract:OBJECTIVE:To compare the effect of ouabain on the blood pressure of rats with that of digoxin to find the evidences of the relationship between endogenous ouabain (EO) and development of hypertension. METHODS:Sprague-Dawley rats, which were divided into 3 groups, were infused with ouabain (23 x 75 micrograms.kg-1/day,...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Wang H,Lu Z,Yuan W

    更新日期:1997-12-01 00:00:00

  • Endovascular treatment of cerebral arteriovenous malformations with Onyx embolization.

    abstract:BACKGROUND:In the past 5 years, new treatment materials and techniques offering a different concept in endovascular treatment have been described for cerebral arteriovenous malformations (CAVMs). The aim of this study was to assess the endovascular treatment of CAVMs by using a liquid embolic material, Onyx (Micro Ther...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: He HW,Jiang CH,Liu HB,Li YX,Zhang JB,Wu ZX

    更新日期:2005-12-20 00:00:00

  • Sutureless choledochoduodenostomy with an intraluminal degradable stent in dog model.

    abstract:BACKGROUND:It is difficult and time-consuming for carrying out conventional hand-sewn bilioenteric anastomosis, especially for small bile duct anastomosis and laparoscopic procedure. In order to simplify it, we have developed a novel procedure of sutureless bilioenteric anastomosis with an intraluminal degradable stent...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Zhu LH,Liang X,Lin H,Wang YF,Zhu YP,Cai XJ

    更新日期:2011-07-05 00:00:00

  • Clinical manifestations and immunological features of primary Sjögren's syndrome with liver involvement: analysis of thirty cases.

    abstract:OBJECTIVE:To evaluate the incidence, severity, clinical manifestations and immunological features relevant to liver involvement in 135 cases of primary Sjögren's syndrome. METHODS:One hundred and thirty-five patients with definite primary Sjögren's syndrome were analyzed retrospectively for liver involvement by the ab...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Zhang Z,Dong Y

    更新日期:1998-03-01 00:00:00

  • Activation and coreceptor expression of T lymphocytes induced by highly active antiretroviral therapy in Chinese HIV/AIDS patients.

    abstract:BACKGROUND:At the end of 2005, 650,000 people lived with human immunodeficiency virus type-1 (HIV-1) in China, of whom 75 000 were AIDS patients. Many AIDS patients received highly active antiretroviral therapy (HAART) supported by the "China CARES" program but the immune responses of HAART were seldom reported. This s...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Zhang ZN,Shang H,Jiang YJ,Liu J,Dai D,Diao YY,Geng WQ,Jin X,Wang YN

    更新日期:2006-12-05 00:00:00

  • Neoadjuvant Chemoradiotherapy Improving Survival Outcomes for Esophageal Carcinoma: An Updated Meta-analysis.

    abstract:BACKGROUND:The effectiveness of neoadjuvant chemoradiotherapy (NCRT) treatment for patients with esophageal carcinoma (EC) remains controversial. The aim of this study was to compare the effect of NCRT followed by surgery (NCRTS) with surgery alone (SA) for EC. METHODS:The PubMed, EMBASE, and the Cochrane Library data...

    journal_title:Chinese medical journal

    pub_type: 杂志文章,meta分析

    doi:10.4103/0366-6999.195464

    authors: Wang DB,Sun ZY,Deng LM,Zhu DQ,Xia HG,Zhu PZ

    更新日期:2016-12-20 00:00:00

  • Comparison of adjacent segment degeneration five years after single level cervical fusion and cervical arthroplasty: a retrospective controlled study.

    abstract:BACKGROUND:Cervical arthroplasty is indicated to preserve cervical motion and prevent accelerated adjacent segment degeneration. Whether accelerated adjacent segment degeneration is prevented in the long term is unclear. This trial compared adjacent segment degeneration in Bryan disc arthroplasty with that in anterior ...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Sun Y,Zhao YB,Pan SF,Zhou FF,Chen ZQ,Liu ZJ

    更新日期:2012-11-01 00:00:00

  • Postablation neutrophil/lymphocyte ratio correlates with arrhythmia recurrence after catheter ablation of lone atrial fibrillation.

