Abstract:
BACKGROUND:Long-term use of benzalkonium chloride (BAC)-preserved drugs is often associated with ocular surface toxicity. Ocular surface symptoms had a substantial impact on the glaucoma patients' quality of life and compliance. This study aimed to investigate the effects of sodium hyaluronate (SH) on ocular surface toxicity induced by BAC-preserved anti-glaucoma medications treatment. METHODS:Fifty-eight patients (101 eyes), who received topical BAC-preserved anti-glaucoma medications treatment and met the severe dry eye criteria, were included in the analysis. All patients were maintained the original topical anti-glaucoma treatment. In the SH-treated group (56 eyes), unpreserved 0.3% SH eye drops were administered with 3 times daily for 90 days. In the control group (55 eyes), phosphate-buffered saline were administered with 3 times daily for 90 days. Ocular Surface Disease Index (OSDI) questionnaire, break-up time (BUT) test, corneal fluorescein staining, corneal and conjunctival rose Bengal staining, Schirmer test, and conjunctiva impression cytology were performed sequentially on days 0 and 91. RESULTS:Compared with the control group, SH-treated group showed decrease in OSDI scores (Kruskal-Wallis test: H = 38.668, P < 0.001), fluorescein and rose Bengal scores (Wilcoxon signed-ranks test: z = -3.843, P < 0.001, and z = -3.508, P < 0.001, respectively), increase in tear film BUT (t-test: t = -10.994, P < 0.001) and aqueous tear production (t-test: t = -10.328, P < 0.001) on day 91. The goblet cell density was increased (t-test: t = -9.981, P < 0.001), and the morphology of the conjunctival epithelium were also improved after SH treatment. CONCLUSIONS:SH significantly improved both symptoms and signs of ocular surface damage in patients with BAC-preserved anti-glaucoma medications treatment. SH could be proposed as a new attempt to reduce ocular surface toxicity, and alleviate symptoms of ocular surface damage in BAC-preserved anti-glaucoma medications treatment.
journal_name
Chin Med J (Engl)journal_title
Chinese medical journalauthors
Liu X,Yu FF,Zhong YM,Guo XX,Mao Zdoi
10.4103/0366-6999.164927subject
Has Abstractpub_date
2015-09-20 00:00:00pages
2444-9issue
18eissn
0366-6999issn
2542-5641pii
ChinMedJ_2015_128_18_2444_164927journal_volume
128pub_type
临床试验,杂志文章abstract:BACKGROUND:The long-term safety and efficacy of drug-eluting stents (DES) versus bare metal stents (BMS) are unclear and controversial issues in patients with acute ST-elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI). The purpose of this study was to compare the long-t...
journal_title:Chinese medical journal
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abstract::Free radicals in the gasphase of cigarette smoke were determined by spin trapping agent PBN (N-tert-butyl-2-phenyl nitrone) and DMPO (5,5-dimethyl-1-pyrroline-oxide) on electron spin resonance spectrometer. They were identified according to the spectrum parameters calculated from the spectra. The free radicals mainly ...
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更新日期:1997-12-01 00:00:00
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更新日期:1998-03-01 00:00:00
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pub_type: 杂志文章,meta分析
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pub_type: 杂志文章
doi:
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pub_type: 杂志文章,随机对照试验
doi:
更新日期:2014-01-01 00:00:00
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更新日期:2009-02-05 00:00:00
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pub_type: 杂志文章
doi:10.4103/0366-6999.181963
更新日期:2016-05-20 00:00:00
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doi:
更新日期:1998-01-01 00:00:00
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pub_type: 杂志文章
doi:
更新日期:1997-05-01 00:00:00
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pub_type: 杂志文章,meta分析,评审
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更新日期:2015-02-05 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2015-07-20 00:00:00
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pub_type: 临床试验,杂志文章,随机对照试验
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