    abstract:BACKGROUND:Neutrophil/lymphocyte ratio (NLR) has been proposed as a novel marker of systemic inflammation and oxidative stress. The objective of this study was to ascertain the relationship between levels of NLR and recurrence of lone atrial fibrillation (AF) after catheter ablation. METHODS:A total of 379 lone AF pat...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Guo X,Zhang S,Yan X,Chen Y,Yu R,Long D,Sang C,Du X,Dong J,Ma C

    更新日期:2014-01-01 00:00:00

  • Mutation detection of type II hair cortex keratin gene KRT86 in a Chinese Han family with congenital monilethrix.

    abstract:BACKGROUND:Monilethrix is an autosomal dominant hair disorder characterized clinically by alopecia and follicular papules. In this study, we collected a Han monilethrix family to detect the mutations in patients and investigated the correlation between the genotype and phenotype of monilethrix. METHODS:In this study, ...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Ye ZZ,Nan X,Zhao HS,Chen XR,Song QH

    更新日期:2013-08-01 00:00:00

  • Nanoparticles as a vaccine adjuvant of anti-idiotypic antibody against schistosomiasis.

    abstract:BACKGROUND:The development of new adjuvants for human use has been the focus of attention. This study's aim is to explore the possibility of using nanoparticle Ca nanoparticles (CA) as a vaccine adjuvant of anti-idiotypic antibody NP30 against schistosomiasis and its protective mechanisms. METHODS:Nanoparticle CA-NP30...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Feng ZQ,Zhong SG,Li YH,Li YQ,Qiu ZN,Wang ZM,Li J,Dong L,Guan XH

    更新日期:2004-01-01 00:00:00

  • Ultrastructural study of hip joint osteoarthritis. Scanning electron microscopic study of articular cartilage of femoral head.

    abstract::The surface structure of four different articular cartilages of the femoral head was studied with scanning electron microscope in 12 cases of hip joint osteoarthritis. These articular cartilages were mink white, yellow, dusky red and hyperplastic and thickened. The osteoarthritic articular cartilage surface was uneven...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Chai BF,Tang XM

    更新日期:1990-04-01 00:00:00

  • An alternative therapy for drug-resistant epilepsy: transcutaneous auricular vagus nerve stimulation.

    abstract:BACKGROUND:Previous studies demonstrated that vagus nerve stimulation (VNS) is an effective therapy for drug-resistant epilepsy. Acupuncture is also used to treat epilepsy. This study was designed to examine the safety and effectiveness of transcutaneous auricular vagus nerve stimulation (ta-VNS) for patients with drug...

    journal_title:Chinese medical journal

    pub_type: 杂志文章,随机对照试验

    doi:

    authors: Rong P,Liu A,Zhang J,Wang Y,Yang A,Li L,Ben H,Li L,Liu R,He W,Liu H,Huang F,Li X,Wu P,Zhu B

    更新日期:2014-01-01 00:00:00

  • Blood purification therapy in treatment of acute renal failure in infants with melamine-induced stones.

    abstract:BACKGROUND:In 2008, infants in some areas of China suffered from stones of the urinary system which were caused by melamine-contaminated milk formula. Most of the infants were asymptomatic, and a few suffered from acute renal failure induced by urinary obstruction by stones. This study aimed to assess the significance ...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Shen Y,Liu XR,Zhang GJ,Zhou N

    更新日期:2009-02-05 00:00:00

  • Involvement of hydrogen sulfide in the progression of renal fibrosis.

    abstract:OBJECTIVE:Renal fibrosis is the most common manifestation of chronic kidney disease (CKD). Noting that existing treatments of renal fibrosis only slow disease progression but do not cure it, there is an urgent need to identify novel therapies. Hydrogen sulfide (H2S) is a newly discovered endogenous small gas signaling ...

    journal_title:Chinese medical journal

    pub_type: 杂志文章,评审

    doi:10.1097/CM9.0000000000000537

    authors: Wang Y,Xing QQ,Tu JK,Tang WB,Yuan XN,Xie YY,Wang W,Peng ZZ,Huang L,Xu H,Qin J,Xiao XC,Tao LJ,Yuan QJ

    更新日期:2019-12-05 00:00:00

  • Acute Fatty Liver of Pregnancy: A Retrospective Analysis of 56 Cases.

    abstract:BACKGROUND:Acute fatty liver of pregnancy (AFLP) is a rare but life-threatening complication occurring in the third trimester. It is often fatal to both mother and fetus. The complicated clinical manifestations as well as an insufficient understanding of the disease make the precise diagnosis and effective treatment of...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:10.4103/0366-6999.181963

    authors: Zhang YP,Kong WQ,Zhou SP,Gong YH,Zhou R

    更新日期:2016-05-20 00:00:00

  • Studies on the creatine kinase MM isoforms of normal and Duchenne muscular dystrophic patients.

    abstract:OBJECTIVE:To study the changes of creatine kinase MM (CK-MM) isoforms in Duchenne muscular dystrophy (DMD) patients. METHODS:Serum samples from 49 DMD patients and 40 control subjects were collected for CK-MM isoforms measurement. CK-MM isoforms were separated within 30 minutes by electrophoresis on agarose gel with a...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Zhao X,Bi C,Yang Z

    更新日期:1998-01-01 00:00:00

  • Sex hormone receptors of hemangiomas in children.

    abstract:OBJECTIVE:To investigate whether or not estrogen receptor and other sex hormone receptors are present in hemangioma tissues of children. METHODS:Fifty-two specimens of hemangiomas were taken from 52 children. The specimens were doubly stained with hematoxylin-eosin and enzyme-linking affinity immunohistochemistry. The...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Lui W,Zhang S,Hu T,Wei F,Gao Y,Cheng N

    更新日期:1997-05-01 00:00:00

  • Role of connective growth factor in plasminogen activator inhibitor-1 and fibronectin expression induced by transforming growth factor beta1 in renal tubular cells.

    abstract:BACKGROUND:Connective tissue growth factor (CTGF) contributes greatly to renal tubulointerstitial fibrosis, which is the final event leading to end-stage renal failure. This study was designed to investigate the effects of CTGF antisense oligodeoxynucleotides (ODNs) on the expressions of plasminogen activator inhibitor...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Zhang C,Meng XF,Zhu ZH,Yang X,Deng AG

    更新日期:2004-07-01 00:00:00

  • Electromyographic monitoring of facial nerve under different levels of neuromuscular blockade during middle ear microsurgery.

    abstract:BACKGROUND:The evoked electromyography (EMG) is frequently used to identify facial nerve in order to prevent its damage during surgeries. Partial neuromuscular blockade (NMB) has been suggested to favor EMG activity and insure patients' safety. The aim of this study was to determine an adequate level of NMB corresponde...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Cai YR,Xu J,Chen LH,Chi FL

    更新日期:2009-02-05 00:00:00

  • Delayed graft function is correlated with graft loss in recipients of expanded-criteria rather than standard-criteria donor kidneys: a retrospective, multicenter, observation cohort study.

    abstract:BACKGROUND:Although the use of expanded-criteria donors (ECDs) alleviates the problem of organ shortage, it significantly increases the incidence of delayed graft function (DGF). DGF is a common complication after kidney transplantation; however, the effect of DGF on graft loss is uncertain based on the published liter...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:10.1097/CM9.0000000000000666

    authors: Han F,Lin MZ,Zhou HL,Li H,Sun QP,Huang ZY,Hong LQ,Wang G,Cai RM,Sun QQ

    更新日期:2020-03-05 00:00:00

  • Helicobacter pylori Infection is Associated with Occurrence of Proteinuria in Type 2 Diabetes Patients: A Systemic Review and Meta-Analysis.

    abstract:Background:Type 2 diabetes (T2DM) patients are susceptible to Helicobacter pylori (HP), and it has been reported that the occurrence of proteinuria is associated with HP infection in T2DM patients; however, this view remains controversial. This meta-analysis aimed to explore the association between HP infection and the...

    journal_title:Chinese medical journal

    pub_type: 杂志文章,meta分析,评审

    doi:10.4103/0366-6999.245269

    authors: Shi Y,Duan JY,Liu DW,Qiao YJ,Han QX,Pan SK,Tang L,Cai GY,Chen XM,Liu ZS,Zhu HY

    更新日期:2018-11-20 00:00:00

  • Safety and efficacy of a novel technique in the use of fractional flow reserve in complex coronary artery lesions.

    abstract:BACKGROUND:Fractional flow reserve (FFR) has become an increasingly important index when making decisions with respect to revascularization of coronary artery stenosis. However, the pressure guidewire used in obtaining FFR measurements is difficult to control and manipulate in certain complex coronary artery lesions, r...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:10.4103/0366-6999.152664

    authors: He WM,Li CL,Sun Y,Zhou Z,Mai YF

    更新日期:2015-03-20 00:00:00

  • ED 50 and ED 95 of intrathecal bupivacaine coadministered with sufentanil for cesarean delivery under combined spinal-epidural in severely preeclamptic patients.

    abstract:BACKGROUND:Spinal anesthesia was considered as a reasonable anesthetic option in severe preeclampsia when cesarean delivery is indicated, and there is no indwelling epidural catheter or contraindication to spinal anesthesia. However, the ideal dose of intrathecal bupivacaine has not been quantified for cesarean deliver...

    journal_title:Chinese medical journal

    pub_type: 杂志文章,随机对照试验

    doi:10.4103/0366-6999.150083

    authors: Xiao F,Xu WP,Zhang XM,Zhang YF,Wang LZ,Chen XZ

    更新日期:2015-02-05 00:00:00

  • Endolymphatic sac papillary tumor: a case report.

    abstract::Endolymphatic sac papillary tumor (ELST) is an extremely rare and aggressive tumor characterized by hearing loss and temporal bone destruction. A case with clinical, imaging, pathologic and treatment data is reported and relevant literature is reviewed. A 25-year-old woman, with ELST underwent craniotomy for tumor sub...

    journal_title:Chinese medical journal

    pub_type: 杂志文章,评审

    doi:

    authors: Yu SJ,Chen YD,Gao F,Qiu XG,Chang H

    更新日期:2011-11-01 00:00:00

  • New Delhi Metallo-β-Lactamase-Mediated Carbapenem Resistance: Origin, Diagnosis, Treatment and Public Health Concern.

    abstract:OBJECTIVE:To review the origin, diagnosis, treatment and public health concern of New Delhi metallo-β-lactamase (NDM)-producing bacteria. DATA SOURCES:We searched database for studies published in English. The database of PubMed from 2007 to 2015 was used to conduct a search using the keyword term "NDM and Acinetobact...

    journal_title:Chinese medical journal

    pub_type: 杂志文章,评审

    doi:10.4103/0366-6999.160566

    authors: Wei WJ,Yang HF,Ye Y,Li JB

    更新日期:2015-07-20 00:00:00

  • Menopausal depression: comparison of hormone replacement therapy and hormone replacement therapy plus fluoxetine.

    abstract:BACKGROUND:To compare the efficacy and safety of hormone replacement therapy (HRT) combined with fluoxetine, with HRT alone, in post-menopausal women suffering from depression. METHODS:A randomized, open-label, parallel trial was applied. HRT was administered to all patients for 2 cycles, with 14 days of estrogen ther...

    journal_title:Chinese medical journal

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Liu P,He FF,Bai WP,Yu Q,Shi W,Wu YY,He DJ,Xiao JH,Zheng Y,Liao QP

    更新日期:2004-02-01 00:00:00

  • Severe acute respiratory syndrome-associated coronavirus genotype and its characterization.

    abstract:OBJECTIVE:To study the severe acute respiratory syndrome (SARS)-associated coronavirus genotype and its characteristics. METHODS:A SARS-associated coronavirus isolate named ZJ01 was obtained from throat swab samples taken from a patient in Hangzhou, Zhejing province. The complete genome sequence of ZJ01 consisted of 2...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Li L,Wang Z,Lu Y,Bao Q,Chen S,Wu N,Cheng S,Weng J,Zhang Y,Yan J,Mei L,Wang X,Zhu H,Yu Y,Zhang M,Li M,Yao J,Lu Q,Yao P,Bo X,Wo J,Wang S,Hu S

    更新日期:2003-09-01 00:00:00

  • Preliminary experience in HDR brachytherapy for 72 nasopharyngeal carcinoma patients.

    abstract::From April 1989 to July 1991, 72 patients with residual or recurrent nasopharyngeal carcinoma (NPC) were treated by MSH Ir-192 brachytherapy or combined external radiation therapy. All were proven histologically. 39 patients with residual disease and 6 with recurrent lesion at the primary site were identified after on...

    journal_title:Chinese medical journal

    pub_type: 杂志文章

    doi:

    authors: Gao L,Xu GZ,Yin WB,Yan JH,Cai WM,Gu XZ

    更新日期:1993-06-01 00:00:00